Need Help?

Spatially confined sub-tumor microenvironments in pancreatic cancer

Intratumoral heterogeneity is a critical frontier in understanding how the tumor microenvironment (TME) propels malignant progression. Here, we deconvolute the human pancreatic TME through large-scale integration of histology-guided regional multiOMICs with clinical data and patient-derived preclinical models. We discover subTMEs, histologically definable tissue states anchored in fibroblast plasticity, with regional relationships to tumor immunity, subtypes, differentiation, and treatment response. Reactive subTMEs rich in complex but functionally coordinated fibroblast communities were immune-hot and inhabited by aggressive tumor cell phenotypes. The matrix-rich deserted subTMEs harbored less activated fibroblasts and tumor- suppressive features yet were markedly chemoprotective and enriched upon chemotherapy. SubTMEs originated in fibroblast differentiation trajectories and transitory states were notable both in single cell transcriptomics and in situ. The intratumoral co-occurrence of subTMEs produced patient-specific phenotypic and computationally predictable heterogeneity tightly linked to malignant biology. Therefore, heterogeneity within the plentiful, notorious pancreatic TME is not random but marks fundamental tissue organizational units.

Request Access

OICR Data Access Agreement v2.0. Link to Policy Url here

OICR-DAC manages genomic and transcriptomic data sets generated at the Ontario Institute for Cancer Research 1. To access data, you must complete the OICR Data Access Agreement (DAA, see Policy Url above). Fields in red are mandatory. 2. The DAA should include the name(s) of all investigators who will download and/or analyze data. 3. All investigators must be from the same institution, and institutional email addresses must be used. 4. The DAA must be signed by an institutional signatory who has authority to bind the corporation. 5. Once completed, forward to for review. Data access will be granted upon final execution of the agreement. Note: To access and download data, each investigator must submit a “Request Access” form on the EGA website. A separate DAA is not required if they are already named on a fully executed DAA (as per above).

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001002543 Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00002292672 bam 5.0 GB
EGAF00002292678 bam 2.8 GB
EGAF00002292679 bam 5.9 GB
EGAF00002292683 bam 2.9 GB
EGAF00002292693 bam 4.9 GB
EGAF00002292695 bam 3.7 GB
EGAF00002292696 bam 4.9 GB
EGAF00002292706 bam 6.9 GB
EGAF00002292709 bam 4.5 GB
EGAF00002292710 bam 6.7 GB
EGAF00002293345 bam 5.0 GB
EGAF00002293349 bam 5.4 GB
EGAF00002293353 bam 3.5 GB
EGAF00002293367 bam 6.4 GB
EGAF00002293369 bam 2.8 GB
EGAF00002293378 bam 11.5 GB
EGAF00002293401 bam 7.6 GB
EGAF00002293403 bam 5.2 GB
EGAF00002300222 fastq.gz 138.0 MB
EGAF00002300223 fastq.gz 131.9 MB
EGAF00002300226 fastq.gz 506.3 MB
EGAF00002300227 fastq.gz 508.6 MB
EGAF00002300228 fastq.gz 222.6 MB
EGAF00002300229 fastq.gz 225.6 MB
EGAF00002300246 fastq.gz 356.9 MB
EGAF00002300247 fastq.gz 354.6 MB
EGAF00002300250 fastq.gz 340.2 MB
EGAF00002300251 fastq.gz 349.4 MB
EGAF00002300322 fastq.gz 175.1 MB
EGAF00002300323 fastq.gz 164.8 MB
EGAF00002300328 fastq.gz 199.6 MB
EGAF00002300329 fastq.gz 211.6 MB
EGAF00002300330 fastq.gz 293.3 MB
EGAF00002300331 fastq.gz 284.6 MB
EGAF00002300346 fastq.gz 340.7 MB
EGAF00002300347 fastq.gz 358.5 MB
EGAF00002300354 fastq.gz 429.4 MB
EGAF00002300355 fastq.gz 445.7 MB
EGAF00002300362 fastq.gz 290.2 MB
EGAF00002300363 fastq.gz 294.8 MB
EGAF00002300506 fastq.gz 563.3 MB
EGAF00002300507 fastq.gz 556.1 MB
EGAF00002300508 fastq.gz 578.3 MB
EGAF00002300509 fastq.gz 575.9 MB
EGAF00002300518 fastq.gz 821.1 MB
EGAF00002300519 fastq.gz 865.3 MB
EGAF00002300532 fastq.gz 149.3 MB
EGAF00002300533 fastq.gz 150.9 MB
EGAF00002300544 fastq.gz 113.8 MB
EGAF00002300545 fastq.gz 113.0 MB
EGAF00002300546 fastq.gz 248.4 MB
EGAF00002300547 fastq.gz 225.7 MB
EGAF00002300554 fastq.gz 78.8 MB
EGAF00002300555 fastq.gz 77.7 MB
EGAF00002300568 fastq.gz 188.3 MB
EGAF00002300569 fastq.gz 179.1 MB
EGAF00002300572 fastq.gz 243.6 MB
EGAF00002300573 fastq.gz 246.7 MB
EGAF00002300604 fastq.gz 1.0 GB
EGAF00002300605 fastq.gz 1.1 GB
EGAF00002300612 fastq.gz 309.2 MB
EGAF00002300613 fastq.gz 326.1 MB
EGAF00002300618 fastq.gz 348.3 MB
EGAF00002300619 fastq.gz 364.3 MB
EGAF00002300652 fastq.gz 385.9 MB
EGAF00002300653 fastq.gz 351.0 MB
EGAF00002300668 fastq.gz 329.1 MB
EGAF00002300669 fastq.gz 348.0 MB
EGAF00002301238 bam 8.4 GB
EGAF00002301246 bam 7.9 GB
EGAF00002301251 bam 7.6 GB
EGAF00002301252 bam 5.8 GB
EGAF00002301349 bam 5.9 GB
EGAF00002301357 bam 4.7 GB
EGAF00002301359 bam 4.0 GB
EGAF00003212012 bam 6.1 GB
EGAF00003212013 bam 5.9 GB
EGAF00003247568 bam 7.3 GB
EGAF00003249718 fastq.gz 228.2 MB
EGAF00003249719 fastq.gz 229.6 MB
EGAF00003249918 fastq.gz 251.0 MB
EGAF00003249919 fastq.gz 250.6 MB
EGAF00003249972 fastq.gz 167.3 MB
EGAF00003249973 fastq.gz 166.0 MB
EGAF00003945157 bam 2.8 GB
EGAF00004169428 fastq.gz 284.3 MB
EGAF00004169429 fastq.gz 295.7 MB
EGAF00005488983 fastq.gz 213.5 MB
EGAF00005488984 fastq.gz 216.0 MB
EGAF00005488985 fastq.gz 110.8 MB
EGAF00005488986 fastq.gz 113.1 MB
EGAF00005488987 fastq.gz 208.6 MB
EGAF00005488988 fastq.gz 213.5 MB
EGAF00005488989 fastq.gz 67.6 MB
EGAF00005488990 fastq.gz 70.3 MB
EGAF00005488991 fastq.gz 217.8 MB
EGAF00005488992 fastq.gz 224.0 MB
EGAF00005488993 fastq.gz 195.0 MB
EGAF00005488994 fastq.gz 202.2 MB
EGAF00005488995 fastq.gz 344.3 MB
EGAF00005488996 fastq.gz 355.6 MB
EGAF00005488997 fastq.gz 67.2 MB
EGAF00005488998 fastq.gz 69.1 MB
EGAF00005488999 fastq.gz 46.8 MB
EGAF00005489000 fastq.gz 48.4 MB
EGAF00005489001 fastq.gz 220.7 MB
EGAF00005489002 fastq.gz 224.4 MB
EGAF00005489003 fastq.gz 611.3 MB
EGAF00005489004 fastq.gz 619.9 MB
EGAF00005489005 fastq.gz 60.5 MB
EGAF00005489006 fastq.gz 62.6 MB
EGAF00005489007 fastq.gz 126.8 MB
EGAF00005489008 fastq.gz 130.2 MB
EGAF00005489009 fastq.gz 101.1 MB
EGAF00005489010 fastq.gz 104.7 MB
EGAF00005489011 fastq.gz 181.4 MB
EGAF00005489012 fastq.gz 187.9 MB
EGAF00005489013 fastq.gz 60.8 MB
EGAF00005489014 fastq.gz 63.3 MB
EGAF00005489015 fastq.gz 262.1 MB
EGAF00005489016 fastq.gz 268.7 MB
EGAF00005489017 fastq.gz 106.0 MB
EGAF00005489018 fastq.gz 109.5 MB
EGAF00005489019 fastq.gz 204.3 MB
EGAF00005489020 fastq.gz 211.7 MB
EGAF00005489021 fastq.gz 79.6 MB
EGAF00005489022 fastq.gz 79.7 MB
EGAF00005489023 fastq.gz 110.1 MB
EGAF00005489024 fastq.gz 113.8 MB
EGAF00005489025 fastq.gz 244.7 MB
EGAF00005489026 fastq.gz 247.1 MB
EGAF00005489027 fastq.gz 73.2 MB
EGAF00005489028 fastq.gz 72.1 MB
EGAF00005489029 fastq.gz 85.4 MB
EGAF00005489030 fastq.gz 85.7 MB
EGAF00005489031 fastq.gz 60.3 MB
EGAF00005489032 fastq.gz 63.7 MB
EGAF00005489033 fastq.gz 103.9 MB
EGAF00005489034 fastq.gz 106.3 MB
EGAF00005489035 fastq.gz 43.8 MB
EGAF00005489036 fastq.gz 43.3 MB
EGAF00005489037 fastq.gz 163.1 MB
EGAF00005489038 fastq.gz 172.5 MB
EGAF00005489039 fastq.gz 69.1 MB
EGAF00005489040 fastq.gz 71.4 MB
EGAF00005492395 bam 11.8 GB
EGAF00005492396 bam 7.4 GB
EGAF00005492397 bam 9.3 GB
EGAF00005492398 bam 6.2 GB
EGAF00005492399 bam 8.2 GB
EGAF00005492400 bam 11.1 GB
EGAF00005492401 bam 13.5 GB
EGAF00005492402 bam 5.6 GB
EGAF00005492403 bam 5.4 GB
EGAF00005492404 bam 8.7 GB
EGAF00005492405 bam 23.8 GB
EGAF00005492406 bam 4.9 GB
EGAF00005492407 bam 10.7 GB
EGAF00005492408 bam 7.6 GB
EGAF00005492409 bam 6.9 GB
EGAF00005492410 bam 6.5 GB
EGAF00005492411 bam 11.2 GB
EGAF00005492412 bam 4.1 GB
EGAF00005492413 bam 5.9 GB
EGAF00005492414 bam 4.7 GB
EGAF00005492415 bam 6.1 GB
EGAF00005492416 bam 14.9 GB
EGAF00005492417 bam 6.0 GB
EGAF00005492418 bam 9.8 GB
EGAF00005492419 bam 3.2 GB
EGAF00005492420 bam 9.2 GB
EGAF00005492421 bam 5.1 GB
EGAF00005492422 bam 14.3 GB
EGAF00005492423 bam 5.8 GB
174 Files (438.4 GB)