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Hubrecht Organoid Technology Colon Cancer Study

Functional screening on patient-derived organoids identifies a therapeutic bispecific antibody that triggers EGFR degradation in LGR5+ tumor cells

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A policy for access to Colon Cancer Study data.

DATA ACCESS AGREEMENT These terms and conditions govern access to the managed access datasets (details of which are set out in Appendix I) to which the User Institution has requested access. The User Institution agrees to be bound by these terms and conditions. Definitions Authorised Personnel: The individuals at the User Institution to whom HUBRECHT ORGANOID TECHNOLOGY grants access to the Data. This includes the User, the individuals listed in Appendix II and any other individuals for whom the User Institution subsequently requests access to the Data. Details of the initial Authorised Personnel are set out in Appendix II. Data: The managed access datasets to which the User Institution has requested access. Data Producers: HUBRECHT ORGANOID TECHNOLOGY and the collaborators listed in Appendix I responsible for the development, organisation, and oversight of these Data. External Collaborator: A collaborator of the User, working for an institution other than the User Institution. Project: The project for which the User Institution has requested access to these Data. A description of the Project is set out in Appendix II. Publications: Includes, without limitation, articles published in print journals, electronic journals, reviews, books, posters and other written and verbal presentations of research. Research Participant: An individual whose data form part of these Data. Research Purposes: Shall mean research that is seeking to advance the understanding of genetics and genomics, including the treatment of disorders, and work on statistical methods that may be applied to such research. User: The principal investigator for the Project. User Institution(s): The Institution that has requested access to the Data. HUBRECHT ORGANOID TECHNOLOGY: Your Institution details here 1. The User Institution agrees to only use these Data for the purpose of the Project (described in Appendix II) and only for Research Purposes. The User Institution further agrees that it will only use these Data for Research Purposes which are within the limitations (if any) set out in Appendix I. 2. The User Institution agrees to preserve, at all times, the confidentiality of these Data. In particular, it undertakes not to use, or attempt to use these Data to compromise or otherwise infringe the confidentiality of information on Research Participants. Without prejudice to the generality of the foregoing, the User Institution agrees to use at least the measures set out in Appendix I to protect these Data. 3. The User Institution agrees to protect the confidentiality of Research Participants in any research papers or publications that they prepare by taking all reasonable care to limit the possibility of identification. 4. The User Institution agrees not to link or combine these Data to other information or archived data available in a way that could re-identify the Research Participants, even if access to that data has been formally granted to the User Institution or is freely available without restriction. 5. The User Institution agrees only to transfer or disclose these Data, in whole or part, or any material derived from these Data, to the Authorised Personnel. Should the User Institution wish to share these Data with an External Collaborator, the External Collaborator must complete a separate application for access to these Data. 6. The User Institution agrees that the Data Producers, and all other parties involved in the creation, funding or protection of these Data: a) make no warranty or representation, express or implied as to the accuracy, quality or comprehensiveness of these Data; b) exclude to the fullest extent permitted by law all liability for actions, claims, proceedings, demands, losses (including but not limited to loss of profit), costs, awards damages and payments made by the Recipient that may arise (whether directly or indirectly) in any way whatsoever from the Recipient’s use of these Data or from the unavailability of, or break in access to, these Data for whatever reason and; c) bear no responsibility for the further analysis or interpretation of these Data. 7. The User Institution agrees to follow the Fort Lauderdale Guidelines (http://www.wellcome.ac.uk/stellent/groups/corporatesite/@policy_communications/documents/web_document/wtd003207.pdf ) and the Toronto Statement (http://www.nature.com/nature/journal/v461/n7261/full/461168a.html). This includes but is not limited to recognising the contribution of the Data Producers and including a proper acknowledgement in all reports or publications resulting from the use of these Data. 8. The User Institution agrees to follow the Publication Policy in Appendix III. This includes respecting the moratorium period for the Data Producers to publish the first peer-reviewed report describing and analysing these Data. 9. The User Institution agrees not to make intellectual property claims on these Data and not to use intellectual property protection in ways that would prevent or block access to, or use of, any element of these Data, or conclusion drawn directly from these Data. 10. The User Institution can elect to perform further research that would add intellectual and resource capital to these data and decide to obtain intellectual property rights on these downstream discoveries. In this case, the User Institution agrees to implement licensing policies that will not obstruct further research and to follow the U.S. National Institutes of Health Best Practices for the Licensing of Genomic Inventions (2005) (https://www.icgc.org/files/daco/NIH_BestPracticesLicensingGenomicInventions_2005_en.pdf ) in conformity with the Organisation for Economic Co-operation and Development Guidelines for the Licensing of the Genetic Inventions (2006) (http://www.oecd.org/science/biotech/36198812.pdf ). 11. The User Institution agrees to destroy/discard the Data held, once it is no longer used for the Project, unless obliged to retain the data for archival purposes in conformity with audit or legal requirements. 12. The User Institution will notify HUBRECHT ORGANOID TECHNOLOGY within 30 days of any changes or departures of Authorised Personnel. 13. The User Institution will notify HUBRECHT ORGANOID TECHNOLOGY prior to any significant changes to the protocol for the Project. 14. The User Institution will notify HUBRECHT ORGANOID TECHNOLOGY as soon as it becomes aware of a breach of the terms or conditions of this agreement. 15. HUBRECHT ORGANOID TECHNOLOGY may terminate this agreement by written notice to the User Institution. If this agreement terminates for any reason, the User Institution will be required to destroy any Data held, including copies and backup copies. This clause does not prevent the User Institution from retaining these data for archival purpose in conformity with audit or legal requirements. 16. The User Institution accepts that it may be necessary for the Data Producers to alter the terms of this agreement from time to time. As an example, this may include specific provisions relating to the Data required by Data Producers other than HUBRECHT ORGANOID TECHNOLOGY. In the event that changes are required, the Data Producers or their appointed agent will contact the User Institution to inform it of the changes and the User Institution may elect to accept the changes or terminate the agreement. 17. If requested, the User Institution will allow data security and management documentation to be inspected to verify that it is complying with the terms of this agreement. 18. The User Institution agrees to distribute a copy of these terms to the Authorised Personnel. The User Institution will procure that the Authorised Personnel comply with the terms of this agreement. 19. This agreement (and any dispute, controversy, proceedings or claim of whatever nature arising out of this agreement or its formation) shall be construed, interpreted and governed by the laws of England and Wales and shall be subject to the exclusive jurisdiction of the English courts. Agreed for User Institution Signature: Name: Title: Date: Principal Investigator I confirm that I have read and understood this Agreement. Signature: Name: Title: Date: Agreed for HUBRECHT ORGANOID TECHNOLOGY Signature: Name: Title: Date: APPENDIX I – DATASET DETAILS APPENDIX II ––PROJECT DETAILS APPENDIX III –– PUBLICATION POLICY APPENDIX I – DATASET DETAILS (to be completed by the data producer before passing to applicant) Dataset reference (EGA Study ID and Dataset Details) EGAS00001004584 Functional screening on patient-derived organoids identifies a therapeutic bispecific antibody that triggers EGFR degradation in LGR5+ tumor cells Name of project that created the dataset Functional screening on patient-derived organoids identifies a therapeutic bispecific antibody that triggers EGFR degradation in LGR5+ tumor cells Names of other data producers/collaborators Specific limitations on areas of research Minimum protection measures required File access: Data can be held in unencrypted files on an institutional compute system, with Unix user group read/write access for one or more appropriate groups but not Unix world read/write access behind a secure firewall. Laptops holding these data should have password protected logins and screenlocks (set to lock after 5 min of inactivity). If held on USB keys or other portable hard drives, the data must be encrypted. APPENDIX II – PROJECT DETAILS (to be completed by the Requestor) Details of dataset requested i.e., EGA Study and Dataset Accession Number Brief abstract of the Project in which the Data will be used (500 words max) All Individuals who the User Institution to be named as registered users Name of Registered User Email Job Title Supervisor* All Individuals that should have an account created at the EGA Name of Registered User Email Job Title APPENDIX III – PUBLICATION POLICY HUBRECHT ORGANOID TECHNOLOGY intend to publish the results of their analysis of this dataset and do not consider its deposition into public databases to be the equivalent of such publications. HUBRECHT ORGANOID TECHNOLOGY anticipate that the dataset could be useful to other qualified researchers for a variety of purposes. However, some areas of work are subject to a publication moratorium. The publication moratorium covers any publications (including oral communications) that describe the use of the dataset. For research papers, submission for publication should not occur until XX months after these data were first made available on the relevant hosting database, unless HUBRECHT ORGANOID TECHNOLOGY has provided written consent to earlier submission. In any publications based on these data, please describe how the data can be accessed, including the name of the hosting database (e.g., The European Genome-phenome Archive at the European Bioinformatics Institute) and its accession numbers, and acknowledge its use in a form agreed by the User Institution with HUBRECHT ORGANOID TECHNOLOGY.

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001004584 Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00005745378 bam 6.8 GB
EGAF00005745379 bam 6.4 GB
EGAF00005745380 bam 7.1 GB
EGAF00005745381 bam 7.1 GB
EGAF00005745382 bam 7.5 GB
EGAF00005745383 bam 7.1 GB
EGAF00005745384 bam 6.8 GB
EGAF00005745385 bam 4.8 GB
EGAF00005745386 bam 7.6 GB
EGAF00005745387 bam 7.8 GB
EGAF00005745388 bam 7.1 GB
EGAF00005745389 bam 6.8 GB
EGAF00005745390 bam 6.1 GB
EGAF00005745391 bam 5.3 GB
EGAF00005745392 bam 7.1 GB
EGAF00005745393 bam 7.9 GB
EGAF00005745394 bam 4.6 GB
EGAF00005745395 bam 8.3 GB
EGAF00005745396 bam 5.3 GB
EGAF00005745397 bam 7.6 GB
EGAF00005745398 bam 6.8 GB
EGAF00005745399 bam 5.2 GB
EGAF00005745400 bam 4.5 GB
EGAF00005745401 bam 4.8 GB
EGAF00005745402 bam 7.1 GB
EGAF00005745403 bam 4.6 GB
EGAF00005745404 bam 4.8 GB
EGAF00005745405 bam 5.9 GB
EGAF00005745406 bam 4.8 GB
EGAF00005745407 bam 7.1 GB
EGAF00005745408 bam 6.3 GB
EGAF00005745409 bam 7.7 GB
EGAF00005745410 bam 5.2 GB
EGAF00005745411 bam 5.7 GB
EGAF00005745412 bam 7.4 GB
EGAF00005745413 bam 7.3 GB
EGAF00005745414 bam 4.5 GB
EGAF00005745415 bam 4.9 GB
EGAF00005745416 bam 6.9 GB
EGAF00005745417 bam 6.4 GB
EGAF00005745418 bam 4.5 GB
EGAF00005745419 bam 5.6 GB
EGAF00005745420 bam 5.1 GB
EGAF00005745421 bam 5.1 GB
EGAF00005745422 bam 5.2 GB
EGAF00005745423 bam 5.7 GB
EGAF00005745424 bam 5.6 GB
EGAF00005745425 bam 5.5 GB
EGAF00005745426 bam 5.5 GB
EGAF00005745427 bam 5.1 GB
EGAF00005745428 bam 6.0 GB
EGAF00005745429 bam 8.5 GB
EGAF00005745430 bam 7.6 GB
EGAF00005745431 bam 5.4 GB
EGAF00005745432 bam 8.5 GB
EGAF00005745433 bam 5.5 GB
EGAF00005745434 bam 5.6 GB
EGAF00005745435 bam 7.8 GB
EGAF00005745436 bam 4.5 GB
EGAF00005745437 bam 8.2 GB
EGAF00005745438 bam 7.3 GB
EGAF00005745439 bam 8.0 GB
EGAF00005745440 bam 7.6 GB
EGAF00005745441 bam 4.2 GB
EGAF00005745442 bam 8.3 GB
EGAF00005745443 bam 4.4 GB
EGAF00005745444 bam 3.6 GB
EGAF00005745445 bam 4.5 GB
EGAF00005745446 bam 8.1 GB
EGAF00005745447 bam 8.0 GB
EGAF00005745496 bam 4.8 GB
EGAF00005745497 bam 7.3 GB
EGAF00005745498 bam 7.7 GB
EGAF00005745499 bam 4.2 GB
EGAF00005745500 bam 5.4 GB
EGAF00005745501 bam 4.8 GB
EGAF00005745502 bam 6.8 GB
EGAF00005745503 bam 4.0 GB
EGAF00005745504 bam 4.4 GB
EGAF00005745505 bam 5.5 GB
EGAF00005745506 bam 5.7 GB
EGAF00005745507 bam 5.3 GB
EGAF00005745508 bam 5.8 GB
EGAF00005745509 bam 4.6 GB
EGAF00005745510 bam 5.5 GB
EGAF00005745511 bam 4.6 GB
EGAF00005745512 bam 4.9 GB
EGAF00005745513 bam 4.2 GB
EGAF00005745514 bam 2.3 GB
EGAF00005745515 bam 8.2 GB
EGAF00005745516 bam 4.6 GB
EGAF00005745517 bam 4.4 GB
EGAF00005745518 bam 6.0 GB
EGAF00005745519 bam 7.5 GB
EGAF00005745520 bam 7.8 GB
EGAF00005745521 bam 7.7 GB
EGAF00005745522 bam 7.0 GB
EGAF00005745523 bam 7.6 GB
EGAF00005745524 bam 4.8 GB
EGAF00005745525 bam 4.6 GB
EGAF00005745526 bam 7.8 GB
EGAF00005745527 bam 5.4 GB
EGAF00005745528 bam 5.3 GB
EGAF00005745529 bam 5.3 GB
EGAF00005745530 bam 6.2 GB
EGAF00005745531 bam 8.1 GB
EGAF00005745532 bam 4.4 GB
EGAF00005745533 bam 3.3 GB
EGAF00005745534 bam 5.3 GB
EGAF00005745535 bam 5.0 GB
EGAF00005745536 bam 4.6 GB
EGAF00005745537 bam 5.0 GB
EGAF00005746345 bam 6.3 GB
EGAF00005746348 bam 5.8 GB
EGAF00005746355 bam 6.2 GB
EGAF00005746362 bam 7.3 GB
EGAF00005746369 bam 8.2 GB
EGAF00005746378 bam 5.6 GB
EGAF00005746661 bam 5.4 GB
EGAF00005746662 bam 7.6 GB
EGAF00005746665 bam 7.6 GB
EGAF00005746674 bam 5.5 GB
EGAF00005746753 bam 7.2 GB
EGAF00005746756 bam 8.1 GB
EGAF00005746935 bam 7.6 GB
EGAF00005746942 bam 6.4 GB
EGAF00005746951 bam 7.7 GB
EGAF00005746988 bam 7.6 GB
EGAF00005747045 bam 5.3 GB
EGAF00005747048 bam 7.4 GB
EGAF00005747049 bam 6.1 GB
EGAF00005747056 bam 6.7 GB
EGAF00005747057 bam 7.4 GB
EGAF00005747058 bam 5.2 GB
EGAF00005747265 bam 5.4 GB
EGAF00005747266 bam 4.8 GB
EGAF00005747269 bam 5.3 GB
EGAF00005747304 bam 6.6 GB
EGAF00005747305 bam 6.5 GB
139 Files (847.6 GB)