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The transcriptomic response of skeletal muscle in life-long high-level trained and untrained men after acute exercise

To investigate the influence of lifelong exercise training on the response of skeletal muscle to a bout of acute exercise we generated global transcriptomic data from long-term endurance (8 men) and strength (8 men) trained individuals and healthy age-matched untrained controls (8 men). Skeletal muscle biopsies were taken from M. vastus lateralis before, directly after, and after 1h and 3hrs following acute exercise. All subjects completed one bout of acute endurance exercise and one bout of acute resistance exercise, separated by 4-8 weeks. All 192 samples were multiplexed in 4 lanes and sequenced (2x250bp paired end) on the Illumina NovaSeq 6000.

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DATA ACCESS AGREEMENT These terms and conditions govern access to the managed access datasets (details of which are set out in Appendix I) to which the User Institution has requested access. The User Institution agrees to be bound by these terms and conditions. Definitions Authorised Personnel: The individuals at the User Institution to whom the Data access committee at the Molecular Exercise Physiology group (hereinafter called DAC-MolFys) grants access to the Data. This includes the User, the individuals listed in Appendix II and any other individuals for whom the User Institution subsequently requests access to the Data. Details of the initial Authorised Personnel are set out in Appendix II. Data: The managed access datasets to which the User Institution has requested access. Data Producers: DAC-MolFys and the collaborators listed in Appendix I responsible for the development, organisation, and oversight of these Data. External Collaborator: A collaborator of the User, working for an institution other than the User Institution. Project: The project for which the User Institution has requested access to these Data. A description of the Project is set out in Appendix II. Publications: Includes, without limitation, articles published in print journals, electronic journals, reviews, books, posters and other written and verbal presentations of research. Research Participant: An individual whose data form part of these Data. Research Purposes: Shall mean research that is seeking to advance the understanding of genetics and genomics, including the treatment of disorders, and work on statistical methods that may be applied to such research. User: The principal investigator for the Project. User Institution(s): The Institution that has requested access to the Data. DAC-MolFys: Karolinska Institutet, Department for Physiology and Pharmacology, Stockholm, Sweden 1. The User Institution agrees to only use these Data for the purpose of the Project (described in Appendix II) and only for Research Purposes. The User Institution further agrees that it will only use these Data for Research Purposes which are within the limitations (if any) set out in Appendix I. 2. The User Institution agrees to preserve, at all times, the confidentiality of these Data. In particular, it undertakes not to use, or attempt to use these Data to compromise or otherwise infringe the confidentiality of information on Research Participants. Without prejudice to the generality of the foregoing, the User Institution agrees to use at least the measures set out in Appendix I to protect these Data. 3. The User Institution agrees to protect the confidentiality of Research Participants in any research papers or publications that they prepare by taking all reasonable care to limit the possibility of identification. 4. The User Institution agrees not to link or combine these Data to other information or archived data available in a way that could re-identify the Research Participants, even if access to that data has been formally granted to the User Institution or is freely available without restriction. 5. The User Institution agrees only to transfer or disclose these Data, in whole or part, or any material derived from these Data, to the Authorised Personnel. Should the User Institution wish to share these Data with an External Collaborator, the External Collaborator must complete a separate application for access to these Data. 6. The User Institution agrees that the Data Producers, and all other parties involved in the creation, funding or protection of these Data: a) make no warranty or representation, express or implied as to the accuracy, quality or comprehensiveness of these Data; b) exclude to the fullest extent permitted by law all liability for actions, claims, proceedings, demands, losses (including but not limited to loss of profit), costs, awards damages and payments made by the Recipient that may arise (whether directly or indirectly) in any way whatsoever from the Recipient’s use of these Data or from the unavailability of, or break in access to, these Data for whatever reason and; c) bear no responsibility for the further analysis or interpretation of these Data. 7. The User Institution agrees to follow the Fort Lauderdale Guidelines (http://www.wellcome.ac.uk/stellent/groups/corporatesite/@policy_communications/documents/web_document/wtd003207.pdf ) and the Toronto Statement (http://www.nature.com/nature/journal/v461/n7261/full/461168a.html). This includes but is not limited to recognising the contribution of the Data Producers and including a proper acknowledgement in all reports or publications resulting from the use of these Data. 8. The User Institution agrees to follow the Publication Policy in Appendix III. This includes respecting the moratorium period for the Data Producers to publish the first peer-reviewed report describing and analysing these Data. 9. The User Institution agrees not to make intellectual property claims on these Data and not to use intellectual property protection in ways that would prevent or block access to, or use of, any element of these Data, or conclusion drawn directly from these Data. 10. The User Institution can elect to perform further research that would add intellectual and resource capital to these data and decide to obtain intellectual property rights on these downstream discoveries. In this case, the User Institution agrees to implement licensing policies that will not obstruct further research and to follow the U.S. National Institutes of Health Best Practices for the Licensing of Genomic Inventions (2005) (https://www.icgc.org/files/daco/NIH_BestPracticesLicensingGenomicInventions_2005_en.pdf ) in conformity with the Organisation for Economic Co-operation and Development Guidelines for the Licensing of the Genetic Inventions (2006) (http://www.oecd.org/science/biotech/36198812.pdf ). 11. The User Institution agrees to destroy/discard the Data held, once it is no longer used for the Project, unless obliged to retain the data for archival purposes in conformity with audit or legal requirements. 12. The User Institution will notify DAC-MolFys within 30 days of any changes or departures of Authorised Personnel. 13. The User Institution will notify DAC-MolFys prior to any significant changes to the protocol for the Project. 14. The User Institution will notify DAC-MolFys as soon as it becomes aware of a breach of the terms or conditions of this agreement. 15. DAC-MolFys may terminate this agreement by written notice to the User Institution. If this agreement terminates for any reason, the User Institution will be required to destroy any Data held, including copies and backup copies. This clause does not prevent the User Institution from retaining these data for archival purpose in conformity with audit or legal requirements. 16. The User Institution accepts that it may be necessary for the Data Producers to alter the terms of this agreement from time to time. As an example, this may include specific provisions relating to the Data required by Data Producers other than DAC-MolFys. In the event that changes are required, the Data Producers or their appointed agent will contact the User Institution to inform it of the changes and the User Institution may elect to accept the changes or terminate the agreement. 17. If requested, the User Institution will allow data security and management documentation to be inspected to verify that it is complying with the terms of this agreement. 18. The User Institution agrees to distribute a copy of these terms to the Authorised Personnel. The User Institution will procure that the Authorised Personnel comply with the terms of this agreement. 19. This agreement (and any dispute, controversy, proceedings or claim of whatever nature arising out of this agreement or its formation) shall be construed, interpreted and governed by the laws of Sweden and shall be subject to the exclusive jurisdiction of the Swedish courts.

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001006139 Transcriptome Sequencing
  • Updated the scope of the study to reflect current dataset additions.
  • Updated the scope of the dataset to reflect that the female cohort will soon be added as a separate dataset to the linked study.
  • Dataset Released

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00006131478 bam 2.1 GB
EGAF00006131479 bam 1.3 GB
EGAF00006131480 bam 1.8 GB
EGAF00006131481 bam 1.6 GB
EGAF00006131482 bam 2.2 GB
EGAF00006131483 bam 2.3 GB
EGAF00006131484 bam 2.4 GB
EGAF00006131485 bam 2.5 GB
EGAF00006131486 bam 2.0 GB
EGAF00006131487 bam 2.1 GB
EGAF00006131488 bam 3.8 GB
EGAF00006131489 bam 2.4 GB
EGAF00006131490 bam 2.9 GB
EGAF00006131491 bam 2.5 GB
EGAF00006131492 bam 2.4 GB
EGAF00006131493 bam 2.7 GB
EGAF00006131494 bam 3.4 GB
EGAF00006131495 bam 2.2 GB
EGAF00006131496 bam 3.9 GB
EGAF00006131497 bam 1.9 GB
EGAF00006131498 bam 3.2 GB
EGAF00006131499 bam 2.7 GB
EGAF00006131500 bam 2.6 GB
EGAF00006131501 bam 3.0 GB
EGAF00006131502 bam 3.4 GB
EGAF00006131503 bam 2.1 GB
EGAF00006131504 bam 2.7 GB
EGAF00006131505 bam 2.2 GB
EGAF00006131506 bam 2.4 GB
EGAF00006131507 bam 2.9 GB
EGAF00006131508 bam 2.5 GB
EGAF00006131509 bam 2.3 GB
EGAF00006131510 bam 2.5 GB
EGAF00006131511 bam 2.3 GB
EGAF00006131512 bam 2.0 GB
EGAF00006131513 bam 2.7 GB
EGAF00006131514 bam 3.5 GB
EGAF00006131515 bam 2.0 GB
EGAF00006131516 bam 1.9 GB
EGAF00006131517 bam 2.1 GB
EGAF00006131518 bam 2.5 GB
EGAF00006131519 bam 2.6 GB
EGAF00006131520 bam 3.3 GB
EGAF00006131521 bam 3.0 GB
EGAF00006131522 bam 1.9 GB
EGAF00006131523 bam 3.3 GB
EGAF00006131524 bam 1.9 GB
EGAF00006131525 bam 3.1 GB
EGAF00006131526 bam 2.7 GB
EGAF00006131527 bam 2.5 GB
EGAF00006131528 bam 2.2 GB
EGAF00006131529 bam 1.7 GB
EGAF00006131530 bam 2.8 GB
EGAF00006131531 bam 2.7 GB
EGAF00006131532 bam 2.6 GB
EGAF00006131533 bam 2.7 GB
EGAF00006131534 bam 2.1 GB
EGAF00006131535 bam 2.1 GB
EGAF00006131536 bam 2.0 GB
EGAF00006131537 bam 2.6 GB
EGAF00006131538 bam 2.9 GB
EGAF00006131539 bam 2.2 GB
EGAF00006131540 bam 1.6 GB
EGAF00006131541 bam 2.3 GB
EGAF00006131542 bam 1.8 GB
EGAF00006131543 bam 1.9 GB
EGAF00006131544 bam 3.6 GB
EGAF00006131545 bam 3.6 GB
EGAF00006131546 bam 2.5 GB
EGAF00006131547 bam 1.6 GB
EGAF00006131548 bam 2.4 GB
EGAF00006131549 bam 2.6 GB
EGAF00006131550 bam 2.6 GB
EGAF00006131551 bam 2.4 GB
EGAF00006131552 bam 3.1 GB
EGAF00006131553 bam 2.4 GB
EGAF00006131554 bam 2.6 GB
EGAF00006131555 bam 1.7 GB
EGAF00006131556 bam 2.8 GB
EGAF00006131557 bam 2.3 GB
EGAF00006131558 bam 2.0 GB
EGAF00006131559 bam 2.5 GB
EGAF00006131560 bam 3.6 GB
EGAF00006131561 bam 2.8 GB
EGAF00006131562 bam 3.2 GB
EGAF00006131563 bam 1.7 GB
EGAF00006131564 bam 2.9 GB
EGAF00006131565 bam 2.5 GB
EGAF00006131566 bam 2.4 GB
EGAF00006131567 bam 2.0 GB
EGAF00006131568 bam 3.2 GB
EGAF00006131569 bam 3.3 GB
EGAF00006131570 bam 2.6 GB
EGAF00006131571 bam 3.1 GB
EGAF00006131572 bam 3.1 GB
EGAF00006131573 bam 2.1 GB
EGAF00006131574 bam 2.8 GB
EGAF00006131575 bam 2.4 GB
EGAF00006131576 bam 2.5 GB
EGAF00006131577 bam 2.3 GB
EGAF00006131578 bam 2.6 GB
EGAF00006131579 bam 2.5 GB
EGAF00006131580 bam 2.7 GB
EGAF00006131581 bam 2.2 GB
EGAF00006131582 bam 1.5 GB
EGAF00006131583 bam 2.4 GB
EGAF00006131584 bam 2.6 GB
EGAF00006131585 bam 2.4 GB
EGAF00006131586 bam 2.5 GB
EGAF00006131587 bam 2.4 GB
EGAF00006131588 bam 2.4 GB
EGAF00006131589 bam 3.0 GB
EGAF00006131590 bam 2.4 GB
EGAF00006131591 bam 2.4 GB
EGAF00006131592 bam 2.2 GB
EGAF00006131593 bam 2.5 GB
EGAF00006131594 bam 2.5 GB
EGAF00006131595 bam 2.4 GB
EGAF00006131596 bam 3.0 GB
EGAF00006131597 bam 1.9 GB
EGAF00006131598 bam 2.7 GB
EGAF00006131599 bam 2.5 GB
EGAF00006131600 bam 2.7 GB
EGAF00006131601 bam 2.2 GB
EGAF00006131602 bam 2.6 GB
EGAF00006131603 bam 1.8 GB
EGAF00006131604 bam 2.2 GB
EGAF00006131605 bam 2.7 GB
EGAF00006131606 bam 2.6 GB
EGAF00006131607 bam 2.0 GB
EGAF00006131608 bam 1.6 GB
EGAF00006131609 bam 2.3 GB
EGAF00006131610 bam 2.4 GB
EGAF00006131611 bam 2.5 GB
EGAF00006131612 bam 2.7 GB
EGAF00006131613 bam 2.7 GB
EGAF00006131614 bam 2.8 GB
EGAF00006131615 bam 2.3 GB
EGAF00006131616 bam 2.7 GB
EGAF00006131617 bam 2.6 GB
EGAF00006131618 bam 2.8 GB
EGAF00006131619 bam 2.3 GB
EGAF00006131620 bam 1.7 GB
EGAF00006131621 bam 2.4 GB
EGAF00006131622 bam 2.8 GB
EGAF00006131623 bam 2.6 GB
EGAF00006131624 bam 2.6 GB
EGAF00006131625 bam 2.7 GB
EGAF00006131626 bam 2.7 GB
EGAF00006131627 bam 2.5 GB
EGAF00006131628 bam 3.1 GB
EGAF00006131629 bam 2.9 GB
EGAF00006131630 bam 2.6 GB
EGAF00006131631 bam 2.3 GB
EGAF00006131632 bam 2.3 GB
EGAF00006131633 bam 2.4 GB
EGAF00006131634 bam 2.3 GB
EGAF00006131635 bam 2.0 GB
EGAF00006131636 bam 2.2 GB
EGAF00006131637 bam 2.3 GB
EGAF00006131638 bam 2.1 GB
EGAF00006131639 bam 2.5 GB
EGAF00006131640 bam 2.5 GB
EGAF00006131641 bam 1.9 GB
EGAF00006131642 bam 2.7 GB
EGAF00006131643 bam 2.6 GB
EGAF00006131644 bam 2.6 GB
EGAF00006131645 bam 2.4 GB
EGAF00006131646 bam 2.4 GB
EGAF00006131647 bam 2.5 GB
EGAF00006131648 bam 2.3 GB
EGAF00006131649 bam 2.8 GB
EGAF00006131650 bam 2.1 GB
EGAF00006131651 bam 2.5 GB
EGAF00006131652 bam 2.6 GB
EGAF00006131653 bam 2.3 GB
EGAF00006131654 bam 2.4 GB
EGAF00006131655 bam 2.2 GB
EGAF00006131656 bam 3.0 GB
EGAF00006131657 bam 2.9 GB
EGAF00006131658 bam 2.4 GB
EGAF00006131659 bam 2.4 GB
EGAF00006131660 bam 2.1 GB
EGAF00006131661 bam 2.4 GB
EGAF00006131662 bam 2.7 GB
EGAF00006131663 bam 2.3 GB
EGAF00006131664 bam 2.4 GB
EGAF00006131665 bam 2.8 GB
EGAF00006131666 bam 2.4 GB
EGAF00006131667 bam 1.7 GB
EGAF00006131668 bam 1.8 GB
EGAF00006131669 bam 1.8 GB
192 Files (474.4 GB)