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Comparison with genomic measurement

Heatrich-BS was performed on 5 healthy volunteers and 15 CRC patient cell-free DNA. The Heatrich-BS predicted tumor fractions were compared with tumor burden values obtained by genomic methods such as targeted amplicon sequencing and low pass sequencing.

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Policy for processing data access request

Policy for processing data access requests This policy describes how the NUS cfDNA Data Access Committee (DAC) will process requests for datasets stored in the European Genome-phenome Archive (EGA), when those datasets are made available by manuscripts that specifically reference this policy. Purpose 1. To ensure that applicants are qualified investigators, affiliated with an academic, non- profit, or government research organization. 2. To ensure that users of the data agree to comply with applicable laws, including requirements as outlined in any governing consent and appropriate ethical approvals, along with any restrictions for the data in question. General principles Introduction The DAC will consider applications for access to datasets stored in the EGA when authorized to do so in accordance with this policy. Access to data will be granted to qualified researchers for appropriate use. A qualified researcher refers to a scientist who is employed, or legitimately affiliated with an academic, non-profit, or government research organization. Access to data will be granted to researchers for appropriate use and will be governed by the provisions and terms contained in the Data Access Agreement and consistent with an informed consent (if applicable). The DAC is concerned only with access to the data stored within the EGA with this DAC as the designated data access committee. Access is conditional upon availability of data and a signed agreement governing issues related to publication, data use, data storage, data disposal, ethical approval, and confidentiality. Application procedure To request access to data from the EGA, you will be asked to complete a basic application form and to agree to the terms and conditions laid out in the Data Access Agreement (DAA). The DAA must be signed by both a representative with institutional authority to sign on behalf of your organization, and the principal investigator responsible for the research project. You will also be requested to list personnel who will be granted access to the data for the purposes of the research project. If your application is successful, you will be asked to designate a “registered user”, under the authority of the principal investigator, who will be issued with a username and password by the EGA to enable access to the database. The DAC will consider applications that include named collaborators, but each institution must sign a separate DAA. Should you wish to share the data with additional collaborators not previously approved, they must make a separate application for access to the data. You agree to use the data only for the approved purpose and project described in your application; use of the data for a new purpose or new or expanded project will require a new application and approval. Assessment criteria Each application will be assessed to determine if: ● it has been submitted by a qualified researcher or researchers, embedded in a recognized research institution that can provide institutional responsibility for appropriate research governance ● the project described constitutes “biomedical research” in the context of the consent process, and is likely to be understood as such by the sample donors ● it breaches any of the ethical permissions or restrictions in the consent forms for any component cohort or collection The DAC will use these practices in its assessment: ● The DAC explicitly does NOT attempt to peer review the scientific quality of proposals. However, it does ask for a brief summary of the research to be undertaken, in order to judge whether it falls within the scope of the consents. Reporting The DAC may periodically report publicly on the requests received and their disposition, including reasons for access refusal. Acknowledgments Purpose adapted from the Blueprint Data Access Committee Terms of Reference. General principles adapted from the Blueprint Data Access Committee General Principles.

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001006198 Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00006143482 fastq.gz 261.2 MB
EGAF00006143483 fastq.gz 285.6 MB
EGAF00006143492 fastq.gz 129.2 MB
EGAF00006143493 fastq.gz 142.8 MB
EGAF00006143512 fastq.gz 263.0 MB
EGAF00006143513 fastq.gz 283.9 MB
EGAF00006143514 fastq.gz 417.9 MB
EGAF00006143515 fastq.gz 479.2 MB
EGAF00006143524 fastq.gz 84.2 MB
EGAF00006143525 fastq.gz 94.6 MB
EGAF00006143526 fastq.gz 591.2 MB
EGAF00006143527 fastq.gz 665.6 MB
EGAF00006143530 fastq.gz 530.2 MB
EGAF00006143531 fastq.gz 605.0 MB
EGAF00006143562 fastq.gz 174.4 MB
EGAF00006143563 fastq.gz 193.8 MB
EGAF00006143564 fastq.gz 537.5 MB
EGAF00006143565 fastq.gz 579.1 MB
EGAF00006143568 fastq.gz 33.2 MB
EGAF00006143569 fastq.gz 36.0 MB
EGAF00006143586 fastq.gz 210.6 MB
EGAF00006143587 fastq.gz 228.1 MB
EGAF00006143590 fastq.gz 113.5 MB
EGAF00006143591 fastq.gz 123.6 MB
EGAF00006143594 fastq.gz 84.3 MB
EGAF00006143595 fastq.gz 91.5 MB
EGAF00006143638 fastq.gz 403.0 MB
EGAF00006143639 fastq.gz 448.3 MB
EGAF00006143646 fq.gz 185.0 MB
EGAF00006143647 fq.gz 179.9 MB
EGAF00006143648 fq.gz 151.8 MB
EGAF00006143649 fq.gz 149.1 MB
EGAF00006143650 fq.gz 704.5 MB
EGAF00006143651 fq.gz 669.3 MB
EGAF00006143658 fastq.gz 143.3 MB
EGAF00006143659 fastq.gz 155.4 MB
EGAF00006143660 fastq.gz 284.2 MB
EGAF00006143661 fastq.gz 334.7 MB
EGAF00006143662 fastq.gz 350.9 MB
EGAF00006143663 fastq.gz 401.4 MB
40 Files (11.8 GB)