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Single-cell analysis reveals transcriptomic and epigenomic impacts on the maternal-fetal interface upon SARS-CoV-2 infection

We assessed the transcriptome and chromatin states of patient and control samples at both bulk and single-cell resolutions with RNA-seq and ATAC-seq. Maternal-fetal interface samples were collected from 7 patients infected with SARS-CoV-2 during late pregnancy, and from 7 gestational age-matched control donors. Raw and processed files are provided in this dataset.

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EU-STANDS4PM_hDAA_v1.0.docx

In signing this Agreement: 1. You, the Data Recipient, agree to only use the Data for the Purpose of the Project. 2. You agree to preserve, at all times, the confidentiality of information and Data pertaining to Data Subjects. You undertake not to use or attempt to use the Data to compromise or otherwise infringe the confidentiality of information on Data Subjects and their right to privacy. 3. You agree not to attempt to identify Data Subjects. 4. You and your Authorised Personnel agree to take into consideration any usage restrictions (if any), stemming from consent, i.e. the appropriate lawful basis for processing the Data, as well as any usage restrictions stemming from any applicable internal policies of your Institution. 5. You agree that in handling this Data You will follow an up-to-date information technology (IT) policy that must include, at a minimum, the following items: a. Logging and auditing of Access to the Data and to the computer network; b. Password protection to computer network and/or strong data encryption; c. Virus and malware protection to computers on the computer network; d. Secure backup procedure; 6. You acknowledge that Access to the Data is granted for the duration of the Project described in Section I, as well as any new Project under the same research field or area. Any use of the Data for a Project of another research field or area will need to be approved under a new Agreement. 7. You recognize that nothing in this Agreement shall operate to transfer to You any intellectual property rights to the Data. 8. You agree not to make intellectual property claims on the Data and not to use intellectual property protection in ways that would prevent or block Access to, or use of, any element of the Data. 9. You can elect to perform further Research that would add intellectual and resource capital to the Data, and decide to obtain intellectual property rights on these downstream discoveries. In this case, You agree to implement licensing policies that will not obstruct further Research, following the Organisation for Economic Co-operation and Development Guidelines. 10. You agree that the Research Project 1) bears no legal responsibility for the accuracy or comprehensiveness of the Data; 2) accepts no liability for indirect, consequential, or incidental damages or losses arising from use of the Data; and 3) bears no responsibility for the further analysis or interpretation of these Data over and above that published by the Controller(s). 11. You agree to hold the Data Subject(s) and Data Controller(s) harmless and to defend and indemnify all these parties against all liabilities, demands, damages, expenses, and losses arising out of Your use for any Purpose of the Data. 12. You agree to a moratorium on publishing global analyses of the dataset until the Data Controller(s) have published their own global analysis or twelve (12) months, the maximum, have passed from the time the Data were deposited, whichever occurs first. You acknowledge that prompt publication or public disclosure of the results of the Research Project is encouraged. You also agree that by publishing Your global analyses of the Data, you will not disclose any results generated from the Data. 13. You agree to acknowledge the contribution of the Data Controller(s) in all oral and written presentations, disclosures, and Publications resulting from all analyses of the Data. 14. You agree to use the Data in Your laboratory. Any Authorised Personnel shall work under Your direct supervision. You agree to distribute a copy of these terms to the Authorised Personnel. 15. You may not transfer any information included in the Data to anyone unless specifically designated in the Research Project, or by prior specific or general written authorisation of the Data Controller(s) responsible for the generation of the original Data in each case. 16. You may not transfer the Data itself to anyone outside the Institution, unless the Controller(s) has (have) approved such transfer and its terms in writing. 17. Should You wish to share the Data with an external collaborator, the external collaborator must complete a separate Data Access Agreement. 18. You shall ensure that ‘all’ who have Access to the Data, namely You and Your Authorised Personnel, will be listed out, and are made aware and be bound by the terms of this Agreement. You remain solely and fully responsible for Your Authorised Personnel’s non-compliance with the provision of the Agreement and/or applicable laws. 19. In case of a breach of security resulting from ‘accidental’ use of Data by You and Your Authorised Personnel, which leads to disclosure of Data, then You must report this to Data Controller(s) within 72 hours maximum, and follow any relevant rule as provided by the GDPR. 20. In case of a ‘non-accidental or minor’ breach of hDAA by You You will further be required to destroy any Data held. 21. You accept that this Agreement will terminate immediately upon ‘any’ breach by You, or its termination (see Section I). 22. You endeavour to settle any dispute with the Data Controller(s) amicably. If you are unable to reach an Agreement, you will meet and negotiate in good faith in an effort to resolve the issue. If the issue has not been resolved within a reasonable period (e.g. 30 calendar days), you are both entitled to submit it for resolution by an arbitrator. 23. Further, the language of the proceedings will be ‘English’ if not otherwise agreed. The award of the arbitration will be final and binding upon the parties concerned. 24. This Agreement (and any dispute, controversy, proceedings, or claim of whatever nature arising out of it or its formation) shall be interpreted, governed by and construed in accordance with the Laws of England and Wales, and shall be subject to the exclusive jurisdiction of the English Courts.

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001006263 Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00006166189 fastq.gz 2.0 GB
EGAF00006166190 fastq.gz 2.1 GB
EGAF00006166191 fastq.gz 2.3 GB
EGAF00006166192 fastq.gz 2.4 GB
EGAF00006166193 fastq.gz 28.8 GB
EGAF00006166196 fastq.gz 1.8 GB
EGAF00006166197 fastq.gz 1.9 GB
EGAF00006166198 fastq.gz 2.8 GB
EGAF00006166199 fastq.gz 2.8 GB
EGAF00006166200 fastq.gz 1.8 GB
EGAF00006166201 fastq.gz 1.9 GB
EGAF00006166202 fastq.gz 2.5 GB
EGAF00006166203 fastq.gz 2.5 GB
EGAF00006166204 fastq.gz 10.0 GB
EGAF00006166205 fastq.gz 31.9 GB
EGAF00006166206 fastq.gz 36.2 GB
EGAF00006166207 fastq.gz 9.0 GB
EGAF00006166208 fastq.gz 1.5 GB
EGAF00006166209 fastq.gz 1.6 GB
EGAF00006166210 fastq.gz 2.1 GB
EGAF00006166211 fastq.gz 2.2 GB
EGAF00006166212 fastq.gz 35.1 GB
EGAF00006166213 fastq.gz 9.0 GB
EGAF00006166214 fastq.gz 9.5 GB
EGAF00006166215 fastq.gz 30.2 GB
EGAF00006166218 fastq.gz 34.2 GB
EGAF00006166219 fastq.gz 1.9 GB
EGAF00006166220 fastq.gz 2.1 GB
EGAF00006166221 fastq.gz 2.0 GB
EGAF00006166222 fastq.gz 2.3 GB
EGAF00006166223 fastq.gz 10.3 GB
EGAF00006166224 fastq.gz 33.3 GB
EGAF00006166225 fastq.gz 2.5 GB
EGAF00006166226 fastq.gz 2.6 GB
EGAF00006166227 fastq.gz 19.4 GB
EGAF00006166228 fastq.gz 61.2 GB
EGAF00006166229 fastq.gz 35.5 GB
EGAF00006166230 fastq.gz 2.2 GB
EGAF00006166231 fastq.gz 2.3 GB
EGAF00006166232 fastq.gz 2.9 GB
EGAF00006166233 fastq.gz 3.1 GB
EGAF00006166234 fastq.gz 29.6 GB
EGAF00006166235 fastq.gz 1.7 GB
EGAF00006166236 fastq.gz 1.8 GB
EGAF00006166237 fastq.gz 2.3 GB
EGAF00006166238 fastq.gz 2.3 GB
EGAF00006166239 fastq.gz 9.7 GB
EGAF00006166240 fastq.gz 30.8 GB
EGAF00006166241 fastq.gz 1.6 GB
EGAF00006166242 fastq.gz 1.6 GB
EGAF00006166243 fastq.gz 29.9 GB
EGAF00006166244 fastq.gz 7.6 GB
EGAF00006166245 fastq.gz 2.2 GB
EGAF00006166246 fastq.gz 2.3 GB
EGAF00006166247 fastq.gz 29.5 GB
EGAF00006166248 fastq.gz 7.7 GB
EGAF00006166249 fastq.gz 1.4 GB
EGAF00006166250 fastq.gz 1.5 GB
EGAF00006166251 fastq.gz 1.8 GB
EGAF00006166252 fastq.gz 1.9 GB
EGAF00006166253 fastq.gz 14.5 GB
EGAF00006166254 fastq.gz 45.2 GB
EGAF00006166255 fastq.gz 1.7 GB
EGAF00006166256 fastq.gz 1.7 GB
EGAF00006166257 fastq.gz 1.7 GB
EGAF00006166258 fastq.gz 1.8 GB
EGAF00006166259 fastq.gz 33.8 GB
EGAF00006166260 fastq.gz 37.5 GB
EGAF00006166261 fastq.gz 9.1 GB
EGAF00006166262 fastq.gz 1.7 GB
EGAF00006166263 fastq.gz 1.7 GB
EGAF00006166264 fastq.gz 1.5 GB
EGAF00006166265 fastq.gz 1.6 GB
EGAF00006166266 bw 818.9 MB
EGAF00006166274 bw 772.1 MB
EGAF00006166276 bw 197.7 MB
EGAF00006166277 bw 188.2 MB
EGAF00006166281 bw 234.7 MB
EGAF00006166282 bw 226.0 MB
EGAF00006166285 bw 242.1 MB
EGAF00006166286 bw 233.4 MB
EGAF00006166287 bw 312.6 MB
EGAF00006166288 bw 302.8 MB
EGAF00006166292 bw 224.0 MB
EGAF00006166293 bw 216.0 MB
EGAF00006166294 bw 232.7 MB
EGAF00006166295 bw 222.4 MB
EGAF00006166301 bw 241.9 MB
EGAF00006166302 bw 229.2 MB
EGAF00006166303 bw 789.9 MB
EGAF00006166313 bw 307.9 MB
EGAF00006166314 bw 293.1 MB
EGAF00006166321 bw 218.3 MB
EGAF00006166322 bw 208.5 MB
EGAF00006166325 bw 267.8 MB
EGAF00006166326 bw 257.2 MB
EGAF00006166327 bw 806.1 MB
EGAF00006166334 bw 828.6 MB
EGAF00006166335 bw 210.3 MB
EGAF00006166336 bw 200.9 MB
EGAF00006166337 bw 754.7 MB
EGAF00006166338 bw 829.1 MB
EGAF00006166341 bw 833.4 MB
EGAF00006166354 bw 812.3 MB
EGAF00006166357 bw 230.3 MB
EGAF00006166358 bw 219.6 MB
EGAF00006166361 bw 212.4 MB
EGAF00006166362 bw 203.4 MB
EGAF00006166366 bw 799.6 MB
EGAF00008047545 fastq.gz 3.0 GB
EGAF00008047546 tsv 12.5 MB
EGAF00008047547 fastq.gz 5.6 GB
EGAF00008047548 fastq.gz 6.3 GB
EGAF00008047574 fastq.gz 22.5 GB
EGAF00008047575 fastq.gz 5.9 GB
EGAF00008047576 fastq.gz 21.7 GB
EGAF00008047577 fastq.gz 23.2 GB
EGAF00008047578 fastq.gz 6.1 GB
EGAF00008047579 fastq.gz 22.8 GB
EGAF00008047580 fastq.gz 22.9 GB
EGAF00008047581 fastq.gz 5.7 GB
EGAF00008047582 fastq.gz 22.9 GB
EGAF00008047583 fastq.gz 22.8 GB
EGAF00008047584 fastq.gz 5.6 GB
EGAF00008047585 fastq.gz 22.4 GB
EGAF00008047586 fastq.gz 21.9 GB
EGAF00008047587 fastq.gz 5.5 GB
EGAF00008047588 fastq.gz 22.9 GB
EGAF00008047589 fastq.gz 5.8 GB
EGAF00008047591 fastq.gz 23.3 GB
EGAF00008047592 fastq.gz 5.9 GB
EGAF00008047593 fastq.gz 24.0 GB
EGAF00008047594 fastq.gz 22.1 GB
EGAF00008047595 fastq.gz 5.6 GB
EGAF00008047596 fastq.gz 21.7 GB
EGAF00008047653 txt.gz 1.6 kB
EGAF00008047654 txt.gz 1.6 kB
EGAF00008047655 txt.gz 538.9 kB
EGAF00008047656 txt.gz 566.2 kB
EGAF00008047657 txt.gz 163.1 kB
EGAF00008047658 txt.gz 204.3 kB
EGAF00008047659 txt.gz 113.5 kB
EGAF00008047660 txt.gz 114.2 kB
EGAF00008047661 fastq.gz 9.4 GB
EGAF00008047662 fastq.gz 32.6 GB
EGAF00008047764 bw 43.7 MB
EGAF00008047765 fastq.gz 395.2 MB
EGAF00008047766 fastq.gz 408.2 MB
EGAF00008047767 bw 37.1 MB
EGAF00008047768 fastq.gz 327.1 MB
EGAF00008047769 fastq.gz 338.3 MB
EGAF00008047770 bw 36.4 MB
EGAF00008047771 fastq.gz 371.0 MB
EGAF00008047772 fastq.gz 385.4 MB
EGAF00008047773 bw 40.2 MB
EGAF00008047774 fastq.gz 506.1 MB
EGAF00008047775 fastq.gz 523.9 MB
EGAF00008047776 bw 40.2 MB
EGAF00008047777 fastq.gz 390.1 MB
EGAF00008047778 fastq.gz.gz 404.9 MB
EGAF00008047779 bw 37.1 MB
EGAF00008047780 fastq.gz 320.6 MB
EGAF00008047781 fastq.gz 332.1 MB
EGAF00008047782 bw 31.9 MB
EGAF00008047783 fastq.gz 303.1 MB
EGAF00008047784 fastq.gz 313.6 MB
EGAF00008047785 bw 27.4 MB
EGAF00008047786 fastq.gz 338.7 MB
EGAF00008047787 fastq.gz 350.7 MB
EGAF00008047788 bw 59.1 MB
EGAF00008047789 fastq.gz 649.0 MB
EGAF00008047790 fastq.gz 670.8 MB
EGAF00008047791 tsv 14.7 MB
EGAF00008047792 bw 35.5 MB
EGAF00008047793 fastq.gz 352.5 MB
EGAF00008047794 fastq.gz 364.4 MB
EGAF00008047795 bw 38.5 MB
EGAF00008047796 fastq.gz 392.7 MB
EGAF00008047797 fastq.gz 405.2 MB
EGAF00008047798 bw 28.1 MB
EGAF00008047799 fastq.gz 262.3 MB
EGAF00008047800 fastq.gz 272.7 MB
EGAF00008047801 bw 36.2 MB
EGAF00008047802 fastq.gz 451.3 MB
EGAF00008047803 fastq.gz 466.8 MB
EGAF00008047804 bw 35.1 MB
EGAF00008047805 fastq.gz 316.5 MB
EGAF00008047806 fastq.gz 329.4 MB
EGAF00008047807 bw 36.9 MB
EGAF00008047808 fastq.gz 343.4 MB
EGAF00008047809 fastq.gz 356.0 MB
EGAF00008047810 bw 27.1 MB
EGAF00008047811 fastq.gz 393.6 MB
EGAF00008047812 fastq.gz 407.4 MB
EGAF00008047813 bw 31.4 MB
EGAF00008047814 fastq.gz 577.6 MB
EGAF00008047815 fastq.gz 598.7 MB
EGAF00008047816 bw 33.6 MB
EGAF00008047817 fastq.gz 296.4 MB
EGAF00008047818 fastq.gz 305.9 MB
EGAF00008047819 tsv 1.9 MB
EGAF00008047820 bw 8.2 MB
EGAF00008047821 fastq.gz 676.5 MB
EGAF00008047822 fastq.gz 698.1 MB
EGAF00008047823 bw 7.2 MB
EGAF00008047824 fastq.gz 396.2 MB
EGAF00008047825 fastq.gz 409.3 MB
EGAF00008047826 bw 7.5 MB
EGAF00008047827 fastq.gz 501.2 MB
EGAF00008047828 fastq.gz 522.1 MB
EGAF00008047829 bw 3.4 MB
EGAF00008047830 fastq.gz 633.2 MB
EGAF00008047831 fastq.gz 657.3 MB
EGAF00008047832 bw 8.7 MB
EGAF00008047833 fastq.gz 620.7 MB
EGAF00008047834 fastq.gz 642.2 MB
EGAF00008047835 bw 7.5 MB
EGAF00008047836 fastq.gz 452.1 MB
EGAF00008047837 fastq.gz 469.6 MB
EGAF00008047838 bw 4.5 MB
EGAF00008047839 fastq.gz 304.7 MB
EGAF00008047840 fastq.gz 315.4 MB
EGAF00008047841 bw 4.1 MB
EGAF00008047842 fastq.gz 533.4 MB
EGAF00008047843 fastq.gz 550.4 MB
EGAF00008047844 bw 10.5 MB
EGAF00008047845 fastq.gz 415.7 MB
EGAF00008047846 fastq.gz 430.1 MB
EGAF00008050148 bw 100.3 MB
EGAF00008050149 bw 310.6 MB
EGAF00008066609 bw 779.4 MB
EGAF00008066610 bw 379.2 MB
EGAF00008066611 bw 367.8 MB
EGAF00008066612 tsv.gz 1.0 MB
EGAF00008066613 bw 45.6 MB
EGAF00008066614 bw 337.5 MB
EGAF00008066615 bw 428.6 MB
EGAF00008066616 bw 422.8 MB
EGAF00008066617 bw 52.5 MB
EGAF00008066618 bw 45.3 MB
EGAF00008066619 bw 775.7 MB
EGAF00008066620 bw 2.7 GB
EGAF00008066621 bw 393.0 MB
EGAF00008066622 bw 278.6 MB
EGAF00008066623 bw 591.4 MB
EGAF00008066624 bw 349.8 MB
EGAF00008066625 bw 637.4 MB
EGAF00008066626 bw 513.3 MB
EGAF00008066627 bw 25.2 MB
EGAF00008066628 bw 21.4 MB
EGAF00008066629 bw 336.3 MB
EGAF00008066630 bw 393.6 MB
EGAF00008066631 txt.gz 1.8 GB
EGAF00008066632 bw 11.1 MB
EGAF00008066633 bw 13.6 MB
EGAF00008066634 bw 7.6 MB
EGAF00008066635 bw 5.7 MB
EGAF00008066636 bw 10.1 MB
EGAF00008066637 bw 5.2 MB
EGAF00008066638 bw 67.4 MB
EGAF00008066639 bw 47.0 MB
EGAF00008066640 bw 27.2 MB
EGAF00008066641 bw 20.1 MB
EGAF00008066642 bw 20.9 MB
EGAF00008066643 bw 30.4 MB
EGAF00008066644 bw 96.2 MB
EGAF00008066645 bw 54.0 MB
EGAF00008066646 bw 78.7 MB
EGAF00008066647 bw 107.7 MB
EGAF00008066648 bw 83.4 MB
EGAF00008066649 bw 71.8 MB
EGAF00008066650 bw 126.9 MB
EGAF00008066651 bw 163.3 MB
EGAF00008066652 bw 10.7 MB
EGAF00008066653 bw 10.5 MB
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EGAF00008066655 bw 17.1 MB
EGAF00008066656 bw 13.5 MB
EGAF00008066657 bw 16.1 MB
EGAF00008066658 bw 268.3 MB
EGAF00008066659 bw 506.1 MB
EGAF00008066660 bw 20.0 MB
EGAF00008066661 bw 20.5 MB
EGAF00008066662 bw 386.9 MB
EGAF00008066663 bw 346.7 MB
EGAF00008066664 bw 288.3 MB
EGAF00008066665 bw 342.0 MB
EGAF00008066666 bw 276.4 MB
EGAF00008066667 bw 304.4 MB
EGAF00008066668 bw 335.6 MB
EGAF00008066669 bw 38.3 MB
EGAF00008066670 bw 45.6 MB
EGAF00008066671 txt.gz 128.2 MB
EGAF00008066672 txt.gz 3.8 MB
EGAF00008071398 fastq.gz 2.3 GB
EGAF00008071399 fastq.gz 21.8 GB
EGAF00008071400 fastq.gz 23.0 GB
EGAF00008071401 fastq.gz 9.5 GB
EGAF00008071402 fastq.gz 31.6 GB
EGAF00008071403 fastq.gz 9.3 GB
EGAF00008071404 fastq.gz 31.1 GB
EGAF00008071405 fastq.gz 9.4 GB
EGAF00008071406 fastq.gz 31.4 GB
EGAF00008071407 fastq.gz 9.3 GB
EGAF00008071408 fastq.gz 31.2 GB
EGAF00008071409 fastq.gz 9.5 GB
EGAF00008071410 fastq.gz 32.5 GB
EGAF00008071411 fastq.gz 9.4 GB
EGAF00008071412 fastq.gz 31.7 GB
EGAF00008071413 fastq.gz 9.6 GB
EGAF00008071414 fastq.gz 33.0 GB
EGAF00008071415 bw 96.2 MB
312 Files (1.6 TB)