Baseline and progression dataset

RNAseq FASTq files from 44 pre-treatment (Ven-Obi or Clb-Obi) and 44 paired, post-treatment relapsed CD19+ B cells.

88 samples
DAC: EGAC00001002874
Technology: unspecified

Access Policy1 Study Files

Metadata

Request Access

NMDS DUO:0000015 (version: 2021-02-23)no general methods researchThis data use modifier indicates that use does not allow methods development research (e.g., development of software or algorithms).
TS DUO:0000025 (version: 2021-02-23)time limit on useThis data use modifier indicates that use is approved for a specific number of months.
US DUO:0000026 (version: 2021-02-23)user specific restrictionThis data use modifier indicates that use is limited to use by approved users.
PS DUO:0000027 (version: 2021-02-23)project specific restrictionThis data use modifier indicates that use is limited to use within an approved project.
IS DUO:0000028 (version: 2021-02-23)institution specific restrictionThis data use modifier indicates that use is limited to use within an approved institution.

Genentech Data Access Agreement for Academic Institutions

GENENTECH DATA ACCESS COMMITTEE DATA ACCESS AGREEMENT This Data Access Agreement (“Agreement”) between Genentech, Inc. (“Genentech”) and User andUser Institution (as defined below) governs the terms on which access will be granted to thegenotype data obtained from Genentech. In signing this Agreement, User and User Institution agree to be bound by the terms and conditions of access set out in this Agreement. For the sake of clarity, the terms of access set out in this Agreement shall govern activities conducted by the User and the User Institution (as defined below). User Institution and User are referred to within the Agreement as “You” and “Your” for convenience only. Definitions: gRED means Genentech Research and Early Development. Data means all and any human genetic data generated by gRED and requested by User through submission of an Application for Access to Genotype Data and obtained from Genentech under the terms of this Agreement. Data Subject means a person, who has been informed of the purpose for which the Data is held and has given his/her informed consent thereto. User means a researcher who has requested Data by submitting an Application for Access to Genotype Data to gRED and whose User Institution has previously completed this Data Access Agreement with respect to such Data and has received acknowledgement of its acceptance. Publications means, without limitation, articles published in print journals, electronic journals, reviews, books, posters and other written and verbal presentations of research. User Institution means the organization at which the User is employed, affiliated or enrolled. Genentech Data Access Committee means members of the gRED organization that are responsible for making the data access decisions for the genotype data generated by gRED. Terms and Conditions: In signing this Agreement: 1. You agree to use the Data only for the advancement of medical research. 2. You agree not to use the data for the creation of products for sale or for any commercial purpose. 3. You agree to preserve, at all times, the confidentiality of Data pertaining to Data Subjects. In particular, You undertake not to use, or attempt to use the Data to compromise or otherwise infringe the confidentiality of information on Data Subjects and their right to privacy.DSC: Academic Data Access Agreement vMar2021 1 4. You agree not to attempt to link the Data provided under this Agreement to any other data source on the same samples or to link the Data to any person or otherwise identify any Data Subject from the Data. 5. You agree not to transfer or disclose the Data, in whole or part, or any identifiable material derived from the Data, to others, except as necessary for data/safety monitoring or programmanagement. Should You wish to share the Data with a collaborator outside the same Institution, the third party must make a separate application for access to the Data. 6. You agree to use the Data for the approved purpose and project described in your Application for Access to Raw Exome Sequencing and/or RNA Sequencing Data; use of the Data for a new purpose or project will require a new application and approval. You agree to restrict your use of the Data to the analysis of somatic mutations and/or gene expression level only; use of these data to infer genotype is not permitted. 7. You agree that publication of Your purpose, project, and results is restricted for a one (1) year period starting from the publication date of the Genentech publication referencing the Data deposit. You will be free to publish the results of the research using the Data for the approved purpose after the one (1) year period has expired. You will not publish the Data, but will refer to the original Data deposit by Genentech and agree to acknowledge in any such publication that the research makes use of Data generated by Genentech. 8. You accept that Genentech: (a) bears no legal responsibility for the accuracy or comprehensiveness of the Data; and (b) accepts no liability for indirect, consequential, or incidental, damages or losses arising from use of the Data, or from the unavailability of, or break in access to, the Data for whatever reason. 9. You understand and acknowledge that the Data is protected by copyright and other intellectual property rights, and that duplication, except as reasonably required to carry out Your research with the Data, or sale of all or part of the Data on any media is not permitted. 10. You recognize that nothing in this Agreement shall operate to transfer to the User Institution any intellectual property rights relating to the Data. 11. You agree that You will submit a report to the Genentech Data Access Committee, if requested, on completion of the approved purpose. The Genentech Data Access Committee agrees to treat the report and all information, data, results, and conclusions contained within such report as confidential information belonging to the User Institution. 12. (a) You agree to use the Data in accordance with all applicable laws, including but not limited to applicable data privacy laws. (b)The Genentech Data Access Committee reserves the right to request and inspect data security and management documentation to ensure the adequacy of data protection measures. 13. This Agreement shall be effective as of the date of the last party to sign below (“Effective Date”) and shall terminate three (3) years after the Effective Date, unless terminated sooner pursuant to Section 14 below. Upon termination, You will be required to destroy any Data held. 14. You accept that this Agreement will terminate immediately upon any breach of this Agreement by You. Either party may terminate this Agreement upon thirty (30) days written notice for any reason. The following Sections of this Agreement shall survive its expiration or termination:DSC: Academic Data Access Agreement vMar2021 2 Sections 1 – 10, 12(a), and 14-17 15. Nothing herein shall create any association, partnership, joint venture, fiduciary duty or the relation of principal and agent between the parties hereto, it being understood that each party is acting as an independent contractor, and neither party shall have the authority to bind the other or the other’s representatives in any way. 16. Except as required by law or permitted under Section 7, neither party shall use or refer to this Agreement in the public media, or use the names or marks of the other party without express prior written permission. 17. This Agreement may be executed by the parties hereto in separate counterparts, each of which when so executed and delivered shall be deemed an original, but all such counterparts shall together constitute one and the same agreement. The parties agree that execution of this Agreement by exchanging facsimile, PDF, or e-Signature (as defined below) signatures shall have the same legal force and effect as the exchange of original signatures. Pursuant to this Agreement, e-Signatures shall mean a signature that consists of one or more letters, characters, numbers or other symbols in digital form incorporated in, attached to or associated with the electronic document, that (a) is unique to the person making the signature; (b) the technology or process used to make the signature is under the sole control of the person making the signature; (b) the technology or process can be used to identify the person using the technology or process; and (d) the electronic signature can be linked with an electronic document in such a way that it can be used to determine whether the electronic document has been changed since the electronic signature was incorporated in, attached to or associated with the electronic document. The written form shall be required to make changes to this clause as well. IN WITNESS WHEREOF, the parties have caused this Agreement to be executed by their respective duly authorized representatives as set forth below. Genentech, Inc. For and on behalf of User Institution: (Institutional or Administrative Authority) Signature: Signature: Print Name: Print Name: Title: Title: Date: Date: Read and acknowledged by User/Applicant: Signature: Print Name: Title: Date:DSC: Academic Data Access Agreement vMar2021 3

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID	Study Title	Study Type
EGAS00001006596	Transcriptomic profiles of chronic lymphocytic leukemia before and after frontline therapy: 5-year results from the randomized CLL14 study	Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID	File Type	Size
EGAF00007133940	fastq.gz	3.7 GB
EGAF00007133941	fastq.gz	3.7 GB
EGAF00007133942	fastq.gz	3.1 GB
EGAF00007133943	fastq.gz	3.2 GB
EGAF00007133944	fastq.gz	2.3 GB
EGAF00007133945	fastq.gz	2.4 GB
EGAF00007133946	fastq.gz	3.3 GB
EGAF00007133947	fastq.gz	3.4 GB
EGAF00007133948	fastq.gz	2.4 GB
EGAF00007133949	fastq.gz	2.4 GB
EGAF00007133954	fastq.gz	2.2 GB
EGAF00007133955	fastq.gz	2.1 GB
EGAF00007133968	fastq.gz	1.9 GB
EGAF00007133969	fastq.gz	1.9 GB
EGAF00007133974	fastq.gz	1.8 GB
EGAF00007133975	fastq.gz	1.9 GB
EGAF00007133990	fastq.gz	2.3 GB
EGAF00007133991	fastq.gz	2.3 GB
EGAF00007134002	fastq.gz	1.8 GB
EGAF00007134003	fastq.gz	1.9 GB
EGAF00007134008	fastq.gz	2.0 GB
EGAF00007134009	fastq.gz	2.0 GB
EGAF00007134024	fastq.gz	1.6 GB
EGAF00007134025	fastq.gz	1.7 GB
EGAF00007134028	fastq.gz	1.9 GB
EGAF00007134029	fastq.gz	1.9 GB
EGAF00007134048	fastq.gz	1.9 GB
EGAF00007134049	fastq.gz	1.9 GB
EGAF00007134060	fastq.gz	1.7 GB
EGAF00007134061	fastq.gz	1.7 GB
EGAF00007134070	fastq.gz	2.4 GB
EGAF00007134071	fastq.gz	2.5 GB
EGAF00007134078	fastq.gz	2.5 GB
EGAF00007134079	fastq.gz	2.6 GB
EGAF00007134080	fastq.gz	1.4 GB
EGAF00007134081	fastq.gz	1.5 GB
EGAF00007134082	fastq.gz	1.6 GB
EGAF00007134083	fastq.gz	1.7 GB
EGAF00007134088	fastq.gz	2.7 GB
EGAF00007134089	fastq.gz	2.7 GB
EGAF00007134096	fastq.gz	2.9 GB
EGAF00007134097	fastq.gz	3.0 GB
EGAF00007134114	fastq.gz	1.8 GB
EGAF00007134115	fastq.gz	1.8 GB
EGAF00007134126	fastq.gz	1.6 GB
EGAF00007134127	fastq.gz	1.7 GB
EGAF00007134128	fastq.gz	1.8 GB
EGAF00007134129	fastq.gz	1.9 GB
EGAF00007134134	fastq.gz	2.8 GB
EGAF00007134135	fastq.gz	2.8 GB
EGAF00007134146	fastq.gz	1.9 GB
EGAF00007134147	fastq.gz	1.9 GB
EGAF00007134188	fastq.gz	1.8 GB
EGAF00007134189	fastq.gz	1.9 GB
EGAF00007134200	fastq.gz	1.9 GB
EGAF00007134201	fastq.gz	1.9 GB
EGAF00007134208	fastq.gz	2.9 GB
EGAF00007134209	fastq.gz	2.9 GB
EGAF00007134236	fastq.gz	1.6 GB
EGAF00007134237	fastq.gz	1.7 GB
EGAF00007134246	fastq.gz	2.8 GB
EGAF00007134247	fastq.gz	2.8 GB
EGAF00007134254	fastq.gz	2.7 GB
EGAF00007134255	fastq.gz	2.8 GB
EGAF00007134256	fastq.gz	1.8 GB
EGAF00007134257	fastq.gz	1.9 GB
EGAF00007134266	fastq.gz	1.6 GB
EGAF00007134267	fastq.gz	1.7 GB
EGAF00007134314	fastq.gz	2.7 GB
EGAF00007134315	fastq.gz	2.7 GB
EGAF00007134336	fastq.gz	1.9 GB
EGAF00007134337	fastq.gz	2.0 GB
EGAF00007134348	fastq.gz	2.5 GB
EGAF00007134349	fastq.gz	2.6 GB
EGAF00007134352	fastq.gz	2.5 GB
EGAF00007134353	fastq.gz	2.5 GB
EGAF00007134354	fastq.gz	1.8 GB
EGAF00007134355	fastq.gz	1.9 GB
EGAF00007134356	fastq.gz	1.6 GB
EGAF00007134357	fastq.gz	1.7 GB
EGAF00007134368	fastq.gz	1.7 GB
EGAF00007134369	fastq.gz	1.8 GB
EGAF00007134372	fastq.gz	2.7 GB
EGAF00007134373	fastq.gz	2.7 GB
EGAF00007134390	fastq.gz	2.2 GB
EGAF00007134391	fastq.gz	2.4 GB
EGAF00007134426	fastq.gz	3.6 GB
EGAF00007134427	fastq.gz	3.8 GB
EGAF00007134436	fastq.gz	2.8 GB
EGAF00007134437	fastq.gz	2.9 GB
EGAF00007134450	fastq.gz	1.6 GB
EGAF00007134451	fastq.gz	1.7 GB
EGAF00007134466	fastq.gz	1.8 GB
EGAF00007134467	fastq.gz	1.8 GB
EGAF00007134474	fastq.gz	1.9 GB
EGAF00007134475	fastq.gz	1.9 GB
EGAF00007134480	fastq.gz	3.0 GB
EGAF00007134481	fastq.gz	3.1 GB
EGAF00007134482	fastq.gz	3.0 GB
EGAF00007134483	fastq.gz	3.0 GB
EGAF00007134484	fastq.gz	2.5 GB
EGAF00007134485	fastq.gz	2.6 GB
EGAF00007134494	fastq.gz	2.7 GB
EGAF00007134495	fastq.gz	2.7 GB
EGAF00007134496	fastq.gz	1.8 GB
EGAF00007134497	fastq.gz	1.8 GB
EGAF00007134500	fastq.gz	1.8 GB
EGAF00007134501	fastq.gz	1.9 GB
EGAF00007134502	fastq.gz	2.1 GB
EGAF00007134503	fastq.gz	2.2 GB
EGAF00007134516	fastq.gz	2.7 GB
EGAF00007134517	fastq.gz	2.7 GB
EGAF00007134536	fastq.gz	2.6 GB
EGAF00007134537	fastq.gz	2.8 GB
EGAF00007134538	fastq.gz	2.6 GB
EGAF00007134539	fastq.gz	2.7 GB
EGAF00007134542	fastq.gz	1.7 GB
EGAF00007134543	fastq.gz	1.8 GB
EGAF00007134544	fastq.gz	1.7 GB
EGAF00007134545	fastq.gz	1.7 GB
EGAF00007134556	fastq.gz	3.0 GB
EGAF00007134557	fastq.gz	3.0 GB
EGAF00007134566	fastq.gz	2.5 GB
EGAF00007134567	fastq.gz	2.6 GB
EGAF00007134568	fastq.gz	1.7 GB
EGAF00007134569	fastq.gz	1.8 GB
EGAF00007134576	fastq.gz	1.7 GB
EGAF00007134577	fastq.gz	1.8 GB
EGAF00007134608	fastq.gz	1.7 GB
EGAF00007134609	fastq.gz	1.8 GB
EGAF00007134614	fastq.gz	2.7 GB
EGAF00007134615	fastq.gz	2.8 GB
EGAF00007134618	fastq.gz	2.7 GB
EGAF00007134619	fastq.gz	2.8 GB
EGAF00007134632	fastq.gz	1.9 GB
EGAF00007134633	fastq.gz	1.9 GB
EGAF00007134646	fastq.gz	2.6 GB
EGAF00007134647	fastq.gz	2.6 GB
EGAF00007134654	fastq.gz	1.7 GB
EGAF00007134655	fastq.gz	1.8 GB
EGAF00007134666	fastq.gz	1.9 GB
EGAF00007134667	fastq.gz	2.0 GB
EGAF00007134694	fastq.gz	2.6 GB
EGAF00007134695	fastq.gz	2.7 GB
EGAF00007134708	fastq.gz	2.6 GB
EGAF00007134709	fastq.gz	2.7 GB
EGAF00007134716	fastq.gz	1.7 GB
EGAF00007134717	fastq.gz	1.7 GB
EGAF00007134734	fastq.gz	1.9 GB
EGAF00007134735	fastq.gz	1.9 GB
EGAF00007134738	fastq.gz	2.0 GB
EGAF00007134739	fastq.gz	2.0 GB
EGAF00007134742	fastq.gz	1.9 GB
EGAF00007134743	fastq.gz	2.0 GB
EGAF00007134752	fastq.gz	1.9 GB
EGAF00007134753	fastq.gz	1.9 GB
EGAF00007134758	fastq.gz	2.5 GB
EGAF00007134759	fastq.gz	2.5 GB
EGAF00007134762	fastq.gz	2.4 GB
EGAF00007134763	fastq.gz	2.5 GB
EGAF00007134772	fastq.gz	2.0 GB
EGAF00007134773	fastq.gz	2.0 GB
EGAF00007134776	fastq.gz	1.8 GB
EGAF00007134777	fastq.gz	1.9 GB
EGAF00007134800	fastq.gz	1.6 GB
EGAF00007134801	fastq.gz	1.7 GB
EGAF00007134806	fastq.gz	1.8 GB
EGAF00007134807	fastq.gz	1.8 GB
EGAF00007134820	fastq.gz	2.9 GB
EGAF00007134821	fastq.gz	2.9 GB
EGAF00007134832	fastq.gz	2.8 GB
EGAF00007134833	fastq.gz	2.9 GB
EGAF00007134842	fastq.gz	1.9 GB
EGAF00007134843	fastq.gz	1.9 GB
EGAF00007134862	fastq.gz	2.6 GB
EGAF00007134863	fastq.gz	2.7 GB
176 Files (395.3 GB)