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Distinct embryonic phylogenies and driver events of infant Wilms tumor - RNA

Cancers of adults typically arise through progressive rounds of clonal diversification and intratumoral selective sweeps which generate a long mutational trunk with shorter subclonal branches. Here, we investigated whether tumors of young children exhibit the same phylogenetic configuration. We studied three infants, including two newborns, with the childhood kidney cancer, Wilms tumour, through whole genome sequencing of bulk tissues, of single cell derived organoids, and of microdissections. All three cancers exhibited unusual driver events, with tumours of newborns harbouring FOXR2 rearrangements, delineating a distinct variant of Wilms tumour. Phylogenetic analyses suggest that tumors were seeded in an early, possibly confined window of development. Unusually, following seeding there was extensive polyclonal diversification with little evidence of clonal sweeps, leading to a distinct phylogenetic configuration more reminiscent of normal tissues rather than of adult cancers. These findings indicate that some childhood cancers may diversify via unorthodox phylogenetic pathways.

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Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001005244 Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00007829966 cram 1.9 GB
EGAF00007829967 cram 1.9 GB
EGAF00007829968 cram 2.0 GB
EGAF00007829969 cram 1.9 GB
EGAF00007829970 cram 2.3 GB
EGAF00007829971 cram 2.0 GB
EGAF00007829972 cram 2.3 GB
EGAF00007829973 cram 2.1 GB
EGAF00007829974 cram 1.3 GB
EGAF00007829975 cram 1.1 GB
EGAF00007829976 cram 2.0 GB
EGAF00007829977 cram 2.2 GB
EGAF00007829978 cram 2.9 GB
EGAF00007829979 cram 2.7 GB
EGAF00007829980 cram 1.8 GB
EGAF00007829981 cram 2.4 GB
EGAF00007829982 cram 2.1 GB
EGAF00007829983 cram 1.7 GB
EGAF00007829984 cram 2.1 GB
EGAF00007829985 cram 2.5 GB
EGAF00007829986 cram 1.1 GB
EGAF00007829987 cram 1.8 GB
EGAF00007829988 cram 3.0 GB
EGAF00007829989 cram 2.8 GB
EGAF00007829990 cram 2.3 GB
EGAF00007829991 cram 2.3 GB
EGAF00007829992 cram 2.3 GB
EGAF00007829993 cram 2.7 GB
EGAF00007829994 cram 2.0 GB
EGAF00007829995 cram 1.7 GB
EGAF00007829996 cram 2.1 GB
EGAF00007829997 cram 2.5 GB
EGAF00007829998 cram 2.5 GB
EGAF00007829999 cram 2.6 GB
EGAF00007830000 cram 2.5 GB
EGAF00007830001 cram 2.3 GB
EGAF00007830008 cram 1.2 GB
EGAF00007830009 cram 1.6 GB
EGAF00007830010 cram 1.9 GB
EGAF00007830016 cram 2.8 GB
EGAF00007830044 cram 423.3 MB
EGAF00007830045 cram 436.3 MB
EGAF00007830046 cram 419.0 MB
EGAF00007830047 cram 429.4 MB
44 Files (87.0 GB)