Population-based analysis of POT1 variants in a cutaneous melanoma case-control cohort

Pathogenic germline variants in the protection of telomeres 1 gene (POT1) have been associated with predisposition to a range of tumor types, including melanoma, glioma, leukemia and cardioangiosarcoma. We sequenced all coding exons of the POT1 gene in 2,929 European-descent melanoma cases and 3,298 controls, identifying 43 protein-changing genetic variants. We performed functional studies on each of these variants and explored their possible contribution to disease risk.

6226 samples
DAC: EGAC00001000000
Technology: Illumina MiSeq

Access Policy1 Study Files

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Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID	Study Title	Study Type
EGAS00001006870	Population_based_analysis_of_POT1_variants_in_a_cutaneous_melanoma_case_control_cohort	Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID	File Type	Size
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EGAF00007846042	bam	837.0 kB
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EGAF00007846115	bam	936.6 kB
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EGAF00007846118	bam	1.3 MB
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EGAF00007846120	bam	809.7 kB
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EGAF00007846123	bam	624.0 kB
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EGAF00007846125	bam	1.5 MB
EGAF00007846126	bam	964.7 kB
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EGAF00007846130	bam	2.5 MB
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EGAF00007846134	bam	1.5 MB
EGAF00007846135	bam	1.9 MB
EGAF00007846136	bam	1.5 MB
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EGAF00007846139	bam	1.8 MB
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EGAF00007846141	bam	1.4 MB
EGAF00007846142	bam	1.9 MB
EGAF00007846143	bam	1.3 MB
6226 Files (10.1 GB)