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POETIC clinical Trial Ki67 Bookend Breast Cancer Targeted Exome and RNAseq Project

Using RNAseq, we compare the 15% of poorest responders (PRs, n=177) as measured by proportional Ki67 changes after 2 weeks of neoadjuvant aromatase inhibitors to good responders (GRs, n=190) selected from the top 50% responders in the POETIC trial and matched for baseline Ki67 categories. In the POETIC trial, 4,480 postmenopausal women with primary ER+ BC were randomised 2:1 to receive either treatment with a non-steroidal AI (letrozole or anastrozole) for 2 weeks before and 2 weeks after surgery or to no perisurgical treatment. Only AI-treated patients with HER2- tumors, paired baseline and surgery Ki67 available, and baseline Ki67 immunohistochemistry (IHC) >10% (to minimise imprecision in proportional Ki67 falls) were included for selection. Data is baseline RNAseq and targeted exome DNA sequencing analysis of POETIC Good/Poor Responders to aromatase inhibitors based on change in Ki67.

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DUO:0000007
version: 2021-02-23

disease specific research

This data use permission indicates that use is allowed provided it is related to the specified disease.

ModifiersMONDO:0007254

The datasets from the POETIC clinical trial are available under restricted access for privacy and legal issues. Access to data or samples can be obtained by submission and approval of a data and sample request form to the POETIC Trial Management Group, which meets several times a year.

The datasets from the POETIC clinical trial are available under restricted access for privacy and legal issues. Access to data or samples can be obtained by submission and approval of a data and sample request form to the POETIC Trial Management Group, which meets several times a year. Please contact Dr. Maggie Cheang or Prof. Judith Bliss and request the data and sample request form. Once the form is filled out and returned, then it will be submitted to the Trial Management Group for approval. The management group meets several times per year.

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001007302 RNASeq
EGAS00001007303 Exome Sequencing

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Quality Report
Located in
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EGAF00008087404 bam 1.4 GB Report
EGAF00008087405 bam 1.6 GB Report
EGAF00008087406 bam 2.1 GB Report
EGAF00008087407 bam 1.7 GB Report
EGAF00008087408 bam 3.2 GB Report
EGAF00008087409 bam 1.6 GB Report
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EGAF00008087411 bam 1.5 GB Report
EGAF00008087412 bam 1.7 GB Report
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EGAF00008087414 bam 2.2 GB Report
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EGAF00008087417 bam 1.9 GB Report
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EGAF00008087419 bam 1.6 GB Report
EGAF00008087420 bam 1.7 GB Report
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EGAF00008087422 bam 1.9 GB Report
EGAF00008087423 bam 2.1 GB Report
EGAF00008087424 bam 1.6 GB Report
EGAF00008087425 bam 1.8 GB Report
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EGAF00008087427 bam 2.7 GB Report
EGAF00008087428 bam 2.3 GB Report
EGAF00008087429 bam 2.6 GB Report
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EGAF00008087433 bam 3.1 GB Report
EGAF00008087434 bam 2.4 GB Report
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EGAF00008087445 bam 1.9 GB Report
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EGAF00008087447 bam 1.6 GB Report
EGAF00008087448 bam 1.9 GB Report
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EGAF00008087450 bam 2.7 GB Report
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EGAF00008087463 bam 1.9 GB Report
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EGAF00008087465 bam 2.5 GB Report
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EGAF00008087487 bam 1.9 GB Report
EGAF00008087488 bam 1.8 GB Report
EGAF00008087489 bam 2.1 GB Report
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EGAF00008087491 bam 1.8 GB Report
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EGAF00008087493 bam 2.1 GB Report
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EGAF00008087495 bam 2.1 GB Report
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EGAF00008087497 bam 2.2 GB Report
EGAF00008087498 bam 2.6 GB Report
EGAF00008087499 bam 1.9 GB Report
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EGAF00008087503 bam 1.6 GB Report
EGAF00008087504 bam 1.8 GB Report
EGAF00008087505 bam 2.0 GB Report
EGAF00008087506 bam 2.6 GB Report
EGAF00008087507 bam 2.1 GB Report
EGAF00008087508 bam 1.9 GB Report
EGAF00008087509 bam 2.8 GB Report
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EGAF00008087511 bam 2.0 GB Report
EGAF00008087512 bam 2.3 GB Report
EGAF00008087513 bam 1.9 GB Report
EGAF00008087514 bam 2.5 GB Report
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EGAF00008087516 bam 2.0 GB Report
EGAF00008087517 bam 2.3 GB Report
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EGAF00008087521 bam 2.6 GB Report
EGAF00008087522 bam 2.4 GB Report
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EGAF00008087526 bam 2.3 GB Report
EGAF00008087527 bam 2.0 GB Report
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EGAF00008087529 bam 2.0 GB Report
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EGAF00008087533 bam 2.3 GB Report
EGAF00008087534 bam 2.1 GB Report
EGAF00008087535 bam 2.1 GB Report
EGAF00008087536 bam 486.1 MB Report
EGAF00008087537 bam 2.0 GB Report
EGAF00008087538 bam 2.1 GB Report
EGAF00008087539 bam 2.1 GB Report
EGAF00008087540 bam 1.8 GB Report
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EGAF00008087543 bam 1.9 GB Report
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EGAF00008087545 bam 2.3 GB Report
EGAF00008087546 bam 3.9 GB Report
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EGAF00008087554 bam 2.5 GB Report
EGAF00008087555 bam 1.9 GB Report
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EGAF00008087560 bam 2.0 GB Report
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EGAF00008087566 bam 1.9 GB Report
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EGAF00008087568 bam 1.8 GB Report
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EGAF00008087570 bam 2.3 GB Report
EGAF00008087571 bam 2.4 GB Report
EGAF00008087572 bam 1.9 GB Report
EGAF00008087573 bam 2.3 GB Report
EGAF00008087574 bam 2.1 GB Report
EGAF00008087575 bam 1.9 GB Report
EGAF00008087576 bam 1.8 GB Report
EGAF00008087577 bam 1.7 GB Report
EGAF00008087578 bam 2.1 GB Report
EGAF00008087579 bam 1.9 GB Report
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EGAF00008087582 bam 2.0 GB Report
EGAF00008087583 bam 1.9 GB Report
EGAF00008087584 bam 2.2 GB Report
EGAF00008087585 bam 2.2 GB Report
EGAF00008087586 bam 2.1 GB Report
EGAF00008087587 bam 444.8 MB Report
EGAF00008087588 bam 2.1 GB Report
EGAF00008087589 bam 2.4 GB Report
EGAF00008087590 bam 2.1 GB Report
EGAF00008087591 bam 2.0 GB Report
EGAF00008087592 bam 1.8 GB Report
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EGAF00008087594 bam 2.5 GB Report
EGAF00008087595 bam 2.1 GB Report
EGAF00008087596 bam 2.2 GB Report
EGAF00008087597 bam 2.1 GB Report
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EGAF00008087599 bam 1.7 GB Report
EGAF00008087600 bam 1.8 GB Report
EGAF00008087601 bam 2.1 GB Report
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EGAF00008087603 bam 2.4 GB Report
EGAF00008087604 bam 1.8 GB Report
EGAF00008087605 bam 2.6 GB Report
EGAF00008087606 bam 2.3 GB Report
EGAF00008087607 bam 2.1 GB Report
EGAF00008087608 bam 1.9 GB Report
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EGAF00008087610 bam 2.5 GB Report
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EGAF00008087612 bam 2.2 GB Report
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EGAF00008087614 bam 2.4 GB Report
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EGAF00008087620 bam 2.7 GB Report
EGAF00008087621 bam 3.1 GB Report
EGAF00008087622 bam 1.8 GB Report
EGAF00008087623 bam 1.5 GB Report
EGAF00008087624 bam 1.9 GB Report
EGAF00008087625 bam 1.5 GB Report
EGAF00008087626 bam 2.0 GB Report
EGAF00008087627 bam 1.6 GB Report
EGAF00008087628 bam 1.3 GB Report
EGAF00008087629 bam 2.0 GB Report
EGAF00008087630 bam 2.1 GB Report
EGAF00008087631 bam 2.1 GB Report
EGAF00008087632 bam 2.5 GB Report
EGAF00008087633 bam 2.0 GB Report
EGAF00008089002 txt 2.3 MB
EGAF00008089003 txt 123.5 MB
707 Files (1.3 TB)