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Targeted Validation Samples

The dataset consists of targeted sequencing data obtained from an independent cohort of 11 patients to validate discriminative DMRs (differentially methylated regions) for Acute coronary syndrome (ACS) subtypes. The cohort includes 2 healthy subjects, 4 STEMI (ST-segment elevation myocardial infarction), 3 NSTEMI (non-ST-segment elevation myocardial infarction), and 2 UA (unstable angina) patients. The sequencing panel targeted 18,831 CpGs for analysis, reaching at least 5 reads coverage for 75% of the targeted CpGs in each sample. The sequencing was performed using the NEBNext Enzymatic Methyl-seq Module and the Nonacus Cell3TMTarget: Library Preparation kit, followed by probe hybridization, capture enrichment, and sequencing on the Novaseq 6000 platform, generating 400 million reads. The dataset is in raw fastq format.

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The Policy for Controlled-Access Data Access establishes a framework for responsible and ethical access to controlled-access data. By implementing a Data Access Committee and rigorous application review processes, the policy ensures the protection of privacy, confidentiality, and compliance with legal and ethical requirements. It emphasizes data security, responsible data governance, and transparent communication with applicants and stakeholders. Regular policy reviews and updates guarantee alignment with advancements in technology, regulations, and ethical standards. By adhering to this policy, the DAC facilitates access to controlled-access data for research purposes while prioritizing privacy, confidentiality, and the responsible use of data.

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001007263 Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00008093179 fastq.gz 1.8 GB
EGAF00008093180 fastq.gz 1.7 GB
EGAF00008093181 fastq.gz 2.1 GB
EGAF00008093182 fastq.gz 2.0 GB
EGAF00008093183 fastq.gz 1.6 GB
EGAF00008093184 fastq.gz 1.5 GB
EGAF00008093185 fastq.gz 2.2 GB
EGAF00008093186 fastq.gz 2.0 GB
EGAF00008093187 fastq.gz 1.7 GB
EGAF00008093188 fastq.gz 1.6 GB
EGAF00008093189 fastq.gz 2.1 GB
EGAF00008093190 fastq.gz 2.0 GB
EGAF00008093191 fastq.gz 2.0 GB
EGAF00008093192 fastq.gz 1.9 GB
EGAF00008093193 fastq.gz 1.8 GB
EGAF00008093194 fastq.gz 1.7 GB
EGAF00008093195 fastq.gz 1.5 GB
EGAF00008093196 fastq.gz 1.5 GB
EGAF00008093197 fastq.gz 1.8 GB
EGAF00008093198 fastq.gz 1.7 GB
EGAF00008093199 fastq.gz 2.0 GB
EGAF00008093200 fastq.gz 1.9 GB
22 Files (40.0 GB)