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Neoantigen Immunogenicity Landscapes and Evolution of Tumor Ecosystems During Immunotherapy with Nivolumab

We performed Whole Exome (WXS) and RNASeq sequencing on samples obtained from the same site before and during therapy from our prospective clinical trial (CA209-153, NCT02066636) of nivolumab in advanced Non-small cell lung cancer (NSCLC) patients that progressed on chemotherapy. There are 58 pre and 42 on therapy WXS samples and 24 pre and 12 on therapy RNASeq samples. All WXS tumor samples have matching normal samples.

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Clinical data will be shared at the discretion of Bristol Myers Squib; please contact Dr. William Geese william.geese@bms.com

Clinical data will be shared at the discretion of Bristol Myers Squib; please contact Dr. William Geese william.geese@bms.com

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001007508 Other
EGAS00001007509 Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00008207533 fastq.gz 2.5 GB
EGAF00008207534 fastq.gz 2.7 GB
EGAF00008207535 fastq.gz 5.0 GB
EGAF00008207536 fastq.gz 5.5 GB
EGAF00008207537 fastq.gz 5.1 GB
EGAF00008207538 fastq.gz 5.8 GB
EGAF00008207539 fastq.gz 5.7 GB
EGAF00008207540 fastq.gz 6.1 GB
EGAF00008207541 fastq.gz 8.2 GB
EGAF00008207542 fastq.gz 11.1 GB
EGAF00008207543 fastq.gz 2.7 GB
EGAF00008207544 fastq.gz 2.8 GB
EGAF00008207545 fastq.gz 7.5 GB
EGAF00008207546 fastq.gz 9.4 GB
EGAF00008207547 fastq.gz 786.9 MB
EGAF00008207548 fastq.gz 783.3 MB
EGAF00008207549 fastq.gz 2.2 GB
EGAF00008207550 fastq.gz 2.4 GB
EGAF00008207551 fastq.gz 7.2 GB
EGAF00008207552 fastq.gz 8.5 GB
EGAF00008207553 fastq.gz 2.4 GB
EGAF00008207554 fastq.gz 2.3 GB
EGAF00008207555 fastq.gz 5.7 GB
EGAF00008207556 fastq.gz 6.1 GB
EGAF00008207557 fastq.gz 6.2 GB
EGAF00008207558 fastq.gz 6.8 GB
EGAF00008207559 fastq.gz 7.5 GB
EGAF00008207560 fastq.gz 9.4 GB
EGAF00008207561 fastq.gz 1.8 GB
EGAF00008207562 fastq.gz 1.8 GB
EGAF00008207563 fastq.gz 5.2 GB
EGAF00008207564 fastq.gz 5.8 GB
EGAF00008207565 fastq.gz 5.9 GB
EGAF00008207566 fastq.gz 7.2 GB
EGAF00008207567 fastq.gz 2.4 GB
EGAF00008207568 fastq.gz 2.7 GB
EGAF00008207569 fastq.gz 6.7 GB
EGAF00008207570 fastq.gz 7.8 GB
EGAF00008207571 fastq.gz 6.4 GB
EGAF00008207572 fastq.gz 6.8 GB
EGAF00008207573 fastq.gz 9.9 GB
EGAF00008207574 fastq.gz 10.9 GB
EGAF00008207575 fastq.gz 732.8 MB
EGAF00008207576 fastq.gz 734.9 MB
EGAF00008207577 fastq.gz 6.0 GB
EGAF00008207578 fastq.gz 7.1 GB
EGAF00008207579 fastq.gz 2.3 GB
EGAF00008207580 fastq.gz 2.3 GB
EGAF00008207581 fastq.gz 1.9 GB
EGAF00008207582 fastq.gz 2.1 GB
EGAF00008207583 fastq.gz 5.9 GB
EGAF00008207584 fastq.gz 6.6 GB
EGAF00008207585 fastq.gz 5.9 GB
EGAF00008207586 fastq.gz 6.1 GB
EGAF00008207587 fastq.gz 2.9 GB
EGAF00008207588 fastq.gz 3.3 GB
EGAF00008207589 fastq.gz 9.0 GB
EGAF00008207590 fastq.gz 11.0 GB
EGAF00008207591 fastq.gz 4.8 GB
EGAF00008207592 fastq.gz 5.8 GB
EGAF00008207593 fastq.gz 2.6 GB
EGAF00008207594 fastq.gz 2.8 GB
EGAF00008207595 fastq.gz 5.4 GB
EGAF00008207596 fastq.gz 6.3 GB
EGAF00008207597 fastq.gz 4.2 GB
EGAF00008207598 fastq.gz 4.8 GB
EGAF00008207599 fastq.gz 4.0 GB
EGAF00008207600 fastq.gz 4.5 GB
EGAF00008207601 fastq.gz 7.2 GB
EGAF00008207602 fastq.gz 8.4 GB
EGAF00008207603 fastq.gz 6.0 GB
EGAF00008207604 fastq.gz 6.7 GB
EGAF00008207605 fastq.gz 5.6 GB
EGAF00008207606 fastq.gz 5.9 GB
EGAF00008207607 fastq.gz 7.1 GB
EGAF00008207608 fastq.gz 9.0 GB
EGAF00008207609 fastq.gz 3.3 GB
EGAF00008207610 fastq.gz 3.3 GB
EGAF00008207611 fastq.gz 3.6 GB
EGAF00008207612 fastq.gz 4.3 GB
EGAF00008207613 fastq.gz 5.9 GB
EGAF00008207614 fastq.gz 7.1 GB
EGAF00008207615 fastq.gz 5.1 GB
EGAF00008207616 fastq.gz 5.8 GB
EGAF00008207617 fastq.gz 7.8 GB
EGAF00008207618 fastq.gz 9.0 GB
EGAF00008207619 fastq.gz 8.8 GB
EGAF00008207620 fastq.gz 10.4 GB
EGAF00008207621 fastq.gz 4.1 GB
EGAF00008207622 fastq.gz 4.6 GB
EGAF00008207623 fastq.gz 4.6 GB
EGAF00008207624 fastq.gz 5.4 GB
EGAF00008207625 fastq.gz 3.2 GB
EGAF00008207626 fastq.gz 3.6 GB
EGAF00008207627 fastq.gz 6.3 GB
EGAF00008207628 fastq.gz 6.9 GB
EGAF00008207629 fastq.gz 5.6 GB
EGAF00008207630 fastq.gz 6.3 GB
EGAF00008207631 fastq.gz 5.2 GB
EGAF00008207632 fastq.gz 5.6 GB
EGAF00008207633 fastq.gz 4.9 GB
EGAF00008207634 fastq.gz 6.3 GB
EGAF00008207635 fastq.gz 3.1 GB
EGAF00008207636 fastq.gz 3.1 GB
EGAF00008207637 fastq.gz 3.7 GB
EGAF00008207638 fastq.gz 4.7 GB
EGAF00008207639 fastq.gz 8.9 GB
EGAF00008207640 fastq.gz 10.3 GB
EGAF00008207641 fastq.gz 1.7 GB
EGAF00008207642 fastq.gz 1.7 GB
EGAF00008207643 fastq.gz 5.3 GB
EGAF00008207644 fastq.gz 6.0 GB
EGAF00008207645 fastq.gz 2.4 GB
EGAF00008207646 fastq.gz 2.5 GB
EGAF00008207647 fastq.gz 3.5 GB
EGAF00008207648 fastq.gz 4.1 GB
EGAF00008207649 fastq.gz 7.2 GB
EGAF00008207650 fastq.gz 8.3 GB
EGAF00008207651 fastq.gz 5.7 GB
EGAF00008207652 fastq.gz 6.7 GB
EGAF00008207653 fastq.gz 3.4 GB
EGAF00008207654 fastq.gz 3.9 GB
EGAF00008207655 fastq.gz 8.2 GB
EGAF00008207656 fastq.gz 9.6 GB
EGAF00008207657 fastq.gz 7.0 GB
EGAF00008207658 fastq.gz 8.1 GB
EGAF00008207659 fastq.gz 6.6 GB
EGAF00008207660 fastq.gz 8.1 GB
EGAF00008207661 fastq.gz 4.8 GB
EGAF00008207662 fastq.gz 5.8 GB
EGAF00008207663 fastq.gz 2.1 GB
EGAF00008207664 fastq.gz 2.3 GB
EGAF00008207665 fastq.gz 5.1 GB
EGAF00008207666 fastq.gz 6.0 GB
EGAF00008207667 fastq.gz 2.4 GB
EGAF00008207668 fastq.gz 2.6 GB
EGAF00008207669 fastq.gz 5.3 GB
EGAF00008207670 fastq.gz 6.0 GB
EGAF00008207671 fastq.gz 2.0 GB
EGAF00008207672 fastq.gz 2.2 GB
EGAF00008207673 fastq.gz 6.0 GB
EGAF00008207674 fastq.gz 6.8 GB
EGAF00008207675 fastq.gz 6.4 GB
EGAF00008207676 fastq.gz 7.0 GB
EGAF00008207677 fastq.gz 4.7 GB
EGAF00008207678 fastq.gz 5.7 GB
EGAF00008207679 fastq.gz 7.6 GB
EGAF00008207680 fastq.gz 9.2 GB
EGAF00008207681 fastq.gz 5.2 GB
EGAF00008207682 fastq.gz 5.5 GB
EGAF00008207683 fastq.gz 417.0 MB
EGAF00008207684 fastq.gz 423.9 MB
EGAF00008207685 fastq.gz 1.9 GB
EGAF00008207686 fastq.gz 2.0 GB
EGAF00008207687 fastq.gz 6.0 GB
EGAF00008207688 fastq.gz 6.5 GB
EGAF00008207689 fastq.gz 3.4 GB
EGAF00008207690 fastq.gz 3.9 GB
EGAF00008207691 fastq.gz 7.5 GB
EGAF00008207692 fastq.gz 9.2 GB
EGAF00008207693 fastq.gz 1.2 GB
EGAF00008207694 fastq.gz 1.1 GB
EGAF00008207695 fastq.gz 5.8 GB
EGAF00008207696 fastq.gz 7.0 GB
EGAF00008207697 fastq.gz 1.5 GB
EGAF00008207698 fastq.gz 1.5 GB
EGAF00008207699 fastq.gz 2.3 GB
EGAF00008207700 fastq.gz 2.5 GB
EGAF00008207701 fastq.gz 6.5 GB
EGAF00008207702 fastq.gz 7.1 GB
EGAF00008207703 fastq.gz 6.4 GB
EGAF00008207704 fastq.gz 6.7 GB
EGAF00008207705 fastq.gz 363.0 MB
EGAF00008207706 fastq.gz 372.9 MB
EGAF00008207707 fastq.gz 1.9 GB
EGAF00008207708 fastq.gz 2.1 GB
EGAF00008207709 fastq.gz 5.7 GB
EGAF00008207710 fastq.gz 6.4 GB
EGAF00008207711 fastq.gz 3.5 GB
EGAF00008207712 fastq.gz 3.9 GB
EGAF00008207713 fastq.gz 6.4 GB
EGAF00008207714 fastq.gz 7.4 GB
EGAF00008207715 fastq.gz 3.1 GB
EGAF00008207716 fastq.gz 3.4 GB
EGAF00008207717 fastq.gz 3.7 GB
EGAF00008207718 fastq.gz 4.3 GB
EGAF00008207719 fastq.gz 3.2 GB
EGAF00008207720 fastq.gz 3.3 GB
EGAF00008207721 fastq.gz 5.8 GB
EGAF00008207722 fastq.gz 6.7 GB
EGAF00008207723 fastq.gz 2.7 GB
EGAF00008207724 fastq.gz 3.0 GB
EGAF00008207725 fastq.gz 5.3 GB
EGAF00008207726 fastq.gz 6.5 GB
EGAF00008207727 fastq.gz 1.6 GB
EGAF00008207728 fastq.gz 1.7 GB
EGAF00008207729 fastq.gz 2.8 GB
EGAF00008207730 fastq.gz 3.1 GB
EGAF00008207731 fastq.gz 1.9 GB
EGAF00008207732 fastq.gz 2.0 GB
EGAF00008207733 fastq.gz 5.3 GB
EGAF00008207734 fastq.gz 5.7 GB
EGAF00008207735 fastq.gz 5.8 GB
EGAF00008207736 fastq.gz 6.6 GB
EGAF00008207737 fastq.gz 2.2 GB
EGAF00008207738 fastq.gz 2.3 GB
EGAF00008207739 fastq.gz 6.1 GB
EGAF00008207740 fastq.gz 8.2 GB
EGAF00008207741 fastq.gz 2.8 GB
EGAF00008207742 fastq.gz 2.8 GB
EGAF00008207743 fastq.gz 8.0 GB
EGAF00008207744 fastq.gz 9.1 GB
EGAF00008207745 fastq.gz 4.2 GB
EGAF00008207746 fastq.gz 4.2 GB
EGAF00008207747 fastq.gz 4.1 GB
EGAF00008207748 fastq.gz 5.0 GB
EGAF00008207749 fastq.gz 6.2 GB
EGAF00008207750 fastq.gz 7.0 GB
EGAF00008207751 fastq.gz 3.8 GB
EGAF00008207752 fastq.gz 4.6 GB
EGAF00008207753 fastq.gz 5.7 GB
EGAF00008207754 fastq.gz 6.5 GB
EGAF00008207755 fastq.gz 2.2 GB
EGAF00008207756 fastq.gz 2.5 GB
EGAF00008207757 fastq.gz 5.3 GB
EGAF00008207758 fastq.gz 6.2 GB
EGAF00008207759 fastq.gz 3.1 GB
EGAF00008207760 fastq.gz 3.4 GB
EGAF00008207761 fastq.gz 7.2 GB
EGAF00008207762 fastq.gz 7.9 GB
EGAF00008207763 fastq.gz 3.5 GB
EGAF00008207764 fastq.gz 3.5 GB
EGAF00008207765 fastq.gz 5.5 GB
EGAF00008207766 fastq.gz 6.7 GB
EGAF00008207767 fastq.gz 1.7 GB
EGAF00008207768 fastq.gz 1.7 GB
EGAF00008207769 fastq.gz 7.6 GB
EGAF00008207770 fastq.gz 8.8 GB
EGAF00008207771 fastq.gz 6.0 GB
EGAF00008207772 fastq.gz 6.8 GB
EGAF00008207773 fastq.gz 2.6 GB
EGAF00008207774 fastq.gz 2.8 GB
EGAF00008207775 fastq.gz 6.9 GB
EGAF00008207776 fastq.gz 7.8 GB
EGAF00008207777 fastq.gz 551.7 MB
EGAF00008207778 fastq.gz 565.3 MB
EGAF00008207779 fastq.gz 7.0 GB
EGAF00008207780 fastq.gz 8.1 GB
EGAF00008207781 fastq.gz 534.5 MB
EGAF00008207782 fastq.gz 551.1 MB
EGAF00008207783 fastq.gz 2.1 GB
EGAF00008207784 fastq.gz 2.2 GB
EGAF00008207785 fastq.gz 4.6 GB
EGAF00008207786 fastq.gz 5.0 GB
EGAF00008207787 fastq.gz 7.5 GB
EGAF00008207788 fastq.gz 8.9 GB
EGAF00008207789 fastq.gz 2.8 GB
EGAF00008207790 fastq.gz 3.2 GB
EGAF00008207791 fastq.gz 6.0 GB
EGAF00008207792 fastq.gz 7.2 GB
EGAF00008207793 fastq.gz 2.0 GB
EGAF00008207794 fastq.gz 2.1 GB
EGAF00008207795 fastq.gz 5.1 GB
EGAF00008207796 fastq.gz 5.8 GB
EGAF00008207797 fastq.gz 5.8 GB
EGAF00008207798 fastq.gz 6.3 GB
EGAF00008207799 fastq.gz 1.9 GB
EGAF00008207800 fastq.gz 2.0 GB
EGAF00008207801 fastq.gz 6.9 GB
EGAF00008207802 fastq.gz 8.2 GB
EGAF00008207803 fastq.gz 8.8 GB
EGAF00008207804 fastq.gz 10.5 GB
EGAF00008207805 fastq.gz 579.0 MB
EGAF00008207806 fastq.gz 577.7 MB
EGAF00008207807 fastq.gz 3.3 GB
EGAF00008207808 fastq.gz 3.7 GB
EGAF00008207809 fastq.gz 6.8 GB
EGAF00008207810 fastq.gz 7.3 GB
EGAF00008207811 fastq.gz 3.4 GB
EGAF00008207812 fastq.gz 3.5 GB
EGAF00008207813 fastq.gz 6.7 GB
EGAF00008207814 fastq.gz 7.6 GB
EGAF00008207815 fastq.gz 2.0 GB
EGAF00008207816 fastq.gz 2.0 GB
EGAF00008207817 fastq.gz 2.8 GB
EGAF00008207818 fastq.gz 3.1 GB
EGAF00008207819 fastq.gz 7.4 GB
EGAF00008207820 fastq.gz 9.0 GB
EGAF00008207821 fastq.gz 1.8 GB
EGAF00008207822 fastq.gz 1.8 GB
EGAF00008207823 fastq.gz 5.6 GB
EGAF00008207824 fastq.gz 6.7 GB
EGAF00008207825 fastq.gz 1.9 GB
EGAF00008207826 fastq.gz 1.9 GB
EGAF00008207827 fastq.gz 2.5 GB
EGAF00008207828 fastq.gz 2.7 GB
EGAF00008207829 fastq.gz 6.6 GB
EGAF00008207830 fastq.gz 7.0 GB
EGAF00008207831 fastq.gz 5.1 GB
EGAF00008207832 fastq.gz 5.7 GB
EGAF00008207833 fastq.gz 3.1 GB
EGAF00008207834 fastq.gz 3.5 GB
EGAF00008207835 fastq.gz 6.2 GB
EGAF00008207836 fastq.gz 6.5 GB
EGAF00008207837 fastq.gz 850.7 MB
EGAF00008207838 fastq.gz 893.3 MB
EGAF00008207839 fastq.gz 2.4 GB
EGAF00008207840 fastq.gz 2.7 GB
EGAF00008207841 fastq.gz 9.2 GB
EGAF00008207842 fastq.gz 9.6 GB
EGAF00008207843 fastq.gz 2.9 GB
EGAF00008207844 fastq.gz 2.9 GB
EGAF00008207845 fastq.gz 4.3 GB
EGAF00008207846 fastq.gz 4.8 GB
EGAF00008207847 fastq.gz 7.8 GB
EGAF00008207848 fastq.gz 8.3 GB
EGAF00008207849 fastq.gz 6.3 GB
EGAF00008207850 fastq.gz 7.6 GB
EGAF00008207851 fastq.gz 2.9 GB
EGAF00008207852 fastq.gz 3.3 GB
EGAF00008207853 fastq.gz 7.3 GB
EGAF00008207854 fastq.gz 8.4 GB
EGAF00008207855 fastq.gz 3.9 GB
EGAF00008207856 fastq.gz 4.5 GB
EGAF00008207857 fastq.gz 4.3 GB
EGAF00008207858 fastq.gz 5.0 GB
EGAF00008207859 fastq.gz 3.0 GB
EGAF00008207860 fastq.gz 3.0 GB
EGAF00008207861 fastq.gz 6.5 GB
EGAF00008207862 fastq.gz 7.9 GB
EGAF00008207863 fastq.gz 1.8 GB
EGAF00008207864 fastq.gz 1.8 GB
EGAF00008207865 fastq.gz 2.7 GB
EGAF00008207866 fastq.gz 3.0 GB
EGAF00008207867 fastq.gz 4.9 GB
EGAF00008207868 fastq.gz 5.8 GB
EGAF00008207869 fastq.gz 6.4 GB
EGAF00008207870 fastq.gz 7.2 GB
EGAF00008207871 fastq.gz 1.6 GB
EGAF00008207872 fastq.gz 1.5 GB
EGAF00008207873 fastq.gz 2.4 GB
EGAF00008207874 fastq.gz 2.6 GB
EGAF00008207875 fastq.gz 6.9 GB
EGAF00008207876 fastq.gz 7.8 GB
EGAF00008207877 fastq.gz 2.6 GB
EGAF00008207878 fastq.gz 2.9 GB
EGAF00008207879 fastq.gz 4.9 GB
EGAF00008207880 fastq.gz 5.6 GB
EGAF00008207881 fastq.gz 5.4 GB
EGAF00008207882 fastq.gz 6.4 GB
EGAF00008207883 fastq.gz 2.0 GB
EGAF00008207884 fastq.gz 2.1 GB
EGAF00008207885 fastq.gz 7.5 GB
EGAF00008207886 fastq.gz 8.6 GB
EGAF00008207887 fastq.gz 2.9 GB
EGAF00008207888 fastq.gz 3.0 GB
EGAF00008207889 fastq.gz 1.8 GB
EGAF00008207890 fastq.gz 1.8 GB
EGAF00008207891 fastq.gz 4.1 GB
EGAF00008207892 fastq.gz 4.5 GB
EGAF00008207893 fastq.gz 6.6 GB
EGAF00008207894 fastq.gz 7.2 GB
EGAF00008207895 fastq.gz 5.7 GB
EGAF00008207896 fastq.gz 6.7 GB
EGAF00008207897 fastq.gz 3.8 GB
EGAF00008207898 fastq.gz 4.4 GB
EGAF00008207899 fastq.gz 8.1 GB
EGAF00008207900 fastq.gz 9.8 GB
EGAF00008207901 fastq.gz 2.0 GB
EGAF00008207902 fastq.gz 2.1 GB
EGAF00008207903 fastq.gz 6.1 GB
EGAF00008207904 fastq.gz 6.9 GB
EGAF00008207905 fastq.gz 7.2 GB
EGAF00008207906 fastq.gz 8.1 GB
EGAF00008207907 fastq.gz 3.6 GB
EGAF00008207908 fastq.gz 4.5 GB
EGAF00008207909 fastq.gz 4.6 GB
EGAF00008207910 fastq.gz 5.2 GB
EGAF00008207911 fastq.gz 6.6 GB
EGAF00008207912 fastq.gz 7.9 GB
EGAF00008207913 fastq.gz 2.3 GB
EGAF00008207914 fastq.gz 2.5 GB
EGAF00008207915 fastq.gz 5.4 GB
EGAF00008207916 fastq.gz 6.3 GB
EGAF00008207917 fastq.gz 2.3 GB
EGAF00008207918 fastq.gz 2.5 GB
EGAF00008207919 fastq.gz 5.6 GB
EGAF00008207920 fastq.gz 6.5 GB
EGAF00008207921 fastq.gz 4.6 GB
EGAF00008207922 fastq.gz 4.7 GB
EGAF00008207923 fastq.gz 2.2 GB
EGAF00008207924 fastq.gz 2.3 GB
EGAF00008207925 fastq.gz 7.4 GB
EGAF00008207926 fastq.gz 8.7 GB
EGAF00008207927 fastq.gz 6.3 GB
EGAF00008207928 fastq.gz 7.1 GB
EGAF00008207929 fastq.gz 5.3 GB
EGAF00008207930 fastq.gz 5.8 GB
EGAF00008207931 fastq.gz 2.4 GB
EGAF00008207932 fastq.gz 2.5 GB
400 Files (2.0 TB)