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Oxidative phosphorylation is a key ontogenetic feature of monocyte immunometabolism promoting myeloid differentiation after birth

The dataset consists of 12 samples of monocytes, which were analyzed using RNA-sequencing (RNA-seq). These samples were categorized into four distinct groups, each comprising three samples. The dataset was designed to investigate the transcriptomic and metabolic profiles of monocytes across different age groups and stimulation conditions. 3 neonatal controls, 3 neonatal LPS stimulated, 3 adult controls and 3 adult LPS stimulated samples.

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Neonatal immune responses differ from adults. Neonatal monocytes rely on glycolysis for inflammation while maintaining high oxidative phosphorylation (OXPHOS) for differentiation. This metabolic pattern gradually changes in the first five years of life, with dietary changes unable to fully reverse it. Key regulators include E2F1, MYB, STAT1, and FLI1. This unique immunometabolism adapts gradually in response to childhood microbial challenges.

Access to data generated is made available by completing the data access agreement for review by the data access committee and will be granted exclusively to qualified investigators for appropriate use.

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001007555 Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00008243265 fastq.gz 528.3 MB
EGAF00008243266 fastq.gz 555.1 MB
EGAF00008243267 fastq.gz 1.9 GB
EGAF00008243268 fastq.gz 2.0 GB
EGAF00008243269 fastq.gz 1.2 GB
EGAF00008243270 fastq.gz 1.2 GB
EGAF00008243271 fastq.gz 1.8 GB
EGAF00008243272 fastq.gz 1.7 GB
EGAF00008243273 fastq.gz 1.8 GB
EGAF00008243274 fastq.gz 1.9 GB
EGAF00008243275 fastq.gz 1.6 GB
EGAF00008243276 fastq.gz 1.7 GB
EGAF00008243277 fastq.gz 794.9 MB
EGAF00008243278 fastq.gz 846.8 MB
EGAF00008243279 fastq.gz 636.7 MB
EGAF00008243280 fastq.gz 674.7 MB
EGAF00008243281 fastq.gz 927.0 MB
EGAF00008243282 fastq.gz 988.2 MB
EGAF00008243283 fastq.gz 4.4 GB
EGAF00008243284 fastq.gz 4.4 GB
EGAF00008243285 fastq.gz 4.3 GB
EGAF00008243286 fastq.gz 4.6 GB
EGAF00008243287 fastq.gz 1.3 GB
EGAF00008243288 fastq.gz 1.4 GB
24 Files (43.2 GB)