Age-specific nasal epithelial responses to SARS-CoV-2 infection : GEX
In this study, we investigate differences in the cellular landscape and functionality of ex vivo cultured nasal epithelial cells in response to SARS-CoV-2 infection across different age groups: paediatric (<12y), adult (30-50y), and older adults (>70y). We unravel, that while ciliated cells serve as primary sites for viral replication consistently across all age groups, a distinctive goblet inflammatory subtype emerges in infected paediatric cultures, characterized by heightened expression of interferon-stimulated genes and incomplete viral replication. Conversely, older adult cultures infected with SARS-CoV-2 exhibit a proportional surge in basaloid-like cells, which not only facilitate viral dissemination but also demonstrate associations with altered epithelial repair pathways.
- 20/02/2024
- 17 samples
- DAC: EGAC00001000205
- Technology: Illumina NovaSeq 6000
Wellcome Trust Sanger Institute Data Sharing Policy
Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.
| Study ID | Study Title | Study Type |
|---|---|---|
| EGAS00001004391 | Transcriptome Analysis |
This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.
| ID | File Type | Size | Quality Report |
Located in
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|---|---|---|---|---|
| EGAF00008404559 | cram | 14.1 GB | Report |
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| EGAF00008404560 | cram | 13.6 GB | Report |
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| EGAF00008404561 | cram | 17.1 GB | Report |
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| EGAF00008404562 | cram | 15.8 GB | Report |
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| EGAF00008404563 | cram | 14.7 GB | Report |
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| EGAF00008404564 | cram | 14.9 GB | Report |
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| EGAF00008404565 | cram | 9.8 GB | Report |
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| EGAF00008404566 | cram | 2.8 GB | Report |
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| EGAF00008404567 | cram | 3.9 GB | Report |
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| EGAF00008404568 | cram | 2.9 GB | Report |
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| EGAF00008404569 | cram | 2.5 GB | Report |
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| EGAF00008404570 | cram | 3.4 GB | Report |
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| EGAF00008404571 | cram | 2.1 GB | Report |
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| EGAF00008404572 | cram | 3.1 GB | Report |
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| EGAF00008404573 | cram | 3.2 GB | Report |
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| EGAF00008404574 | cram | 2.7 GB | Report |
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| EGAF00008404575 | cram | 3.0 GB | Report |
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| EGAF00008404576 | cram | 3.3 GB | Report |
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| EGAF00008404577 | cram | 1.4 GB | Report |
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| EGAF00008404578 | cram | 2.8 GB | Report |
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| EGAF00008404579 | cram | 2.4 GB | Report |
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| EGAF00008404580 | cram | 3.7 GB | Report |
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| EGAF00008404581 | cram | 2.5 GB | Report |
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| EGAF00008404582 | cram | 4.0 GB | Report |
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| EGAF00008404583 | cram | 2.4 GB | Report |
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| EGAF00008404584 | cram | 3.0 GB | Report |
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| EGAF00008404585 | cram | 1.9 GB | Report |
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| EGAF00008404586 | cram | 4.1 GB | Report |
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| EGAF00008404587 | cram | 2.7 GB | Report |
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| EGAF00008404588 | cram | 3.0 GB | Report |
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| EGAF00008404589 | cram | 2.3 GB | Report |
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| EGAF00008404590 | cram | 2.8 GB | Report |
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| EGAF00008404591 | cram | 3.7 GB | Report |
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| EGAF00008404592 | cram | 3.3 GB | Report |
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| EGAF00008404593 | cram | 3.0 GB | Report |
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| EGAF00008404594 | cram | 2.8 GB | Report |
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| EGAF00008404595 | cram | 3.9 GB | Report |
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| EGAF00008404596 | cram | 2.9 GB | Report |
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| EGAF00008404597 | cram | 2.5 GB | Report |
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| EGAF00008404598 | cram | 3.3 GB | Report |
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| EGAF00008404599 | cram | 2.1 GB | Report |
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| EGAF00008404600 | cram | 3.1 GB | Report |
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| EGAF00008404601 | cram | 3.1 GB | Report |
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| EGAF00008404602 | cram | 2.7 GB | Report |
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| EGAF00008404603 | cram | 3.0 GB | Report |
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| EGAF00008404604 | cram | 3.3 GB | Report |
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| EGAF00008404605 | cram | 1.4 GB | Report |
|
| EGAF00008404606 | cram | 2.8 GB | Report |
|
| EGAF00008404607 | cram | 2.4 GB | Report |
|
| EGAF00008404608 | cram | 3.7 GB | Report |
|
| EGAF00008404609 | cram | 2.5 GB | Report |
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| EGAF00008404610 | cram | 4.0 GB | Report |
|
| EGAF00008404611 | cram | 2.4 GB | Report |
|
| EGAF00008404612 | cram | 3.0 GB | Report |
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| EGAF00008404613 | cram | 1.9 GB | Report |
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| EGAF00008404614 | cram | 4.1 GB | Report |
|
| EGAF00008404615 | cram | 2.7 GB | Report |
|
| EGAF00008404616 | cram | 3.0 GB | Report |
|
| EGAF00008404617 | cram | 2.3 GB | Report |
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| EGAF00008404618 | cram | 2.8 GB | Report |
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| EGAF00008404619 | cram | 3.7 GB | Report |
|
| EGAF00008404620 | cram | 3.3 GB | Report |
|
| EGAF00008404621 | cram | 3.0 GB | Report |
|
| EGAF00008404622 | cram | 1.2 GB | Report |
|
| EGAF00008404623 | cram | 2.5 GB | Report |
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| EGAF00008404624 | cram | 2.4 GB | Report |
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| EGAF00008404625 | cram | 1.7 GB | Report |
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| EGAF00008404626 | cram | 1.9 GB | Report |
|
| EGAF00008404627 | cram | 2.0 GB | Report |
|
| EGAF00008404628 | cram | 1.7 GB | Report |
|
| EGAF00008404629 | cram | 1.3 GB | Report |
|
| EGAF00008404630 | cram | 1.7 GB | Report |
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| EGAF00008404631 | cram | 2.2 GB | Report |
|
| EGAF00008404632 | cram | 1.8 GB | Report |
|
| EGAF00008404633 | cram | 3.1 GB | Report |
|
| EGAF00008404634 | cram | 2.1 GB | Report |
|
| EGAF00008404635 | cram | 2.2 GB | Report |
|
| EGAF00008404636 | cram | 954.7 MB | Report |
|
| EGAF00008404637 | cram | 2.1 GB | Report |
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| EGAF00008404638 | cram | 1.6 GB | Report |
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| EGAF00008404639 | cram | 1.4 GB | Report |
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| EGAF00008404640 | cram | 1.3 GB | Report |
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| EGAF00008404641 | cram | 2.0 GB | Report |
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| EGAF00008404642 | cram | 1.1 GB | Report |
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| EGAF00008404643 | cram | 1.2 GB | Report |
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| EGAF00008404644 | cram | 1.5 GB | Report |
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| EGAF00008404645 | cram | 1.9 GB | Report |
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| EGAF00008404646 | cram | 1.7 GB | Report |
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| EGAF00008404647 | cram | 1.7 GB | Report |
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| EGAF00008404648 | cram | 1.7 GB | Report |
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| EGAF00008404649 | cram | 1.2 GB | Report |
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| EGAF00008404650 | cram | 1.9 GB | Report |
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| EGAF00008404651 | cram | 1.8 GB | Report |
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| EGAF00008404652 | cram | 1.7 GB | Report |
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| EGAF00008404653 | cram | 961.4 MB | Report |
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| EGAF00008404654 | cram | 1.6 GB | Report |
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| EGAF00008404655 | cram | 1.6 GB | Report |
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| EGAF00008404656 | cram | 1.5 GB | Report |
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| EGAF00008404657 | cram | 1.4 GB | Report |
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| EGAF00008404658 | cram | 1.8 GB | Report |
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| EGAF00008404659 | cram | 1.4 GB | Report |
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| EGAF00008404660 | cram | 1.4 GB | Report |
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| EGAF00008404661 | cram | 1.2 GB | Report |
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| EGAF00008404662 | cram | 1.8 GB | Report |
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| EGAF00008404663 | cram | 2.4 GB | Report |
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| EGAF00008404664 | cram | 2.5 GB | Report |
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| EGAF00008404665 | cram | 1.1 GB | Report |
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| EGAF00008404666 | cram | 2.0 GB | Report |
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| EGAF00008404667 | cram | 1.5 GB | Report |
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| EGAF00008404668 | cram | 1.8 GB | Report |
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| EGAF00008404669 | cram | 1.8 GB | Report |
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| EGAF00008404670 | cram | 1.4 GB | Report |
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| EGAF00008404671 | cram | 2.3 GB | Report |
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| EGAF00008404672 | cram | 1.9 GB | Report |
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| EGAF00008404673 | cram | 1.4 GB | Report |
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| EGAF00008404674 | cram | 7.7 GB | Report |
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| EGAF00008404675 | cram | 10.0 GB | Report |
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| EGAF00008404676 | cram | 6.5 GB | Report |
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| EGAF00008404677 | cram | 963.9 MB | Report |
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| EGAF00008404678 | cram | 2.5 GB | Report |
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| EGAF00008404679 | cram | 1.2 GB | Report |
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| EGAF00008404680 | cram | 2.2 GB | Report |
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| EGAF00008404681 | cram | 1.2 GB | Report |
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| EGAF00008404682 | cram | 2.5 GB | Report |
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| EGAF00008404683 | cram | 2.4 GB | Report |
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| EGAF00008404684 | cram | 1.7 GB | Report |
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| EGAF00008404685 | cram | 1.9 GB | Report |
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| EGAF00008404686 | cram | 2.0 GB | Report |
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| EGAF00008404687 | cram | 1.7 GB | Report |
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| EGAF00008404688 | cram | 1.3 GB | Report |
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| EGAF00008404689 | cram | 1.7 GB | Report |
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| EGAF00008404690 | cram | 2.2 GB | Report |
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| EGAF00008404691 | cram | 1.8 GB | Report |
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| EGAF00008404692 | cram | 3.1 GB | Report |
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| EGAF00008404693 | cram | 2.1 GB | Report |
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| EGAF00008404694 | cram | 2.2 GB | Report |
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| EGAF00008404695 | cram | 955.7 MB | Report |
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| EGAF00008404696 | cram | 2.1 GB | Report |
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| EGAF00008404697 | cram | 1.6 GB | Report |
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| EGAF00008404698 | cram | 1.4 GB | Report |
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| EGAF00008404699 | cram | 1.3 GB | Report |
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| EGAF00008404700 | cram | 2.0 GB | Report |
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| EGAF00008404701 | cram | 1.1 GB | Report |
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| EGAF00008404702 | cram | 1.2 GB | Report |
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| EGAF00008404703 | cram | 1.5 GB | Report |
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| EGAF00008404704 | cram | 1.9 GB | Report |
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| EGAF00008404705 | cram | 1.7 GB | Report |
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| EGAF00008404706 | cram | 1.7 GB | Report |
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| EGAF00008404707 | cram | 1.7 GB | Report |
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| EGAF00008404708 | cram | 1.2 GB | Report |
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| EGAF00008404709 | cram | 1.9 GB | Report |
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| EGAF00008404710 | cram | 1.9 GB | Report |
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| EGAF00008404711 | cram | 1.8 GB | Report |
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| EGAF00008404712 | cram | 966.6 MB | Report |
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| EGAF00008404713 | cram | 1.6 GB | Report |
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| EGAF00008404714 | cram | 1.6 GB | Report |
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| EGAF00008404715 | cram | 1.5 GB | Report |
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| EGAF00008404716 | cram | 1.4 GB | Report |
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| EGAF00008404717 | cram | 1.8 GB | Report |
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| EGAF00008404718 | cram | 1.4 GB | Report |
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| EGAF00008404719 | cram | 1.4 GB | Report |
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| EGAF00008404720 | cram | 1.2 GB | Report |
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| EGAF00008404721 | cram | 1.9 GB | Report |
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| EGAF00008404722 | cram | 2.4 GB | Report |
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| EGAF00008404723 | cram | 2.5 GB | Report |
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| EGAF00008404724 | cram | 1.1 GB | Report |
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| EGAF00008404725 | cram | 2.0 GB | Report |
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| EGAF00008404726 | cram | 1.5 GB | Report |
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| EGAF00008404727 | cram | 1.8 GB | Report |
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| EGAF00008404728 | cram | 1.8 GB | Report |
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| EGAF00008404729 | cram | 1.4 GB | Report |
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| EGAF00008404730 | cram | 2.3 GB | Report |
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| EGAF00008404731 | cram | 1.9 GB | Report |
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| EGAF00008404732 | cram | 1.4 GB | Report |
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| EGAF00008404733 | cram | 7.7 GB | Report |
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| EGAF00008404734 | cram | 10.0 GB | Report |
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| EGAF00008404735 | cram | 6.5 GB | Report |
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| EGAF00008404736 | cram | 965.4 MB | Report |
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| EGAF00008404737 | cram | 2.5 GB | Report |
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| EGAF00008404738 | cram | 1.2 GB | Report |
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| EGAF00008404739 | cram | 2.2 GB | Report |
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| 181 Files (504.7 GB) | ||||