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As the EGA is co-managed by the EMBL-EBI and CRG, files could be located in the UK and/or Spain, as indicated by their respective flags.

Alternatively, files could be located in one of the international Federated EGA nodes, as indicated next to the node's flag.
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WES data for Early evolutionary branching across spatial domains predisposes to clonal replacement under chemotherapy in neuroblastoma

Neuroblastoma (NB) is one of the most lethal childhood cancers due its propensity to treatment resistance. By spatial mapping of subclone geographies before and after chemotherapy across 89 tumor regions from 12 NBs, we find that densely packed territories of closely related subclones present at diagnosis are replaced under effective treatment by islands of distantly related survivor subclones, originating from a different most recent ancestor compared to lineages dominating before treatment. Conversely, in tumors that progressed under treatment, ancestors of subclones dominating later in disease are present already at diagnosis. Chemotherapy treated xenografts and cell culture models replicates these two contrasting scenarios and shows branching evolution to be a constant feature of proliferating NB cells. Phylogenies based on whole genome sequencing of 505 individual NB cells indicate that a rich repertoire of parallel subclones, emerges already with the first oncogenic mutations and lays the foundation for clonal replacement under treatment.

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Data Access Policy for data generated by the Gisselsson Group at the Department of Clinical Genetics, Lund University.

The data access agreement provided by the data access committee stipulates that in order to get access to the deposited genetic data, the user will need to agree to: • use the data only for academic research purposes; • cite the original article in any resulting publication; • protect the confidentiality of the data; • provide appropriate data security; • not attempt to identify individual participants from whom data were obtained; • not redistribute the data, or any subset or derivative, that could be used to identify the research participant

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001007650 Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Quality Report
Located in
i
EGAF00008560409 fastq.gz 4.8 GB Report
EGAF00008560410 fastq.gz 5.0 GB Report
EGAF00008560411 fastq.gz 2.5 GB Report
EGAF00008560412 fastq.gz 2.5 GB Report
EGAF00008560413 fastq.gz 4.8 GB Report
EGAF00008560414 fastq.gz 4.8 GB Report
EGAF00008560415 fastq.gz 4.3 GB Report
EGAF00008560416 fastq.gz 4.4 GB Report
EGAF00008560417 fastq.gz 5.0 GB Report
EGAF00008560418 fastq.gz 5.0 GB Report
EGAF00008560419 fastq.gz 5.9 GB Report
EGAF00008560420 fastq.gz 5.9 GB Report
EGAF00008560421 fastq.gz 5.0 GB Report
EGAF00008560422 fastq.gz 5.0 GB Report
EGAF00008560423 fastq.gz 3.4 GB Report
EGAF00008560424 fastq.gz 3.5 GB Report
EGAF00008560425 fastq.gz 11.2 GB Report
EGAF00008560426 fastq.gz 11.5 GB Report
EGAF00008560427 fastq.gz 4.7 GB Report
EGAF00008560428 fastq.gz 4.7 GB Report
EGAF00008560429 fastq.gz 3.7 GB Report
EGAF00008560430 fastq.gz 3.7 GB Report
EGAF00008560431 fastq.gz 4.8 GB Report
EGAF00008560432 fastq.gz 4.9 GB Report
EGAF00008560433 fastq.gz 3.8 GB Report
EGAF00008560434 fastq.gz 3.8 GB Report
EGAF00008560435 fastq.gz 3.7 GB Report
EGAF00008560436 fastq.gz 3.8 GB Report
EGAF00008560437 fastq.gz 3.2 GB Report
EGAF00008560438 fastq.gz 3.2 GB Report
EGAF00008560439 fastq.gz 1.5 GB Report
EGAF00008560440 fastq.gz 1.5 GB Report
EGAF00008560441 fastq.gz 2.1 GB Report
EGAF00008560442 fastq.gz 2.1 GB Report
EGAF00008560443 fastq.gz 3.1 GB Report
EGAF00008560444 fastq.gz 3.2 GB Report
EGAF00008560445 fastq.gz 3.4 GB Report
EGAF00008560446 fastq.gz 3.4 GB Report
EGAF00008560447 fastq.gz 6.9 GB Report
EGAF00008560448 fastq.gz 7.2 GB Report
EGAF00008560449 fastq.gz 3.9 GB Report
EGAF00008560450 fastq.gz 3.9 GB Report
EGAF00008560451 fastq.gz 2.9 GB Report
EGAF00008560452 fastq.gz 2.9 GB Report
EGAF00008560453 fastq.gz 2.2 GB Report
EGAF00008560454 fastq.gz 2.3 GB Report
EGAF00008560455 fastq.gz 2.4 GB Report
EGAF00008560456 fastq.gz 2.5 GB Report
EGAF00008560457 fastq.gz 1.9 GB Report
EGAF00008560458 fastq.gz 2.0 GB Report
EGAF00008560459 fastq.gz 7.4 GB Report
EGAF00008560460 fastq.gz 7.6 GB Report
EGAF00008560461 fastq.gz 11.7 GB Report
EGAF00008560462 fastq.gz 11.9 GB Report
EGAF00008560463 fastq.gz 2.1 GB Report
EGAF00008560464 fastq.gz 2.2 GB Report
EGAF00008560465 fastq.gz 5.6 GB Report
EGAF00008560466 fastq.gz 5.7 GB Report
EGAF00008560467 fastq.gz 3.6 GB Report
EGAF00008560468 fastq.gz 3.6 GB Report
EGAF00008560469 fastq.gz 9.5 GB Report
EGAF00008560470 fastq.gz 9.6 GB Report
EGAF00008560471 fastq.gz 5.7 GB Report
EGAF00008560472 fastq.gz 5.7 GB Report
EGAF00008560473 fastq.gz 6.4 GB Report
EGAF00008560474 fastq.gz 6.5 GB Report
EGAF00008560475 fastq.gz 12.0 GB Report
EGAF00008560476 fastq.gz 12.3 GB Report
EGAF00008560477 fastq.gz 5.6 GB Report
EGAF00008560478 fastq.gz 5.8 GB Report
EGAF00008560479 fastq.gz 7.9 GB Report
EGAF00008560480 fastq.gz 8.1 GB Report
EGAF00008560481 fastq.gz 4.0 GB Report
EGAF00008560482 fastq.gz 4.2 GB Report
EGAF00008560483 fastq.gz 3.9 GB Report
EGAF00008560484 fastq.gz 4.0 GB Report
EGAF00008560485 fastq.gz 4.2 GB Report
EGAF00008560486 fastq.gz 4.3 GB Report
78 Files (385.1 GB)