Combination Immune Checkpoint Inhibition in Australian Rare Cancers_WES
Combination immune checkpoint inhibition (ICI) with anti-CTLA-4 and anti-PD-1 blockade has demonstrated significant clinical activity across tumour types. Rare cancer patients have limited treatment options due to the scarcity of studies of novel treatment options, so they are often offered chemotherapies untested in their disease. ONJ2016-001/CA209-538 is a prospective, multicentre clinical trial of combination ICI (ipilimumab and nivolumab) in patients with advanced rare cancers, including biliary tract, adrenocortical, rare gynaecological and neuroendocrine cancers (https://clinicaltrials.gov/ct2/show/NCT02923934). The primary endpoint is clinical benefit rate (complete response + partial response + stable disease >3 months) by RECIST 1.1. This study involves generation and analysis of pre-treatment formalin fixed paraffin embedded (FFPE) tumour DNA sequencing data, paired with germline DNA sequencing data, to potentially identify genomic biomarkers that may associate with clinical benefit or other clinical efficacy / toxicity metrics.
- 1 sample
- DAC: EGAC00001000205
- Technology: Illumina NovaSeq 6000
Wellcome Trust Sanger Institute Data Sharing Policy
Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.
| Study ID | Study Title | Study Type |
|---|---|---|
| EGAS00001005709 | Cancer Genomics |
This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.
| ID | File Type | Size | Located in | |
|---|---|---|---|---|
| EGAF00007944611 | cram | 4.8 GB | ||
| EGAF00007944612 | cram | 4.7 GB | ||
| EGAF00007944613 | cram | 4.2 GB | ||
| EGAF00007944614 | cram | 4.7 GB | ||
| EGAF00007944615 | cram | 4.6 GB | ||
| EGAF00007944616 | cram | 4.2 GB | ||
| EGAF00007944617 | cram | 4.0 GB | ||
| EGAF00007944618 | cram | 4.5 GB | ||
| EGAF00007944619 | cram | 4.3 GB | ||
| EGAF00007944620 | cram | 4.3 GB | ||
| EGAF00007944621 | cram | 3.9 GB | ||
| EGAF00007944622 | cram | 4.2 GB | ||
| EGAF00007944623 | cram | 4.3 GB | ||
| EGAF00007944624 | cram | 5.8 GB | ||
| EGAF00007944625 | cram | 4.8 GB | ||
| EGAF00007944626 | cram | 4.1 GB | ||
| EGAF00007944627 | cram | 4.1 GB | ||
| EGAF00007944628 | cram | 4.4 GB | ||
| EGAF00007944629 | cram | 4.9 GB | ||
| EGAF00007944630 | cram | 4.8 GB | ||
| EGAF00007944631 | cram | 4.4 GB | ||
| EGAF00007944632 | cram | 4.1 GB | ||
| EGAF00007944633 | cram | 3.9 GB | ||
| EGAF00007944634 | cram | 5.4 GB | ||
| EGAF00007944635 | cram | 5.0 GB | ||
| EGAF00007944636 | cram | 4.3 GB | ||
| EGAF00007944637 | cram | 3.9 GB | ||
| EGAF00007944638 | cram | 3.9 GB | ||
| EGAF00007944639 | cram | 4.8 GB | ||
| EGAF00007944640 | cram | 4.5 GB | ||
| EGAF00007944641 | cram | 4.4 GB | ||
| EGAF00007944642 | cram | 4.3 GB | ||
| EGAF00007944643 | cram | 5.3 GB | ||
| EGAF00007944644 | cram | 4.2 GB | ||
| EGAF00007944645 | cram | 4.1 GB | ||
| EGAF00007944646 | cram | 5.2 GB | ||
| EGAF00007944647 | cram | 4.8 GB | ||
| EGAF00007944648 | cram | 5.4 GB | ||
| EGAF00007944649 | cram | 4.8 GB | ||
| EGAF00007944650 | cram | 4.2 GB | ||
| EGAF00007944651 | cram | 3.9 GB | ||
| EGAF00007944652 | cram | 4.1 GB | ||
| EGAF00007944653 | cram | 3.8 GB | ||
| EGAF00007944654 | cram | 4.3 GB | ||
| EGAF00007944655 | cram | 3.9 GB | ||
| EGAF00007944656 | cram | 3.8 GB | ||
| EGAF00007944657 | cram | 4.6 GB | ||
| EGAF00007944658 | cram | 4.5 GB | ||
| EGAF00007944659 | cram | 5.6 GB | ||
| EGAF00007944660 | cram | 3.3 GB | ||
| EGAF00007944661 | cram | 4.3 GB | ||
| EGAF00007944662 | cram | 4.8 GB | ||
| EGAF00007944663 | cram | 4.7 GB | ||
| EGAF00007944664 | cram | 3.8 GB | ||
| EGAF00007944665 | cram | 4.6 GB | ||
| EGAF00007944666 | cram | 4.4 GB | ||
| EGAF00007944667 | cram | 4.2 GB | ||
| EGAF00007944668 | cram | 3.7 GB | ||
| EGAF00007944669 | cram | 3.3 GB | ||
| EGAF00007944670 | cram | 4.6 GB | ||
| EGAF00007944671 | cram | 3.5 GB | ||
| EGAF00007944672 | cram | 3.9 GB | ||
| EGAF00007944673 | cram | 3.2 GB | ||
| EGAF00007944674 | cram | 4.2 GB | ||
| EGAF00007944675 | cram | 3.4 GB | ||
| EGAF00007944676 | cram | 4.1 GB | ||
| EGAF00007944677 | cram | 4.0 GB | ||
| EGAF00007944678 | cram | 4.1 GB | ||
| EGAF00007944679 | cram | 4.1 GB | ||
| EGAF00007944680 | cram | 3.4 GB | ||
| EGAF00007944681 | cram | 4.3 GB | ||
| EGAF00007944682 | cram | 4.2 GB | ||
| EGAF00007944683 | cram | 4.4 GB | ||
| EGAF00007944684 | cram | 5.3 GB | ||
| EGAF00007944685 | cram | 4.7 GB | ||
| EGAF00007944686 | cram | 3.1 GB | ||
| EGAF00007944687 | cram | 4.1 GB | ||
| EGAF00007944688 | cram | 5.4 GB | ||
| EGAF00007944689 | cram | 4.5 GB | ||
| EGAF00007944690 | cram | 5.2 GB | ||
| EGAF00007944691 | cram | 3.4 GB | ||
| EGAF00007944692 | cram | 3.4 GB | ||
| EGAF00007944693 | cram | 4.4 GB | ||
| EGAF00007944694 | cram | 4.0 GB | ||
| EGAF00007944695 | cram | 4.0 GB | ||
| EGAF00007944696 | cram | 3.7 GB | ||
| EGAF00007944697 | cram | 4.1 GB | ||
| EGAF00007944698 | cram | 3.5 GB | ||
| EGAF00007944699 | cram | 5.1 GB | ||
| EGAF00007944700 | cram | 4.6 GB | ||
| EGAF00007944701 | cram | 3.7 GB | ||
| EGAF00007944702 | cram | 3.9 GB | ||
| EGAF00007944703 | cram | 4.0 GB | ||
| EGAF00007944704 | cram | 4.8 GB | ||
| EGAF00007944705 | cram | 4.7 GB | ||
| EGAF00007944706 | cram | 4.6 GB | ||
| EGAF00007944707 | cram | 3.9 GB | ||
| EGAF00007944708 | cram | 4.4 GB | ||
| EGAF00007944709 | cram | 4.2 GB | ||
| EGAF00007944710 | cram | 4.3 GB | ||
| EGAF00007944711 | cram | 4.4 GB | ||
| EGAF00007944712 | cram | 4.6 GB | ||
| EGAF00007944713 | cram | 4.7 GB | ||
| EGAF00007944714 | cram | 4.2 GB | ||
| EGAF00007944715 | cram | 3.7 GB | ||
| EGAF00007944716 | cram | 4.1 GB | ||
| EGAF00007944717 | cram | 4.3 GB | ||
| EGAF00007944718 | cram | 4.2 GB | ||
| EGAF00007944719 | cram | 4.7 GB | ||
| EGAF00007944720 | cram | 4.5 GB | ||
| EGAF00007944721 | cram | 4.3 GB | ||
| EGAF00007944722 | cram | 5.5 GB | ||
| EGAF00007944723 | cram | 4.7 GB | ||
| EGAF00007944724 | cram | 8.9 GB | ||
| EGAF00007944725 | cram | 6.1 GB | ||
| EGAF00007944726 | cram | 7.7 GB | ||
| EGAF00007944727 | cram | 6.2 GB | ||
| EGAF00007944728 | cram | 9.4 GB | ||
| EGAF00007944729 | cram | 708.8 MB | ||
| EGAF00007944730 | cram | 8.2 GB | ||
| EGAF00007944731 | cram | 8.1 GB | ||
| EGAF00007944732 | cram | 8.1 GB | ||
| EGAF00007944733 | cram | 10.3 GB | ||
| EGAF00007944734 | cram | 7.8 GB | ||
| EGAF00007944735 | cram | 12.9 GB | ||
| EGAF00007944736 | cram | 7.0 GB | ||
| EGAF00007944737 | cram | 11.8 GB | ||
| EGAF00007944738 | cram | 5.6 GB | ||
| EGAF00007944739 | cram | 5.8 GB | ||
| EGAF00007944740 | cram | 6.8 GB | ||
| EGAF00007944741 | cram | 10.4 GB | ||
| EGAF00007944742 | cram | 7.3 GB | ||
| EGAF00007944743 | cram | 11.0 GB | ||
| EGAF00007944744 | cram | 6.9 GB | ||
| EGAF00007944745 | cram | 8.1 GB | ||
| EGAF00007944746 | cram | 13.7 GB | ||
| EGAF00007944747 | cram | 6.1 GB | ||
| EGAF00007944748 | cram | 9.1 GB | ||
| EGAF00007944749 | cram | 15.8 GB | ||
| EGAF00007944750 | cram | 8.4 GB | ||
| EGAF00007944751 | cram | 8.3 GB | ||
| EGAF00007944752 | cram | 6.9 GB | ||
| EGAF00007944753 | cram | 7.1 GB | ||
| EGAF00007944754 | cram | 7.1 MB | ||
| EGAF00007944755 | cram | 13.5 GB | ||
| EGAF00007944756 | cram | 10.2 GB | ||
| EGAF00007944757 | cram | 5.3 GB | ||
| EGAF00007944758 | cram | 13.5 GB | ||
| EGAF00007944759 | cram | 8.1 GB | ||
| EGAF00007944760 | cram | 7.8 GB | ||
| EGAF00007944761 | cram | 12.4 GB | ||
| EGAF00007944762 | cram | 6.3 GB | ||
| EGAF00007944763 | cram | 6.8 GB | ||
| EGAF00007944764 | cram | 7.2 GB | ||
| EGAF00007944765 | cram | 4.8 GB | ||
| EGAF00007944766 | cram | 9.4 GB | ||
| EGAF00007944767 | cram | 8.0 GB | ||
| EGAF00007944768 | cram | 9.9 GB | ||
| EGAF00007944769 | cram | 7.6 GB | ||
| EGAF00007944770 | cram | 7.2 GB | ||
| EGAF00007944771 | cram | 11.1 GB | ||
| EGAF00007944772 | cram | 5.5 GB | ||
| EGAF00007944773 | cram | 10.6 GB | ||
| EGAF00007944774 | cram | 7.3 GB | ||
| EGAF00007944775 | cram | 10.7 GB | ||
| EGAF00007944776 | cram | 6.6 GB | ||
| EGAF00007944777 | cram | 9.1 GB | ||
| EGAF00007944778 | cram | 9.7 GB | ||
| EGAF00007944779 | cram | 3.7 GB | ||
| EGAF00007944780 | cram | 9.5 GB | ||
| EGAF00007944781 | cram | 5.1 GB | ||
| EGAF00007944782 | cram | 1.3 GB | ||
| EGAF00007944783 | cram | 8.3 GB | ||
| EGAF00007944784 | cram | 7.3 GB | ||
| EGAF00007944785 | cram | 9.2 GB | ||
| EGAF00007944786 | cram | 6.9 GB | ||
| EGAF00007944787 | cram | 11.6 GB | ||
| EGAF00007944788 | cram | 8.3 GB | ||
| EGAF00007944789 | cram | 6.0 GB | ||
| EGAF00007944790 | cram | 8.3 GB | ||
| EGAF00007944791 | cram | 11.9 GB | ||
| EGAF00007944792 | cram | 8.3 GB | ||
| EGAF00007944793 | cram | 8.8 GB | ||
| EGAF00007944794 | cram | 7.5 GB | ||
| EGAF00007944795 | cram | 2.0 GB | ||
| EGAF00007944796 | cram | 657.3 MB | ||
| EGAF00007944797 | cram | 5.5 GB | ||
| EGAF00007944798 | cram | 9.3 GB | ||
| EGAF00007944799 | cram | 4.4 GB | ||
| EGAF00007944800 | cram | 7.2 GB | ||
| EGAF00007944801 | cram | 4.8 GB | ||
| EGAF00007944802 | cram | 5.6 GB | ||
| EGAF00007944803 | cram | 6.8 GB | ||
| EGAF00007944804 | cram | 5.4 GB | ||
| EGAF00007944805 | cram | 1.1 GB | ||
| EGAF00007944806 | cram | 6.0 GB | ||
| EGAF00007944807 | cram | 16.2 GB | ||
| EGAF00007944808 | cram | 6.0 GB | ||
| EGAF00007944809 | cram | 8.1 GB | ||
| EGAF00007944810 | cram | 7.4 GB | ||
| EGAF00007944811 | cram | 15.0 GB | ||
| EGAF00007944812 | cram | 15.4 GB | ||
| EGAF00007944813 | cram | 1.4 GB | ||
| EGAF00007944814 | cram | 7.2 GB | ||
| EGAF00007944815 | cram | 104.0 MB | ||
| EGAF00007944816 | cram | 8.6 GB | ||
| EGAF00007944817 | cram | 9.8 GB | ||
| EGAF00007944818 | cram | 8.2 GB | ||
| EGAF00007944819 | cram | 4.6 GB | ||
| EGAF00007944820 | cram | 6.4 GB | ||
| EGAF00007944821 | cram | 11.7 GB | ||
| EGAF00007944822 | cram | 7.9 GB | ||
| EGAF00007944823 | cram | 5.2 GB | ||
| EGAF00007944824 | cram | 9.4 GB | ||
| EGAF00007944825 | cram | 12.6 GB | ||
| EGAF00007944826 | cram | 471.5 MB | ||
| EGAF00007944827 | cram | 3.0 GB | ||
| EGAF00007944828 | cram | 10.8 GB | ||
| EGAF00007944829 | cram | 12.8 GB | ||
| EGAF00007944830 | cram | 3.5 GB | ||
| EGAF00007944831 | cram | 11.5 GB | ||
| EGAF00007944832 | cram | 7.1 GB | ||
| EGAF00007944833 | cram | 8.5 GB | ||
| 223 Files (1.3 TB) | ||||