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Single-Cell DNA Methylation Profiling via scTAMseq

This dataset comprises single-cell DNA methylation and nuclear genotyping profiles of 7 total bone marrow aspirates (donors A.1-A.7) and 5 CD34+-enriched bone marrow samples (donors B.1-B.5) generated using the scTAMseq protocol. Sequencing was performed on the Mission Bio Tapestri platform, targeting a panel of 448 CpGs to assess epigenetic patterns and We also included 147 genomic regions commonly mutated in clonal hematopoiesis and 20 regions targeting chromosome Y. Samples B.1 & B.5, B.2 & B.4 and A.2 & A.5 were, in pairs, multiplexed into single tapestri lanes.

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Research use only. Project specific restriction

We will share data for scientific research upon reasonably justified requests. Users must present a signed Data Access Agreement available upon request. Terms of the DAA are not negotiable. Before asking for request through EGA, please email lars.velten@crg.eu

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001008056 Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Quality Report
Located in
EGAF00008674373 fastq.gz 102.3 GB
EGAF00008674374 fastq.gz 102.3 GB
EGAF00008674375 fastq.gz 69.8 GB
EGAF00008674376 fastq.gz 79.9 GB
EGAF00008674377 fastq.gz 131.2 GB
EGAF00008674378 fastq.gz 141.2 GB
EGAF00008674379 fastq.gz 88.9 GB
EGAF00008674380 fastq.gz 91.6 GB
EGAF00008674381 fastq.gz 37.5 GB
EGAF00008674382 fastq.gz 41.4 GB
EGAF00008674383 fastq.gz 44.0 GB
EGAF00008674384 fastq.gz 43.9 GB
EGAF00008674385 fastq.gz 16.3 GB
EGAF00008674386 fastq.gz 18.5 GB
EGAF00008674387 fastq.gz 84.1 GB
EGAF00008674388 fastq.gz 94.6 GB
EGAF00008674389 fastq.gz 55.1 GB
EGAF00008674390 fastq.gz 61.4 GB
18 Files (1.3 TB)