The G2 gene expression signature and MYC overexpression are independent poor prognostic factors in childhood high-grade osteosarcoma
Key objective Are the prognostic transcriptomic G1/G2 gene expression signature, MYC overexpression, and MYC amplification replicable stratifying biomarkers for future clinical trials in high-grade osteosarcoma? Knowledge gathered In an unselected cohort, the G2 gene expression signature and MYC overexpression, but not MYC amplification, were independently associated with poor event-free and overall survival. Relevance Transcriptomic biomarkers may serve as stratifying factors that guide the management of patients with high-grade osteosarcoma. Current data underlines the importance of prospective validation of the G1/G2 signature and MYC overexpression in an international, multicenter, study.
- 20/03/2025
- 1 sample
- DAC: EGAC00001001864
DUO:0000007 version: 2021-02-23
disease specific research
This data use permission indicates that use is allowed provided it is related to the specified disease.
ModifiersMONDO_0006517
Data Access Agreement of data controlled by the Data Access Commitee of the Princess Maxima Center for Pediatric Oncology
The Princess Maxima Center for pediatric oncology default access policy to enable re-production of research and re-use of data for scientific purposes. Please contact the DAC (EGAC00001001864) for the most up to date policies.
Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.
| Study ID | Study Title | Study Type |
|---|---|---|
| EGAS00001007099 | Other | |
| EGAS00001008073 | Other |
- Changed sample subject id
- Dataset Released
This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.
| ID | File Type | Size | Quality Report |
Located in
i
|
|---|---|---|---|---|
| EGAF00007984715 | cram | 6.4 GB | Report |
|
| EGAF00007984745 | cram | 4.8 GB | Report |
|
| EGAF00007984766 | cram | 3.4 GB | Report |
|
| EGAF00007984798 | cram | 4.5 GB | Report |
|
| EGAF00007984812 | cram | 4.6 GB | Report |
|
| EGAF00007984824 | cram | 6.4 GB | Report |
|
| EGAF00008681973 | cram | 8.0 GB |
|
|
| EGAF00008681974 | cram | 3.6 GB |
|
|
| EGAF00008681977 | cram | 4.9 GB |
|
|
| EGAF00008681994 | cram | 3.8 GB |
|
|
| EGAF00008681999 | cram | 4.6 GB |
|
|
| EGAF00008682001 | cram | 3.7 GB |
|
|
| EGAF00008682003 | cram | 2.6 GB |
|
|
| EGAF00008682006 | cram | 4.0 GB |
|
|
| EGAF00008682007 | cram | 5.6 GB |
|
|
| EGAF00008682009 | cram | 4.3 GB |
|
|
| EGAF00008682011 | cram | 3.2 GB |
|
|
| EGAF00008682013 | cram | 3.4 GB |
|
|
| EGAF00008682015 | cram | 6.5 GB |
|
|
| EGAF00008682017 | cram | 4.4 GB |
|
|
| EGAF00008682019 | cram | 3.5 GB |
|
|
| EGAF00008682022 | cram | 4.5 GB |
|
|
| EGAF00008682024 | cram | 6.8 GB |
|
|
| EGAF00008682026 | cram | 5.4 GB |
|
|
| EGAF00008682028 | cram | 6.1 GB |
|
|
| EGAF00008682030 | cram | 5.3 GB |
|
|
| EGAF00008682033 | cram | 3.7 GB |
|
|
| EGAF00008682035 | cram | 5.7 GB |
|
|
| EGAF00008682037 | cram | 7.3 GB |
|
|
| EGAF00008682039 | cram | 4.7 GB |
|
|
| EGAF00008682041 | cram | 4.7 GB |
|
|
| EGAF00008682043 | cram | 7.2 GB |
|
|
| EGAF00008682045 | cram | 5.7 GB |
|
|
| EGAF00008682049 | cram | 4.7 GB |
|
|
| EGAF00008682051 | cram | 9.3 GB |
|
|
| EGAF00008682053 | cram | 5.6 GB |
|
|
| 36 Files (182.9 GB) | ||||