Systemic mutagen exposures reported by normal kidney cell genomes - peripheral blood samples (NanoSeq)
Lifestyle, environmental and other exposures to exogenous mutagens generate somatic mutations in normal human cells in vivo and increase cancer risk. However, the global repertoire of exogenous mutagen exposures is uncertain. Using single-molecule duplex sequencing of normal kidney (n=319) and blood (n=272) samples from 10 countries, we show that kidney proximal tubule cells exhibit higher mutation rates than most normal cell types despite low cell division rates. Compared to cells from kidney glomeruli, medulla, distal tubules, or peripheral blood, proximal tubule cells show marked enrichment of mutational signatures due to the exogenous carcinogenic mutagens, aristolochic acids, and of several signatures of unknown causes. The results suggest the existence of multiple, common, systemically circulated mutagens affecting human populations and indicate that the genomes of kidney proximal tubule cells report such exposures with high sensitivity.
- 05/03/2026
- 1 sample
- DAC: EGAC00001000000
- Technology: Illumina NovaSeq 6000
DUO:0000019 version: 2021-02-23
publication required
This data use modifier indicates that requestor agrees to make results of studies using the data available to the larger scientific community.
DUO:0000026 version: 2021-02-23
user specific restriction
This data use modifier indicates that use is limited to use by approved users.
DUO:0000028 version: 2021-02-23
institution specific restriction
This data use modifier indicates that use is limited to use within an approved institution.
DUO:0000042 version: 2021-02-23
general research use
This data use permission indicates that use is allowed for general research use for any research purpose.
Wellcome Trust Sanger Institute Cancer Genome Group Data Sharing Policy
Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.
| Study ID | Study Title | Study Type |
|---|---|---|
| EGAS00001006774 | Whole Genome Sequencing |
This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.
| ID | File Type | Size | Quality Report |
Located in
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|---|---|---|---|---|
| EGAF00009006260 | cram | 18.0 GB |
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| EGAF00009006261 | cram | 16.1 GB |
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| EGAF00009006262 | cram | 15.8 GB |
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| EGAF00009006263 | cram | 14.4 GB |
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| EGAF00009006264 | cram | 18.3 GB |
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| EGAF00009006265 | cram | 19.8 GB |
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| EGAF00009006266 | cram | 15.2 GB |
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| EGAF00009006267 | cram | 18.7 GB |
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| EGAF00009006268 | cram | 16.8 GB |
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| EGAF00009006269 | cram | 15.0 GB |
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| EGAF00009006270 | cram | 15.7 GB |
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| EGAF00009006271 | cram | 13.7 GB |
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| EGAF00009006272 | cram | 15.8 GB |
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| EGAF00009006273 | cram | 16.8 GB |
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| EGAF00009006274 | cram | 16.6 GB |
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| EGAF00009006275 | cram | 14.2 GB |
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| EGAF00009006276 | cram | 18.9 GB |
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| EGAF00009006277 | cram | 14.5 GB |
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| EGAF00009006278 | cram | 15.9 GB |
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| EGAF00009006279 | cram | 14.3 GB |
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| EGAF00009006280 | cram | 17.7 GB |
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| EGAF00009006281 | cram | 15.8 GB |
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| EGAF00009006282 | cram | 16.2 GB |
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| EGAF00009006283 | cram | 15.4 GB |
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| EGAF00009006284 | cram | 14.0 GB |
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| EGAF00009006285 | cram | 13.9 GB |
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| EGAF00009006286 | cram | 15.5 GB |
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| EGAF00009006287 | cram | 16.9 GB |
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| EGAF00009006288 | cram | 13.9 GB |
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| EGAF00009006289 | cram | 15.1 GB |
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| EGAF00009006290 | cram | 15.7 GB |
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| EGAF00009006291 | cram | 14.8 GB |
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| EGAF00009006292 | cram | 15.2 GB |
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| EGAF00009006293 | cram | 13.5 GB |
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| EGAF00009006294 | cram | 16.9 GB |
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| EGAF00009006295 | cram | 13.8 GB |
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| EGAF00009006296 | cram | 16.4 GB |
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| EGAF00009006297 | cram | 16.1 GB |
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| EGAF00009006298 | cram | 14.0 GB |
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| EGAF00009006299 | cram | 12.6 GB |
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| EGAF00009006300 | cram | 15.9 GB |
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| EGAF00009006301 | cram | 15.2 GB |
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| EGAF00009006302 | cram | 16.0 GB |
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| EGAF00009006303 | cram | 15.9 GB |
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| EGAF00009006304 | cram | 13.4 GB |
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| EGAF00009006305 | cram | 15.7 GB |
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| EGAF00009006306 | cram | 16.8 GB |
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| EGAF00009006307 | cram | 15.3 GB |
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| EGAF00009006308 | cram | 15.1 GB |
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| EGAF00009006309 | cram | 13.6 GB |
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| EGAF00009006310 | cram | 14.5 GB |
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| EGAF00009006311 | cram | 12.2 GB |
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| EGAF00009006312 | cram | 15.1 GB |
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| EGAF00009006313 | cram | 14.3 GB |
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| EGAF00009006314 | cram | 11.2 GB |
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| EGAF00009006315 | cram | 12.0 GB |
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| EGAF00009006316 | cram | 12.1 GB |
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| EGAF00009006317 | cram | 14.1 GB |
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| EGAF00009006318 | cram | 14.8 GB |
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| EGAF00009006319 | cram | 17.0 GB |
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| EGAF00009006320 | cram | 12.1 GB |
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| EGAF00009006321 | cram | 12.7 GB |
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| EGAF00009006322 | cram | 16.1 GB |
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| EGAF00009006323 | cram | 12.6 GB |
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| EGAF00009006324 | cram | 15.8 GB |
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| EGAF00009006325 | cram | 13.7 GB |
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| EGAF00009006326 | cram | 12.2 GB |
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| EGAF00009006327 | cram | 15.1 GB |
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| EGAF00009006328 | cram | 13.8 GB |
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| EGAF00009006329 | cram | 13.6 GB |
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| EGAF00009006330 | cram | 13.0 GB |
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| EGAF00009006331 | cram | 13.5 GB |
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| EGAF00009006332 | cram | 17.0 GB |
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| EGAF00009006333 | cram | 14.5 GB |
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| EGAF00009006334 | cram | 14.7 GB |
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| EGAF00009006335 | cram | 16.8 GB |
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| EGAF00009006336 | cram | 14.1 GB |
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| EGAF00009006337 | cram | 12.9 GB |
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| EGAF00009006338 | cram | 15.2 GB |
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| EGAF00009006339 | cram | 14.7 GB |
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| EGAF00009006340 | cram | 14.8 GB |
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| EGAF00009006341 | cram | 15.8 GB |
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| EGAF00009006342 | cram | 15.4 GB |
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| EGAF00009006343 | cram | 16.5 GB |
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| EGAF00009006344 | cram | 12.9 GB |
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| EGAF00009006345 | cram | 14.1 GB |
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| EGAF00009006346 | cram | 16.0 GB |
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| EGAF00009006347 | cram | 15.8 GB |
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| EGAF00009006348 | cram | 13.8 GB |
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| EGAF00009006349 | cram | 14.4 GB |
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| EGAF00009006350 | cram | 14.6 GB |
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| EGAF00009006351 | cram | 12.6 GB |
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| EGAF00009006352 | cram | 12.8 GB |
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| EGAF00009006353 | cram | 14.5 GB |
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| EGAF00009006354 | cram | 13.9 GB |
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| EGAF00009006355 | cram | 13.3 GB |
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| EGAF00009006356 | cram | 17.3 GB |
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| EGAF00009006357 | cram | 15.7 GB |
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| EGAF00009006358 | cram | 16.2 GB |
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| EGAF00009006359 | cram | 16.7 GB |
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| EGAF00009006360 | cram | 15.8 GB |
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| EGAF00009006361 | cram | 12.9 GB |
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| EGAF00009006362 | cram | 16.7 GB |
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| EGAF00009006363 | cram | 14.6 GB |
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| EGAF00009006364 | cram | 15.0 GB |
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| EGAF00009006365 | cram | 15.2 GB |
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| EGAF00009006366 | cram | 14.5 GB |
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| EGAF00009006367 | cram | 16.0 GB |
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| EGAF00009006368 | cram | 13.9 GB |
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| EGAF00009006369 | cram | 14.2 GB |
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| EGAF00009006370 | cram | 14.6 GB |
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| EGAF00009006371 | cram | 13.8 GB |
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| EGAF00009006372 | cram | 15.6 GB |
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| EGAF00009006373 | cram | 12.4 GB |
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| EGAF00009006374 | cram | 11.8 GB |
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| EGAF00009006375 | cram | 12.0 GB |
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| EGAF00009006376 | cram | 19.9 GB |
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| EGAF00009006377 | cram | 17.1 GB |
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| EGAF00009006378 | cram | 12.6 GB |
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| EGAF00009006379 | cram | 14.8 GB |
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| EGAF00009006380 | cram | 14.8 GB |
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| EGAF00009006381 | cram | 12.7 GB |
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| EGAF00009006382 | cram | 16.7 GB |
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| EGAF00009006383 | cram | 15.8 GB |
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| EGAF00009006384 | cram | 19.0 GB |
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| EGAF00009006385 | cram | 14.0 GB |
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| EGAF00009006386 | cram | 19.8 GB |
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| EGAF00009006387 | cram | 15.8 GB |
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| EGAF00009006388 | cram | 17.6 GB |
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| EGAF00009006389 | cram | 16.4 GB |
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| EGAF00009006390 | cram | 11.8 GB |
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| EGAF00009006391 | cram | 17.7 GB |
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| EGAF00009006392 | cram | 13.3 GB |
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| EGAF00009006393 | cram | 15.1 GB |
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| EGAF00009006394 | cram | 15.8 GB |
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| EGAF00009006395 | cram | 15.4 GB |
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| EGAF00009006396 | cram | 12.6 GB |
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| EGAF00009006397 | cram | 15.0 GB |
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| EGAF00009006398 | cram | 17.8 GB |
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| EGAF00009006399 | cram | 12.9 GB |
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| EGAF00009006400 | cram | 13.0 GB |
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| EGAF00009006401 | cram | 13.2 GB |
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| EGAF00009006402 | cram | 12.8 GB |
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| EGAF00009006403 | cram | 15.7 GB |
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| EGAF00009006404 | cram | 13.9 GB |
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| EGAF00009006405 | cram | 16.8 GB |
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| EGAF00009006406 | cram | 16.5 GB |
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| EGAF00009006407 | cram | 17.3 GB |
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| EGAF00009006408 | cram | 15.0 GB |
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| EGAF00009006409 | cram | 15.0 GB |
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| EGAF00009006410 | cram | 13.7 GB |
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| EGAF00009006411 | cram | 13.3 GB |
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| EGAF00009006412 | cram | 11.3 GB |
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| EGAF00009006413 | cram | 15.3 GB |
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| EGAF00009006414 | cram | 14.7 GB |
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| EGAF00009006415 | cram | 14.0 GB |
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| EGAF00009006416 | cram | 12.7 GB |
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| EGAF00009006417 | cram | 17.1 GB |
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| EGAF00009006418 | cram | 14.9 GB |
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| EGAF00009006419 | cram | 14.4 GB |
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| EGAF00009006420 | cram | 14.6 GB |
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| EGAF00009006421 | cram | 14.4 GB |
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| EGAF00009006422 | cram | 13.7 GB |
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| EGAF00009006423 | cram | 12.4 GB |
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| EGAF00009006424 | cram | 12.7 GB |
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| EGAF00009006425 | cram | 15.0 GB |
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| EGAF00009006426 | cram | 16.7 GB |
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| EGAF00009006427 | cram | 13.9 GB |
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| EGAF00009006428 | cram | 14.3 GB |
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| EGAF00009006429 | cram | 12.6 GB |
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| EGAF00009006430 | cram | 12.2 GB |
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| EGAF00009006431 | cram | 16.0 GB |
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| EGAF00009006432 | cram | 14.2 GB |
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| EGAF00009006433 | cram | 14.1 GB |
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| EGAF00009006434 | cram | 12.0 GB |
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| EGAF00009006435 | cram | 14.0 GB |
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| EGAF00009006436 | cram | 12.1 GB |
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| EGAF00009006437 | cram | 13.1 GB |
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| EGAF00009006438 | cram | 15.6 GB |
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| EGAF00009006439 | cram | 16.3 GB |
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| EGAF00009006440 | cram | 15.0 GB |
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| EGAF00009006441 | cram | 13.5 GB |
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| EGAF00009006442 | cram | 12.1 GB |
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| EGAF00009006443 | cram | 11.5 GB |
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| EGAF00009006444 | cram | 12.3 GB |
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| EGAF00009006445 | cram | 13.3 GB |
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| EGAF00009006446 | cram | 12.2 GB |
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| EGAF00009006447 | cram | 14.1 GB |
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| EGAF00009006448 | cram | 14.1 GB |
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| EGAF00009006449 | cram | 14.5 GB |
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| EGAF00009006450 | cram | 15.2 GB |
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| EGAF00009006451 | cram | 15.4 GB |
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| EGAF00009006452 | cram | 15.5 GB |
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| EGAF00009006453 | cram | 17.5 GB |
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| EGAF00009006454 | cram | 11.6 GB |
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| EGAF00009006455 | cram | 13.2 GB |
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| EGAF00009006456 | cram | 12.7 GB |
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| EGAF00009006457 | cram | 12.7 GB |
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| EGAF00009006458 | cram | 16.2 GB |
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| EGAF00009006459 | cram | 12.8 GB |
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| EGAF00009006460 | cram | 18.9 GB |
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| EGAF00009006461 | cram | 13.6 GB |
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| EGAF00009006462 | cram | 12.2 GB |
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| EGAF00009006463 | cram | 13.9 GB |
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| EGAF00009006464 | cram | 17.4 GB |
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| EGAF00009006465 | cram | 13.7 GB |
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| EGAF00009006466 | cram | 12.8 GB |
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| EGAF00009006467 | cram | 14.0 GB |
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| EGAF00009006468 | cram | 13.6 GB |
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| EGAF00009006469 | cram | 14.4 GB |
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| EGAF00009006470 | cram | 12.7 GB |
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| EGAF00009006471 | cram | 13.9 GB |
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| EGAF00009006472 | cram | 13.5 GB |
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| EGAF00009006473 | cram | 13.5 GB |
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| EGAF00009006474 | cram | 12.6 GB |
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| EGAF00009006475 | cram | 19.5 GB |
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| EGAF00009006476 | cram | 17.7 GB |
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| EGAF00009006477 | cram | 12.5 GB |
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| EGAF00009006478 | cram | 13.9 GB |
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| EGAF00009006479 | cram | 12.7 GB |
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| EGAF00009006480 | cram | 15.5 GB |
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| EGAF00009006481 | cram | 15.8 GB |
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| EGAF00009006482 | cram | 16.7 GB |
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| EGAF00009006483 | cram | 14.8 GB |
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| EGAF00009006484 | cram | 15.9 GB |
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| EGAF00009006485 | cram | 16.1 GB |
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| EGAF00009006486 | cram | 13.4 GB |
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| EGAF00009006487 | cram | 16.0 GB |
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| EGAF00009006488 | cram | 11.4 GB |
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| EGAF00009006489 | cram | 13.3 GB |
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| EGAF00009006490 | cram | 15.6 GB |
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| EGAF00009006491 | cram | 14.9 GB |
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| EGAF00009006492 | cram | 17.2 GB |
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| EGAF00009006493 | cram | 15.5 GB |
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| EGAF00009006494 | cram | 13.5 GB |
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| EGAF00009006495 | cram | 14.2 GB |
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| EGAF00009006496 | cram | 14.0 GB |
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| EGAF00009006497 | cram | 14.2 GB |
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| EGAF00009006498 | cram | 16.2 GB |
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| EGAF00009006499 | cram | 13.2 GB |
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| EGAF00009006500 | cram | 17.0 GB |
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| EGAF00009006501 | cram | 16.3 GB |
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| EGAF00009006502 | cram | 11.9 GB |
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| EGAF00009006503 | cram | 12.7 GB |
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| EGAF00009006504 | cram | 16.0 GB |
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| EGAF00009006505 | cram | 13.8 GB |
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| EGAF00009006506 | cram | 15.6 GB |
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| EGAF00009006507 | cram | 13.1 GB |
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| EGAF00009006508 | cram | 12.6 GB |
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| EGAF00009006509 | cram | 10.1 GB |
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| EGAF00009006510 | cram | 15.7 GB |
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| EGAF00009006511 | cram | 10.5 GB |
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| EGAF00009006512 | cram | 11.9 GB |
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| EGAF00009006513 | cram | 12.9 GB |
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| EGAF00009006514 | cram | 14.4 GB |
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| EGAF00009006515 | cram | 13.2 GB |
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| EGAF00009023372 | cram | 12.7 GB |
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| EGAF00009023373 | cram | 12.5 GB |
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| EGAF00009023374 | cram | 11.2 GB |
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| EGAF00009023375 | cram | 14.6 GB |
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| EGAF00009023376 | cram | 12.5 GB |
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| EGAF00009023377 | cram | 12.6 GB |
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| EGAF00009023378 | cram | 13.9 GB |
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| EGAF00009023379 | cram | 13.3 GB |
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| EGAF00009023380 | cram | 16.1 GB |
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| EGAF00009023381 | cram | 17.2 GB |
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| EGAF00009023382 | cram | 14.0 GB |
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| EGAF00009023383 | cram | 13.8 GB |
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| EGAF00009023384 | cram | 17.8 GB |
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| EGAF00009023385 | cram | 12.4 GB |
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| EGAF00009023386 | cram | 15.3 GB |
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| EGAF00009023387 | cram | 15.4 GB |
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| 272 Files (4.0 TB) | ||||