Systemic mutagen exposures reported by normal kidney cell genomes - bulk kidney samples (NanoSeq)
Lifestyle, environmental and other exposures to exogenous mutagens generate somatic mutations in normal human cells in vivo and increase cancer risk. However, the global repertoire of exogenous mutagen exposures is uncertain. Using single-molecule duplex sequencing of normal kidney (n=319) and blood (n=272) samples from 10 countries, we show that kidney proximal tubule cells exhibit higher mutation rates than most normal cell types despite low cell division rates. Compared to cells from kidney glomeruli, medulla, distal tubules, or peripheral blood, proximal tubule cells show marked enrichment of mutational signatures due to the exogenous carcinogenic mutagens, aristolochic acids, and of several signatures of unknown causes. The results suggest the existence of multiple, common, systemically circulated mutagens affecting human populations and indicate that the genomes of kidney proximal tubule cells report such exposures with high sensitivity.
- 05/03/2026
- 1 sample
- DAC: EGAC00001000000
- Technology: Illumina NovaSeq 6000
DUO:0000019 version: 2021-02-23
publication required
This data use modifier indicates that requestor agrees to make results of studies using the data available to the larger scientific community.
DUO:0000026 version: 2021-02-23
user specific restriction
This data use modifier indicates that use is limited to use by approved users.
DUO:0000028 version: 2021-02-23
institution specific restriction
This data use modifier indicates that use is limited to use within an approved institution.
DUO:0000042 version: 2021-02-23
general research use
This data use permission indicates that use is allowed for general research use for any research purpose.
Wellcome Trust Sanger Institute Cancer Genome Group Data Sharing Policy
Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.
| Study ID | Study Title | Study Type |
|---|---|---|
| EGAS00001005135 | Cancer Genomics | |
| EGAS00001005451 | Whole Genome Sequencing |
This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.
| ID | File Type | Size | Quality Report |
Located in
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|
|---|---|---|---|---|
| EGAF00009005843 | cram | 26.7 GB |
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| EGAF00009005844 | cram | 24.2 GB |
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| EGAF00009006015 | cram | 16.0 GB |
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| EGAF00009006016 | cram | 21.8 GB |
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| EGAF00009006017 | cram | 15.2 GB |
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| EGAF00009006018 | cram | 20.0 GB |
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| EGAF00009006019 | cram | 16.9 GB |
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| EGAF00009006020 | cram | 18.3 GB |
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| EGAF00009006021 | cram | 20.1 GB |
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| EGAF00009006022 | cram | 19.0 GB |
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| EGAF00009006023 | cram | 15.6 GB |
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| EGAF00009006024 | cram | 16.5 GB |
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| EGAF00009006025 | cram | 15.5 GB |
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| EGAF00009006026 | cram | 16.4 GB |
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| EGAF00009006027 | cram | 23.8 GB |
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| EGAF00009006028 | cram | 19.6 GB |
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| EGAF00009006029 | cram | 21.9 GB |
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| EGAF00009006030 | cram | 22.4 GB |
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| EGAF00009006031 | cram | 21.4 GB |
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| EGAF00009006032 | cram | 20.2 GB |
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| EGAF00009006033 | cram | 23.3 GB |
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| EGAF00009006034 | cram | 14.8 GB |
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| EGAF00009006035 | cram | 18.2 GB |
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| EGAF00009006036 | cram | 19.1 GB |
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| EGAF00009006037 | cram | 24.1 GB |
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| EGAF00009006038 | cram | 17.3 GB |
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| EGAF00009006039 | cram | 17.9 GB |
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| EGAF00009006040 | cram | 17.6 GB |
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| EGAF00009006041 | cram | 16.3 GB |
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| EGAF00009006042 | cram | 16.9 GB |
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| EGAF00009006043 | cram | 23.1 GB |
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| EGAF00009006044 | cram | 17.9 GB |
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| EGAF00009006045 | cram | 18.9 GB |
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| EGAF00009006046 | cram | 16.3 GB |
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| EGAF00009006047 | cram | 22.8 GB |
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| EGAF00009006048 | cram | 17.1 GB |
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| EGAF00009006049 | cram | 22.3 GB |
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| EGAF00009006050 | cram | 21.8 GB |
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| EGAF00009006051 | cram | 22.6 GB |
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| EGAF00009006052 | cram | 20.0 GB |
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| EGAF00009006053 | cram | 21.2 GB |
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| EGAF00009006054 | cram | 18.2 GB |
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| EGAF00009006055 | cram | 19.7 GB |
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| EGAF00009006056 | cram | 24.5 GB |
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| EGAF00009006057 | cram | 17.7 GB |
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| EGAF00009006058 | cram | 17.4 GB |
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| EGAF00009006059 | cram | 17.1 GB |
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| EGAF00009006060 | cram | 19.2 GB |
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| EGAF00009006061 | cram | 17.1 GB |
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| EGAF00009006062 | cram | 19.8 GB |
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| EGAF00009006063 | cram | 22.3 GB |
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| EGAF00009006064 | cram | 23.0 GB |
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| EGAF00009006065 | cram | 18.4 GB |
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| EGAF00009006066 | cram | 20.0 GB |
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| EGAF00009006067 | cram | 19.8 GB |
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| EGAF00009006068 | cram | 25.2 GB |
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| EGAF00009006069 | cram | 23.0 GB |
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| EGAF00009006070 | cram | 21.5 GB |
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| EGAF00009006071 | cram | 23.8 GB |
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| EGAF00009006072 | cram | 22.6 GB |
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| EGAF00009006073 | cram | 17.9 GB |
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| EGAF00009006074 | cram | 20.7 GB |
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| EGAF00009006075 | cram | 22.2 GB |
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| EGAF00009006076 | cram | 21.6 GB |
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| EGAF00009006077 | cram | 18.9 GB |
|
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| EGAF00009006078 | cram | 20.2 GB |
|
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| EGAF00009006079 | cram | 21.3 GB |
|
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| EGAF00009006080 | cram | 22.2 GB |
|
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| EGAF00009006081 | cram | 21.2 GB |
|
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| EGAF00009006082 | cram | 16.5 GB |
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| EGAF00009006083 | cram | 19.5 GB |
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| EGAF00009006084 | cram | 18.0 GB |
|
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| EGAF00009006085 | cram | 19.7 GB |
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| EGAF00009006086 | cram | 21.5 GB |
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| EGAF00009006087 | cram | 20.4 GB |
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| EGAF00009006088 | cram | 26.9 GB |
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| EGAF00009006089 | cram | 20.5 GB |
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| EGAF00009006090 | cram | 18.8 GB |
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| EGAF00009006091 | cram | 19.8 GB |
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| EGAF00009006092 | cram | 20.6 GB |
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| EGAF00009006093 | cram | 20.1 GB |
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| EGAF00009006094 | cram | 18.1 GB |
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| EGAF00009006095 | cram | 25.1 GB |
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| EGAF00009006096 | cram | 22.2 GB |
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| EGAF00009006107 | cram | 17.5 GB |
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| EGAF00009006108 | cram | 18.4 GB |
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| EGAF00009006109 | cram | 19.1 GB |
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| EGAF00009006110 | cram | 21.9 GB |
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| EGAF00009006111 | cram | 16.6 GB |
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| EGAF00009006112 | cram | 18.3 GB |
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| EGAF00009006113 | cram | 19.5 GB |
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| EGAF00009006114 | cram | 21.1 GB |
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| EGAF00009006115 | cram | 16.3 GB |
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| EGAF00009006116 | cram | 18.3 GB |
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| EGAF00009006117 | cram | 18.3 GB |
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| EGAF00009006118 | cram | 17.0 GB |
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| EGAF00009006119 | cram | 18.7 GB |
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| EGAF00009006120 | cram | 16.5 GB |
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| EGAF00009006121 | cram | 14.7 GB |
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| EGAF00009006122 | cram | 14.6 GB |
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| EGAF00009006123 | cram | 17.0 GB |
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| EGAF00009006124 | cram | 16.3 GB |
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| EGAF00009006125 | cram | 17.5 GB |
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| EGAF00009006126 | cram | 20.0 GB |
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| EGAF00009006127 | cram | 19.8 GB |
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| EGAF00009006128 | cram | 17.2 GB |
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| EGAF00009006129 | cram | 21.8 GB |
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| EGAF00009006130 | cram | 17.4 GB |
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| EGAF00009006131 | cram | 18.2 GB |
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| EGAF00009006132 | cram | 15.9 GB |
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| EGAF00009006133 | cram | 18.3 GB |
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| EGAF00009006134 | cram | 17.9 GB |
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| EGAF00009006135 | cram | 22.0 GB |
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| EGAF00009006136 | cram | 15.7 GB |
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| EGAF00009006137 | cram | 20.1 GB |
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| EGAF00009006138 | cram | 18.2 GB |
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| EGAF00009006139 | cram | 19.2 GB |
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| EGAF00009006140 | cram | 19.6 GB |
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| EGAF00009006141 | cram | 19.3 GB |
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| EGAF00009006142 | cram | 17.9 GB |
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| EGAF00009006143 | cram | 18.3 GB |
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| EGAF00009006144 | cram | 17.7 GB |
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| EGAF00009006145 | cram | 18.6 GB |
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| EGAF00009006146 | cram | 17.7 GB |
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| EGAF00009006147 | cram | 16.9 GB |
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| EGAF00009006148 | cram | 19.0 GB |
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| EGAF00009006149 | cram | 19.6 GB |
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| EGAF00009006150 | cram | 18.2 GB |
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| EGAF00009006151 | cram | 18.7 GB |
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| EGAF00009006152 | cram | 20.9 GB |
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| EGAF00009006153 | cram | 15.6 GB |
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| EGAF00009006154 | cram | 15.0 GB |
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| EGAF00009006155 | cram | 15.6 GB |
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| EGAF00009006156 | cram | 17.4 GB |
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| EGAF00009006157 | cram | 17.3 GB |
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| EGAF00009006158 | cram | 15.3 GB |
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| EGAF00009006159 | cram | 19.9 GB |
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| EGAF00009006160 | cram | 16.1 GB |
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| EGAF00009006161 | cram | 18.4 GB |
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| EGAF00009006162 | cram | 18.0 GB |
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| EGAF00009006163 | cram | 17.4 GB |
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| EGAF00009006164 | cram | 17.6 GB |
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| EGAF00009006165 | cram | 17.0 GB |
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| EGAF00009006166 | cram | 20.1 GB |
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| EGAF00009006167 | cram | 16.1 GB |
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| EGAF00009006168 | cram | 15.7 GB |
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| EGAF00009006169 | cram | 18.5 GB |
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| EGAF00009006170 | cram | 17.6 GB |
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| EGAF00009006171 | cram | 16.1 GB |
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| EGAF00009006172 | cram | 16.4 GB |
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| EGAF00009006173 | cram | 17.9 GB |
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| EGAF00009006174 | cram | 17.6 GB |
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| EGAF00009006175 | cram | 16.8 GB |
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| EGAF00009006176 | cram | 18.6 GB |
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| EGAF00009006177 | cram | 16.8 GB |
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| EGAF00009006178 | cram | 20.9 GB |
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| EGAF00009006179 | cram | 14.8 GB |
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| EGAF00009006180 | cram | 15.4 GB |
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| EGAF00009006181 | cram | 15.6 GB |
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| EGAF00009006182 | cram | 17.4 GB |
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| EGAF00009006183 | cram | 19.9 GB |
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| EGAF00009006184 | cram | 17.4 GB |
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| EGAF00009006185 | cram | 18.6 GB |
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| EGAF00009006186 | cram | 16.2 GB |
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| EGAF00009006187 | cram | 20.5 GB |
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| EGAF00009006188 | cram | 18.2 GB |
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| EGAF00009006189 | cram | 20.2 GB |
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| EGAF00009006190 | cram | 16.7 GB |
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| EGAF00009006191 | cram | 15.9 GB |
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| EGAF00009006192 | cram | 18.9 GB |
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| EGAF00009006193 | cram | 16.8 GB |
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| EGAF00009006194 | cram | 14.9 GB |
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| EGAF00009006195 | cram | 15.4 GB |
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| EGAF00009006196 | cram | 15.7 GB |
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| EGAF00009006197 | cram | 18.1 GB |
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| EGAF00009006198 | cram | 16.5 GB |
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| EGAF00009006199 | cram | 18.0 GB |
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| EGAF00009006200 | cram | 17.8 GB |
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| EGAF00009006201 | cram | 19.3 GB |
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| EGAF00009006202 | cram | 17.9 GB |
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| EGAF00009006203 | cram | 19.0 GB |
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| EGAF00009006204 | cram | 17.4 GB |
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| EGAF00009006205 | cram | 18.1 GB |
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| EGAF00009006206 | cram | 20.9 GB |
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| EGAF00009006207 | cram | 18.7 GB |
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| EGAF00009006208 | cram | 18.1 GB |
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| EGAF00009006209 | cram | 19.2 GB |
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| EGAF00009006210 | cram | 19.7 GB |
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| EGAF00009006211 | cram | 18.8 GB |
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| EGAF00009006212 | cram | 21.7 GB |
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| EGAF00009006213 | cram | 18.8 GB |
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| EGAF00009006214 | cram | 16.7 GB |
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| EGAF00009006215 | cram | 17.7 GB |
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| EGAF00009006216 | cram | 15.4 GB |
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| EGAF00009006217 | cram | 16.0 GB |
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| EGAF00009006218 | cram | 13.9 GB |
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| EGAF00009006219 | cram | 18.4 GB |
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| EGAF00009006220 | cram | 18.4 GB |
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| EGAF00009006221 | cram | 16.7 GB |
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| EGAF00009006222 | cram | 20.1 GB |
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| EGAF00009006223 | cram | 17.5 GB |
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| EGAF00009006224 | cram | 15.6 GB |
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| EGAF00009006225 | cram | 14.1 GB |
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| EGAF00009006226 | cram | 16.6 GB |
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| EGAF00009006227 | cram | 17.0 GB |
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| EGAF00009006228 | cram | 18.3 GB |
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| EGAF00009006229 | cram | 15.3 GB |
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| EGAF00009006230 | cram | 18.6 GB |
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| EGAF00009006231 | cram | 16.4 GB |
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| EGAF00009006232 | cram | 17.4 GB |
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| EGAF00009006233 | cram | 16.3 GB |
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| EGAF00009006234 | cram | 14.5 GB |
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| EGAF00009006235 | cram | 16.0 GB |
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| EGAF00009006236 | cram | 16.9 GB |
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| EGAF00009006237 | cram | 17.0 GB |
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| EGAF00009006238 | cram | 14.9 GB |
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| EGAF00009006239 | cram | 16.2 GB |
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| EGAF00009006240 | cram | 17.6 GB |
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| EGAF00009006241 | cram | 13.5 GB |
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| EGAF00009006242 | cram | 16.5 GB |
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| EGAF00009006243 | cram | 16.9 GB |
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| EGAF00009006244 | cram | 17.3 GB |
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| EGAF00009006245 | cram | 17.0 GB |
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| EGAF00009006246 | cram | 17.1 GB |
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| EGAF00009006247 | cram | 19.6 GB |
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| EGAF00009006248 | cram | 16.2 GB |
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| EGAF00009006249 | cram | 16.5 GB |
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| EGAF00009006250 | cram | 15.1 GB |
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| EGAF00009006251 | cram | 17.2 GB |
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| EGAF00009006252 | cram | 14.5 GB |
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| EGAF00009006253 | cram | 14.0 GB |
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| EGAF00009006254 | cram | 14.6 GB |
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| EGAF00009006255 | cram | 14.2 GB |
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| EGAF00009006256 | cram | 15.7 GB |
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| EGAF00009006257 | cram | 14.9 GB |
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| EGAF00009006258 | cram | 14.6 GB |
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| EGAF00009006259 | cram | 15.8 GB |
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| EGAF00009007206 | cram | 14.6 GB |
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| EGAF00009007207 | cram | 14.6 GB |
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| EGAF00009007208 | cram | 13.1 GB |
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| EGAF00009007209 | cram | 13.5 GB |
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| EGAF00009007210 | cram | 11.9 GB |
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| EGAF00009007211 | cram | 16.5 GB |
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| EGAF00009007212 | cram | 15.8 GB |
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| EGAF00009007213 | cram | 14.1 GB |
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| EGAF00009007214 | cram | 15.8 GB |
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| EGAF00009007215 | cram | 13.7 GB |
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| EGAF00009007222 | cram | 13.8 GB |
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| EGAF00009007223 | cram | 15.2 GB |
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| EGAF00009007224 | cram | 16.6 GB |
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| EGAF00009007225 | cram | 17.3 GB |
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| EGAF00009007226 | cram | 14.9 GB |
|
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| EGAF00009007227 | cram | 18.1 GB |
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| EGAF00009007228 | cram | 14.6 GB |
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| EGAF00009007229 | cram | 15.9 GB |
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| EGAF00009007230 | cram | 15.4 GB |
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| EGAF00009007231 | cram | 13.6 GB |
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| EGAF00009007232 | cram | 14.4 GB |
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| EGAF00009007233 | cram | 16.3 GB |
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| EGAF00009007234 | cram | 17.2 GB |
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| EGAF00009007235 | cram | 15.4 GB |
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| EGAF00009007236 | cram | 13.8 GB |
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| EGAF00009007237 | cram | 16.3 GB |
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| EGAF00009007238 | cram | 16.9 GB |
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| EGAF00009007239 | cram | 14.1 GB |
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| EGAF00009007277 | cram | 13.7 GB |
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| EGAF00009007278 | cram | 12.5 GB |
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| EGAF00009007279 | cram | 12.6 GB |
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| EGAF00009007280 | cram | 11.2 GB |
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| EGAF00009007281 | cram | 13.5 GB |
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| EGAF00009007282 | cram | 14.1 GB |
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| EGAF00009007283 | cram | 13.5 GB |
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| EGAF00009007284 | cram | 15.0 GB |
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| EGAF00009007285 | cram | 12.1 GB |
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| EGAF00009007286 | cram | 13.8 GB |
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| EGAF00009007287 | cram | 13.6 GB |
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| EGAF00009007288 | cram | 11.9 GB |
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| EGAF00009007289 | cram | 12.8 GB |
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| EGAF00009007290 | cram | 13.7 GB |
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| EGAF00009007291 | cram | 14.2 GB |
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| EGAF00009007292 | cram | 12.7 GB |
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| EGAF00009007293 | cram | 15.6 GB |
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| EGAF00009007294 | cram | 13.5 GB |
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| EGAF00009007295 | cram | 13.2 GB |
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| EGAF00009007296 | cram | 12.1 GB |
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| EGAF00009007297 | cram | 12.9 GB |
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| EGAF00009007298 | cram | 13.7 GB |
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| EGAF00009007299 | cram | 13.9 GB |
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| EGAF00009007300 | cram | 12.3 GB |
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| EGAF00009007301 | cram | 12.4 GB |
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| EGAF00009007302 | cram | 15.6 GB |
|
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| EGAF00009007303 | cram | 15.6 GB |
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| EGAF00009007304 | cram | 14.7 GB |
|
|
| EGAF00009007305 | cram | 14.7 GB |
|
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| EGAF00009007306 | cram | 15.3 GB |
|
|
| EGAF00009007307 | cram | 17.9 GB |
|
|
| EGAF00009007308 | cram | 15.5 GB |
|
|
| EGAF00009007309 | cram | 18.6 GB |
|
|
| EGAF00009007310 | cram | 16.0 GB |
|
|
| EGAF00009007311 | cram | 15.9 GB |
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| 300 Files (5.3 TB) | ||||