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Common early-life exposure of the colorectal epithelium to the microbiome-derived mutagen colibactin

Colibactin is a mutagen produced by bacterial strains in the colorectal microbiomes of some healthy people. It generates somatic mutations characterised by the mutational signatures SBS88 and ID18 in normal human colorectal epithelial cells in vivo. Increasing prevalence of colibactin mutagenesis during the 20th century is hypothesised to have caused recent international increases in early-onset colorectal cancer incidence. Here, we establish the early-life prevalence, timing, mutation burdens and distribution through the colon of colibactin mutagenesis by sequencing normal colorectal epithelial cell genomes to detect SBS88 and ID18 in children and adolescents from the UK and Denmark biopsied between 2016 and 2024. Colibactin mutagenesis was found in ~40% individuals. It starts soon after birth and often ceases by age five years, although some children show longer exposures. Mutation burdens are higher in the left than right colon and show substantial variation between exposed individuals, in some causing >100-fold increases in total mutation loads compared to unexposed children of the same age. Therefore, colorectal mutagenesis by colibactin is currently common in some populations, occurs during early childhood and can produce markedly elevated somatic mutation burdens. The future public health implications of this widespread mutagen exposure will depend on clarification of its role in colorectal cancer causation.

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Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001007921 Whole Genome Sequencing

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Quality Report
Located in
EGAF00009006560 cram 8.3 GB
EGAF00009006561 cram 8.2 GB
EGAF00009006562 cram 8.9 GB
EGAF00009006563 cram 7.9 GB
EGAF00009006564 cram 7.9 GB
EGAF00009006565 cram 6.5 GB
EGAF00009006566 cram 7.0 GB
EGAF00009006567 cram 10.5 GB
EGAF00009006568 cram 6.9 GB
EGAF00009006569 cram 7.9 GB
EGAF00009006570 cram 8.1 GB
EGAF00009006571 cram 6.5 GB
EGAF00009006572 cram 7.1 GB
EGAF00009006573 cram 7.1 GB
EGAF00009006574 cram 7.6 GB
EGAF00009006575 cram 8.9 GB
EGAF00009006576 cram 7.5 GB
EGAF00009006577 cram 8.9 GB
EGAF00009006578 cram 8.7 GB
EGAF00009006579 cram 7.6 GB
EGAF00009006580 cram 7.4 GB
EGAF00009006581 cram 11.6 GB
EGAF00009006582 cram 9.8 GB
EGAF00009006583 cram 12.2 GB
EGAF00009006584 cram 7.7 GB
EGAF00009006585 cram 7.8 GB
EGAF00009006586 cram 7.1 GB
EGAF00009006587 cram 8.2 GB
EGAF00009006588 cram 9.0 GB
EGAF00009006589 cram 7.9 GB
EGAF00009006590 cram 9.6 GB
EGAF00009006591 cram 8.8 GB
EGAF00009006592 cram 6.0 GB
EGAF00009006593 cram 7.1 GB
EGAF00009006594 cram 8.7 GB
EGAF00009006595 cram 7.6 GB
EGAF00009006596 cram 8.8 GB
EGAF00009006597 cram 7.5 GB
EGAF00009006598 cram 7.4 GB
EGAF00009006599 cram 9.6 GB
EGAF00009006600 cram 7.9 GB
EGAF00009006601 cram 8.8 GB
EGAF00009006602 cram 7.0 GB
EGAF00009006603 cram 10.0 GB
EGAF00009006604 cram 7.4 GB
EGAF00009006605 cram 9.0 GB
EGAF00009006606 cram 7.9 GB
EGAF00009006607 cram 6.8 GB
EGAF00009006608 cram 8.1 GB
EGAF00009006609 cram 8.6 GB
EGAF00009006610 cram 6.8 GB
EGAF00009006611 cram 14.1 GB
EGAF00009006612 cram 6.8 GB
EGAF00009006613 cram 7.2 GB
EGAF00009006614 cram 8.1 GB
EGAF00009006615 cram 7.4 GB
EGAF00009006616 cram 8.8 GB
EGAF00009006617 cram 6.7 GB
EGAF00009006618 cram 9.0 GB
EGAF00009006619 cram 8.3 GB
EGAF00009006620 cram 5.6 GB
EGAF00009006621 cram 5.2 GB
EGAF00009006622 cram 5.5 GB
EGAF00009006623 cram 5.6 GB
EGAF00009006624 cram 6.0 GB
EGAF00009006625 cram 6.1 GB
EGAF00009006626 cram 5.2 GB
EGAF00009006627 cram 5.7 GB
EGAF00009006628 cram 6.2 GB
EGAF00009006629 cram 5.2 GB
EGAF00009006630 cram 5.0 GB
EGAF00009006631 cram 5.7 GB
EGAF00009006632 cram 5.0 GB
EGAF00009006633 cram 7.8 GB
EGAF00009006634 cram 5.4 GB
EGAF00009006635 cram 5.9 GB
EGAF00009006636 cram 5.5 GB
EGAF00009006637 cram 5.7 GB
EGAF00009006638 cram 6.4 GB
EGAF00009006639 cram 5.9 GB
EGAF00009006640 cram 5.7 GB
EGAF00009006641 cram 4.8 GB
EGAF00009006642 cram 6.0 GB
EGAF00009006643 cram 5.8 GB
EGAF00009006644 cram 4.9 GB
EGAF00009006645 cram 5.2 GB
EGAF00009006646 cram 5.2 GB
EGAF00009006647 cram 6.6 GB
EGAF00009006648 cram 5.0 GB
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EGAF00009006650 cram 6.0 GB
EGAF00009006651 cram 5.6 GB
EGAF00009006652 cram 4.9 GB
EGAF00009006653 cram 5.6 GB
EGAF00009006654 cram 6.1 GB
EGAF00009006655 cram 4.5 GB
EGAF00009006656 cram 5.7 GB
EGAF00009006657 cram 6.0 GB
EGAF00009006658 cram 5.9 GB
EGAF00009006659 cram 6.2 GB
EGAF00009006660 cram 6.7 GB
EGAF00009006661 cram 5.4 GB
EGAF00009006662 cram 7.9 GB
EGAF00009006663 cram 8.1 GB
EGAF00009006664 cram 6.2 GB
EGAF00009006665 cram 4.5 GB
EGAF00009006666 cram 4.9 GB
EGAF00009006667 cram 5.3 GB
EGAF00009006668 cram 6.0 GB
EGAF00009006669 cram 9.3 GB
EGAF00009006670 cram 5.8 GB
EGAF00009006671 cram 8.4 GB
EGAF00009006672 cram 8.3 GB
EGAF00009006673 cram 9.0 GB
EGAF00009006674 cram 8.0 GB
EGAF00009006675 cram 8.0 GB
EGAF00009006676 cram 6.6 GB
EGAF00009006677 cram 7.1 GB
EGAF00009006678 cram 10.6 GB
EGAF00009006679 cram 7.0 GB
EGAF00009006680 cram 8.0 GB
EGAF00009006681 cram 8.1 GB
EGAF00009006682 cram 6.6 GB
EGAF00009006683 cram 7.2 GB
EGAF00009006684 cram 7.2 GB
EGAF00009006685 cram 7.7 GB
EGAF00009006686 cram 9.1 GB
EGAF00009006687 cram 7.6 GB
EGAF00009006688 cram 9.0 GB
EGAF00009006689 cram 8.8 GB
EGAF00009006690 cram 7.6 GB
EGAF00009006691 cram 7.5 GB
EGAF00009006692 cram 11.8 GB
EGAF00009006693 cram 9.8 GB
EGAF00009006694 cram 12.3 GB
EGAF00009006695 cram 7.8 GB
EGAF00009006696 cram 7.9 GB
EGAF00009006697 cram 7.2 GB
EGAF00009006698 cram 8.3 GB
EGAF00009006699 cram 9.2 GB
EGAF00009006700 cram 8.0 GB
EGAF00009006701 cram 9.7 GB
EGAF00009006702 cram 8.9 GB
EGAF00009006703 cram 6.1 GB
EGAF00009006704 cram 7.1 GB
EGAF00009006705 cram 8.8 GB
EGAF00009006706 cram 7.8 GB
EGAF00009006707 cram 8.9 GB
EGAF00009006708 cram 7.6 GB
EGAF00009006709 cram 7.5 GB
EGAF00009006710 cram 9.6 GB
EGAF00009006711 cram 8.0 GB
EGAF00009006712 cram 8.9 GB
EGAF00009006713 cram 7.1 GB
EGAF00009006714 cram 10.2 GB
EGAF00009006715 cram 7.4 GB
EGAF00009006716 cram 9.1 GB
EGAF00009006717 cram 8.0 GB
EGAF00009006718 cram 6.9 GB
EGAF00009006719 cram 8.1 GB
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EGAF00009006721 cram 6.9 GB
EGAF00009006722 cram 14.3 GB
EGAF00009006723 cram 6.9 GB
EGAF00009006724 cram 7.3 GB
EGAF00009006725 cram 8.2 GB
EGAF00009006726 cram 7.4 GB
EGAF00009006727 cram 8.9 GB
EGAF00009006728 cram 6.7 GB
EGAF00009006729 cram 9.1 GB
EGAF00009006730 cram 8.5 GB
EGAF00009006731 cram 6.9 GB
EGAF00009006732 cram 7.6 GB
EGAF00009006733 cram 7.3 GB
EGAF00009006734 cram 6.2 GB
EGAF00009006735 cram 7.0 GB
EGAF00009006736 cram 6.8 GB
EGAF00009006737 cram 6.5 GB
EGAF00009006738 cram 6.5 GB
EGAF00009006739 cram 6.0 GB
EGAF00009006740 cram 6.6 GB
EGAF00009006741 cram 8.0 GB
EGAF00009006742 cram 6.4 GB
EGAF00009006743 cram 7.5 GB
EGAF00009006744 cram 7.6 GB
EGAF00009006745 cram 6.1 GB
EGAF00009006746 cram 7.4 GB
EGAF00009006747 cram 6.8 GB
EGAF00009006748 cram 6.7 GB
EGAF00009006749 cram 8.2 GB
EGAF00009006750 cram 7.1 GB
EGAF00009006751 cram 7.0 GB
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EGAF00009006753 cram 7.5 GB
EGAF00009006754 cram 6.7 GB
EGAF00009006755 cram 6.6 GB
EGAF00009006756 cram 7.2 GB
EGAF00009006757 cram 6.4 GB
EGAF00009006758 cram 4.0 GB
EGAF00009006759 cram 7.4 GB
EGAF00009006760 cram 5.8 GB
EGAF00009006761 cram 5.9 GB
EGAF00009006762 cram 8.0 GB
EGAF00009006763 cram 6.3 GB
EGAF00009006764 cram 6.3 GB
EGAF00009006765 cram 7.5 GB
EGAF00009006766 cram 6.9 GB
EGAF00009006767 cram 6.4 GB
EGAF00009006768 cram 6.4 GB
EGAF00009006769 cram 6.8 GB
EGAF00009006770 cram 7.8 GB
EGAF00009006771 cram 8.0 GB
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EGAF00009006773 cram 7.2 GB
EGAF00009006774 cram 8.7 GB
EGAF00009006775 cram 9.4 GB
EGAF00009006776 cram 9.1 GB
EGAF00009006777 cram 7.7 GB
EGAF00009006778 cram 8.8 GB
EGAF00009006779 cram 8.5 GB
EGAF00009006780 cram 8.1 GB
EGAF00009006781 cram 8.1 GB
EGAF00009006782 cram 7.6 GB
EGAF00009006783 cram 8.3 GB
EGAF00009006784 cram 10.0 GB
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EGAF00009006787 cram 9.5 GB
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EGAF00009006789 cram 9.3 GB
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EGAF00009006792 cram 10.2 GB
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EGAF00009006800 cram 7.9 GB
EGAF00009006801 cram 5.0 GB
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EGAF00009006810 cram 7.9 GB
EGAF00009006811 cram 8.0 GB
EGAF00009006812 cram 8.4 GB
EGAF00009006813 cram 9.7 GB
EGAF00009006814 cram 9.9 GB
EGAF00009006815 cram 8.5 GB
EGAF00009006816 cram 8.8 GB
EGAF00009006817 cram 4.9 GB
EGAF00009006818 cram 4.7 GB
EGAF00009006819 cram 5.6 GB
EGAF00009006820 cram 6.2 GB
EGAF00009006821 cram 6.0 GB
EGAF00009006822 cram 4.7 GB
EGAF00009006823 cram 4.9 GB
EGAF00009006824 cram 5.1 GB
EGAF00009006825 cram 5.2 GB
EGAF00009006826 cram 5.6 GB
EGAF00009006827 cram 5.7 GB
EGAF00009006828 cram 5.1 GB
EGAF00009006829 cram 5.4 GB
EGAF00009006830 cram 5.5 GB
EGAF00009006831 cram 6.6 GB
EGAF00009006832 cram 6.6 GB
EGAF00009006833 cram 4.6 GB
EGAF00009006834 cram 5.2 GB
EGAF00009006835 cram 4.8 GB
EGAF00009006836 cram 5.5 GB
EGAF00009006837 cram 5.4 GB
EGAF00009006838 cram 4.6 GB
EGAF00009006839 cram 5.2 GB
EGAF00009006840 cram 5.5 GB
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EGAF00009006843 cram 4.6 GB
EGAF00009006844 cram 5.7 GB
EGAF00009006845 cram 5.3 GB
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EGAF00009006847 cram 4.9 GB
EGAF00009006848 cram 5.3 GB
EGAF00009006849 cram 6.5 GB
EGAF00009006850 cram 5.3 GB
EGAF00009006851 cram 5.1 GB
EGAF00009006852 cram 7.1 GB
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EGAF00009006854 cram 6.3 GB
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EGAF00009006864 cram 5.1 GB
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EGAF00009006867 cram 6.5 GB
EGAF00009006868 cram 6.1 GB
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EGAF00009006870 cram 5.6 GB
EGAF00009006871 cram 5.4 GB
EGAF00009006872 cram 6.0 GB
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EGAF00009006875 cram 5.5 GB
EGAF00009006876 cram 6.0 GB
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EGAF00009006880 cram 6.1 GB
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EGAF00009006882 cram 1.7 GB
EGAF00009006883 cram 2.0 GB
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EGAF00009006885 cram 1.9 GB
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EGAF00009006887 cram 1.9 GB
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EGAF00009006890 cram 1.6 GB
EGAF00009006891 cram 1.9 GB
EGAF00009006892 cram 11.0 GB
EGAF00009006893 cram 13.5 GB
EGAF00009006894 cram 24.9 GB
EGAF00009006895 cram 15.0 GB
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EGAF00009006897 cram 16.2 GB
EGAF00009006898 cram 15.2 GB
EGAF00009006899 cram 12.5 GB
EGAF00009006900 cram 12.4 GB
EGAF00009006901 cram 15.2 GB
EGAF00009006902 cram 15.4 GB
EGAF00009006903 cram 22.2 GB
EGAF00009006904 cram 15.9 GB
EGAF00009006905 cram 16.6 GB
EGAF00009006906 cram 12.3 GB
EGAF00009006907 cram 22.8 GB
EGAF00009006908 cram 18.6 GB
EGAF00009006909 cram 17.3 GB
EGAF00009006910 cram 16.2 GB
EGAF00009006911 cram 15.0 GB
EGAF00009006912 cram 15.4 GB
EGAF00009006913 cram 15.2 GB
EGAF00009006914 cram 16.5 GB
EGAF00009006915 cram 13.1 GB
EGAF00009006916 cram 13.8 GB
EGAF00009006917 cram 12.6 GB
EGAF00009006918 cram 13.6 GB
EGAF00009006919 cram 18.0 GB
EGAF00009006920 cram 16.6 GB
EGAF00009006921 cram 13.8 GB
EGAF00009006922 cram 15.4 GB
EGAF00009006923 cram 13.7 GB
EGAF00009006924 cram 15.5 GB
EGAF00009006925 cram 14.7 GB
EGAF00009006926 cram 15.6 GB
EGAF00009006927 cram 14.7 GB
EGAF00009006928 cram 13.4 GB
EGAF00009006929 cram 15.7 GB
EGAF00009006930 cram 14.7 GB
EGAF00009006931 cram 14.8 GB
EGAF00009006932 cram 14.2 GB
EGAF00009006933 cram 15.5 GB
EGAF00009006934 cram 16.4 GB
EGAF00009006935 cram 15.7 GB
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EGAF00009006937 cram 16.5 GB
EGAF00009006938 cram 17.1 GB
EGAF00009006939 cram 12.5 GB
EGAF00009006940 cram 15.6 GB
EGAF00009006941 cram 14.8 GB
EGAF00009006942 cram 21.8 GB
EGAF00009006943 cram 14.2 GB
EGAF00009006944 cram 7.6 GB
EGAF00009006945 cram 10.1 GB
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EGAF00009006958 cram 8.3 GB
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EGAF00009006960 cram 8.2 GB
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EGAF00009006972 cram 7.2 GB
EGAF00009006973 cram 8.5 GB
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EGAF00009006976 cram 7.3 GB
EGAF00009006977 cram 8.1 GB
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EGAF00009007008 cram 6.1 GB
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EGAF00009007010 cram 6.7 GB
EGAF00009007011 cram 6.1 GB
EGAF00009007012 cram 8.1 GB
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EGAF00009007015 cram 6.7 GB
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EGAF00009007017 cram 9.3 GB
EGAF00009007018 cram 12.2 GB
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EGAF00009007022 cram 8.0 GB
EGAF00009007023 cram 11.8 GB
EGAF00009007024 cram 7.7 GB
EGAF00009007025 cram 8.4 GB
EGAF00009007026 cram 8.6 GB
EGAF00009007027 cram 8.2 GB
EGAF00009007028 cram 8.0 GB
EGAF00009007029 cram 7.9 GB
EGAF00009007030 cram 8.7 GB
EGAF00009007031 cram 8.1 GB
EGAF00009007032 cram 9.2 GB
EGAF00009007033 cram 7.9 GB
EGAF00009007034 cram 8.6 GB
EGAF00009007035 cram 8.4 GB
EGAF00009007036 cram 7.7 GB
EGAF00009007037 cram 8.7 GB
EGAF00009007038 cram 13.7 GB
EGAF00009007039 cram 8.6 GB
EGAF00009007040 cram 7.5 GB
EGAF00009007041 cram 7.5 GB
EGAF00009007042 cram 9.0 GB
EGAF00009007043 cram 7.4 GB
EGAF00009007044 cram 8.9 GB
EGAF00009007045 cram 8.1 GB
EGAF00009007046 cram 9.1 GB
EGAF00009007047 cram 8.9 GB
EGAF00009007048 cram 8.2 GB
EGAF00009007049 cram 10.9 GB
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EGAF00009007051 cram 8.5 GB
EGAF00009007052 cram 8.8 GB
EGAF00009007063 cram 16.2 GB
EGAF00009007064 cram 13.4 GB
EGAF00009007065 cram 14.5 GB
EGAF00009007066 cram 12.8 GB
EGAF00009007067 cram 13.1 GB
EGAF00009007068 cram 13.7 GB
EGAF00009007069 cram 17.5 GB
EGAF00009007070 cram 12.5 GB
EGAF00009007071 cram 13.9 GB
EGAF00009007072 cram 13.6 GB
EGAF00009007073 cram 12.2 GB
EGAF00009007074 cram 13.0 GB
EGAF00009007075 cram 12.2 GB
EGAF00009007076 cram 13.7 GB
EGAF00009007077 cram 12.1 GB
EGAF00009007078 cram 16.0 GB
EGAF00009007079 cram 15.9 GB
EGAF00009007080 cram 14.9 GB
EGAF00009007081 cram 16.2 GB
EGAF00009007082 cram 13.6 GB
EGAF00009007083 cram 12.8 GB
EGAF00009007084 cram 20.3 GB
EGAF00009007085 cram 15.6 GB
EGAF00009007086 cram 11.4 GB
EGAF00009007087 cram 16.4 GB
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EGAF00009026913 cram 20.9 GB
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EGAF00009026916 cram 17.3 GB
EGAF00009026917 cram 32.2 GB
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EGAF00009026940 cram 16.6 GB
EGAF00009026941 cram 17.0 GB
EGAF00009026942 cram 19.6 GB
EGAF00009026943 cram 17.7 GB
EGAF00009026944 cram 16.2 GB
EGAF00009026945 cram 14.1 GB
985 Files (10.6 TB)