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Glioma GWAS summary statistics

Meta-analysis association statistics from case-control analysis (includes imputed SNPs)

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Data access agreement for glioma GWAS summary statistics

Human genetic data access agreement for institutions (the “Agreement”) This AGREEMENT is entered into on [ ] and made between: (1) THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL, whose registered address is 123 Old Brompton Road, London SW7 3RP, UK, (the “ICR”) and (2) [ ] (the “Recipient”). WHEREAS A. Further to the data access application dated [ ] attached to this Agreement as Appendix 1 (the “Application”), the Recipient has requested the Data (defined below) in order to carry out the Research (defined below). B. The work will be carried out under the supervision of the Recipient’s Principal Investigator, [ ] (the “Recipient Principal Investigator”) C. In response to the Recipient's request for access to the Data, ICR and the Recipient agree as follows: 1 Definitions 1.1 “Molecular and Population Genetics (MPG) research at ICR” (“MPG-ICR”) shall mean research undertaken in the Molecular and Population Genetics team at ICR; 1.2 “Data” shall mean all and any anonymised human genetic data obtained from the MPG-ICR including the Data Subjects’ age, sex and tumour pathology. Explicitly, Data does not include samples or biological materials; 1.3 “Data Subject” shall mean the person (irrespective of state of health) to whom Data refers; 1.4 “Intellectual Property” means (i) patents, designs, copyright and related rights, database rights, know-how and confidential information; (ii) all other intellectual property rights and similar or equivalent rights anywhere in the world which currently exist or are recognised in the future; and (iii) applications, extensions and renewals in relation to any such rights; 1.5 “Registered User” shall mean the Recipient Principal Investigator or a Researcher that is employed by the Recipient and is bound by confidentiality and non-use obligations in respect of Data. For the avoidance of doubt, “Registered User” may also include students, visiting academics, contractors, sub-contractors or independent consultants provided that any such individual is bound by confidentiality and non-use obligations no less onerous than those binding the Recipient. 1.6 “Research” shall mean research that is more accurately described in the Application, seeking to advance the understanding and treatment of cancer and closely related diseases, and work on statistical methods that may be applied to such research; 1.7 “Researcher(s)” shall mean an individual or individuals carrying out Research under the direct supervision of the Recipient Principal Investigator. 2 Purpose The Recipient agrees to use Data only for the non-commercial Research purposes as described in the Application. Data should not be provided to a third party either directly or in electronic form. 3 Confidentiality Recipient will not disclose the Data to any person except as required by law or a competent authority. The Recipient agrees to preserve, at all times, the confidentiality of Data. In particular, the Recipient undertakes not to use, or attempt to use the Data to deliberately compromise or otherwise infringe the confidentiality of information on Data Subjects and their right to privacy. 4 Data Protection 4.1 The Recipient agrees that it, and its Registered Users, are covered by and shall comply with the obligations contained in the Data Protection Act 2018 as amended from time to time, or other standards and requirements of [ ] privacy and personal information protection laws and regulations. In particular, the Recipient and its Registered Users understand their duties under such legislation in relation to the handling of Data and the rights of Data Subjects. 4.2 The Recipient agrees that it, and its Registered Users, shall not analyse or make any use of the Data in such a way that has the potential to: (a) lead to the identification of any Data Subject; or (b) compromise the anonymity of any Data Subject in any way. 5 Access, Governance and Security 5.1 The Recipient agrees that it shall take all reasonable security precautions to keep the Data confidential; to guard against unauthorised or unlawful processing of the Data; and to prevent accidental loss or destruction of, or damage to, the Data. Such precautions to be no less onerous than those applied in respect of the Recipient’s own confidential information. 5.2 The Recipient agrees to only give access to Data, in whole or part, or any identifiable material derived from the Data, to a Registered User. The Recipient agrees that Registered Users are bound by obligations no less restrictive than those set forth herein. The Recipient further agrees that it accepts full responsibility for any breach of this Agreement by its Registered Users. 5.3 The Recipient agrees that it shall only give Registered Users that are not Researchers (including but not limited to students or new researchers to the field) access to the Data if they are supervised by a Recipient Principal Investigator. 5.4 ICR reserves the right to request and inspect data security and management documentation to ensure the adequacy of data protection measures in countries that have no national laws comparable to that pertaining in the European Economic Area (EEA). 6 Errors The Recipient agrees to notify MPG-ICR team of any errors detected in the Data. 7 Data reissue The Recipient accepts that Data will be reissued from time to time, with suitable versioning. If Data is reissued at the request of sample donors and/or as the result of other ethical scrutiny, the Recipient agrees to destroy all earlier versions of the Data. 8 Intellectual Property 8.1 The Recipient recognises that nothing in this Agreement shall operate to transfer to the Recipient or its Registered Users any Intellectual Property rights in or relating to the Data. Recipient is obligated to refrain from filing applications or in other ways to seek proprietary rights and protection specifically related to the Data. 8.2 Recipient and its Registered Users shall have the right to develop Intellectual Property based on comparisons with their own data. The Recipient shall keep ICR informed of all results, inventions and developments (the “Results”) made through the Recipient’s use of the Data. Recipient shall retain title to any patent or other Intellectual Property rights in all Results made through the use of the Data, except to the extent the Results incorporate the Data. 8.3 Recipient agrees to grant to ICR a non-exclusive, fully paid up, worldwide, irrevocable, royalty-free license to use the Results and any intellectual property arising therefrom for academic research purposes. 8.4 Recipient shall promptly notify ICR of any Results (whether raw or summarized), documentation, reports, and other information recorded in any form that is generated in the performance of the Research by or on behalf of Recipient 8.5 If any of the Results that incorporate, reference or relate to the Data are exploited commercially, the Recipient will grant the ICR an equitable share of any revenues that accrue to the Recipient from such commercial exploitation, having regards to the significance (if any) of the contribution to the Results represented by ICR’s provision of the Data hereunder. 9 Publications 9.1 Should the use of the Data result in one or more scientific publication(s), the Recipient shall acknowledge in the publication(s) or presentation(s) that the Data was provided by ICR/MPG-ICR. If any publishable results arise from the collaborative effort of the Recipient and ICR, then the publication of the study results shall be a joint publication between the Recipient and ICR. If so requested by ICR, Recipient will also declare in any such work that those who carried out the original analysis and collection of the Data bear no responsibility for the further analysis or interpretation of it by the Recipient. 9.2 Authorship will be determined in accordance with academic standards and custom. Proper acknowledgement will be made to the individual team members of the MPG-ICR responsible for the generation of Data. The list of authors can be obtained by emailing Richard Houlston (Richard.Houlston@icr.ac.uk). This file contains details of authors, affiliations, potential conflicts of interest, open access requirements, acknowledgements and funding. 10 Termination of Agreement 10.1 This Agreement will terminate automatically upon any breach of the provisions of this Agreement by the Recipient which the Recipient has not remedied within thirty (30) days’ of a written notice from ICR specifying the alleged breach. 10.2 The Recipient accepts that the changing ethical framework of human genetic research may lead to: (i) alteration to the provisions of this Agreement, in which case the Recipient may accept such alterations or terminate this Agreement; or (ii) the withdrawal of this Agreement in extreme circumstances. 10.3 Either party shall have the right to terminate this Agreement with immediate effect upon giving written notice of termination to the other party. 10.4 In the event that this Agreement is terminated in accordance with this Clause 10, the Recipient shall return or destroy all Data at the direction of MPG-ICR team. For the avoidance of doubt, upon termination by either party all rights acquired by the Recipient to the Data shall cease immediately. 11 Costs The Recipient acknowledges that ICR shall incur costs in providing the Data to the Recipient, including but not limited to administrative costs and the cost of obtaining appropriate data storage devices. 12 Legal statement 12.1 The Recipient acknowledges that ICR and all other parties involved in the creation, funding or protection of the Data: (a) make no warranty or representation, express or implied as to the accuracy, quality or comprehensiveness of the Data; and (b) makes no representations that the use of the Data will not infringe any patent or proprietary rights of third parties. 12.2 The Recipient assumes all liability for costs and damages, which may arise from the use, storage, or disposal of the Data by the Recipient. ICR will not be liable to Recipient for any loss, claim, or demand made by the Recipient, or made against Recipient by any third party, arising from the use or disclosure of the Data by the Recipient, except to the extent permitted by law when caused by the gross negligence or wilful misconduct of ICR. 13 Governing Law In the event of a dispute between the parties, the parties hereto agree that this Agreement shall be governed, construed and enforced by the laws of the party against which an action is brought, without regard to the conflicts of law rules and principles of such laws. 14 General 14.1. The Recipient shall not claim, infer, or imply ICR's endorsement of the Recipient's use of the Data, the Recipient as an institution or its personnel conducting research with the Data, or any resulting product(s). 14.2. Nothing in this Agreement shall be construed as creating a partnership, contract of employment or relationship of principal and agent between the parties hereto. 14.3. This Agreement contains the entire understanding between the parties hereto and supersedes all other negotiations, representations and undertakings in relation to the transfer of the Data. 14.4. Any change in the terms of this Agreement shall be valid only if the change is made in writing, agreed and signed by the parties hereto. 14.5. Except as permitted herein, no third party shall have any right to enforce any term of this Agreement. AGREED by the parties through their authorised signatories For and on behalf of ICR Authorised Signature: Name: Title: Date: For and on behalf of Recipient: Institution: Registered Authorised Signature: Name: Title: Date: Read and Understood: Signature: ________________________________________ Recipient Principal Investigator: Email address: Date: Please send completed forms to: Brittany Rex The Institute of Cancer Research 15 Cotswold Road Belmont Sutton Surrey SM2 5NG MPG-ICR team complies with the requirements of the Data Protection Act 2018 with regard to the collection, storage, processing and disclosure of personal information and is committed to upholding the Act's core Data Protection Principles. Information collected under the Agreement will be used for the purposes of maintaining the Agreement, and may be used for statistical reporting. Appendix 1: The Application

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001003372 Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00002382373 tsv.gz 9.3 MB
EGAF00002382374 tsv.gz 11.0 MB
EGAF00002382375 tsv.gz 7.0 MB
EGAF00002382376 tsv.gz 5.2 MB
EGAF00002382377 tsv.gz 2.0 MB
EGAF00002382378 tsv.gz 1.9 MB
EGAF00002382379 tsv.gz 7.9 MB
EGAF00002382380 tsv.gz 1.9 MB
EGAF00002382381 tsv.gz 3.1 MB
EGAF00002382382 tsv.gz 3.7 MB
EGAF00002382383 tsv.gz 12.0 MB
EGAF00002382384 tsv.gz 10.3 MB
EGAF00002382385 tsv.gz 4.2 MB
EGAF00002382386 tsv.gz 9.2 MB
EGAF00002382387 tsv.gz 10.1 MB
EGAF00002382388 tsv.gz 9.3 MB
EGAF00002382389 tsv.gz 3.8 MB
EGAF00002382390 tsv.gz 11.9 MB
EGAF00002382391 tsv.gz 1.9 MB
EGAF00002382392 tsv.gz 8.5 MB
EGAF00002382393 tsv.gz 6.8 MB
EGAF00002382394 tsv.gz 2.0 MB
EGAF00002382395 tsv.gz 7.8 MB
EGAF00002382396 tsv.gz 4.3 MB
EGAF00002382397 tsv.gz 3.2 MB
EGAF00002382398 tsv.gz 8.3 MB
EGAF00002382399 tsv.gz 4.0 MB
EGAF00002382400 tsv.gz 6.1 MB
EGAF00002382401 tsv.gz 4.3 MB
EGAF00002382402 tsv.gz 7.0 MB
EGAF00002382403 tsv.gz 3.2 MB
EGAF00002382404 tsv.gz 3.1 MB
EGAF00002382405 txt 1.1 kB
EGAF00002382406 tsv.gz 3.7 MB
EGAF00002382407 tsv.gz 7.0 MB
EGAF00002382408 tsv.gz 6.0 MB
EGAF00002382409 tsv.gz 7.2 MB
EGAF00002382410 tsv.gz 8.3 MB
EGAF00002382411 tsv.gz 10.4 MB
EGAF00002382412 tsv.gz 10.1 MB
EGAF00002382413 tsv.gz 6.7 MB
EGAF00002382414 tsv.gz 5.3 MB
EGAF00002382415 tsv.gz 6.0 MB
EGAF00002382416 tsv.gz 5.3 MB
EGAF00002382417 tsv.gz 10.3 MB
EGAF00002382418 tsv.gz 4.1 MB
EGAF00002382419 tsv.gz 4.7 MB
EGAF00002382420 tsv.gz 10.8 MB
EGAF00002382421 tsv.gz 4.6 MB
EGAF00002382422 tsv.gz 9.4 MB
EGAF00002382423 tsv.gz 9.2 MB
EGAF00002382424 tsv.gz 10.9 MB
EGAF00002382425 tsv.gz 3.2 MB
EGAF00002382426 tsv.gz 4.1 MB
EGAF00002382427 tsv.gz 3.2 MB
EGAF00002382428 tsv.gz 9.1 MB
EGAF00002382429 tsv.gz 6.7 MB
EGAF00002382430 tsv.gz 11.8 MB
EGAF00002382431 tsv.gz 7.1 MB
EGAF00002382432 tsv.gz 4.6 MB
EGAF00002382433 tsv.gz 8.0 MB
EGAF00002382434 tsv.gz 1.9 MB
EGAF00002382435 tsv.gz 4.0 MB
EGAF00002382436 tsv.gz 4.4 MB
EGAF00002382437 tsv.gz 4.1 MB
EGAF00002382438 tsv.gz 10.3 MB
EGAF00002382439 tsv.gz 7.1 MB
67 Files (423.7 MB)