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Short-read single-cell RNA-sequencing of the human brain in neurodegenerative diseases

Nuclei were isolated from postmortem human brain tissue, and single-nucleus barcoded cDNA libraries were generated using the 10X Genomics 3' v3.1 kit. Samples were sequenced on an Illumina NovaSeq 6000 to an average of 343 million reads per sample and 52,000 reads per cell.

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Chun Lab Human Data Access Policy

These terms and conditions govern access to the managed access to which the User Institution has requested access. The User Institution agrees to be bound by these terms and conditions. Definitions Authorized Personnel: The individuals at the User Institution to whom the Chun Lab DAC grants access to the Data. This includes the User, the individuals listed on the Signature Page and any other individuals for whom the User Institution subsequently requests access to the Data. Details of the initial Authorized Personnel are listed in the Signature Page. Data: The managed access datasets to which the User Institution has requested access. Data Producers: The Chun Lab DAC and the collaborators listed in the publication author list responsible for the development, organization, and oversight of these Data. External Collaborator: A collaborator of the User, working for an institution other than the User Institution. Project: The project for which the User Institution has requested access to these Data. A description of the Project is included on the Signature Page. Publications: Includes, without limitation, articles published in print journals, electronic journals, reviews, books, posters and other written and verbal presentations of research. Research Participant: An individual whose data form part of these Data. Research Purposes: Shall mean research that is seeking to advance the understanding of genetics and genomics, including the treatment of disorders, and work on statistical methods that may be applied to such research. User: The principal investigator for the Project. User Institution(s): The Institution that has requested access to the Data. Chun Lab DAC: Data Access Committee, Laboratory of Jerold Chun, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California Terms 1. The User Institution agrees to only use these Data for the purpose of the Project (described on the Signature Page) and only for Research Purposes. The User Institution further agrees that it will only use these Data for Research Purposes which are within the limitations set in the Dataset Details. 2. The User Institution agrees to preserve, at all times, the confidentiality of these Data. In particular, it undertakes not to use, or attempt to use these Data to compromise or otherwise infringe the confidentiality of information on Research Participants. Without prejudice to the generality of the foregoing, the User Institution agrees to use at least the measures set out the Dataset Details to protect these Data. 3. The User Institution agrees to protect the confidentiality of Research Participants in any research papers or publications that they prepare by taking all reasonable care to limit the possibility of identification. 4. The User Institution agrees not to link or combine these Data to other information or archived data available in a way that could re-identify the Research Participants, even if access to that data has been formally granted to the User Institution or is freely available without restriction. 5. The User Institution agrees only to transfer or disclose these Data, in whole or part, or any material derived from these Data, to the Authorized Personnel. Should the User Institution wish to share these Data with an External Collaborator, the External Collaborator must complete a separate application for access to these Data. 6. The User Institutions agrees to recognize the contribution of the Data Producers by including a proper acknowledgement in all reports or publications resulting from the use of these Data. 7. The User Institution agrees to destroy/discard the Data held, once it is no longer used for the Project, unless obliged to retain the data for archival purposes in conformity with audit or legal requirements. 8. The User Institution will notify the Chun Lab DAC within 30 days of any changes or departures of Authorized Personnel. 9. The User Institution will notify the Chun Lab DAC prior to any significant changes to the protocol for the Project. 10. The User Institution will notify the Chun Lab DAC as soon as it becomes aware of a breach of the terms or conditions of this agreement. 11. This agreement by written notice. If this agreement terminates for any reason, the User Institution will be required to destroy any Data held, including copies and backup copies. This clause does not prevent the User Institution from retaining these data for archival purpose in conformity with audit or legal requirements. 12. The User Institution accepts that it may be necessary for the Data Producers to alter the terms of this agreement from time to time. As an example, this may include specific provisions relating to the Data required by Data Producers other than the Chun Lab DAC. In the event that changes are required, the Data Producers or their appointed agent will contact the User Institution to inform it of the changes and the User Institution may elect to accept the changes or terminate the agreement. 13. The User Institution agrees to distribute a copy of these terms to the Authorized Personnel. The User Institution will procure that the Authorized Personnel comply with the terms of this agreement.

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS50000000132 RNASeq

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF50000062150 fastq.gz 28.1 GB
EGAF50000062151 fastq.gz 25.1 GB
EGAF50000062152 fastq.gz 32.2 GB
EGAF50000062153 fastq.gz 25.2 GB
EGAF50000062154 fastq.gz 24.6 GB
EGAF50000062155 fastq.gz 24.0 GB
EGAF50000062156 fastq.gz 26.3 GB
EGAF50000062157 fastq.gz 25.0 GB
EGAF50000062158 fastq.gz 34.4 GB
EGAF50000062159 fastq.gz 26.8 GB
EGAF50000062160 fastq.gz 33.9 GB
EGAF50000062161 fastq.gz 24.8 GB
EGAF50000062162 fastq.gz 28.6 GB
EGAF50000062163 fastq.gz 25.3 GB
EGAF50000062164 fastq.gz 26.7 GB
EGAF50000062165 fastq.gz 25.5 GB
EGAF50000062166 fastq.gz 25.1 GB
EGAF50000062167 fastq.gz 24.3 GB
EGAF50000062168 fastq.gz 29.9 GB
EGAF50000062169 fastq.gz 22.6 GB
EGAF50000062170 fastq.gz 25.5 GB
EGAF50000062171 fastq.gz 22.9 GB
EGAF50000062172 fastq.gz 35.4 GB
EGAF50000062173 fastq.gz 27.0 GB
EGAF50000062174 fastq.gz 12.7 GB
EGAF50000062175 fastq.gz 12.4 GB
EGAF50000062176 fastq.gz 29.9 GB
EGAF50000062177 fastq.gz 23.1 GB
EGAF50000062178 fastq.gz 29.9 GB
EGAF50000062179 fastq.gz 28.7 GB
EGAF50000062180 fastq.gz 28.5 GB
EGAF50000062181 fastq.gz 25.0 GB
EGAF50000062182 fastq.gz 30.8 GB
EGAF50000062183 fastq.gz 26.8 GB
EGAF50000062184 fastq.gz 37.0 GB
EGAF50000062185 fastq.gz 28.1 GB
EGAF50000062186 fastq.gz 27.3 GB
EGAF50000062187 fastq.gz 25.6 GB
EGAF50000062188 fastq.gz 28.2 GB
EGAF50000062189 fastq.gz 25.1 GB
EGAF50000062190 fastq.gz 25.5 GB
EGAF50000062191 fastq.gz 22.7 GB
EGAF50000062192 fastq.gz 29.0 GB
EGAF50000062193 fastq.gz 25.8 GB
EGAF50000062194 fastq.gz 24.5 GB
EGAF50000062195 fastq.gz 23.9 GB
EGAF50000062196 fastq.gz 31.8 GB
EGAF50000062197 fastq.gz 30.5 GB
EGAF50000062198 fastq.gz 36.4 GB
EGAF50000062199 fastq.gz 27.9 GB
50 Files (1.3 TB)