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As the EGA is co-managed by the EMBL-EBI and CRG, files could be located in the UK and/or Spain, as indicated by their respective flags.

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ScRNA-seq of human kidney immune cells of patients with ANCA-associated glomerulonephritis, Lupus Nephritis against a healthy nephrectomy control

ANCA-associated glomerulonephritis (AGN) associates with a high risk of end-stage kidneydisease. The role of kidney immune cells in local inflammation remains unclear. This study investigates kidney immune cell diversity and function. Kidney tissue from AGN patients (n=5) and a lupus nephritis (LN) patient (n=1) were aquired during a biopsy procedure for a clinical indication. Needle-core biopsies were obtained for histopathological examination, and an additional pass was performed to retrieve kidney tissue for scRNA-seq. Healthy kidney tissue (n=1) was obtained from a kidney that was surgically removed do tue due to a (non-invasive) papillary urothelial carcinoma. Immediately after collection, kidney tissue was processed into a single-cell suspension and sorted using a 4-color flow cytometry panel to isolate living, CD45+immune cells. To aid in the multi-omic characterization, surface markers and T and B cell repertoires were sequenced in 2 samples (1 AGN patient and the nephrectomy control). These samples were incubated with an oligo-antibody TotalSeq-C cocktail containing 130 unique cell surface antigens.

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Data Access Policy Immuno-nephrology DAC Amsterdam UMC

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS50000000159 RNASeq

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Quality Report
Located in
i
EGAF50000065552 fastq.gz 2.3 GB Report
EGAF50000065553 fastq.gz 29.4 GB Report
EGAF50000065554 fastq_1.gz 2.6 GB Report
EGAF50000065555 fastq_1.gz 7.5 GB Report
EGAF50000065556 fastq.gz 7.9 GB Report
EGAF50000065557 fastq_1.gz 27.5 GB Report
EGAF50000065558 fastq.gz 748.2 MB Report
EGAF50000065559 fastq.gz 2.7 GB Report
EGAF50000065560 fastq.gz 212.6 MB Report
EGAF50000065561 fastq.gz 747.8 MB Report
EGAF50000065562 fastq.gz 473.6 MB Report
EGAF50000065563 fastq.gz 139.3 MB Report
EGAF50000065564 fastq.gz 199.0 MB Report
EGAF50000065565 fastq.gz 670.0 MB Report
EGAF50000065566 fastq.gz 4.3 GB Report
EGAF50000065567 fastq.gz 1.3 GB Report
EGAF50000065568 fastq.gz 3.0 GB Report
EGAF50000065569 fastq.gz 5.4 GB Report
EGAF50000065570 fastq.gz 1.1 GB Report
EGAF50000065571 fastq.gz 4.2 GB Report
EGAF50000065572 fastq.gz 393.5 MB Report
EGAF50000065573 fastq.gz 1.1 GB Report
EGAF50000065574 fastq.gz 242.3 MB Report
EGAF50000065575 fastq.gz 647.6 MB Report
EGAF50000065576 fastq.gz 345.0 MB Report
EGAF50000065577 fastq.gz 934.3 MB Report
EGAF50000065578 fastq.gz 371.3 MB Report
EGAF50000065579 fastq.gz 987.4 MB Report
EGAF50000065580 fastq.gz 1.6 GB Report
EGAF50000065581 fastq.gz 4.4 GB Report
EGAF50000065582 fastq.gz 214.8 MB Report
EGAF50000065583 fastq.gz 755.6 MB Report
EGAF50000065584 fastq.gz 138.9 MB Report
EGAF50000065585 fastq.gz 473.8 MB Report
EGAF50000065586 fastq.gz 245.2 MB Report
EGAF50000065587 fastq.gz 861.7 MB Report
EGAF50000065588 fastq.gz 198.7 MB Report
EGAF50000065589 fastq.gz 673.6 MB Report
EGAF50000065590 fastq.gz 744.0 MB Report
EGAF50000065591 fastq.gz 2.7 GB Report
EGAF50000065592 fastq.gz 7.5 GB Report
EGAF50000065593 fastq.gz 27.4 GB Report
EGAF50000065594 fastq.gz 8.0 GB Report
EGAF50000065595 fastq.gz 16.7 GB Report
EGAF50000065596 fastq.gz 29.0 GB Report
EGAF50000065597 fastq.gz 3.6 GB Report
EGAF50000065598 fastq.gz 12.9 GB Report
EGAF50000065599 fastq.gz 4.4 GB Report
EGAF50000065600 fastq.gz 679.8 MB Report
EGAF50000065601 fastq.gz 2.6 GB Report
EGAF50000065602 fastq.gz 1.3 GB Report
EGAF50000065603 fastq.gz 3.8 GB Report
EGAF50000065604 fastq.gz 677.8 MB Report
EGAF50000065605 fastq.gz 2.5 GB Report
EGAF50000065606 fastq.gz 16.9 GB Report
EGAF50000065607 fastq.gz 4.8 GB Report
EGAF50000065608 fastq.gz 1.4 GB Report
EGAF50000065609 fastq.gz 803.1 MB Report
58 Files (265.4 GB)