BipEx-Landen: Bipolar Exome Sequencing

This research project was a collaboration between the Karolinska Institute and the Stanley Center at the Broad Institute. In this project we sequenced and analyzed the whole exomes of 5,876 Bipolar case/control samples from collaborators in Sweden. Genomic DNA from each samples was sequenced to a mean depth of 20x.

Data Access Committee Policies and Procedures: BipEx: Bipolar Exome Sequencing Broad & Karolinska Institutet EGAS00001005838 Introduction This research project was a collaboration between the Karolinska Institute and the Stanley Center at the Broad Institute. In this project we sequenced and analyzed the whole exomes of 5,876 Bipolar case/control samples from collaborators in Sweden. Genomic DNA from each samples was sequenced to a mean depth of 20x. DAC Role & Membership The role of the Data Access Committee (DAC) is to approve or disapprove data access requests for the dataset in EGA. The DAC has reviewed the consent forms associated with the samples from which these data were derived, and the only data use limitation is that research be limited to disease specific - mental health domains. Therefore, data access requests will be approved as long as the proposed research is mental health related, the identity of the individual requesting access has been validated by the DAC, and the name(s) signed on the Data Transfer Agreement (DTA) for the Applicant and the Institutional/Administrative Authority are different names. The DAC consists of Professor Mikael Landen from the Karolinska Institutet in Sweden and has the necessary expertise to adjudicate requests. Information Required by the DAC The DAC requires the following completed information to be submitted before your request for access is reviewed. Please note that all information needs to be received before any review will be completed. Completed Application for Data Access describing the research project. Copy of Data Access Agreement signed by both the Applicant and the signing official at the User’s Institution Application Process The process for data applicants who are interested in accessing the data is outlined below. Email from data applicant to DAC expressing interest in the dataset. DAC responds with the necessary documentation that is needed to process the application. This includes: Application for Data Access Data Access Agreement Applicant completes all documentation and emails it to DAC. DAC members review documentation and vote via email whether to approve, disapprove, or to discuss the request on a call. DAC notifies applicants that their request has been approved or disapproved. If the applicant has been approved, EGA will then grant access to the data.