Need Help?

PRADO trial - Personalized response-directed surgery and adjuvant therapy after neoadjuvant ipilimumab plus nivolumab in stage III melanoma

The dataset includes WES sequencing data on PRE- treatment biopsies of lymph node metastasis (n=79) The technology used for sequencing is llumina HiSeq. The PRADO trial tested a personalized response-directed treatment approach based on the pathologic response after neoadjuvant ipilimumab plus nivolumab in stage III melanoma patients. In patients achieving a major pathologic response, in their index lymph node (the largest lymph node metastasis at baseline), therapeutic lymph node dissection (TLND) and adjuvant therapy were omitted. Patients with partial response underwent TLND only, whereas patients with pathologic non-response underwent TLND and adjuvant systemic therapy ± synchronous radiotherapy.

Request Access

Netherlands Cancer Institute - Antoni van Leeuwenhoek (NKI-AVL) general policy

Data is available under reasonable request. All data requests will be reviewed by the NKI IRB and must be supported by the Principal Investigator of the study. The researcher will need to sign a data access agreement with the NKI after approval.

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS50000000268 Exome Sequencing

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF50000093695 fastq.gz 3.7 GB
EGAF50000093696 fastq.gz 3.8 GB
EGAF50000093697 fastq.gz 3.4 GB
EGAF50000093698 fastq.gz 3.4 GB
EGAF50000093699 fastq.gz 2.7 GB
EGAF50000093700 fastq.gz 2.8 GB
EGAF50000093701 fastq.gz 3.0 GB
EGAF50000093702 fastq.gz 2.9 GB
EGAF50000093703 fastq.gz 3.6 GB
EGAF50000093704 fastq.gz 3.7 GB
EGAF50000093705 fastq.gz 3.1 GB
EGAF50000093706 fastq.gz 3.1 GB
EGAF50000093707 fastq.gz 3.6 GB
EGAF50000093708 fastq.gz 3.5 GB
EGAF50000093709 fastq.gz 2.2 GB
EGAF50000093710 fastq.gz 2.4 GB
EGAF50000093711 fastq.gz 3.4 GB
EGAF50000093712 fastq.gz 3.5 GB
EGAF50000093713 fastq.gz 3.3 GB
EGAF50000093714 fastq.gz 3.3 GB
EGAF50000093715 fastq.gz 3.5 GB
EGAF50000093716 fastq.gz 3.6 GB
EGAF50000093717 fastq.gz 3.5 GB
EGAF50000093718 fastq.gz 3.6 GB
EGAF50000093719 fastq.gz 3.2 GB
EGAF50000093720 fastq.gz 3.3 GB
EGAF50000093721 fastq.gz 3.7 GB
EGAF50000093722 fastq.gz 3.8 GB
EGAF50000093723 fastq.gz 2.8 GB
EGAF50000093724 fastq.gz 2.8 GB
EGAF50000093725 fastq.gz 4.3 GB
EGAF50000093726 fastq.gz 4.4 GB
EGAF50000093727 fastq.gz 5.9 GB
EGAF50000093728 fastq.gz 6.1 GB
EGAF50000093729 fastq.gz 5.4 GB
EGAF50000093730 fastq.gz 5.6 GB
EGAF50000093731 fastq.gz 5.8 GB
EGAF50000093732 fastq.gz 5.6 GB
EGAF50000093733 fastq.gz 6.1 GB
EGAF50000093734 fastq.gz 5.9 GB
EGAF50000093735 fastq.gz 4.8 GB
EGAF50000093736 fastq.gz 5.0 GB
EGAF50000093737 fastq.gz 3.9 GB
EGAF50000093738 fastq.gz 4.0 GB
EGAF50000093739 fastq.gz 4.4 GB
EGAF50000093740 fastq.gz 4.6 GB
EGAF50000093741 fastq.gz 4.7 GB
EGAF50000093742 fastq.gz 4.9 GB
EGAF50000093743 fastq.gz 4.3 GB
EGAF50000093744 fastq.gz 4.3 GB
EGAF50000093745 fastq.gz 3.9 GB
EGAF50000093746 fastq.gz 3.8 GB
EGAF50000093747 fastq.gz 5.3 GB
EGAF50000093748 fastq.gz 4.8 GB
EGAF50000093749 fastq.gz 5.1 GB
EGAF50000093750 fastq.gz 5.3 GB
EGAF50000093751 fastq.gz 4.1 GB
EGAF50000093752 fastq.gz 4.3 GB
EGAF50000093753 fastq.gz 4.2 GB
EGAF50000093754 fastq.gz 4.1 GB
EGAF50000093755 fastq.gz 3.5 GB
EGAF50000093756 fastq.gz 3.8 GB
EGAF50000093757 fastq.gz 4.2 GB
EGAF50000093758 fastq.gz 4.0 GB
EGAF50000093759 fastq.gz 5.7 GB
EGAF50000093760 fastq.gz 5.8 GB
EGAF50000093761 fastq.gz 4.8 GB
EGAF50000093762 fastq.gz 4.9 GB
EGAF50000093763 fastq.gz 3.5 GB
EGAF50000093764 fastq.gz 3.5 GB
EGAF50000093765 fastq.gz 4.6 GB
EGAF50000093766 fastq.gz 4.7 GB
EGAF50000093767 fastq.gz 4.8 GB
EGAF50000093768 fastq.gz 5.0 GB
EGAF50000093769 fastq.gz 4.5 GB
EGAF50000093770 fastq.gz 4.3 GB
EGAF50000093771 fastq.gz 5.3 GB
EGAF50000093772 fastq.gz 5.5 GB
EGAF50000093773 fastq.gz 7.1 GB
EGAF50000093774 fastq.gz 6.8 GB
EGAF50000093775 fastq.gz 5.2 GB
EGAF50000093776 fastq.gz 5.4 GB
EGAF50000093777 fastq.gz 5.5 GB
EGAF50000093778 fastq.gz 5.6 GB
EGAF50000093779 fastq.gz 6.8 GB
EGAF50000093780 fastq.gz 7.1 GB
EGAF50000093781 fastq.gz 5.5 GB
EGAF50000093782 fastq.gz 5.6 GB
EGAF50000093783 fastq.gz 5.9 GB
EGAF50000093784 fastq.gz 6.1 GB
EGAF50000093785 fastq.gz 7.0 GB
EGAF50000093786 fastq.gz 7.3 GB
EGAF50000093787 fastq.gz 4.7 GB
EGAF50000093788 fastq.gz 4.9 GB
EGAF50000093789 fastq.gz 5.5 GB
EGAF50000093790 fastq.gz 5.3 GB
EGAF50000093791 fastq.gz 4.1 GB
EGAF50000093792 fastq.gz 3.9 GB
EGAF50000093793 fastq.gz 5.2 GB
EGAF50000093794 fastq.gz 5.4 GB
EGAF50000093795 fastq.gz 5.0 GB
EGAF50000093796 fastq.gz 4.9 GB
EGAF50000093797 fastq.gz 4.6 GB
EGAF50000093798 fastq.gz 4.7 GB
EGAF50000093799 fastq.gz 5.3 GB
EGAF50000093800 fastq.gz 5.5 GB
EGAF50000093801 fastq.gz 5.2 GB
EGAF50000093802 fastq.gz 5.0 GB
EGAF50000093803 fastq.gz 5.3 GB
EGAF50000093804 fastq.gz 5.6 GB
EGAF50000093805 fastq.gz 4.1 GB
EGAF50000093806 fastq.gz 4.2 GB
EGAF50000093807 fastq.gz 4.3 GB
EGAF50000093808 fastq.gz 4.5 GB
EGAF50000093809 fastq.gz 5.5 GB
EGAF50000093810 fastq.gz 5.2 GB
EGAF50000093811 fastq.gz 4.3 GB
EGAF50000093812 fastq.gz 4.4 GB
EGAF50000093813 fastq.gz 3.7 GB
EGAF50000093814 fastq.gz 3.9 GB
EGAF50000093815 fastq.gz 4.4 GB
EGAF50000093816 fastq.gz 4.3 GB
EGAF50000093817 fastq.gz 4.2 GB
EGAF50000093818 fastq.gz 4.4 GB
EGAF50000093819 fastq.gz 3.9 GB
EGAF50000093820 fastq.gz 4.0 GB
EGAF50000093821 fastq.gz 4.8 GB
EGAF50000093822 fastq.gz 4.6 GB
EGAF50000093823 fastq.gz 4.0 GB
EGAF50000093824 fastq.gz 4.1 GB
EGAF50000093825 fastq.gz 4.3 GB
EGAF50000093826 fastq.gz 4.4 GB
EGAF50000093827 fastq.gz 5.3 GB
EGAF50000093828 fastq.gz 5.2 GB
EGAF50000093829 fastq.gz 4.9 GB
EGAF50000093830 fastq.gz 5.0 GB
EGAF50000093831 fastq.gz 5.3 GB
EGAF50000093832 fastq.gz 5.2 GB
EGAF50000093833 fastq.gz 4.7 GB
EGAF50000093834 fastq.gz 4.8 GB
EGAF50000093835 fastq.gz 4.4 GB
EGAF50000093836 fastq.gz 4.6 GB
EGAF50000093837 fastq.gz 5.3 GB
EGAF50000093838 fastq.gz 5.2 GB
EGAF50000093839 fastq.gz 4.8 GB
EGAF50000093840 fastq.gz 4.9 GB
EGAF50000093841 fastq.gz 6.1 GB
EGAF50000093842 fastq.gz 6.3 GB
EGAF50000093843 fastq.gz 4.4 GB
EGAF50000093844 fastq.gz 4.4 GB
EGAF50000093845 fastq.gz 7.4 GB
EGAF50000093846 fastq.gz 7.8 GB
EGAF50000093847 fastq.gz 4.2 GB
EGAF50000093848 fastq.gz 4.5 GB
EGAF50000093849 fastq.gz 4.1 GB
EGAF50000093850 fastq.gz 4.3 GB
EGAF50000093851 fastq.gz 5.4 GB
EGAF50000093852 fastq.gz 5.4 GB
EGAF50000093853 fastq.gz 4.1 GB
EGAF50000093854 fastq.gz 4.2 GB
EGAF50000093855 fastq.gz 5.6 GB
EGAF50000093856 fastq.gz 5.4 GB
EGAF50000093857 fastq.gz 4.8 GB
EGAF50000093858 fastq.gz 5.0 GB
EGAF50000093859 fastq.gz 3.8 GB
EGAF50000093860 fastq.gz 3.9 GB
EGAF50000093861 fastq.gz 5.1 GB
EGAF50000093862 fastq.gz 4.9 GB
EGAF50000093863 fastq.gz 5.9 GB
EGAF50000093864 fastq.gz 6.1 GB
EGAF50000093865 fastq.gz 7.7 GB
EGAF50000093866 fastq.gz 7.4 GB
EGAF50000093867 fastq.gz 5.1 GB
EGAF50000093868 fastq.gz 5.1 GB
EGAF50000093869 fastq.gz 5.5 GB
EGAF50000093870 fastq.gz 5.6 GB
EGAF50000093871 fastq.gz 4.0 GB
EGAF50000093872 fastq.gz 4.0 GB
EGAF50000093873 fastq.gz 4.0 GB
EGAF50000093874 fastq.gz 4.1 GB
EGAF50000093875 fastq.gz 4.3 GB
EGAF50000093876 fastq.gz 4.4 GB
EGAF50000093877 fastq.gz 3.7 GB
EGAF50000093878 fastq.gz 3.6 GB
EGAF50000093879 fastq.gz 4.0 GB
EGAF50000093880 fastq.gz 3.9 GB
EGAF50000093881 fastq.gz 3.4 GB
EGAF50000093882 fastq.gz 3.5 GB
EGAF50000093883 fastq.gz 3.1 GB
EGAF50000093884 fastq.gz 3.2 GB
EGAF50000093885 fastq.gz 3.6 GB
EGAF50000093886 fastq.gz 3.7 GB
EGAF50000093887 fastq.gz 3.5 GB
EGAF50000093888 fastq.gz 3.6 GB
EGAF50000093889 fastq.gz 4.8 GB
EGAF50000093890 fastq.gz 4.7 GB
EGAF50000093891 fastq.gz 3.0 GB
EGAF50000093892 fastq.gz 2.9 GB
EGAF50000093893 fastq.gz 2.7 GB
EGAF50000093894 fastq.gz 2.7 GB
EGAF50000093895 fastq.gz 3.2 GB
EGAF50000093896 fastq.gz 3.2 GB
EGAF50000093897 fastq.gz 3.6 GB
EGAF50000093898 fastq.gz 3.7 GB
EGAF50000093899 fastq.gz 3.2 GB
EGAF50000093900 fastq.gz 3.1 GB
EGAF50000093901 fastq.gz 2.7 GB
EGAF50000093902 fastq.gz 2.8 GB
EGAF50000093903 fastq.gz 4.0 GB
EGAF50000093904 fastq.gz 4.1 GB
EGAF50000093905 fastq.gz 2.9 GB
EGAF50000093906 fastq.gz 3.0 GB
EGAF50000093907 fastq.gz 3.6 GB
EGAF50000093908 fastq.gz 3.7 GB
EGAF50000093909 fastq.gz 3.2 GB
EGAF50000093910 fastq.gz 3.2 GB
EGAF50000093911 fastq.gz 3.2 GB
EGAF50000093912 fastq.gz 3.1 GB
EGAF50000093913 fastq.gz 3.9 GB
EGAF50000093914 fastq.gz 4.0 GB
EGAF50000093915 fastq.gz 3.0 GB
EGAF50000093916 fastq.gz 3.1 GB
EGAF50000093917 fastq.gz 3.3 GB
EGAF50000093918 fastq.gz 3.3 GB
EGAF50000093919 fastq.gz 3.8 GB
EGAF50000093920 fastq.gz 3.6 GB
EGAF50000093921 fastq.gz 4.2 GB
EGAF50000093922 fastq.gz 4.3 GB
EGAF50000093923 fastq.gz 3.4 GB
EGAF50000093924 fastq.gz 3.5 GB
EGAF50000093925 fastq.gz 2.8 GB
EGAF50000093926 fastq.gz 2.9 GB
EGAF50000093927 fastq.gz 4.0 GB
EGAF50000093928 fastq.gz 4.2 GB
EGAF50000093929 fastq.gz 2.9 GB
EGAF50000093930 fastq.gz 3.0 GB
EGAF50000093931 fastq.gz 3.1 GB
EGAF50000093932 fastq.gz 3.0 GB
EGAF50000093933 fastq.gz 3.0 GB
EGAF50000093934 fastq.gz 3.1 GB
EGAF50000093935 fastq.gz 2.9 GB
EGAF50000093936 fastq.gz 2.9 GB
EGAF50000093937 fastq.gz 3.1 GB
EGAF50000093938 fastq.gz 3.2 GB
EGAF50000093939 fastq.gz 2.5 GB
EGAF50000093940 fastq.gz 2.5 GB
EGAF50000093941 fastq.gz 2.6 GB
EGAF50000093942 fastq.gz 2.8 GB
EGAF50000093943 fastq.gz 3.0 GB
EGAF50000093944 fastq.gz 2.9 GB
EGAF50000093945 fastq.gz 3.7 GB
EGAF50000093946 fastq.gz 3.8 GB
EGAF50000093947 fastq.gz 2.8 GB
EGAF50000093948 fastq.gz 2.9 GB
EGAF50000093949 fastq.gz 2.5 GB
EGAF50000093950 fastq.gz 2.6 GB
EGAF50000093951 fastq.gz 3.2 GB
EGAF50000093952 fastq.gz 3.1 GB
EGAF50000093953 fastq.gz 2.8 GB
EGAF50000093954 fastq.gz 2.9 GB
EGAF50000093955 fastq.gz 2.5 GB
EGAF50000093956 fastq.gz 2.6 GB
EGAF50000093957 fastq.gz 2.7 GB
EGAF50000093958 fastq.gz 2.8 GB
EGAF50000093959 fastq.gz 2.2 GB
EGAF50000093960 fastq.gz 2.2 GB
EGAF50000093961 fastq.gz 2.9 GB
EGAF50000093962 fastq.gz 3.0 GB
EGAF50000093963 fastq.gz 3.1 GB
EGAF50000093964 fastq.gz 3.2 GB
EGAF50000093965 fastq.gz 3.2 GB
EGAF50000093966 fastq.gz 3.3 GB
EGAF50000093967 fastq.gz 3.4 GB
EGAF50000093968 fastq.gz 3.5 GB
EGAF50000093969 fastq.gz 3.2 GB
EGAF50000093970 fastq.gz 3.4 GB
EGAF50000093971 fastq.gz 2.6 GB
EGAF50000093972 fastq.gz 2.7 GB
EGAF50000093973 fastq.gz 2.9 GB
EGAF50000093974 fastq.gz 2.9 GB
EGAF50000093975 fastq.gz 3.2 GB
EGAF50000093976 fastq.gz 3.3 GB
EGAF50000093977 fastq.gz 2.8 GB
EGAF50000093978 fastq.gz 2.9 GB
EGAF50000093979 fastq.gz 3.4 GB
EGAF50000093980 fastq.gz 3.5 GB
EGAF50000093981 fastq.gz 3.5 GB
EGAF50000093982 fastq.gz 3.5 GB
EGAF50000093983 fastq.gz 2.8 GB
EGAF50000093984 fastq.gz 2.9 GB
EGAF50000093985 fastq.gz 2.6 GB
EGAF50000093986 fastq.gz 2.7 GB
EGAF50000093987 fastq.gz 3.2 GB
EGAF50000093988 fastq.gz 3.3 GB
EGAF50000093989 fastq.gz 2.6 GB
EGAF50000093990 fastq.gz 2.5 GB
EGAF50000093991 fastq.gz 2.4 GB
EGAF50000093992 fastq.gz 2.5 GB
EGAF50000093993 fastq.gz 3.3 GB
EGAF50000093994 fastq.gz 3.3 GB
EGAF50000093995 fastq.gz 3.1 GB
EGAF50000093996 fastq.gz 3.2 GB
EGAF50000093997 fastq.gz 2.7 GB
EGAF50000093998 fastq.gz 2.8 GB
EGAF50000093999 fastq.gz 3.3 GB
EGAF50000094000 fastq.gz 3.4 GB
EGAF50000094001 fastq.gz 3.0 GB
EGAF50000094002 fastq.gz 3.0 GB
EGAF50000094003 fastq.gz 3.0 GB
EGAF50000094004 fastq.gz 3.2 GB
EGAF50000094005 fastq.gz 3.9 GB
EGAF50000094006 fastq.gz 4.0 GB
EGAF50000094007 fastq.gz 3.5 GB
EGAF50000094008 fastq.gz 3.6 GB
EGAF50000094009 fastq.gz 2.3 GB
EGAF50000094010 fastq.gz 2.5 GB
316 Files (1.3 TB)