About file location

As the EGA is co-managed by the EMBL-EBI and CRG, files could be located in the UK and/or Spain, as indicated by their respective flags.

Alternatively, files could be located in one of the international Federated EGA nodes, as indicated next to the node's flag.
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RNA-sequencing from duodenal bipsies of Celiac disease patients

Samples, in a form of PAXgene fixed and paraffin-embedded biopsies, were collected from the multi-site, double-blind, randomized, placebo-controlled trial, aimed at dose-finding and assessing the efficacy and tolerability of a 6-week treatment with ZED1227 capsules vs. placebo in subjects with well-controlled celiac disease undergoing gluten challenge. Total RNA was extracted from the PaxFPE biopsy specimens (n = 116) using additional cuttings from the samples on which histomorphometry was previously assessed. For the extraction, an RNeasy Kit (Qiagen, Hilden, Germany) was used according to the manufacturer’s instructions. Library preparation and next-generation sequencing (NGS) were performed by the Qiagen NGS Service. A total of 10 ng of purified RNA was converted into cDNA NGS libraries. Library preparation was quality controlled using capillary electrophoresis. Based on the quality of the inserts and the concentration measurements, the libraries were pooled in equimolar ratios and then sequenced on a NextSeq (Illumina Inc., San Diego, USA) sequencing instrument according to the manufacturer’s instructions, with 100 bp read length for read 1 and 27bp for read 2. The raw data were de-multiplexed, and FASTQ files for each sample were generated using bcl2fastq2 software (Illumina Inc., San Diego, USA).

Request Access

DUO:0000018
version: 2021-02-23

not for profit, non commercial use only

This data use modifier indicates that use of the data is limited to not-for-profit organizations and not-for-profit use, non-commercial use.

DUO:0000020
version: 2021-02-23

collaboration required

This data use modifier indicates that the requestor must agree to collaboration with the primary study investigator(s).

DUO:0000021
version: 2021-02-23

ethics approval required

This data use modifier indicates that the requestor must provide documentation of local IRB/ERB approval.

DUO:0000042
version: 2021-02-23

general research use

This data use permission indicates that use is allowed for general research use for any research purpose.

Two researchers from Tampere and one from Dr Falkpharma GmbH

Data will be shared if the proposed project falls within the patient/caretaker consent

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS50000000337 Transcriptome Sequencing

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Quality Report
Located in
i
EGAF50000108142 fastq.gz 60.3 MB Report
EGAF50000108143 fastq.gz 186.3 MB Report
EGAF50000108144 fastq.gz 91.4 MB Report
EGAF50000108145 fastq.gz 301.7 MB Report
EGAF50000108146 fastq.gz 211.7 MB Report
EGAF50000108147 fastq.gz 65.7 MB Report
EGAF50000108148 fastq.gz 269.6 MB Report
EGAF50000108149 fastq.gz 82.7 MB Report
EGAF50000108150 fastq.gz 64.9 MB Report
EGAF50000108151 fastq.gz 207.9 MB Report
EGAF50000108152 fastq.gz 71.9 MB Report
EGAF50000108153 fastq.gz 216.6 MB Report
EGAF50000108154 fastq.gz 76.4 MB Report
EGAF50000108155 fastq.gz 251.9 MB Report
EGAF50000108156 fastq.gz 71.1 MB Report
EGAF50000108157 fastq.gz 232.1 MB Report
EGAF50000108158 fastq.gz 71.2 MB Report
EGAF50000108159 fastq.gz 231.5 MB Report
EGAF50000108160 fastq.gz 67.5 MB Report
EGAF50000108161 fastq.gz 220.8 MB Report
EGAF50000108162 fastq.gz 64.1 MB Report
EGAF50000108163 fastq.gz 209.9 MB Report
EGAF50000108164 fastq.gz 74.4 MB Report
EGAF50000108165 fastq.gz 248.1 MB Report
EGAF50000108166 fastq.gz 82.6 MB Report
EGAF50000108167 fastq.gz 270.3 MB Report
EGAF50000108168 fastq.gz 77.5 MB Report
EGAF50000108169 fastq.gz 247.8 MB Report
EGAF50000108170 fastq.gz 205.7 MB Report
EGAF50000108171 fastq.gz 63.8 MB Report
EGAF50000108172 fastq.gz 69.2 MB Report
EGAF50000108173 fastq.gz 221.2 MB Report
EGAF50000108174 fastq.gz 194.6 MB Report
EGAF50000108175 fastq.gz 59.7 MB Report
EGAF50000108176 fastq.gz 52.1 MB Report
EGAF50000108177 fastq.gz 168.9 MB Report
EGAF50000108178 fastq.gz 70.5 MB Report
EGAF50000108179 fastq.gz 235.9 MB Report
EGAF50000108180 fastq.gz 47.3 MB Report
EGAF50000108181 fastq.gz 153.9 MB Report
EGAF50000108182 fastq.gz 76.7 MB Report
EGAF50000108183 fastq.gz 251.6 MB Report
EGAF50000108184 fastq.gz 59.0 MB Report
EGAF50000108185 fastq.gz 185.1 MB Report
EGAF50000108186 fastq.gz 96.6 MB Report
EGAF50000108187 fastq.gz 317.7 MB Report
EGAF50000108188 fastq.gz 70.3 MB Report
EGAF50000108189 fastq.gz 230.1 MB Report
EGAF50000108190 fastq.gz 91.5 MB Report
EGAF50000108191 fastq.gz 300.9 MB Report
EGAF50000108192 fastq.gz 218.1 MB Report
EGAF50000108193 fastq.gz 67.7 MB Report
EGAF50000108194 fastq.gz 45.7 MB Report
EGAF50000108195 fastq.gz 146.7 MB Report
EGAF50000108196 fastq.gz 60.8 MB Report
EGAF50000108197 fastq.gz 196.2 MB Report
EGAF50000108198 fastq.gz 187.2 MB Report
EGAF50000108199 fastq.gz 57.8 MB Report
EGAF50000108200 fastq.gz 156.6 MB Report
EGAF50000108201 fastq.gz 49.8 MB Report
EGAF50000108202 fastq.gz 137.7 MB Report
EGAF50000108203 fastq.gz 43.3 MB Report
EGAF50000108204 fastq.gz 295.7 MB Report
EGAF50000108205 fastq.gz 89.9 MB Report
EGAF50000108206 fastq.gz 206.6 MB Report
EGAF50000108207 fastq.gz 62.8 MB Report
EGAF50000108208 fastq.gz 69.4 MB Report
EGAF50000108209 fastq.gz 228.0 MB Report
EGAF50000108210 fastq.gz 165.8 MB Report
EGAF50000108211 fastq.gz 51.9 MB Report
EGAF50000108212 fastq.gz 190.8 MB Report
EGAF50000108213 fastq.gz 58.3 MB Report
EGAF50000108214 fastq.gz 91.4 MB Report
EGAF50000108215 fastq.gz 300.6 MB Report
EGAF50000108216 fastq.gz 76.2 MB Report
EGAF50000108217 fastq.gz 244.6 MB Report
EGAF50000108218 fastq.gz 80.4 MB Report
EGAF50000108219 fastq.gz 268.9 MB Report
EGAF50000108220 fastq.gz 77.5 MB Report
EGAF50000108221 fastq.gz 256.1 MB Report
EGAF50000108222 fastq.gz 70.2 MB Report
EGAF50000108223 fastq.gz 228.1 MB Report
EGAF50000108224 fastq.gz 90.4 MB Report
EGAF50000108225 fastq.gz 296.1 MB Report
EGAF50000108226 fastq.gz 90.0 MB Report
EGAF50000108227 fastq.gz 299.0 MB Report
EGAF50000108228 fastq.gz 83.2 MB Report
EGAF50000108229 fastq.gz 267.7 MB Report
EGAF50000108230 fastq.gz 59.0 MB Report
EGAF50000108231 fastq.gz 187.9 MB Report
EGAF50000108232 fastq.gz 87.7 MB Report
EGAF50000108233 fastq.gz 280.5 MB Report
EGAF50000108234 fastq.gz 58.3 MB Report
EGAF50000108235 fastq.gz 189.6 MB Report
EGAF50000108236 fastq.gz 103.3 MB Report
EGAF50000108237 fastq.gz 343.4 MB Report
EGAF50000108238 fastq.gz 94.9 MB Report
EGAF50000108239 fastq.gz 315.7 MB Report
EGAF50000108240 fastq.gz 73.2 MB Report
EGAF50000108241 fastq.gz 242.3 MB Report
EGAF50000108242 fastq.gz 95.5 MB Report
EGAF50000108243 fastq.gz 305.2 MB Report
EGAF50000108244 fastq.gz 62.6 MB Report
EGAF50000108245 fastq.gz 198.6 MB Report
EGAF50000108246 fastq.gz 73.3 MB Report
EGAF50000108247 fastq.gz 224.3 MB Report
EGAF50000108248 fastq.gz 65.7 MB Report
EGAF50000108249 fastq.gz 216.7 MB Report
EGAF50000108250 fastq.gz 76.5 MB Report
EGAF50000108251 fastq.gz 248.6 MB Report
EGAF50000108252 fastq.gz 105.6 MB Report
EGAF50000108253 fastq.gz 350.8 MB Report
EGAF50000108254 fastq.gz 84.1 MB Report
EGAF50000108255 fastq.gz 270.0 MB Report
EGAF50000108256 fastq.gz 25.1 MB Report
EGAF50000108257 fastq.gz 78.5 MB Report
EGAF50000108258 fastq.gz 199.5 MB Report
EGAF50000108259 fastq.gz 62.4 MB Report
EGAF50000108260 fastq.gz 83.3 MB Report
EGAF50000108261 fastq.gz 276.3 MB Report
EGAF50000108262 fastq.gz 85.9 MB Report
EGAF50000108263 fastq.gz 271.9 MB Report
EGAF50000108264 fastq.gz 77.4 MB Report
EGAF50000108265 fastq.gz 253.2 MB Report
EGAF50000108266 fastq.gz 85.0 MB Report
EGAF50000108267 fastq.gz 274.8 MB Report
EGAF50000108268 fastq.gz 85.3 MB Report
EGAF50000108269 fastq.gz 280.6 MB Report
EGAF50000108270 fastq.gz 80.7 MB Report
EGAF50000108271 fastq.gz 264.5 MB Report
EGAF50000108272 fastq.gz 79.9 MB Report
EGAF50000108273 fastq.gz 252.0 MB Report
EGAF50000108274 fastq.gz 92.4 MB Report
EGAF50000108275 fastq.gz 306.0 MB Report
EGAF50000108276 fastq.gz 96.8 MB Report
EGAF50000108277 fastq.gz 319.7 MB Report
EGAF50000108278 fastq.gz 107.6 MB Report
EGAF50000108279 fastq.gz 360.3 MB Report
EGAF50000108280 fastq.gz 108.5 MB Report
EGAF50000108281 fastq.gz 366.0 MB Report
EGAF50000108282 fastq.gz 86.1 MB Report
EGAF50000108283 fastq.gz 288.1 MB Report
EGAF50000108284 fastq.gz 117.1 MB
EGAF50000108285 fastq.gz 36.2 MB
EGAF50000108286 fastq.gz 86.4 MB Report
EGAF50000108287 fastq.gz 287.1 MB Report
EGAF50000108288 fastq.gz 254.4 MB Report
EGAF50000108289 fastq.gz 77.7 MB Report
EGAF50000108290 fastq.gz 86.5 MB Report
EGAF50000108291 fastq.gz 289.2 MB Report
EGAF50000108292 fastq.gz 90.2 MB Report
EGAF50000108293 fastq.gz 295.8 MB Report
EGAF50000108294 fastq.gz 70.8 MB Report
EGAF50000108295 fastq.gz 233.0 MB Report
EGAF50000108296 fastq.gz 92.6 MB Report
EGAF50000108297 fastq.gz 299.5 MB Report
EGAF50000108298 fastq.gz 71.2 MB Report
EGAF50000108299 fastq.gz 234.3 MB Report
EGAF50000108300 fastq.gz 67.9 MB Report
EGAF50000108301 fastq.gz 220.8 MB Report
EGAF50000108302 fastq.gz 53.5 MB Report
EGAF50000108303 fastq.gz 170.6 MB Report
EGAF50000108304 fastq.gz 106.4 MB Report
EGAF50000108305 fastq.gz 356.0 MB Report
EGAF50000108306 fastq.gz 233.7 MB Report
EGAF50000108307 fastq.gz 72.3 MB Report
EGAF50000108308 fastq.gz 85.9 MB Report
EGAF50000108309 fastq.gz 285.7 MB Report
EGAF50000108310 fastq.gz 127.2 MB Report
EGAF50000108311 fastq.gz 416.7 MB Report
EGAF50000108312 fastq.gz 63.0 MB Report
EGAF50000108313 fastq.gz 202.7 MB Report
EGAF50000108314 fastq.gz 78.6 MB Report
EGAF50000108315 fastq.gz 249.4 MB Report
EGAF50000108316 fastq.gz 72.9 MB Report
EGAF50000108317 fastq.gz 244.5 MB Report
EGAF50000108318 fastq.gz 87.0 MB Report
EGAF50000108319 fastq.gz 291.0 MB Report
EGAF50000108320 fastq.gz 178.1 MB Report
EGAF50000108321 fastq.gz 54.1 MB Report
EGAF50000108322 fastq.gz 67.7 MB Report
EGAF50000108323 fastq.gz 223.3 MB Report
EGAF50000108324 fastq.gz 108.7 MB Report
EGAF50000108325 fastq.gz 365.4 MB Report
EGAF50000108326 fastq.gz 176.3 MB Report
EGAF50000108327 fastq.gz 54.2 MB Report
EGAF50000108328 fastq.gz 80.9 MB Report
EGAF50000108329 fastq.gz 268.8 MB Report
EGAF50000108330 fastq.gz 100.5 MB Report
EGAF50000108331 fastq.gz 338.4 MB Report
EGAF50000108332 fastq.gz 325.5 MB Report
EGAF50000108333 fastq.gz 98.6 MB Report
EGAF50000108334 fastq.gz 85.5 MB Report
EGAF50000108335 fastq.gz 284.9 MB Report
EGAF50000108336 fastq.gz 70.8 MB Report
EGAF50000108337 fastq.gz 236.9 MB Report
EGAF50000108338 fastq.gz 99.6 MB Report
EGAF50000108339 fastq.gz 333.6 MB Report
EGAF50000108340 fastq.gz 120.4 MB Report
EGAF50000108341 fastq.gz 405.2 MB Report
EGAF50000108342 fastq.gz 84.0 MB Report
EGAF50000108343 fastq.gz 271.8 MB Report
EGAF50000108344 fastq.gz 81.7 MB Report
EGAF50000108345 fastq.gz 264.3 MB Report
EGAF50000108346 fastq.gz 157.4 MB Report
EGAF50000108347 fastq.gz 50.1 MB Report
EGAF50000108348 fastq.gz 68.5 MB Report
EGAF50000108349 fastq.gz 227.7 MB Report
EGAF50000108350 fastq.gz 108.6 MB Report
EGAF50000108351 fastq.gz 362.4 MB Report
EGAF50000108352 fastq.gz 91.2 MB Report
EGAF50000108353 fastq.gz 299.7 MB Report
EGAF50000108354 fastq.gz 125.4 MB Report
EGAF50000108355 fastq.gz 420.3 MB Report
EGAF50000108356 fastq.gz 82.3 MB Report
EGAF50000108357 fastq.gz 271.1 MB Report
EGAF50000108358 fastq.gz 69.2 MB Report
EGAF50000108359 fastq.gz 225.8 MB Report
EGAF50000108360 fastq.gz 96.0 MB Report
EGAF50000108361 fastq.gz 321.0 MB Report
EGAF50000108362 fastq.gz 77.1 MB Report
EGAF50000108363 fastq.gz 252.6 MB Report
EGAF50000108364 fastq.gz 75.8 MB Report
EGAF50000108365 fastq.gz 247.5 MB Report
EGAF50000108366 fastq.gz 265.5 MB Report
EGAF50000108367 fastq.gz 81.0 MB Report
EGAF50000108368 fastq.gz 94.2 MB Report
EGAF50000108369 fastq.gz 314.5 MB Report
EGAF50000108370 fastq.gz 89.2 MB Report
EGAF50000108371 fastq.gz 299.2 MB Report
EGAF50000108372 fastq.gz 77.4 MB Report
EGAF50000108373 fastq.gz 254.5 MB Report
EGAF50000108375 txt 13.5 MB
233 Files (38.5 GB)