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Epigenetic memory of SARS-CoV-2 mRNA vaccination in monocyte-derived macrophages

Immune memory is key to effective antimicrobial responses, but the impact of mRNA vaccines on this process is not fully understood. Our research shows that SARS-CoV-2 mRNA vaccines alter the epigenetic profile of human macrophages, specifically enhancing histone acetylation, which is linked to immune training. Significant epigenetic changes, along with increased cytokine release, require two vaccine doses. However, these effects diminish over time but can be restored with a booster dose six months later, maintaining a strong pro-inflammatory response.

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Access to data generated is made available by completing the data access agreement for review by the data access committee and will be granted to qualified investigators for appropriate use.

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS50000000341 Epigenetics

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF50000108403 fastq.gz 423.8 MB
EGAF50000108404 fastq.gz 454.6 MB
EGAF50000108405 fastq.gz 514.8 MB
EGAF50000108406 fastq.gz 473.5 MB
EGAF50000108407 fastq.gz 511.2 MB
EGAF50000108408 fastq.gz 476.5 MB
EGAF50000108409 fastq.gz 436.6 MB
EGAF50000108410 fastq.gz 467.8 MB
EGAF50000108411 fastq.gz 516.9 MB
EGAF50000108412 fastq.gz 564.0 MB
EGAF50000108413 fastq.gz 581.1 MB
EGAF50000108414 fastq.gz 533.2 MB
EGAF50000108415 fastq.gz 371.3 MB
EGAF50000108416 fastq.gz 334.5 MB
EGAF50000108417 fastq.gz 374.6 MB
EGAF50000108418 fastq.gz 420.1 MB
EGAF50000108419 fastq.gz 454.1 MB
EGAF50000108420 fastq.gz 488.4 MB
EGAF50000108421 fastq.gz 459.0 MB
EGAF50000108422 fastq.gz 504.3 MB
EGAF50000108423 fastq.gz 788.4 MB
EGAF50000108424 fastq.gz 730.5 MB
EGAF50000108425 fastq.gz 534.2 MB
EGAF50000108426 fastq.gz 583.9 MB
EGAF50000108427 fastq.gz 420.1 MB
EGAF50000108428 fastq.gz 448.0 MB
EGAF50000108429 fastq.gz 486.4 MB
EGAF50000108430 fastq.gz 527.1 MB
EGAF50000108431 fastq.gz 452.8 MB
EGAF50000108432 fastq.gz 510.7 MB
EGAF50000108433 fastq.gz 503.5 MB
EGAF50000108434 fastq.gz 577.7 MB
EGAF50000108435 fastq.gz 986.6 MB
EGAF50000108436 fastq.gz 1.1 GB
EGAF50000108437 fastq.gz 778.7 MB
EGAF50000108438 fastq.gz 862.2 MB
EGAF50000108439 fastq.gz 466.4 MB
EGAF50000108440 fastq.gz 434.1 MB
EGAF50000108441 fastq.gz 534.2 MB
EGAF50000108442 fastq.gz 576.4 MB
EGAF50000108443 fastq.gz 584.5 MB
EGAF50000108444 fastq.gz 635.3 MB
EGAF50000108445 fastq.gz 1.1 GB
EGAF50000108446 fastq.gz 1.3 GB
EGAF50000108447 fastq.gz 561.8 MB
EGAF50000108448 fastq.gz 603.4 MB
EGAF50000108449 fastq.gz 465.2 MB
EGAF50000108450 fastq.gz 502.2 MB
EGAF50000108451 fastq.gz 520.6 MB
EGAF50000108452 fastq.gz 567.3 MB
EGAF50000108453 fastq.gz 507.6 MB
EGAF50000108454 fastq.gz 557.9 MB
EGAF50000108455 fastq.gz 477.7 MB
EGAF50000108456 fastq.gz 424.9 MB
EGAF50000108457 fastq.gz 396.3 MB
EGAF50000108458 fastq.gz 445.9 MB
EGAF50000108459 fastq.gz 466.5 MB
EGAF50000108460 fastq.gz 512.4 MB
EGAF50000108461 fastq.gz 407.5 MB
EGAF50000108462 fastq.gz 381.9 MB
EGAF50000108463 fastq.gz 662.8 MB
EGAF50000108464 fastq.gz 720.3 MB
EGAF50000108465 fastq.gz 489.3 MB
EGAF50000108466 fastq.gz 532.4 MB
EGAF50000108467 fastq.gz 534.7 MB
EGAF50000108468 fastq.gz 583.4 MB
EGAF50000108469 fastq.gz 422.7 MB
EGAF50000108470 fastq.gz 462.8 MB
EGAF50000108471 fastq.gz 552.2 MB
EGAF50000108472 fastq.gz 598.7 MB
EGAF50000108473 fastq.gz 454.6 MB
EGAF50000108474 fastq.gz 428.6 MB
EGAF50000108475 fastq.gz 532.4 MB
EGAF50000108476 fastq.gz 590.7 MB
EGAF50000108477 fastq.gz 517.7 MB
EGAF50000108478 fastq.gz 561.3 MB
EGAF50000108479 fastq.gz 411.7 MB
EGAF50000108480 fastq.gz 459.1 MB
EGAF50000108481 fastq.gz 419.9 MB
EGAF50000108482 fastq.gz 466.6 MB
80 Files (43.5 GB)