Need Help?

Proteomic predictors of individualized nutrient-specific insulin secretion in health and disease

Population level variation and molecular mechanisms behind insulin secretion in response to carbohydrate, protein, and fat remain uncharacterized despite ramifications for personalized nutrition. We now define prototypical insulin secretion dynamics in response to the three macronutrients in islets from 140 cadaveric donors, including those diagnosed with type 2 diabetes. We leverage the insulin response heterogeneity and use transcriptomics and proteomics to identify molecular pathways of specific nutrient responsiveness. Surprisingly, we find robust insulin secretion to fatty acid stimulus in ~8% of donors, challenging the idea that fat has negligible effects on insulin release. Distinct islet proteomes with differences in metabolic signalling networks convey this hyper-responsiveness to fat relative to carbohydrate. By comparing human islets to human embryonic stem cell-derived islet clusters, we show that, unlike glucose-responsiveness, fat hyper-responsiveness is equivalent and may be a hallmark of functionally immature cells. Our study represents the first comparison of dynamic responses to nutrients and multi-omics analysis in human insulin secreting cells. Responses of different people’s islets to carbohydrate, protein, and fat lay the groundwork for personalized nutrition.

Request Access

Data Access Policy of the Datasets from the Translational Genomics of Diabetes Lab at Stanford University

DATA ACCESS AGREEMENT This agreement governs the terms on which access will be granted to the RNA sequencing data generated as part of the CALCOCO2 study. In signing this agreement, You are agreeing to be bound by the terms and conditions of access set out in this agreement. For the sake of clarity, the terms of access set out in this agreement apply both to the User and the User’s Institution (as defined below). User Institution and User are referred to within the agreement as “You” and “Your” shall be construed accordingly. Definitions: Investigators means the group of investigators based in Stanford, US and Oxford, UK which have generated the Data. Data means all and any human genetic data obtained from the Investigators. Data Subject means a person, who has been informed of the purpose for which the Data is held and has given his/her informed consent thereto. User means a researcher whose User Institution has previously completed this Data Access Agreement and has received acknowledgement of its acceptance. Publications means, without limitation, articles published in print journals, electronic journals, reviews, books, posters and other written and verbal presentations of research. User Institution means the organization at which the User is employed, affiliated or enrolled. Terms and Conditions: In signing this Agreement: 1. You agree to use the Data only for the advancement of medical research, according to the consent obtained from sample donors. 2. You agree not to use the Data or any part thereof for the creation of products for sale or for any commercial purpose. 3. You agree to preserve, at all times, the confidentiality of information and Data pertaining to Data Subjects. In particular, You undertake not to use, or attempt to use the Data to compromise or otherwise infringe the confidentiality of information on Data Subjects and their right to privacy. 4. You agree not to attempt to link the data provided under this agreement to other information or archive data available for the data sets provided, even if access to that data has been formally granted to you, or it is freely available without restriction, without specific permission being sought from the relevant access committees. 5. You agree not to transfer or disclose the Data, in whole or part, or any identifiable material derived from the Data, to others, except as necessary for data/safety monitoring or programme management. Should You wish to share the Data with a collaborator outside the same Institution, the third party must make a separate application for access to the Data. 6. You agree to use the data for the approved purpose and project described in your application; use of the data for a new purpose or project will require a new application and approval. 7. You agree to acknowledge in any work based in whole or part on the Data, the published paper from which the Data derives. 8. You accept that the Investigators, the original data creators, depositors or copyright holders, or the funders of the Data or any part of the Data supplied: a. bear no legal responsibility for the accuracy or comprehensiveness of the Data; and b. accept no liability for indirect, consequential, or incidental, damages or losses arising from use of the Data, or from the unavailability of, or break in access to, the Data for whatever reason. 9. You understand and acknowledge that the Data is protected by copyright and other intellectual property rights, and that duplication, except as reasonably required to carry out Your research with the Data, or sale of all or part of the Data on any media is not permitted. 10. You recognise that nothing in this agreement shall operate to transfer to the User Institution any intellectual property rights relating to the Data. The User Institution has the right to develop intellectual property based on comparisons with their own data. 11. You accept that this agreement will terminate immediately upon any breach of this agreement by You and You will be required to destroy any Data held. 12. You accept that it may be necessary for the Investigators or its appointed agent to alter the terms of this agreement from time to time in order to address new concerns. In this event, the Investigators or its appointed agent will contact You to inform You of any changes and You agree that Your continued use of the Data shall be dependent on the parties entering into a new version of the Agreement. 13. You accept that the Data is protected by and subject to international laws and that You are responsible for ensuring compliance with any such applicable law. The Translational Genomics of Diabetes Lab Data Access Committee reserves the right to request and inspect data security and management documentation to ensure the adequacy of data protection measures in countries that have no national laws comparable to that which pertain in the EAA. 14. This agreement shall be construed, interpreted and governed by the laws of US and UK and shall be subject to the non-exclusive jurisdiction of the US and UK courts.

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001007241 RNASeq

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00008072481 fq.gz 139.0 MB
EGAF00008072482 fq.gz 143.8 MB
EGAF00008072483 fq.gz 139.4 MB
EGAF00008072484 fq.gz 148.1 MB
EGAF00008072485 fq.gz 140.2 MB
EGAF00008072486 fq.gz 146.7 MB
EGAF00008072487 fq.gz 140.4 MB
EGAF00008072488 fq.gz 146.5 MB
EGAF00008072489 fq.gz 137.7 MB
EGAF00008072490 fq.gz 145.0 MB
EGAF00008072491 fq.gz 137.5 MB
EGAF00008072492 fq.gz 151.6 MB
EGAF00008072493 fq.gz 138.4 MB
EGAF00008072494 fq.gz 151.8 MB
EGAF00008072495 fq.gz 138.0 MB
EGAF00008072496 fq.gz 149.7 MB
EGAF00008072497 fq.gz 139.1 MB
EGAF00008072498 fq.gz 148.0 MB
EGAF00008072499 fq.gz 138.9 MB
EGAF00008072500 fq.gz 145.2 MB
EGAF00008072501 fq.gz 138.0 MB
EGAF00008072502 fq.gz 143.1 MB
EGAF00008072503 fq.gz 138.6 MB
EGAF00008072504 fq.gz 142.5 MB
EGAF00008072505 fq.gz 139.3 MB
EGAF00008072506 fq.gz 142.7 MB
EGAF00008072507 fq.gz 150.9 MB
EGAF00008072508 fq.gz 157.4 MB
EGAF00008072509 fq.gz 151.9 MB
EGAF00008072510 fq.gz 163.2 MB
EGAF00008072511 fq.gz 152.7 MB
EGAF00008072512 fq.gz 161.7 MB
EGAF00008072513 fq.gz 152.6 MB
EGAF00008072514 fq.gz 161.2 MB
EGAF00008072515 fq.gz 148.9 MB
EGAF00008072516 fq.gz 158.9 MB
EGAF00008072517 fq.gz 150.0 MB
EGAF00008072518 fq.gz 167.6 MB
EGAF00008072519 fq.gz 150.6 MB
EGAF00008072520 fq.gz 167.5 MB
EGAF00008072521 fq.gz 150.4 MB
EGAF00008072522 fq.gz 165.7 MB
EGAF00008072523 fq.gz 151.6 MB
EGAF00008072524 fq.gz 163.8 MB
EGAF00008072525 fq.gz 151.2 MB
EGAF00008072526 fq.gz 160.3 MB
EGAF00008072527 fq.gz 150.3 MB
EGAF00008072528 fq.gz 156.2 MB
EGAF00008072529 fq.gz 151.1 MB
EGAF00008072530 fq.gz 156.0 MB
EGAF00008072531 fq.gz 152.0 MB
EGAF00008072532 fq.gz 156.4 MB
EGAF00008072533 fq.gz 153.4 MB
EGAF00008072534 fq.gz 157.5 MB
EGAF00008072535 fq.gz 153.3 MB
EGAF00008072536 fq.gz 161.7 MB
EGAF00008072537 fq.gz 154.1 MB
EGAF00008072538 fq.gz 160.2 MB
EGAF00008072539 fq.gz 154.2 MB
EGAF00008072540 fq.gz 159.7 MB
EGAF00008072541 fq.gz 151.3 MB
EGAF00008072542 fq.gz 158.2 MB
EGAF00008072543 fq.gz 151.4 MB
EGAF00008072544 fq.gz 165.7 MB
EGAF00008072545 fq.gz 152.1 MB
EGAF00008072546 fq.gz 165.6 MB
EGAF00008072547 fq.gz 152.0 MB
EGAF00008072548 fq.gz 163.6 MB
EGAF00008072549 fq.gz 153.2 MB
EGAF00008072550 fq.gz 161.7 MB
EGAF00008072551 fq.gz 152.8 MB
EGAF00008072552 fq.gz 158.5 MB
EGAF00008072553 fq.gz 152.5 MB
EGAF00008072554 fq.gz 156.9 MB
EGAF00008072555 fq.gz 153.4 MB
EGAF00008072556 fq.gz 156.5 MB
EGAF00008072557 fq.gz 154.2 MB
EGAF00008072558 fq.gz 156.7 MB
EGAF00008072559 fq.gz 151.5 MB
EGAF00008072560 fq.gz 155.1 MB
EGAF00008072561 fq.gz 151.9 MB
EGAF00008072562 fq.gz 159.7 MB
EGAF00008072563 fq.gz 152.4 MB
EGAF00008072564 fq.gz 158.0 MB
EGAF00008072565 fq.gz 152.5 MB
EGAF00008072566 fq.gz 157.6 MB
EGAF00008072567 fq.gz 149.3 MB
EGAF00008072568 fq.gz 155.7 MB
EGAF00008072569 fq.gz 149.8 MB
EGAF00008072570 fq.gz 163.3 MB
EGAF00008072571 fq.gz 150.8 MB
EGAF00008072572 fq.gz 163.6 MB
EGAF00008072573 fq.gz 150.3 MB
EGAF00008072574 fq.gz 161.4 MB
EGAF00008072575 fq.gz 151.4 MB
EGAF00008072576 fq.gz 159.4 MB
EGAF00008072577 fq.gz 151.0 MB
EGAF00008072578 fq.gz 156.2 MB
EGAF00008072579 fq.gz 149.8 MB
EGAF00008072580 fq.gz 153.6 MB
EGAF00008072581 fq.gz 150.4 MB
EGAF00008072582 fq.gz 153.0 MB
EGAF00008072583 fq.gz 151.5 MB
EGAF00008072584 fq.gz 153.6 MB
EGAF00008072585 fq.gz 159.6 MB
EGAF00008072586 fq.gz 166.4 MB
EGAF00008072587 fq.gz 159.0 MB
EGAF00008072588 fq.gz 169.9 MB
EGAF00008072589 fq.gz 159.8 MB
EGAF00008072590 fq.gz 168.3 MB
EGAF00008072591 fq.gz 159.7 MB
EGAF00008072592 fq.gz 167.6 MB
EGAF00008072593 fq.gz 156.9 MB
EGAF00008072594 fq.gz 166.2 MB
EGAF00008072595 fq.gz 157.6 MB
EGAF00008072596 fq.gz 174.6 MB
EGAF00008072597 fq.gz 158.2 MB
EGAF00008072598 fq.gz 174.5 MB
EGAF00008072599 fq.gz 157.9 MB
EGAF00008072600 fq.gz 172.3 MB
EGAF00008072601 fq.gz 158.7 MB
EGAF00008072602 fq.gz 169.9 MB
EGAF00008072603 fq.gz 158.6 MB
EGAF00008072604 fq.gz 166.9 MB
EGAF00008072605 fq.gz 157.5 MB
EGAF00008072606 fq.gz 164.3 MB
EGAF00008072607 fq.gz 158.1 MB
EGAF00008072608 fq.gz 163.7 MB
EGAF00008072609 fq.gz 159.1 MB
EGAF00008072610 fq.gz 164.1 MB
EGAF00008072611 fq.gz 171.2 MB
EGAF00008072612 fq.gz 177.5 MB
EGAF00008072613 fq.gz 171.0 MB
EGAF00008072614 fq.gz 182.5 MB
EGAF00008072615 fq.gz 172.3 MB
EGAF00008072616 fq.gz 181.0 MB
EGAF00008072617 fq.gz 172.5 MB
EGAF00008072618 fq.gz 180.4 MB
EGAF00008072619 fq.gz 169.0 MB
EGAF00008072620 fq.gz 178.4 MB
EGAF00008072621 fq.gz 169.9 MB
EGAF00008072622 fq.gz 188.5 MB
EGAF00008072623 fq.gz 171.0 MB
EGAF00008072624 fq.gz 188.7 MB
EGAF00008072625 fq.gz 170.8 MB
EGAF00008072626 fq.gz 186.4 MB
EGAF00008072627 fq.gz 171.9 MB
EGAF00008072628 fq.gz 183.9 MB
EGAF00008072629 fq.gz 171.9 MB
EGAF00008072630 fq.gz 180.5 MB
EGAF00008072631 fq.gz 168.6 MB
EGAF00008072632 fq.gz 175.1 MB
EGAF00008072633 fq.gz 169.2 MB
EGAF00008072634 fq.gz 174.3 MB
EGAF00008072635 fq.gz 170.3 MB
EGAF00008072636 fq.gz 174.6 MB
EGAF00008072637 fq.gz 155.7 MB
EGAF00008072638 fq.gz 162.1 MB
EGAF00008072639 fq.gz 156.1 MB
EGAF00008072640 fq.gz 167.1 MB
EGAF00008072641 fq.gz 156.9 MB
EGAF00008072642 fq.gz 165.6 MB
EGAF00008072643 fq.gz 156.9 MB
EGAF00008072644 fq.gz 164.8 MB
EGAF00008072645 fq.gz 153.8 MB
EGAF00008072646 fq.gz 163.0 MB
EGAF00008072647 fq.gz 154.7 MB
EGAF00008072648 fq.gz 171.8 MB
EGAF00008072649 fq.gz 155.7 MB
EGAF00008072650 fq.gz 172.0 MB
EGAF00008072651 fq.gz 155.2 MB
EGAF00008072652 fq.gz 169.8 MB
EGAF00008072653 fq.gz 156.4 MB
EGAF00008072654 fq.gz 168.0 MB
EGAF00008072655 fq.gz 156.0 MB
EGAF00008072656 fq.gz 164.5 MB
EGAF00008072657 fq.gz 154.4 MB
EGAF00008072658 fq.gz 161.3 MB
EGAF00008072659 fq.gz 155.0 MB
EGAF00008072660 fq.gz 160.6 MB
EGAF00008072661 fq.gz 156.0 MB
EGAF00008072662 fq.gz 161.0 MB
EGAF00008072663 fq.gz 137.6 MB
EGAF00008072664 fq.gz 142.5 MB
EGAF00008072665 fq.gz 137.5 MB
EGAF00008072666 fq.gz 146.5 MB
EGAF00008072667 fq.gz 138.3 MB
EGAF00008072668 fq.gz 145.1 MB
EGAF00008072669 fq.gz 138.3 MB
EGAF00008072670 fq.gz 144.6 MB
EGAF00008072671 fq.gz 135.8 MB
EGAF00008072672 fq.gz 143.3 MB
EGAF00008072673 fq.gz 136.0 MB
EGAF00008072674 fq.gz 150.4 MB
EGAF00008072675 fq.gz 136.7 MB
EGAF00008072676 fq.gz 150.4 MB
EGAF00008072677 fq.gz 136.3 MB
EGAF00008072678 fq.gz 148.2 MB
EGAF00008072679 fq.gz 137.3 MB
EGAF00008072680 fq.gz 146.5 MB
EGAF00008072681 fq.gz 137.3 MB
EGAF00008072682 fq.gz 144.0 MB
EGAF00008072683 fq.gz 136.6 MB
EGAF00008072684 fq.gz 141.8 MB
EGAF00008072685 fq.gz 136.9 MB
EGAF00008072686 fq.gz 140.9 MB
EGAF00008072687 fq.gz 137.9 MB
EGAF00008072688 fq.gz 141.3 MB
EGAF00008072689 fq.gz 458.9 MB
EGAF00008072690 fq.gz 503.9 MB
EGAF00008072691 fq.gz 461.5 MB
EGAF00008072692 fq.gz 481.4 MB
EGAF00008072693 fq.gz 451.5 MB
EGAF00008072694 fq.gz 472.3 MB
EGAF00008072695 fq.gz 453.3 MB
EGAF00008072696 fq.gz 504.9 MB
EGAF00008072697 fq.gz 429.1 MB
EGAF00008072698 fq.gz 470.5 MB
EGAF00008072699 fq.gz 434.3 MB
EGAF00008072700 fq.gz 469.3 MB
EGAF00008072701 fq.gz 447.7 MB
EGAF00008072702 fq.gz 488.1 MB
EGAF00008072703 fq.gz 157.5 MB
EGAF00008072704 fq.gz 164.1 MB
EGAF00008072705 fq.gz 156.8 MB
EGAF00008072706 fq.gz 167.2 MB
EGAF00008072707 fq.gz 157.7 MB
EGAF00008072708 fq.gz 165.9 MB
EGAF00008072709 fq.gz 157.9 MB
EGAF00008072710 fq.gz 165.5 MB
EGAF00008072711 fq.gz 154.7 MB
EGAF00008072712 fq.gz 163.6 MB
EGAF00008072713 fq.gz 156.4 MB
EGAF00008072714 fq.gz 173.3 MB
EGAF00008072715 fq.gz 157.3 MB
EGAF00008072716 fq.gz 173.5 MB
EGAF00008072717 fq.gz 157.0 MB
EGAF00008072718 fq.gz 171.5 MB
EGAF00008072719 fq.gz 158.4 MB
EGAF00008072720 fq.gz 169.7 MB
EGAF00008072721 fq.gz 158.2 MB
EGAF00008072722 fq.gz 166.6 MB
EGAF00008072723 fq.gz 155.2 MB
EGAF00008072724 fq.gz 161.6 MB
EGAF00008072725 fq.gz 156.0 MB
EGAF00008072726 fq.gz 161.2 MB
EGAF00008072727 fq.gz 157.0 MB
EGAF00008072728 fq.gz 161.7 MB
EGAF00008072729 fq.gz 361.0 MB
EGAF00008072730 fq.gz 397.5 MB
EGAF00008072731 fq.gz 363.6 MB
EGAF00008072732 fq.gz 380.3 MB
EGAF00008072733 fq.gz 356.4 MB
EGAF00008072734 fq.gz 374.0 MB
EGAF00008072735 fq.gz 359.7 MB
EGAF00008072736 fq.gz 402.2 MB
EGAF00008072737 fq.gz 346.0 MB
EGAF00008072738 fq.gz 381.1 MB
EGAF00008072739 fq.gz 345.9 MB
EGAF00008072740 fq.gz 375.1 MB
EGAF00008072741 fq.gz 349.6 MB
EGAF00008072742 fq.gz 382.2 MB
EGAF00008072743 fq.gz 430.9 MB
EGAF00008072744 fq.gz 471.8 MB
EGAF00008072745 fq.gz 434.0 MB
EGAF00008072746 fq.gz 450.7 MB
EGAF00008072747 fq.gz 425.1 MB
EGAF00008072748 fq.gz 442.9 MB
EGAF00008072749 fq.gz 424.2 MB
EGAF00008072750 fq.gz 471.5 MB
EGAF00008072751 fq.gz 411.9 MB
EGAF00008072752 fq.gz 450.3 MB
EGAF00008072753 fq.gz 415.2 MB
EGAF00008072754 fq.gz 446.9 MB
EGAF00008072755 fq.gz 421.2 MB
EGAF00008072756 fq.gz 457.1 MB
EGAF00008072757 fq.gz 378.7 MB
EGAF00008072758 fq.gz 414.2 MB
EGAF00008072759 fq.gz 384.3 MB
EGAF00008072760 fq.gz 398.9 MB
EGAF00008072761 fq.gz 376.3 MB
EGAF00008072762 fq.gz 391.9 MB
EGAF00008072763 fq.gz 376.2 MB
EGAF00008072764 fq.gz 417.3 MB
EGAF00008072765 fq.gz 360.9 MB
EGAF00008072766 fq.gz 394.9 MB
EGAF00008072767 fq.gz 362.9 MB
EGAF00008072768 fq.gz 390.9 MB
EGAF00008072769 fq.gz 368.2 MB
EGAF00008072770 fq.gz 399.8 MB
EGAF00008072771 fq.gz 359.4 MB
EGAF00008072772 fq.gz 393.5 MB
EGAF00008072773 fq.gz 364.8 MB
EGAF00008072774 fq.gz 380.5 MB
EGAF00008072775 fq.gz 357.2 MB
EGAF00008072776 fq.gz 373.8 MB
EGAF00008072777 fq.gz 347.7 MB
EGAF00008072778 fq.gz 386.6 MB
EGAF00008072779 fq.gz 343.6 MB
EGAF00008072780 fq.gz 379.7 MB
EGAF00008072781 fq.gz 346.4 MB
EGAF00008072782 fq.gz 376.5 MB
EGAF00008072783 fq.gz 355.0 MB
EGAF00008072784 fq.gz 389.4 MB
EGAF00008072785 fq.gz 386.3 MB
EGAF00008072786 fq.gz 422.4 MB
EGAF00008072787 fq.gz 387.8 MB
EGAF00008072788 fq.gz 402.9 MB
EGAF00008072789 fq.gz 379.8 MB
EGAF00008072790 fq.gz 395.9 MB
EGAF00008072791 fq.gz 378.7 MB
EGAF00008072792 fq.gz 420.1 MB
EGAF00008072793 fq.gz 368.3 MB
EGAF00008072794 fq.gz 402.2 MB
EGAF00008072795 fq.gz 368.8 MB
EGAF00008072796 fq.gz 396.8 MB
EGAF00008072797 fq.gz 373.5 MB
EGAF00008072798 fq.gz 405.1 MB
EGAF00008072799 fq.gz 429.8 MB
EGAF00008072800 fq.gz 459.8 MB
EGAF00008072801 fq.gz 428.0 MB
EGAF00008072802 fq.gz 471.3 MB
EGAF00008072803 fq.gz 442.4 MB
EGAF00008072804 fq.gz 475.0 MB
EGAF00008072805 fq.gz 455.0 MB
EGAF00008072806 fq.gz 482.8 MB
EGAF00008072807 fq.gz 449.7 MB
EGAF00008072808 fq.gz 482.6 MB
EGAF00008072809 fq.gz 450.7 MB
EGAF00008072810 fq.gz 483.4 MB
EGAF00008072811 fq.gz 511.7 MB
EGAF00008072812 fq.gz 544.4 MB
EGAF00008072813 fq.gz 511.6 MB
EGAF00008072814 fq.gz 560.5 MB
EGAF00008072815 fq.gz 527.3 MB
EGAF00008072816 fq.gz 563.3 MB
EGAF00008072817 fq.gz 541.0 MB
EGAF00008072818 fq.gz 571.5 MB
EGAF00008072819 fq.gz 534.9 MB
EGAF00008072820 fq.gz 571.5 MB
EGAF00008072821 fq.gz 537.8 MB
EGAF00008072822 fq.gz 574.2 MB
EGAF00008072823 fq.gz 446.4 MB
EGAF00008072824 fq.gz 479.8 MB
EGAF00008072825 fq.gz 445.7 MB
EGAF00008072826 fq.gz 493.5 MB
EGAF00008072827 fq.gz 460.2 MB
EGAF00008072828 fq.gz 496.7 MB
EGAF00008072829 fq.gz 471.2 MB
EGAF00008072830 fq.gz 502.5 MB
EGAF00008072831 fq.gz 466.1 MB
EGAF00008072832 fq.gz 503.0 MB
EGAF00008072833 fq.gz 468.2 MB
EGAF00008072834 fq.gz 504.8 MB
EGAF00008072835 fq.gz 495.7 MB
EGAF00008072836 fq.gz 536.9 MB
EGAF00008072837 fq.gz 500.9 MB
EGAF00008072838 fq.gz 558.9 MB
EGAF00008072839 fq.gz 514.5 MB
EGAF00008072840 fq.gz 559.2 MB
EGAF00008072841 fq.gz 525.6 MB
EGAF00008072842 fq.gz 564.5 MB
EGAF00008072843 fq.gz 519.1 MB
EGAF00008072844 fq.gz 563.9 MB
EGAF00008072845 fq.gz 523.6 MB
EGAF00008072846 fq.gz 568.3 MB
EGAF00008072847 fq.gz 461.3 MB
EGAF00008072848 fq.gz 497.7 MB
EGAF00008072849 fq.gz 462.9 MB
EGAF00008072850 fq.gz 513.6 MB
EGAF00008072851 fq.gz 476.8 MB
EGAF00008072852 fq.gz 515.5 MB
EGAF00008072853 fq.gz 488.6 MB
EGAF00008072854 fq.gz 522.0 MB
EGAF00008072855 fq.gz 482.5 MB
EGAF00008072856 fq.gz 521.0 MB
EGAF00008072857 fq.gz 486.5 MB
EGAF00008072858 fq.gz 525.1 MB
EGAF00008072859 fq.gz 542.1 MB
EGAF00008072860 fq.gz 577.1 MB
EGAF00008072861 fq.gz 546.3 MB
EGAF00008072862 fq.gz 597.3 MB
EGAF00008072863 fq.gz 559.3 MB
EGAF00008072864 fq.gz 595.9 MB
EGAF00008072865 fq.gz 570.1 MB
EGAF00008072866 fq.gz 599.9 MB
EGAF00008072867 fq.gz 564.3 MB
EGAF00008072868 fq.gz 601.3 MB
EGAF00008072869 fq.gz 568.4 MB
EGAF00008072870 fq.gz 605.0 MB
EGAF00008072871 fq.gz 573.4 MB
EGAF00008072872 fq.gz 616.6 MB
EGAF00008072873 fq.gz 576.6 MB
EGAF00008072874 fq.gz 637.8 MB
EGAF00008072875 fq.gz 593.5 MB
EGAF00008072876 fq.gz 639.7 MB
EGAF00008072877 fq.gz 605.9 MB
EGAF00008072878 fq.gz 645.0 MB
EGAF00008072879 fq.gz 598.8 MB
EGAF00008072880 fq.gz 644.9 MB
EGAF00008072881 fq.gz 604.1 MB
EGAF00008072882 fq.gz 650.5 MB
EGAF00008072883 fq.gz 482.1 MB
EGAF00008072884 fq.gz 521.7 MB
EGAF00008072885 fq.gz 484.5 MB
EGAF00008072886 fq.gz 540.6 MB
EGAF00008072887 fq.gz 499.0 MB
EGAF00008072888 fq.gz 542.5 MB
EGAF00008072889 fq.gz 511.3 MB
EGAF00008072890 fq.gz 549.2 MB
EGAF00008072891 fq.gz 505.4 MB
EGAF00008072892 fq.gz 549.3 MB
EGAF00008072893 fq.gz 508.8 MB
EGAF00008072894 fq.gz 552.8 MB
EGAF00008072895 fq.gz 460.8 MB
EGAF00008072896 fq.gz 494.7 MB
EGAF00008072897 fq.gz 463.4 MB
EGAF00008072898 fq.gz 511.4 MB
EGAF00008072899 fq.gz 476.6 MB
EGAF00008072900 fq.gz 512.7 MB
EGAF00008072901 fq.gz 488.6 MB
EGAF00008072902 fq.gz 519.4 MB
EGAF00008072903 fq.gz 482.6 MB
EGAF00008072904 fq.gz 518.9 MB
EGAF00008072905 fq.gz 485.9 MB
EGAF00008072906 fq.gz 522.0 MB
EGAF00008072907 fq.gz 439.0 MB
EGAF00008072908 fq.gz 475.2 MB
EGAF00008072909 fq.gz 441.8 MB
EGAF00008072910 fq.gz 492.5 MB
EGAF00008072911 fq.gz 454.1 MB
EGAF00008072912 fq.gz 493.0 MB
EGAF00008072913 fq.gz 465.4 MB
EGAF00008072914 fq.gz 498.9 MB
EGAF00008072915 fq.gz 460.4 MB
EGAF00008072916 fq.gz 499.2 MB
EGAF00008072917 fq.gz 463.2 MB
EGAF00008072918 fq.gz 502.2 MB
EGAF00008072919 fq.gz 577.5 MB
EGAF00008072920 fq.gz 615.2 MB
EGAF00008072921 fq.gz 582.7 MB
EGAF00008072922 fq.gz 638.5 MB
EGAF00008072923 fq.gz 599.8 MB
EGAF00008072924 fq.gz 640.3 MB
EGAF00008072925 fq.gz 612.8 MB
EGAF00008072926 fq.gz 646.1 MB
EGAF00008072927 fq.gz 606.1 MB
EGAF00008072928 fq.gz 646.9 MB
EGAF00008072929 fq.gz 610.6 MB
EGAF00008072930 fq.gz 651.3 MB
EGAF00008072931 fq.gz 1.5 GB
EGAF00008072932 fq.gz 1.5 GB
EGAF00008072933 fq.gz 1.4 GB
EGAF00008072934 fq.gz 1.4 GB
EGAF00008072935 fq.gz 1.3 GB
EGAF00008072936 fq.gz 1.4 GB
EGAF00008072937 fq.gz 1.4 GB
EGAF00008072938 fq.gz 1.4 GB
EGAF00008072939 fq.gz 1.4 GB
EGAF00008072940 fq.gz 1.5 GB
EGAF00008072941 fq.gz 1.4 GB
EGAF00008072942 fq.gz 1.5 GB
EGAF00008072943 fq.gz 1.4 GB
EGAF00008072944 fq.gz 1.4 GB
EGAF00008072945 fq.gz 1.4 GB
EGAF00008072946 fq.gz 1.4 GB
EGAF00008072947 fq.gz 1.4 GB
EGAF00008072948 fq.gz 1.5 GB
EGAF00008072949 fq.gz 1.4 GB
EGAF00008072950 fq.gz 1.4 GB
EGAF00008072951 fq.gz 1.4 GB
EGAF00008072952 fq.gz 1.5 GB
EGAF00008072953 fq.gz 1.5 GB
EGAF00008072954 fq.gz 1.5 GB
EGAF00008072955 fq.gz 1.4 GB
EGAF00008072956 fq.gz 1.4 GB
EGAF00008072957 fq.gz 1.4 GB
EGAF00008072958 fq.gz 1.5 GB
EGAF00008072959 fq.gz 1.4 GB
EGAF00008072960 fq.gz 1.4 GB
EGAF00008072961 fq.gz 1.4 GB
EGAF00008072962 fq.gz 1.5 GB
EGAF00008072963 fq.gz 1.5 GB
EGAF00008072964 fq.gz 1.6 GB
EGAF00008072965 fq.gz 1.4 GB
EGAF00008072966 fq.gz 1.5 GB
EGAF00008072967 fq.gz 1.5 GB
EGAF00008072968 fq.gz 1.5 GB
EGAF00008072969 fq.gz 1.4 GB
EGAF00008072970 fq.gz 1.4 GB
EGAF00008072971 fq.gz 1.4 GB
EGAF00008072972 fq.gz 1.5 GB
EGAF00008072973 fq.gz 1.4 GB
EGAF00008072974 fq.gz 1.5 GB
EGAF00008072975 fq.gz 1.4 GB
EGAF00008072976 fq.gz 1.5 GB
EGAF00008072977 fq.gz 1.4 GB
EGAF00008072978 fq.gz 1.5 GB
EGAF00008072979 fq.gz 1.4 GB
EGAF00008072980 fq.gz 1.4 GB
EGAF00008072981 fq.gz 1.4 GB
EGAF00008072982 fq.gz 1.5 GB
EGAF00008072983 fq.gz 1.5 GB
EGAF00008072984 fq.gz 1.6 GB
EGAF00008072985 fq.gz 1.4 GB
EGAF00008072986 fq.gz 1.5 GB
EGAF00008072987 fq.gz 1.4 GB
EGAF00008072988 fq.gz 1.5 GB
EGAF00008072989 fq.gz 1.3 GB
EGAF00008072990 fq.gz 1.4 GB
EGAF00008072991 fq.gz 1.4 GB
EGAF00008072992 fq.gz 1.5 GB
EGAF00008072993 fq.gz 1.5 GB
EGAF00008072994 fq.gz 1.6 GB
EGAF00008072995 fq.gz 1.4 GB
EGAF00008072996 fq.gz 1.5 GB
EGAF00008072997 fq.gz 1.5 GB
EGAF00008072998 fq.gz 1.6 GB
EGAF00008072999 fq.gz 1.4 GB
EGAF00008073000 fq.gz 1.5 GB
EGAF00008073001 fq.gz 1.3 GB
EGAF00008073002 fq.gz 1.4 GB
EGAF00008073003 fq.gz 1.3 GB
EGAF00008073004 fq.gz 1.4 GB
EGAF00008073005 fq.gz 2.4 GB
EGAF00008073006 fq.gz 2.5 GB
EGAF00008073007 fq.gz 1.3 GB
EGAF00008073008 fq.gz 1.4 GB
EGAF00008073009 fq.gz 1.4 GB
EGAF00008073010 fq.gz 1.5 GB
EGAF00008073011 fq.gz 1.4 GB
EGAF00008073012 fq.gz 1.5 GB
EGAF00008073013 fq.gz 1.4 GB
EGAF00008073014 fq.gz 1.5 GB
EGAF00008073015 fq.gz 1.4 GB
EGAF00008073016 fq.gz 1.5 GB
EGAF00008073017 fq.gz 1.3 GB
EGAF00008073018 fq.gz 1.4 GB
EGAF00008073019 fq.gz 1.4 GB
EGAF00008073020 fq.gz 1.4 GB
EGAF00008073021 fq.gz 1.4 GB
EGAF00008073022 fq.gz 1.4 GB
EGAF00008073023 fq.gz 1.4 GB
EGAF00008073024 fq.gz 1.5 GB
EGAF00008073025 fq.gz 877.5 MB
EGAF00008073026 fq.gz 933.5 MB
EGAF00008073027 fq.gz 1.4 GB
EGAF00008073028 fq.gz 1.4 GB
EGAF00008073029 fq.gz 1.3 GB
EGAF00008073030 fq.gz 1.4 GB
EGAF00008073031 fq.gz 1.5 GB
EGAF00008073032 fq.gz 1.6 GB
EGAF00008073033 fq.gz 1.3 GB
EGAF00008073034 fq.gz 1.3 GB
EGAF00008073035 fq.gz 1.9 GB
EGAF00008073036 fq.gz 2.0 GB
EGAF00008073037 fq.gz 2.1 GB
EGAF00008073038 fq.gz 2.3 GB
EGAF00008073039 fq.gz 2.4 GB
EGAF00008073040 fq.gz 2.5 GB
EGAF00008073041 fq.gz 1.6 GB
EGAF00008073042 fq.gz 1.7 GB
EGAF00008073043 fq.gz 2.1 GB
EGAF00008073044 fq.gz 2.3 GB
EGAF00008073045 fq.gz 1.7 GB
EGAF00008073046 fq.gz 1.8 GB
EGAF00008073047 fq.gz 1.9 GB
EGAF00008073048 fq.gz 2.1 GB
EGAF00008073049 fq.gz 1.4 GB
EGAF00008073050 fq.gz 1.5 GB
EGAF00008073051 fq.gz 1.6 GB
EGAF00008073052 fq.gz 1.6 GB
EGAF00008073053 fq.gz 1.5 GB
EGAF00008073054 fq.gz 1.7 GB
EGAF00008073055 fq.gz 1.5 GB
EGAF00008073056 fq.gz 1.6 GB
EGAF00008073057 fq.gz 1.5 GB
EGAF00008073058 fq.gz 1.5 GB
EGAF00008073059 fq.gz 1.5 GB
EGAF00008073060 fq.gz 1.6 GB
EGAF00008073061 fq.gz 1.6 GB
EGAF00008073062 fq.gz 1.6 GB
EGAF00008073063 fq.gz 1.5 GB
EGAF00008073064 fq.gz 1.7 GB
EGAF00008073065 fq.gz 1.6 GB
EGAF00008073066 fq.gz 1.6 GB
EGAF00008073067 fq.gz 1.5 GB
EGAF00008073068 fq.gz 1.5 GB
EGAF00008073069 fq.gz 1.5 GB
EGAF00008073070 fq.gz 1.5 GB
590 Files (353.1 GB)