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Bulk RNA sequencing of human T and B cells before and after interleukin-2 immunotherapy

Bulk RNA sequencing of flow cytometry sorted human CD4+ regulatory T (Treg), CD4+ conventional T (Tcon), CD8+ T, and CD19+ B cells from systemic lupus erythematosus patients collected at baseline (day 0, before interleukin-2 immunotherpay), day 5 (after 1 treatment cycle of interleukin-2 immunotherapy), and day 68 (after 4 treatment cycles of interleukin-2 immunotherapy). The dataset comprises files from the above-mentioned 4 immune cell subsets, collected at 3 time points (day 0, day 5, and day 68) of 12 systemic lupus erythematosus patients. Due to technical reasons, day 5 samples of patient SLE_012 could not be processed and are thus missing. The complete dataset totals in 140 raw sequencing files (fastq format).

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Access to raw sequencing files from human participants

Sequencing files from healthy human participants and patients, collected under ethical approvals 2016-01440 and 2017-00886, have restricted access. These files are only available to researchers from countries that comply with Swiss human data confidentiality and security regulations. Furthermore, requesting researchers must adhere to the conditions outlined in the corresponding ethical approvals. These conditions include strict confidentiality requirements and a prohibition on further distribution of the data. Access to these files is governed by a Data Transfer Agreement (DTA) between the relevant institutions, which must be executed prior to the transfer of any data. The DTA will detail all terms and conditions of data usage, ensuring compliance with ethical and legal standards. This process ensures the protection of sensitive information while facilitating research collaboration.

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS50000000458 RNASeq
  • As the article was published on August 12, 2024, the corresponding Pubmed ID was added to the corresponding studies. No other changes were implemented.
  • Dataset Released

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF50000158054 fastq.gz 1.3 GB
EGAF50000158055 fastq.gz 960.8 MB
EGAF50000158056 fastq.gz 1.5 GB
EGAF50000158057 fastq.gz 1.2 GB
EGAF50000158058 fastq.gz 905.3 MB
EGAF50000158059 fastq.gz 1.2 GB
EGAF50000158060 fastq.gz 1.2 GB
EGAF50000158061 fastq.gz 1.7 GB
EGAF50000158062 fastq.gz 1.4 GB
EGAF50000158063 fastq.gz 1.6 GB
EGAF50000158064 fastq.gz 1.6 GB
EGAF50000158065 fastq.gz 1.2 GB
EGAF50000158066 fastq.gz 1.4 GB
EGAF50000158067 fastq.gz 1.2 GB
EGAF50000158068 fastq.gz 1.1 GB
EGAF50000158069 fastq.gz 1.3 GB
EGAF50000158070 fastq.gz 1.2 GB
EGAF50000158071 fastq.gz 1.1 GB
EGAF50000158072 fastq.gz 1.3 GB
EGAF50000158073 fastq.gz 1.2 GB
EGAF50000158074 fastq.gz 1.5 GB
EGAF50000158075 fastq.gz 1.1 GB
EGAF50000158076 fastq.gz 1.3 GB
EGAF50000158077 fastq.gz 1.1 GB
EGAF50000158078 fastq.gz 1.3 GB
EGAF50000158079 fastq.gz 1.4 GB
EGAF50000158080 fastq.gz 1.2 GB
EGAF50000158081 fastq.gz 1.2 GB
EGAF50000158082 fastq.gz 1.4 GB
EGAF50000158083 fastq.gz 1.5 GB
EGAF50000158084 fastq.gz 1.8 GB
EGAF50000158085 fastq.gz 1.2 GB
EGAF50000158086 fastq.gz 1.8 GB
EGAF50000158087 fastq.gz 1.6 GB
EGAF50000158088 fastq.gz 1.4 GB
EGAF50000158089 fastq.gz 1.7 GB
EGAF50000158090 fastq.gz 1.5 GB
EGAF50000158091 fastq.gz 1.8 GB
EGAF50000158092 fastq.gz 1.0 GB
EGAF50000158093 fastq.gz 1.2 GB
EGAF50000158094 fastq.gz 1.3 GB
EGAF50000158095 fastq.gz 1.2 GB
EGAF50000158096 fastq.gz 1.0 GB
EGAF50000158097 fastq.gz 1.6 GB
EGAF50000158098 fastq.gz 1.1 GB
EGAF50000158099 fastq.gz 939.0 MB
EGAF50000158100 fastq.gz 1.3 GB
EGAF50000158101 fastq.gz 1.6 GB
EGAF50000158102 fastq.gz 1.6 GB
EGAF50000158103 fastq.gz 1.3 GB
EGAF50000158104 fastq.gz 1.6 GB
EGAF50000158105 fastq.gz 1.2 GB
EGAF50000158106 fastq.gz 1.5 GB
EGAF50000158107 fastq.gz 1.4 GB
EGAF50000158108 fastq.gz 1.7 GB
EGAF50000158109 fastq.gz 1.3 GB
EGAF50000158110 fastq.gz 1.1 GB
EGAF50000158111 fastq.gz 1.2 GB
EGAF50000158112 fastq.gz 1.5 GB
EGAF50000158113 fastq.gz 1.4 GB
EGAF50000158114 fastq.gz 1.6 GB
EGAF50000158115 fastq.gz 1.7 GB
EGAF50000158116 fastq.gz 1.5 GB
EGAF50000158117 fastq.gz 1.8 GB
EGAF50000158118 fastq.gz 1.7 GB
EGAF50000158119 fastq.gz 1.2 GB
EGAF50000158120 fastq.gz 1.4 GB
EGAF50000158121 fastq.gz 1.3 GB
EGAF50000158122 fastq.gz 1.6 GB
EGAF50000158123 fastq.gz 3.2 GB
EGAF50000158124 fastq.gz 1.7 GB
EGAF50000158125 fastq.gz 1.8 GB
EGAF50000158126 fastq.gz 1.5 GB
EGAF50000158127 fastq.gz 279.8 MB
EGAF50000158128 fastq.gz 248.1 MB
EGAF50000158129 fastq.gz 1.8 GB
EGAF50000158130 fastq.gz 2.1 GB
EGAF50000158131 fastq.gz 1.7 GB
EGAF50000158132 fastq.gz 1.3 GB
EGAF50000158133 fastq.gz 1.2 GB
EGAF50000158134 fastq.gz 1.4 GB
EGAF50000158135 fastq.gz 2.8 GB
EGAF50000158136 fastq.gz 1.4 GB
EGAF50000158137 fastq.gz 1.3 GB
EGAF50000158138 fastq.gz 1.6 GB
EGAF50000158139 fastq.gz 1.3 GB
EGAF50000158140 fastq.gz 1.6 GB
EGAF50000158141 fastq.gz 1.9 GB
EGAF50000158142 fastq.gz 1.5 GB
EGAF50000158143 fastq.gz 1.2 GB
EGAF50000158144 fastq.gz 1.5 GB
EGAF50000158145 fastq.gz 1.3 GB
EGAF50000158146 fastq.gz 1.5 GB
EGAF50000158147 fastq.gz 956.7 MB
EGAF50000158148 fastq.gz 1.6 GB
EGAF50000158149 fastq.gz 1.4 GB
EGAF50000158150 fastq.gz 1.3 GB
EGAF50000158151 fastq.gz 1.6 GB
EGAF50000158152 fastq.gz 1.2 GB
EGAF50000158153 fastq.gz 1.6 GB
EGAF50000158154 fastq.gz 1.9 GB
EGAF50000158155 fastq.gz 1.7 GB
EGAF50000158156 fastq.gz 1.4 GB
EGAF50000158157 fastq.gz 1.4 GB
EGAF50000158158 fastq.gz 1.7 GB
EGAF50000158159 fastq.gz 1.1 GB
EGAF50000158160 fastq.gz 1.3 GB
EGAF50000158161 fastq.gz 1.7 GB
EGAF50000158162 fastq.gz 913.4 MB
EGAF50000158163 fastq.gz 1.7 GB
EGAF50000158164 fastq.gz 1.4 GB
EGAF50000158165 fastq.gz 1.3 GB
EGAF50000158166 fastq.gz 1.5 GB
EGAF50000158167 fastq.gz 1.1 GB
EGAF50000158168 fastq.gz 1.4 GB
EGAF50000158169 fastq.gz 1.4 GB
EGAF50000158170 fastq.gz 1.7 GB
EGAF50000158171 fastq.gz 1.3 GB
EGAF50000158172 fastq.gz 1.4 GB
EGAF50000158173 fastq.gz 1.6 GB
EGAF50000158174 fastq.gz 1.3 GB
EGAF50000158175 fastq.gz 1.5 GB
EGAF50000158176 fastq.gz 1.1 GB
EGAF50000158177 fastq.gz 1.3 GB
EGAF50000158178 fastq.gz 1.0 GB
EGAF50000158179 fastq.gz 1.2 GB
EGAF50000158180 fastq.gz 1.3 GB
EGAF50000158181 fastq.gz 1.5 GB
EGAF50000158182 fastq.gz 1.2 GB
EGAF50000158183 fastq.gz 1.5 GB
EGAF50000158184 fastq.gz 1.4 GB
EGAF50000158185 fastq.gz 1.1 GB
EGAF50000158186 fastq.gz 1.1 GB
EGAF50000158187 fastq.gz 1.3 GB
EGAF50000158188 fastq.gz 1.5 GB
EGAF50000158189 fastq.gz 1.3 GB
EGAF50000158190 fastq.gz 1.3 GB
EGAF50000158191 fastq.gz 1.5 GB
EGAF50000158192 fastq.gz 1.8 GB
EGAF50000158193 fastq.gz 1.3 GB
EGAF50000158194 fastq.gz 1.2 GB
EGAF50000158195 fastq.gz 972.8 MB
EGAF50000158196 fastq.gz 11.2 GB
EGAF50000158197 fastq.gz 1.5 GB
EGAF50000158198 fastq.gz 2.9 GB
EGAF50000158199 fastq.gz 920.6 MB
EGAF50000158200 fastq.gz 2.4 GB
EGAF50000158201 fastq.gz 2.0 GB
EGAF50000158202 fastq.gz 2.3 GB
EGAF50000158203 fastq.gz 1.8 GB
EGAF50000158204 fastq.gz 1.5 GB
EGAF50000158205 fastq.gz 2.3 GB
EGAF50000158206 fastq.gz 1.8 GB
EGAF50000158207 fastq.gz 1.1 GB
EGAF50000158210 fastq.gz 1.2 GB
EGAF50000158217 fastq.gz 1.7 GB
EGAF50000158218 fastq.gz 1.1 GB
EGAF50000158219 fastq.gz 1.3 GB
EGAF50000158220 fastq.gz 1.4 GB
EGAF50000158221 fastq.gz 1.1 GB
EGAF50000158222 fastq.gz 1.3 GB
EGAF50000158223 fastq.gz 1.2 GB
EGAF50000158224 fastq.gz 1.4 GB
EGAF50000158225 fastq.gz 1.4 GB
EGAF50000158226 fastq.gz 1.5 GB
EGAF50000158227 fastq.gz 1.3 GB
EGAF50000158228 fastq.gz 998.6 MB
EGAF50000158229 fastq.gz 1.1 GB
EGAF50000158230 fastq.gz 1.4 GB
EGAF50000158231 fastq.gz 1.2 GB
EGAF50000158232 fastq.gz 858.4 MB
EGAF50000158233 fastq.gz 1.0 GB
EGAF50000158234 fastq.gz 1.2 GB
EGAF50000158235 fastq.gz 1.4 GB
EGAF50000158236 fastq.gz 1.5 GB
EGAF50000158237 fastq.gz 1.4 GB
EGAF50000158238 fastq.gz 1.7 GB
EGAF50000158239 fastq.gz 1.0 GB
EGAF50000158240 fastq.gz 1.2 GB
EGAF50000158241 fastq.gz 1.4 GB
EGAF50000158242 fastq.gz 1.2 GB
EGAF50000158243 fastq.gz 3.0 GB
EGAF50000158247 fastq.gz 1.1 GB
EGAF50000158248 fastq.gz 1.3 GB
EGAF50000158249 fastq.gz 1.2 GB
EGAF50000158250 fastq.gz 1.3 GB
EGAF50000158251 fastq.gz 2.3 GB
EGAF50000158252 fastq.gz 1.2 GB
EGAF50000158253 fastq.gz 1.5 GB
EGAF50000158254 fastq.gz 1.4 GB
EGAF50000158255 fastq.gz 1.2 GB
EGAF50000158256 fastq.gz 1.4 GB
EGAF50000158257 fastq.gz 1.5 GB
EGAF50000158258 fastq.gz 2.0 GB
EGAF50000158259 fastq.gz 1.2 GB
EGAF50000158260 fastq.gz 1.4 GB
EGAF50000158261 fastq.gz 1.1 GB
EGAF50000158262 fastq.gz 1.5 GB
EGAF50000158263 fastq.gz 1.0 GB
EGAF50000158264 fastq.gz 1.4 GB
EGAF50000158265 fastq.gz 1.4 GB
EGAF50000158266 fastq.gz 1.2 GB
EGAF50000158267 fastq.gz 1.5 GB
EGAF50000158268 fastq.gz 1.3 GB
EGAF50000158269 fastq.gz 2.0 GB
EGAF50000158270 fastq.gz 1.6 GB
EGAF50000158271 fastq.gz 1.5 GB
EGAF50000158272 fastq.gz 1.2 GB
EGAF50000158273 fastq.gz 984.6 MB
EGAF50000158274 fastq.gz 1.3 GB
EGAF50000158275 fastq.gz 1.6 GB
EGAF50000158276 fastq.gz 1.2 GB
EGAF50000158277 fastq.gz 684.6 MB
EGAF50000158278 fastq.gz 1.3 GB
EGAF50000158279 fastq.gz 1.1 GB
EGAF50000158280 fastq.gz 1.2 GB
EGAF50000158281 fastq.gz 740.6 MB
EGAF50000158282 fastq.gz 5.2 GB
EGAF50000158283 fastq.gz 6.1 GB
EGAF50000158284 fastq.gz 813.6 MB
EGAF50000158285 fastq.gz 1.3 GB
EGAF50000158286 fastq.gz 1.1 GB
EGAF50000158287 fastq.gz 1.4 GB
EGAF50000158288 fastq.gz 1.6 GB
EGAF50000158289 fastq.gz 918.0 MB
EGAF50000158290 fastq.gz 1.6 GB
EGAF50000158291 fastq.gz 1.0 GB
EGAF50000158292 fastq.gz 1.3 GB
EGAF50000158295 fastq.gz 1.6 GB
EGAF50000158296 fastq.gz 1.9 GB
EGAF50000158297 fastq.gz 1.6 GB
EGAF50000158298 fastq.gz 1.7 GB
EGAF50000158299 fastq.gz 1.1 GB
EGAF50000158300 fastq.gz 1.3 GB
EGAF50000158301 fastq.gz 1.9 GB
EGAF50000158302 fastq.gz 1.9 GB
EGAF50000158303 fastq.gz 1.7 GB
EGAF50000158304 fastq.gz 3.5 GB
EGAF50000158305 fastq.gz 1.3 GB
EGAF50000158306 fastq.gz 1.6 GB
EGAF50000158307 fastq.gz 1.2 GB
EGAF50000158308 fastq.gz 1.4 GB
EGAF50000158309 fastq.gz 1.1 GB
EGAF50000158310 fastq.gz 13.3 GB
EGAF50000158313 fastq.gz 1.2 GB
EGAF50000158314 fastq.gz 1.5 GB
EGAF50000158315 fastq.gz 1.0 GB
EGAF50000158316 fastq.gz 1.3 GB
EGAF50000158317 fastq.gz 967.4 MB
EGAF50000158318 fastq.gz 1.6 GB
EGAF50000158319 fastq.gz 1.6 GB
EGAF50000158320 fastq.gz 1.3 GB
EGAF50000158321 fastq.gz 1.4 GB
EGAF50000158322 fastq.gz 1.2 GB
EGAF50000158323 fastq.gz 1.4 GB
EGAF50000158324 fastq.gz 1.1 GB
EGAF50000158325 fastq.gz 1.4 GB
EGAF50000158326 fastq.gz 1.9 GB
EGAF50000158327 fastq.gz 2.3 GB
EGAF50000158328 fastq.gz 1.3 GB
EGAF50000158330 fastq.gz 1.3 GB
EGAF50000158331 fastq.gz 1.1 GB
EGAF50000158332 fastq.gz 2.0 GB
EGAF50000158333 fastq.gz 2.4 GB
EGAF50000158335 fastq.gz 1.8 GB
EGAF50000158336 fastq.gz 2.0 GB
EGAF50000158337 fastq.gz 1.5 GB
EGAF50000158338 fastq.gz 1.2 GB
EGAF50000158339 fastq.gz 1.5 GB
EGAF50000158340 fastq.gz 1.8 GB
EGAF50000158341 fastq.gz 2.0 GB
EGAF50000158342 fastq.gz 1.3 GB
EGAF50000158344 fastq.gz 2.8 GB
EGAF50000158345 fastq.gz 1.6 GB
EGAF50000158346 fastq.gz 1.3 GB
EGAF50000158347 fastq.gz 1.8 GB
EGAF50000158348 fastq.gz 2.1 GB
EGAF50000158349 fastq.gz 1.3 GB
EGAF50000158350 fastq.gz 1.6 GB
EGAF50000158351 fastq.gz 1.6 GB
280 Files (431.4 GB)