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Plasma mutation profile of precursor lesions and colorectal cancer using the Oncomine Colon cfDNA Assay

Colorectal cancer (CRC) is the second leading cause of cancer death worldwide. Early detection of precursor lesions or early-stage cancer could hamper cancer development or improve survival rates. Liquid biopsy, which detects tumor biomarkers, such as mutations, in blood, is a promising avenue for cancer screening. To assess the presence of genetic variants in plasma cell-free tumor DNA from patients with precursor lesions and colorectal cancer using the commercial Oncomine Colon cfDNA Assay. Cell-free DNA (cfDNA) samples from the blood plasma of 52 Brazilian patients were analyzed. Eight patients did not have any significant lesions (five normal colonoscopies and three hyperplastic polyps), 24 exhibited precursor lesions (13 nonadvanced adenomas, ten advanced adenomas, and one sessile serrated lesion), and 20 patients with cancer (CRC). The mutation profile of 14 CRC-associated genes were determined by next-generation sequencing (NGS) using the Oncomine Colon cfDNA Assay in the Ion Torrent PGM/S5 sequencer.

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Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS50000000471 Cancer Genomics

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF50000158853 292.3 MB
EGAF50000158854 417.2 MB
EGAF50000158855 235.3 MB
EGAF50000158856 372.4 MB
EGAF50000158857 332.9 MB
EGAF50000158858 413.3 MB
EGAF50000158859 438.3 MB
EGAF50000158860 391.1 MB
EGAF50000158861 430.2 MB
EGAF50000158862 258.6 MB
EGAF50000158863 552.4 MB
EGAF50000158864 265.2 MB
EGAF50000158865 226.8 MB
EGAF50000158866 220.6 MB
EGAF50000158867 335.5 MB
EGAF50000158868 226.8 MB
EGAF50000158869 171.4 MB
EGAF50000158870 251.6 MB
EGAF50000158871 296.7 MB
EGAF50000158872 291.2 MB
EGAF50000158873 281.6 MB
EGAF50000158874 307.8 MB
EGAF50000158875 218.0 MB
EGAF50000158876 306.8 MB
EGAF50000158877 271.5 MB
EGAF50000158878 432.4 MB
EGAF50000158879 297.1 MB
EGAF50000158880 217.8 MB
EGAF50000158881 422.3 MB
EGAF50000158882 280.9 MB
EGAF50000158883 521.4 MB
EGAF50000158884 203.0 MB
EGAF50000158885 442.0 MB
EGAF50000158886 374.1 MB
EGAF50000158887 295.4 MB
EGAF50000158888 389.7 MB
EGAF50000158889 312.8 MB
EGAF50000158890 323.4 MB
EGAF50000158891 296.1 MB
EGAF50000158892 312.0 MB
EGAF50000158893 361.2 MB
EGAF50000158894 333.5 MB
EGAF50000158895 306.4 MB
EGAF50000158896 305.3 MB
EGAF50000158897 434.9 MB
EGAF50000158898 353.7 MB
EGAF50000158899 365.6 MB
EGAF50000158900 240.4 MB
EGAF50000158901 253.3 MB
EGAF50000158902 143.0 MB
EGAF50000158903 171.1 MB
EGAF50000158904 160.1 MB
52 Files (16.4 GB)