Plasma mutation profile of precursor lesions and colorectal cancer using the Oncomine Colon cfDNA Assay
Colorectal cancer (CRC) is the second leading cause of cancer death worldwide. Early detection of precursor lesions or early-stage cancer could hamper cancer development or improve survival rates. Liquid biopsy, which detects tumor biomarkers, such as mutations, in blood, is a promising avenue for cancer screening. To assess the presence of genetic variants in plasma cell-free tumor DNA from patients with precursor lesions and colorectal cancer using the commercial Oncomine Colon cfDNA Assay. Cell-free DNA (cfDNA) samples from the blood plasma of 52 Brazilian patients were analyzed. Eight patients did not have any significant lesions (five normal colonoscopies and three hyperplastic polyps), 24 exhibited precursor lesions (13 nonadvanced adenomas, ten advanced adenomas, and one sessile serrated lesion), and 20 patients with cancer (CRC). The mutation profile of 14 CRC-associated genes were determined by next-generation sequencing (NGS) using the Oncomine Colon cfDNA Assay in the Ion Torrent PGM/S5 sequencer.
- 16/08/2024
- 52 samples
- DAC: EGAC50000000013
- Technology: Ion Torrent S5
- NPUNCU DUO:0000018 (version: 2021-02-23)not for profit, non commercial use onlyThis data use modifier indicates that use of the data is limited to not-for-profit organizations and not-for-profit use, non-commercial use.
- COL DUO:0000020 (version: 2021-02-23)collaboration requiredThis data use modifier indicates that the requestor must agree to collaboration with the primary study investigator(s).
Barretos Cancer Hospital Policy
Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.
Study ID | Study Title | Study Type |
---|---|---|
EGAS50000000471 | Cancer Genomics |
This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.
ID | File Type | Size | Located in | |
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EGAF50000158853 | 292.3 MB | |||
EGAF50000158854 | 417.2 MB | |||
EGAF50000158855 | 235.3 MB | |||
EGAF50000158856 | 372.4 MB | |||
EGAF50000158857 | 332.9 MB | |||
EGAF50000158858 | 413.3 MB | |||
EGAF50000158859 | 438.3 MB | |||
EGAF50000158860 | 391.1 MB | |||
EGAF50000158861 | 430.2 MB | |||
EGAF50000158862 | 258.6 MB | |||
EGAF50000158863 | 552.4 MB | |||
EGAF50000158864 | 265.2 MB | |||
EGAF50000158865 | 226.8 MB | |||
EGAF50000158866 | 220.6 MB | |||
EGAF50000158867 | 335.5 MB | |||
EGAF50000158868 | 226.8 MB | |||
EGAF50000158869 | 171.4 MB | |||
EGAF50000158870 | 251.6 MB | |||
EGAF50000158871 | 296.7 MB | |||
EGAF50000158872 | 291.2 MB | |||
EGAF50000158873 | 281.6 MB | |||
EGAF50000158874 | 307.8 MB | |||
EGAF50000158875 | 218.0 MB | |||
EGAF50000158876 | 306.8 MB | |||
EGAF50000158877 | 271.5 MB | |||
EGAF50000158878 | 432.4 MB | |||
EGAF50000158879 | 297.1 MB | |||
EGAF50000158880 | 217.8 MB | |||
EGAF50000158881 | 422.3 MB | |||
EGAF50000158882 | 280.9 MB | |||
EGAF50000158883 | 521.4 MB | |||
EGAF50000158884 | 203.0 MB | |||
EGAF50000158885 | 442.0 MB | |||
EGAF50000158886 | 374.1 MB | |||
EGAF50000158887 | 295.4 MB | |||
EGAF50000158888 | 389.7 MB | |||
EGAF50000158889 | 312.8 MB | |||
EGAF50000158890 | 323.4 MB | |||
EGAF50000158891 | 296.1 MB | |||
EGAF50000158892 | 312.0 MB | |||
EGAF50000158893 | 361.2 MB | |||
EGAF50000158894 | 333.5 MB | |||
EGAF50000158895 | 306.4 MB | |||
EGAF50000158896 | 305.3 MB | |||
EGAF50000158897 | 434.9 MB | |||
EGAF50000158898 | 353.7 MB | |||
EGAF50000158899 | 365.6 MB | |||
EGAF50000158900 | 240.4 MB | |||
EGAF50000158901 | 253.3 MB | |||
EGAF50000158902 | 143.0 MB | |||
EGAF50000158903 | 171.1 MB | |||
EGAF50000158904 | 160.1 MB | |||
52 Files (16.4 GB) |