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RNA-Seq of human longitudinal whole blood samples from PCR-positive and PCR-negative recent household contacts of COVID-19 index cases.

Little is known about the transcriptomic profile of individuals who are exposed to SARS-CoV-2 yet resist becoming PCR positive. To investigate this, longitudinal whole-blood samples were taken (0, 7, 14, and 28 days after enrolment) from PCR positive and PCR negative SARS-CoV-2-naïve household contacts who were recently exposed to a COVID-19 index. Samples were also taken from pre- and post-pandemic unexposed controls. Total RNA was extracted from PAXgene tubes before undergoing poly(A) selection followed by globin and rRNA depletion. DNA libraries were constructed using the NEBNext® Ultra™ II Directional RNA Library Prep Kit for Illumina. All samples were then sequenced across 2 flowcells of an Illumina HiSeq 4000.

Request Access

Data is available upon reasonable request to the data access committee (Prof. Ajit Lalvani, Dr Joe Fenn and Mr Kieran Madon), Imperial College London).

Data is available upon reasonable request to the data access committee (Prof. Ajit Lalvani, Dr Joe Fenn and Mr Kieran Madon, Imperial College London). Investigators will be asked to provide a short summary of how they wish to use the data in their research prior to granting access.

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS50000000473 RNASeq

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF50000162653 fastq.gz 1.4 GB
EGAF50000162654 fastq.gz 530.8 MB
EGAF50000162655 fastq.gz 1.1 GB
EGAF50000162656 fastq.gz 1.2 GB
EGAF50000162657 fastq.gz 1.2 GB
EGAF50000162658 fastq.gz 1.3 GB
EGAF50000162659 fastq.gz 1.1 GB
EGAF50000162660 fastq.gz 1.1 GB
EGAF50000162661 fastq.gz 1.4 GB
EGAF50000162662 fastq.gz 1.4 GB
EGAF50000162663 fastq.gz 973.0 MB
EGAF50000162664 fastq.gz 1.0 GB
EGAF50000162665 fastq.gz 1.1 GB
EGAF50000162666 fastq.gz 1.1 GB
EGAF50000162667 fastq.gz 1.2 GB
EGAF50000162668 fastq.gz 1.3 GB
EGAF50000162669 fastq.gz 1.2 GB
EGAF50000162670 fastq.gz 1.3 GB
EGAF50000162671 fastq.gz 1.5 GB
EGAF50000162672 fastq.gz 1.7 GB
EGAF50000162673 fastq.gz 1.2 GB
EGAF50000162674 fastq.gz 1.3 GB
EGAF50000162675 fastq.gz 1.0 GB
EGAF50000162676 fastq.gz 1.1 GB
EGAF50000162677 fastq.gz 1.3 GB
EGAF50000162678 fastq.gz 1.4 GB
EGAF50000162679 fastq.gz 2.3 GB
EGAF50000162680 fastq.gz 2.0 GB
EGAF50000162681 fastq.gz 1.1 GB
EGAF50000162682 fastq.gz 1.2 GB
EGAF50000162683 fastq.gz 1.2 GB
EGAF50000162684 fastq.gz 1.3 GB
EGAF50000162685 fastq.gz 1.2 GB
EGAF50000162686 fastq.gz 1.3 GB
EGAF50000162687 fastq.gz 1.6 GB
EGAF50000162688 fastq.gz 1.7 GB
EGAF50000162689 fastq.gz 1.2 GB
EGAF50000162690 fastq.gz 1.3 GB
EGAF50000162691 fastq.gz 2.8 GB
EGAF50000162692 fastq.gz 1.3 GB
EGAF50000162693 fastq.gz 2.9 GB
EGAF50000162694 fastq.gz 1.1 GB
EGAF50000162695 fastq.gz 1.4 GB
EGAF50000162696 fastq.gz 1.2 GB
EGAF50000162697 fastq.gz 1.7 GB
EGAF50000162698 fastq.gz 1.8 GB
EGAF50000162699 fastq.gz 1.5 GB
EGAF50000162700 fastq.gz 1.5 GB
EGAF50000162701 fastq.gz 1.3 GB
EGAF50000162702 fastq.gz 1.4 GB
EGAF50000162703 fastq.gz 1.6 GB
EGAF50000162704 fastq.gz 1.6 GB
EGAF50000162705 fastq.gz 1.2 GB
EGAF50000162706 fastq.gz 1.2 GB
EGAF50000162707 fastq.gz 1.4 GB
EGAF50000162708 fastq.gz 1.4 GB
EGAF50000162709 fastq.gz 1.1 GB
EGAF50000162710 fastq.gz 1.8 GB
EGAF50000162711 fastq.gz 1.2 GB
EGAF50000162712 fastq.gz 1.2 GB
EGAF50000162713 fastq.gz 1.3 GB
EGAF50000162714 fastq.gz 1.3 GB
EGAF50000162715 fastq.gz 1.4 GB
EGAF50000162716 fastq.gz 1.3 GB
EGAF50000162717 fastq.gz 1.3 GB
EGAF50000162718 fastq.gz 1.1 GB
EGAF50000162719 fastq.gz 1.1 GB
EGAF50000162720 fastq.gz 1.3 GB
EGAF50000162721 fastq.gz 1.3 GB
EGAF50000162722 fastq.gz 1.2 GB
EGAF50000162723 fastq.gz 1.3 GB
EGAF50000162724 fastq.gz 1.1 GB
EGAF50000162725 fastq.gz 1.0 GB
EGAF50000162726 fastq.gz 1.2 GB
EGAF50000162727 fastq.gz 917.2 MB
EGAF50000162728 fastq.gz 1.0 GB
EGAF50000162729 fastq.gz 961.6 MB
EGAF50000162730 fastq.gz 1.5 GB
EGAF50000162731 fastq.gz 1.6 GB
EGAF50000162732 fastq.gz 1.3 GB
EGAF50000162733 fastq.gz 1.3 GB
EGAF50000162734 fastq.gz 1.2 GB
EGAF50000162735 fastq.gz 1.3 GB
EGAF50000162736 fastq.gz 1.2 GB
EGAF50000162737 fastq.gz 1.3 GB
EGAF50000162738 fastq.gz 1.5 GB
EGAF50000162739 fastq.gz 1.6 GB
EGAF50000162740 fastq.gz 1.4 GB
EGAF50000162741 fastq.gz 1.0 GB
EGAF50000162742 fastq.gz 1.5 GB
EGAF50000162743 fastq.gz 1.1 GB
EGAF50000162744 fastq.gz 1.3 GB
EGAF50000162745 fastq.gz 1.4 GB
EGAF50000162746 fastq.gz 1.5 GB
EGAF50000162747 fastq.gz 1.6 GB
EGAF50000162748 fastq.gz 1.3 GB
EGAF50000162749 fastq.gz 1.4 GB
EGAF50000162750 fastq.gz 1.3 GB
EGAF50000162751 fastq.gz 1.2 GB
EGAF50000162752 fastq.gz 1.4 GB
EGAF50000162753 fastq.gz 1.1 GB
EGAF50000162754 fastq.gz 1.2 GB
EGAF50000162755 fastq.gz 918.9 MB
EGAF50000162756 fastq.gz 1.1 GB
EGAF50000162757 fastq.gz 955.4 MB
EGAF50000162758 fastq.gz 1.5 GB
EGAF50000162759 fastq.gz 1.5 GB
EGAF50000162760 fastq.gz 1.8 GB
EGAF50000162761 fastq.gz 1.9 GB
EGAF50000162762 fastq.gz 1.4 GB
EGAF50000162763 fastq.gz 1.5 GB
EGAF50000162764 fastq.gz 1.2 GB
EGAF50000162765 fastq.gz 1.3 GB
EGAF50000162766 fastq.gz 1.3 GB
EGAF50000162767 fastq.gz 1.4 GB
EGAF50000162768 fastq.gz 1.3 GB
EGAF50000162769 fastq.gz 1.4 GB
EGAF50000162770 fastq.gz 1.3 GB
EGAF50000162771 fastq.gz 1.4 GB
EGAF50000162772 fastq.gz 1.6 GB
EGAF50000162773 fastq.gz 1.7 GB
EGAF50000162774 fastq.gz 1.3 GB
EGAF50000162775 fastq.gz 1.4 GB
EGAF50000162776 fastq.gz 1.1 GB
EGAF50000162777 fastq.gz 1.2 GB
EGAF50000162778 fastq.gz 1.3 GB
EGAF50000162779 fastq.gz 1.4 GB
EGAF50000162780 fastq.gz 1.2 GB
EGAF50000162781 fastq.gz 1.2 GB
EGAF50000162782 fastq.gz 1.1 GB
EGAF50000162783 fastq.gz 1.1 GB
EGAF50000162784 fastq.gz 1.2 GB
EGAF50000162785 fastq.gz 1.1 GB
EGAF50000162786 fastq.gz 1.3 GB
EGAF50000162787 fastq.gz 1.1 GB
EGAF50000162788 fastq.gz 1.6 GB
EGAF50000162789 fastq.gz 1.7 GB
EGAF50000162790 fastq.gz 1.3 GB
EGAF50000162791 fastq.gz 1.4 GB
EGAF50000162792 fastq.gz 1.1 GB
EGAF50000162793 fastq.gz 1.2 GB
EGAF50000162794 fastq.gz 1.3 GB
EGAF50000162795 fastq.gz 1.4 GB
EGAF50000162796 fastq.gz 1.4 GB
EGAF50000162797 fastq.gz 1.5 GB
EGAF50000162798 fastq.gz 1.3 GB
EGAF50000162799 fastq.gz 1.3 GB
EGAF50000162800 fastq.gz 1.4 GB
EGAF50000162801 fastq.gz 1.5 GB
EGAF50000162802 fastq.gz 1.4 GB
EGAF50000162803 fastq.gz 1.5 GB
EGAF50000162804 fastq.gz 1.3 GB
EGAF50000162805 fastq.gz 1.3 GB
EGAF50000162806 fastq.gz 1.4 GB
EGAF50000162807 fastq.gz 1.5 GB
EGAF50000162808 fastq.gz 1.3 GB
EGAF50000162809 fastq.gz 1.4 GB
EGAF50000162810 fastq.gz 1.2 GB
EGAF50000162811 fastq.gz 1.3 GB
EGAF50000162812 fastq.gz 1.3 GB
EGAF50000162813 fastq.gz 1.4 GB
EGAF50000162814 fastq.gz 1.3 GB
EGAF50000162815 fastq.gz 1.4 GB
EGAF50000162816 fastq.gz 1.2 GB
EGAF50000162817 fastq.gz 1.3 GB
EGAF50000162818 fastq.gz 1.7 GB
EGAF50000162819 fastq.gz 1.0 GB
EGAF50000162820 fastq.gz 1.7 GB
EGAF50000162821 fastq.gz 1.1 GB
EGAF50000162822 fastq.gz 1.2 GB
EGAF50000162823 fastq.gz 1.3 GB
EGAF50000162824 fastq.gz 1.4 GB
EGAF50000162825 fastq.gz 1.5 GB
EGAF50000162826 fastq.gz 1.4 GB
EGAF50000162827 fastq.gz 1.5 GB
EGAF50000162828 fastq.gz 1.3 GB
EGAF50000162829 fastq.gz 1.4 GB
EGAF50000162830 fastq.gz 1.1 GB
EGAF50000162831 fastq.gz 1.2 GB
EGAF50000162832 fastq.gz 1.1 GB
EGAF50000162833 fastq.gz 1.1 GB
EGAF50000162834 fastq.gz 1.1 GB
EGAF50000162835 fastq.gz 1.2 GB
EGAF50000162836 fastq.gz 1.0 GB
EGAF50000162837 fastq.gz 1.1 GB
EGAF50000162838 fastq.gz 1.2 GB
EGAF50000162839 fastq.gz 1.3 GB
EGAF50000162840 fastq.gz 1.1 GB
EGAF50000162841 fastq.gz 1.2 GB
EGAF50000162842 fastq.gz 1.3 GB
EGAF50000162843 fastq.gz 1.3 GB
EGAF50000162844 fastq.gz 1.1 GB
EGAF50000162845 fastq.gz 1.2 GB
EGAF50000162846 fastq.gz 1.0 GB
EGAF50000162847 fastq.gz 1.1 GB
EGAF50000162848 fastq.gz 1.3 GB
EGAF50000162849 fastq.gz 977.3 MB
EGAF50000162850 fastq.gz 1.3 GB
EGAF50000162851 fastq.gz 1.1 GB
EGAF50000162852 fastq.gz 1.4 GB
EGAF50000162853 fastq.gz 1.5 GB
EGAF50000162854 fastq.gz 1.3 GB
EGAF50000162855 fastq.gz 1.1 GB
EGAF50000162856 fastq.gz 1.4 GB
EGAF50000162857 fastq.gz 1.2 GB
EGAF50000162858 fastq.gz 1.3 GB
EGAF50000162859 fastq.gz 1.4 GB
EGAF50000162860 fastq.gz 1.2 GB
EGAF50000162861 fastq.gz 1.1 GB
EGAF50000162862 fastq.gz 1.2 GB
EGAF50000162863 fastq.gz 1.2 GB
EGAF50000162864 fastq.gz 1.1 GB
EGAF50000162865 fastq.gz 1.2 GB
EGAF50000162866 fastq.gz 1.2 GB
EGAF50000162867 fastq.gz 1.3 GB
EGAF50000162868 fastq.gz 1.0 GB
EGAF50000162869 fastq.gz 1.1 GB
EGAF50000162870 fastq.gz 1.3 GB
EGAF50000162871 fastq.gz 1.4 GB
EGAF50000162872 fastq.gz 1.3 GB
EGAF50000162873 fastq.gz 1.0 GB
EGAF50000162874 fastq.gz 1.2 GB
EGAF50000162875 fastq.gz 1.0 GB
EGAF50000162876 fastq.gz 1.1 GB
EGAF50000162877 fastq.gz 1.1 GB
EGAF50000162878 fastq.gz 1.2 GB
EGAF50000162879 fastq.gz 1.2 GB
EGAF50000162880 fastq.gz 1.3 GB
EGAF50000162881 fastq.gz 1.3 GB
EGAF50000162882 fastq.gz 1.4 GB
EGAF50000162883 fastq.gz 953.5 MB
EGAF50000162884 fastq.gz 1.5 GB
EGAF50000162885 fastq.gz 1.0 GB
EGAF50000162886 fastq.gz 1.1 GB
EGAF50000162887 fastq.gz 1.2 GB
EGAF50000162888 fastq.gz 1.3 GB
EGAF50000162889 fastq.gz 1.3 GB
EGAF50000162890 fastq.gz 1.4 GB
EGAF50000162891 fastq.gz 1.4 GB
EGAF50000162892 fastq.gz 1.2 GB
EGAF50000162893 fastq.gz 1.3 GB
EGAF50000162894 fastq.gz 1.1 GB
EGAF50000162895 fastq.gz 1.2 GB
EGAF50000162896 fastq.gz 1.6 GB
EGAF50000162897 fastq.gz 1.1 GB
EGAF50000162898 fastq.gz 1.7 GB
EGAF50000162899 fastq.gz 1.2 GB
EGAF50000162900 fastq.gz 2.0 GB
EGAF50000162901 fastq.gz 2.1 GB
EGAF50000162902 fastq.gz 1.4 GB
EGAF50000162903 fastq.gz 1.5 GB
EGAF50000162904 fastq.gz 1.1 GB
EGAF50000162905 fastq.gz 1.1 GB
EGAF50000162906 fastq.gz 1.2 GB
EGAF50000162907 fastq.gz 1.1 GB
EGAF50000162908 fastq.gz 1.1 GB
EGAF50000162909 fastq.gz 1.2 GB
EGAF50000162910 fastq.gz 1.2 GB
EGAF50000162911 fastq.gz 1.3 GB
EGAF50000162912 fastq.gz 1.3 GB
EGAF50000162913 fastq.gz 1.4 GB
EGAF50000162914 fastq.gz 1.7 GB
EGAF50000162915 fastq.gz 1.3 GB
EGAF50000162916 fastq.gz 1.7 GB
EGAF50000162917 fastq.gz 1.4 GB
EGAF50000162918 fastq.gz 1.7 GB
EGAF50000162919 fastq.gz 1.8 GB
EGAF50000162920 fastq.gz 1.2 GB
EGAF50000162921 fastq.gz 1.2 GB
EGAF50000162922 fastq.gz 940.0 MB
EGAF50000162923 fastq.gz 970.9 MB
EGAF50000162924 fastq.gz 1.3 GB
EGAF50000162925 fastq.gz 1.3 GB
EGAF50000162926 fastq.gz 1.2 GB
EGAF50000162927 fastq.gz 1.2 GB
EGAF50000162928 fastq.gz 1.3 GB
EGAF50000162929 fastq.gz 1.4 GB
EGAF50000162930 fastq.gz 1.2 GB
EGAF50000162931 fastq.gz 1.3 GB
EGAF50000162932 fastq.gz 924.5 MB
EGAF50000162933 fastq.gz 965.5 MB
EGAF50000162934 fastq.gz 1.6 GB
EGAF50000162935 fastq.gz 1.7 GB
EGAF50000162936 fastq.gz 1.5 GB
EGAF50000162937 fastq.gz 1.6 GB
EGAF50000162938 fastq.gz 1.3 GB
EGAF50000162939 fastq.gz 1.4 GB
EGAF50000162940 fastq.gz 1.9 GB
EGAF50000162941 csv 18.7 MB
289 Files (378.6 GB)