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Fecal microbiome of T2D patients undergoing semaglutide or empagliflozin treatment

The gut microbiome has been shown to be affected by the use of many human-targeted medications, and the interaction can be bidirectional. This has been clearly demonstrated for type 2 diabetes medications that have been in clinical use for several decades. However, the bidirectional effects of novel type 2 diabetes drugs semaglutide, empagliflozin, and the gut microbiome have yet to be clearly described. We investigated the effect of semaglutide and empagliflozin initiation on the gut microbiome of type 2 diabetes patients. In addition, we analyzed whether the pre-treatment gut microbiome can predict the treatment efficacy. Twenty subjects (10 women and 10 men) were enrolled in the study between November 2019 and January 2023 from the University of Tartu Hospital, Tartu, Estonia. All participants had been diagnosed with type 2 diabetes. The study group taking semaglutide included 6 women and 4 men, and the group prescribed empagliflozin included 4 women and 6 men. Gut microbiome fecal samples donated at four timepoints (Baseline, Month 1, Month 3; Month 12) were studied using 16S ribosomal RNA gene sequencing and analysis.

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Pseudonymised data and/or biological samples are issued for the purpose of research by the Institute of Genomics of the University of Tartu (hereinafter referred to as the Estonian Biobank). This is based on the Human Genes Research Act (https://www.riigiteataja.ee/en/eli/531102013003/consolide). The Estonian Biobank issues the following data: - descriptions of state of health and lifestyle (phenotype data) - genetic data

1. Preliminary request 2. Request to the Estonian Committee on Bioethics and Human Research 3. Request to the Estonian Biobank 4. Contract for issuing data and/or biological samples 5. Issuing of data and/or biological samples

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS50000000531 Metagenomics

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00008545192 fastq.gz 11.1 MB
EGAF00008545193 fastq.gz 12.1 MB
EGAF00008545194 fastq.gz 12.5 MB
EGAF00008545195 fastq.gz 14.1 MB
EGAF00008545196 fastq.gz 13.0 MB
EGAF00008545197 fastq.gz 14.9 MB
EGAF00008545198 fastq.gz 11.5 MB
EGAF00008545199 fastq.gz 12.9 MB
EGAF00008545200 fastq.gz 17.7 MB
EGAF00008545201 fastq.gz 21.9 MB
EGAF00008545202 fastq.gz 18.2 MB
EGAF00008545203 fastq.gz 20.9 MB
EGAF00008545204 fastq.gz 16.7 MB
EGAF00008545205 fastq.gz 17.6 MB
EGAF00008545206 fastq.gz 16.1 MB
EGAF00008545207 fastq.gz 16.6 MB
EGAF00008545208 fastq.gz 16.5 MB
EGAF00008545209 fastq.gz 18.9 MB
EGAF00008545210 fastq.gz 17.8 MB
EGAF00008545211 fastq.gz 19.9 MB
EGAF00008545212 fastq.gz 17.0 MB
EGAF00008545213 fastq.gz 19.4 MB
EGAF00008545214 fastq.gz 16.4 MB
EGAF00008545215 fastq.gz 19.4 MB
EGAF00008545216 fastq.gz 17.6 MB
EGAF00008545217 fastq.gz 20.1 MB
EGAF00008545218 fastq.gz 17.1 MB
EGAF00008545219 fastq.gz 17.2 MB
EGAF00008545220 fastq.gz 19.2 MB
EGAF00008545221 fastq.gz 18.7 MB
EGAF00008545222 fastq.gz 23.7 MB
EGAF00008545223 fastq.gz 28.0 MB
EGAF00008545224 fastq.gz 16.2 MB
EGAF00008545225 fastq.gz 18.4 MB
EGAF00008545228 fastq.gz 18.6 MB
EGAF00008545229 fastq.gz 30.3 MB
EGAF00008545230 fastq.gz 16.9 MB
EGAF00008545231 fastq.gz 19.0 MB
EGAF00008545232 fastq.gz 27.8 MB
EGAF00008545233 fastq.gz 31.3 MB
EGAF00008545234 fastq.gz 21.1 MB
EGAF00008545235 fastq.gz 23.8 MB
EGAF00008545236 fastq.gz 20.6 MB
EGAF00008545237 fastq.gz 23.3 MB
EGAF00008545238 fastq.gz 18.7 MB
EGAF00008545239 fastq.gz 21.5 MB
EGAF00008545240 fastq.gz 28.7 MB
EGAF00008545241 fastq.gz 33.7 MB
EGAF00008545242 fastq.gz 17.9 MB
EGAF00008545243 fastq.gz 18.0 MB
EGAF00008545244 fastq.gz 17.9 MB
EGAF00008545245 fastq.gz 24.5 MB
EGAF00008545246 fastq.gz 17.9 MB
EGAF00008545247 fastq.gz 18.9 MB
EGAF00008545248 fastq.gz 24.1 MB
EGAF00008545249 fastq.gz 27.9 MB
EGAF00008545250 fastq.gz 26.1 MB
EGAF00008545251 fastq.gz 29.1 MB
EGAF00008545252 fastq.gz 26.0 MB
EGAF00008545253 fastq.gz 30.0 MB
EGAF00008545254 fastq.gz 28.9 MB
EGAF00008545255 fastq.gz 33.6 MB
EGAF00008545256 fastq.gz 29.1 MB
EGAF00008545257 fastq.gz 33.9 MB
EGAF00008545258 fastq.gz 31.6 MB
EGAF00008545259 fastq.gz 38.2 MB
EGAF00008545260 fastq.gz 18.8 MB
EGAF00008545261 fastq.gz 20.9 MB
EGAF00008545262 fastq.gz 35.1 MB
EGAF00008545263 fastq.gz 39.5 MB
EGAF00008545264 fastq.gz 29.3 MB
EGAF00008545265 fastq.gz 32.3 MB
EGAF00008545266 fastq.gz 10.3 MB
EGAF00008545267 fastq.gz 11.2 MB
EGAF00008545268 fastq.gz 14.2 MB
EGAF00008545269 fastq.gz 16.5 MB
EGAF00008545270 fastq.gz 10.7 MB
EGAF00008545271 fastq.gz 11.3 MB
EGAF00008545272 fastq.gz 12.0 MB
EGAF00008545273 fastq.gz 13.8 MB
EGAF00008545274 fastq.gz 31.7 MB
EGAF00008545275 fastq.gz 36.8 MB
EGAF00008545276 fastq.gz 24.1 MB
EGAF00008545277 fastq.gz 27.5 MB
EGAF00008545278 fastq.gz 41.2 MB
EGAF00008545279 fastq.gz 47.2 MB
EGAF00008545280 fastq.gz 30.5 MB
EGAF00008545281 fastq.gz 34.0 MB
EGAF00008545282 fastq.gz 27.8 MB
EGAF00008545283 fastq.gz 33.1 MB
EGAF00008545284 fastq.gz 27.1 MB
EGAF00008545285 fastq.gz 30.9 MB
EGAF00008545286 fastq.gz 31.4 MB
EGAF00008545287 fastq.gz 33.3 MB
EGAF00008545288 fastq.gz 27.5 MB
EGAF00008545289 fastq.gz 30.2 MB
EGAF00008545290 fastq.gz 28.1 MB
EGAF00008545291 fastq.gz 32.6 MB
EGAF00008545292 fastq.gz 33.1 MB
EGAF00008545293 fastq.gz 37.6 MB
EGAF00008545294 fastq.gz 25.0 MB
EGAF00008545295 fastq.gz 28.5 MB
EGAF00008545296 fastq.gz 34.9 MB
EGAF00008545297 fastq.gz 39.9 MB
EGAF00008545298 fastq.gz 27.2 MB
EGAF00008545299 fastq.gz 33.2 MB
EGAF00008545302 fastq.gz 3.1 kB
EGAF00008545303 fastq.gz 3.2 kB
EGAF00008545304 fastq.gz 10.5 MB
EGAF00008545305 fastq.gz 11.9 MB
EGAF00008545306 fastq.gz 12.5 MB
EGAF00008545307 fastq.gz 13.4 MB
EGAF00008545308 fastq.gz 50.4 MB
EGAF00008545309 fastq.gz 59.1 MB
EGAF00008545310 fastq.gz 28.4 kB
EGAF00008545311 fastq.gz 30.8 kB
EGAF00008545312 fastq.gz 10.9 MB
EGAF00008545313 fastq.gz 12.0 MB
EGAF00008545314 fastq.gz 11.5 MB
EGAF00008545315 fastq.gz 12.0 MB
EGAF00008545316 fastq.gz 10.0 MB
EGAF00008545317 fastq.gz 11.5 MB
EGAF00008545318 fastq.gz 11.0 MB
EGAF00008545319 fastq.gz 12.0 MB
EGAF00008545320 fastq.gz 11.8 MB
EGAF00008545321 fastq.gz 13.8 MB
EGAF00008545322 fastq.gz 12.0 MB
EGAF00008545323 fastq.gz 13.5 MB
EGAF00008545324 fastq.gz 10.6 MB
EGAF00008545325 fastq.gz 12.3 MB
EGAF00008545326 fastq.gz 12.1 MB
EGAF00008545327 fastq.gz 13.9 MB
EGAF00008545328 fastq.gz 12.0 MB
EGAF00008545329 fastq.gz 13.9 MB
EGAF00008545330 fastq.gz 10.6 MB
EGAF00008545331 fastq.gz 12.3 MB
EGAF00008545332 fastq.gz 17.6 MB
EGAF00008545333 fastq.gz 20.8 MB
EGAF00008545334 fastq.gz 15.9 MB
EGAF00008545335 fastq.gz 19.0 MB
EGAF00008545336 fastq.gz 18.8 MB
EGAF00008545337 fastq.gz 22.4 MB
EGAF00008545338 fastq.gz 17.8 MB
EGAF00008545339 fastq.gz 21.0 MB
EGAF00008545340 fastq.gz 19.5 MB
EGAF00008545341 fastq.gz 21.9 MB
EGAF00008545342 fastq.gz 19.4 MB
EGAF00008545343 fastq.gz 19.1 MB
EGAF00008545344 fastq.gz 17.1 MB
EGAF00008545345 fastq.gz 17.7 MB
EGAF00008545346 fastq.gz 10.9 MB
EGAF00008545347 fastq.gz 12.5 MB
EGAF00008545348 fastq.gz 11.3 MB
EGAF00008545349 fastq.gz 12.0 MB
154 Files (3.2 GB)