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As the EGA is co-managed by the EMBL-EBI and CRG, files could be located in the UK and/or Spain, as indicated by their respective flags.

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Fecal microbiome of T2D patients undergoing semaglutide or empagliflozin treatment

The gut microbiome has been shown to be affected by the use of many human-targeted medications, and the interaction can be bidirectional. This has been clearly demonstrated for type 2 diabetes medications that have been in clinical use for several decades. However, the bidirectional effects of novel type 2 diabetes drugs semaglutide, empagliflozin, and the gut microbiome have yet to be clearly described. We investigated the effect of semaglutide and empagliflozin initiation on the gut microbiome of type 2 diabetes patients. In addition, we analyzed whether the pre-treatment gut microbiome can predict the treatment efficacy. Twenty subjects (10 women and 10 men) were enrolled in the study between November 2019 and January 2023 from the University of Tartu Hospital, Tartu, Estonia. All participants had been diagnosed with type 2 diabetes. The study group taking semaglutide included 6 women and 4 men, and the group prescribed empagliflozin included 4 women and 6 men. Gut microbiome fecal samples donated at four timepoints (Baseline, Month 1, Month 3; Month 12) were studied using 16S ribosomal RNA gene sequencing and analysis.

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DUO:0000026
version: 2019-01-07

user specific restriction

This data use modifier indicates that use is limited to use by approved users.

DUO:0000027
version: 2019-01-07

project specific restriction

This data use modifier indicates that use is limited to use within an approved project.

DUO:0000042
version: 2019-01-07

general research use

This data use permission indicates that use is allowed for general research use for any research purpose.

Pseudonymised data and/or biological samples are issued for the purpose of research by the Institute of Genomics of the University of Tartu (hereinafter referred to as the Estonian Biobank). This is based on the Human Genes Research Act (https://www.riigiteataja.ee/en/eli/531102013003/consolide). The Estonian Biobank issues the following data: - descriptions of state of health and lifestyle (phenotype data) - genetic data

1. Preliminary request 2. Request to the Estonian Committee on Bioethics and Human Research 3. Request to the Estonian Biobank 4. Contract for issuing data and/or biological samples 5. Issuing of data and/or biological samples

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS50000000531 Metagenomics

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Quality Report
Located in
i
EGAF00008545192 fastq.gz 11.1 MB Report
EGAF00008545193 fastq.gz 12.1 MB Report
EGAF00008545194 fastq.gz 12.5 MB Report
EGAF00008545195 fastq.gz 14.1 MB Report
EGAF00008545196 fastq.gz 13.0 MB Report
EGAF00008545197 fastq.gz 14.9 MB Report
EGAF00008545198 fastq.gz 11.5 MB Report
EGAF00008545199 fastq.gz 12.9 MB Report
EGAF00008545200 fastq.gz 17.7 MB Report
EGAF00008545201 fastq.gz 21.9 MB Report
EGAF00008545202 fastq.gz 18.2 MB Report
EGAF00008545203 fastq.gz 20.9 MB Report
EGAF00008545204 fastq.gz 16.7 MB Report
EGAF00008545205 fastq.gz 17.6 MB Report
EGAF00008545206 fastq.gz 16.1 MB Report
EGAF00008545207 fastq.gz 16.6 MB Report
EGAF00008545208 fastq.gz 16.5 MB Report
EGAF00008545209 fastq.gz 18.9 MB Report
EGAF00008545210 fastq.gz 17.8 MB Report
EGAF00008545211 fastq.gz 19.9 MB Report
EGAF00008545212 fastq.gz 17.0 MB Report
EGAF00008545213 fastq.gz 19.4 MB Report
EGAF00008545214 fastq.gz 16.4 MB Report
EGAF00008545215 fastq.gz 19.4 MB Report
EGAF00008545216 fastq.gz 17.6 MB Report
EGAF00008545217 fastq.gz 20.1 MB Report
EGAF00008545218 fastq.gz 17.1 MB Report
EGAF00008545219 fastq.gz 17.2 MB Report
EGAF00008545220 fastq.gz 19.2 MB Report
EGAF00008545221 fastq.gz 18.7 MB Report
EGAF00008545222 fastq.gz 23.7 MB Report
EGAF00008545223 fastq.gz 28.0 MB Report
EGAF00008545224 fastq.gz 16.2 MB Report
EGAF00008545225 fastq.gz 18.4 MB Report
EGAF00008545228 fastq.gz 18.6 MB Report
EGAF00008545229 fastq.gz 30.3 MB Report
EGAF00008545230 fastq.gz 16.9 MB Report
EGAF00008545231 fastq.gz 19.0 MB Report
EGAF00008545232 fastq.gz 27.8 MB Report
EGAF00008545233 fastq.gz 31.3 MB Report
EGAF00008545234 fastq.gz 21.1 MB Report
EGAF00008545235 fastq.gz 23.8 MB Report
EGAF00008545236 fastq.gz 20.6 MB Report
EGAF00008545237 fastq.gz 23.3 MB Report
EGAF00008545238 fastq.gz 18.7 MB Report
EGAF00008545239 fastq.gz 21.5 MB Report
EGAF00008545240 fastq.gz 28.7 MB Report
EGAF00008545241 fastq.gz 33.7 MB Report
EGAF00008545242 fastq.gz 17.9 MB Report
EGAF00008545243 fastq.gz 18.0 MB Report
EGAF00008545244 fastq.gz 17.9 MB Report
EGAF00008545245 fastq.gz 24.5 MB Report
EGAF00008545246 fastq.gz 17.9 MB Report
EGAF00008545247 fastq.gz 18.9 MB Report
EGAF00008545248 fastq.gz 24.1 MB Report
EGAF00008545249 fastq.gz 27.9 MB Report
EGAF00008545250 fastq.gz 26.1 MB Report
EGAF00008545251 fastq.gz 29.1 MB Report
EGAF00008545252 fastq.gz 26.0 MB Report
EGAF00008545253 fastq.gz 30.0 MB Report
EGAF00008545254 fastq.gz 28.9 MB Report
EGAF00008545255 fastq.gz 33.6 MB Report
EGAF00008545256 fastq.gz 29.1 MB Report
EGAF00008545257 fastq.gz 33.9 MB Report
EGAF00008545258 fastq.gz 31.6 MB Report
EGAF00008545259 fastq.gz 38.2 MB Report
EGAF00008545260 fastq.gz 18.8 MB Report
EGAF00008545261 fastq.gz 20.9 MB Report
EGAF00008545262 fastq.gz 35.1 MB Report
EGAF00008545263 fastq.gz 39.5 MB Report
EGAF00008545264 fastq.gz 29.3 MB Report
EGAF00008545265 fastq.gz 32.3 MB Report
EGAF00008545266 fastq.gz 10.3 MB Report
EGAF00008545267 fastq.gz 11.2 MB Report
EGAF00008545268 fastq.gz 14.2 MB Report
EGAF00008545269 fastq.gz 16.5 MB Report
EGAF00008545270 fastq.gz 10.7 MB Report
EGAF00008545271 fastq.gz 11.3 MB Report
EGAF00008545272 fastq.gz 12.0 MB Report
EGAF00008545273 fastq.gz 13.8 MB Report
EGAF00008545274 fastq.gz 31.7 MB Report
EGAF00008545275 fastq.gz 36.8 MB Report
EGAF00008545276 fastq.gz 24.1 MB Report
EGAF00008545277 fastq.gz 27.5 MB Report
EGAF00008545278 fastq.gz 41.2 MB Report
EGAF00008545279 fastq.gz 47.2 MB Report
EGAF00008545280 fastq.gz 30.5 MB Report
EGAF00008545281 fastq.gz 34.0 MB Report
EGAF00008545282 fastq.gz 27.8 MB Report
EGAF00008545283 fastq.gz 33.1 MB Report
EGAF00008545284 fastq.gz 27.1 MB Report
EGAF00008545285 fastq.gz 30.9 MB Report
EGAF00008545286 fastq.gz 31.4 MB Report
EGAF00008545287 fastq.gz 33.3 MB Report
EGAF00008545288 fastq.gz 27.5 MB Report
EGAF00008545289 fastq.gz 30.2 MB Report
EGAF00008545290 fastq.gz 28.1 MB Report
EGAF00008545291 fastq.gz 32.6 MB Report
EGAF00008545292 fastq.gz 33.1 MB Report
EGAF00008545293 fastq.gz 37.6 MB Report
EGAF00008545294 fastq.gz 25.0 MB Report
EGAF00008545295 fastq.gz 28.5 MB Report
EGAF00008545296 fastq.gz 34.9 MB Report
EGAF00008545297 fastq.gz 39.9 MB Report
EGAF00008545298 fastq.gz 27.2 MB Report
EGAF00008545299 fastq.gz 33.2 MB Report
EGAF00008545302 fastq.gz 3.1 kB Report
EGAF00008545303 fastq.gz 3.2 kB Report
EGAF00008545304 fastq.gz 10.5 MB Report
EGAF00008545305 fastq.gz 11.9 MB Report
EGAF00008545306 fastq.gz 12.5 MB Report
EGAF00008545307 fastq.gz 13.4 MB Report
EGAF00008545308 fastq.gz 50.4 MB Report
EGAF00008545309 fastq.gz 59.1 MB Report
EGAF00008545310 fastq.gz 28.4 kB Report
EGAF00008545311 fastq.gz 30.8 kB Report
EGAF00008545312 fastq.gz 10.9 MB Report
EGAF00008545313 fastq.gz 12.0 MB Report
EGAF00008545314 fastq.gz 11.5 MB Report
EGAF00008545315 fastq.gz 12.0 MB Report
EGAF00008545316 fastq.gz 10.0 MB Report
EGAF00008545317 fastq.gz 11.5 MB Report
EGAF00008545318 fastq.gz 11.0 MB Report
EGAF00008545319 fastq.gz 12.0 MB Report
EGAF00008545320 fastq.gz 11.8 MB Report
EGAF00008545321 fastq.gz 13.8 MB Report
EGAF00008545322 fastq.gz 12.0 MB Report
EGAF00008545323 fastq.gz 13.5 MB Report
EGAF00008545324 fastq.gz 10.6 MB Report
EGAF00008545325 fastq.gz 12.3 MB Report
EGAF00008545326 fastq.gz 12.1 MB Report
EGAF00008545327 fastq.gz 13.9 MB Report
EGAF00008545328 fastq.gz 12.0 MB Report
EGAF00008545329 fastq.gz 13.9 MB Report
EGAF00008545330 fastq.gz 10.6 MB Report
EGAF00008545331 fastq.gz 12.3 MB Report
EGAF00008545332 fastq.gz 17.6 MB Report
EGAF00008545333 fastq.gz 20.8 MB Report
EGAF00008545334 fastq.gz 15.9 MB Report
EGAF00008545335 fastq.gz 19.0 MB Report
EGAF00008545336 fastq.gz 18.8 MB Report
EGAF00008545337 fastq.gz 22.4 MB Report
EGAF00008545338 fastq.gz 17.8 MB Report
EGAF00008545339 fastq.gz 21.0 MB Report
EGAF00008545340 fastq.gz 19.5 MB Report
EGAF00008545341 fastq.gz 21.9 MB Report
EGAF00008545342 fastq.gz 19.4 MB Report
EGAF00008545343 fastq.gz 19.1 MB Report
EGAF00008545344 fastq.gz 17.1 MB Report
EGAF00008545345 fastq.gz 17.7 MB Report
EGAF00008545346 fastq.gz 10.9 MB Report
EGAF00008545347 fastq.gz 12.5 MB Report
EGAF00008545348 fastq.gz 11.3 MB Report
EGAF00008545349 fastq.gz 12.0 MB Report
154 Files (3.2 GB)