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ICARUS-BREAST01 Dataset

A phase II clinical trial (NCT04965766) of patritumab deruxtecan in 99 breast cancer patients. Whole-exome sequencing (WES) is available for 43 tumor samples and 43 blood samples collected at entry into the trial. RNA-squencing is available for 44 samples comprising 22 samples collected at entry into the trial and 22 samples collected during treatment (cycle 1 day 3, cycle 1 day 19, or cycle 2 day 3) from 22 patients.

Request Access

Policy of ICARUS BREAST01

DATA ACCESS AGREEMENT These terms and conditions govern access to the managed access datasets (details of which are set out in Appendix I) to which the User Institution has requested access. The User Institution agrees to be bound by these terms and conditions. Definitions Authorized Personnel: The individuals at the User Institution to whom the Data Access Committee grants access to the Data. This includes the User, the individuals listed in Appendix II and any other individuals for whom the User Institution subsequently requests access to the Data. Details of the initial Authorized Personnel are set out in Appendix II. Data: The managed access datasets to which the User Institution has requested access. Data Producers: The individuals, listed in Appendix I, responsible for the development, organization, and oversight of these Data. External Collaborator: A collaborator of the User, working for an institution other than the User Institution. Project: The project for which the User Institution has requested access to these Data. A description of the Project is set out in Appendix II. Publications: Includes, without limitation, articles published in print journals, electronic journals, reviews, books, posters and other written and verbal presentations of research. Research Participant: An individual whose data form part of these Data. Research Purposes: Shall mean research that is seeking to advance the understanding of genetics and genomics, including the treatment of disorders, and work on statistical methods that may be applied to such research. User: The principal investigator for the Project. User Institution(s): The Institution(s) that has requested access to the Data (detailed in Appendix II). Data Producers Institution(s): The Institution(s) that has produced the Data (detailed in Appendix I). Data Access Committee: The committee responsible for authorizing access to the data. Committee members are listed in Appendix I. 1. The User Institution agrees to only use these Data for the purpose of the Project (described in Appendix II) and only for Research Purposes. The User Institution further agrees that it will only use these Data for Research Purposes which are within the limitations (if any) set out in Appendix I. 2. The User Institution agrees to preserve, at all times, the confidentiality of these Data. In particular, it undertakes not to use, or attempt to use these Data to compromise or otherwise infringe the confidentiality of information on Research Participants. Without prejudice to the generality of the foregoing, the User Institution agrees to use at least the measures set out in Appendix I to protect these Data. 3. The User Institution agrees to protect the confidentiality of Research Participants in any research papers or publications that they prepare by taking all reasonable care to limit the possibility of identification. 4. The User Institution agrees not to link or combine these Data to other information or archived data available in a way that could re-identify the Research Participants, even if access to that data has been formally granted to the User Institution or is freely available without restriction. 5. The User Institution agrees only to transfer or disclose these Data, in whole or part, or any material derived from these Data, to the Authorized Personnel. Should the User Institution wish to share these Data with an External Collaborator, the External Collaborator must complete a separate application for access to these Data. 6. The User Institution agrees that the Data Producers, and all other parties involved in the creation, funding or protection of these Data: a) make no warranty or representation, express or implied as to the accuracy, quality or comprehensiveness of these Data; b) exclude to the fullest extent permitted by law all liability for actions, claims, proceedings, demands, losses (including but not limited to loss of profit), costs, awards damages and payments made by the Recipient that may arise (whether directly or indirectly) in any way whatsoever from the Recipient’s use of these Data or from the unavailability of, or break in access to, these Data for whatever reason and; c) bear no responsibility for the further analysis or interpretation of these Data. 7. The User Institution agrees to follow the Fort Lauderdale Guidelines (https://www.sanger.ac.uk/wp-content/uploads/fortlauderdalereport.pdf) and the Toronto Statement (http://www.nature.com/nature/journal/v461/n7261/full/461168a.html). This includes but is not limited to recognizing the contribution of the Data Producers and including a proper acknowledgment in all reports or publications resulting from the use of these Data. 8. The User Institution agrees to follow the Publication Policy in Appendix III. This includes respecting the moratorium period for the Data Producers to publish the first peer-reviewed report describing and analyzing these Data. 9. The User Institution agrees not to make intellectual property claims on these Data and not to use intellectual property protection in ways that would prevent or block access to, or use of, any element of these Data, or conclusion drawn directly from these Data. 10. The User Institution can elect to perform further research that would add intellectual and resource capital to these data and decide to obtain intellectual property rights on these downstream discoveries. In this case, the User Institution agrees to implement licensing policies that will not obstruct further research and to follow the U.S. National Institutes of Health Best Practices for the Licensing of Genomic Inventions (2005) (https://www.ott.nih.gov/sites/default/files/documents/pdfs/70fr18413.pdf) in conformity with the Organization for Economic Co-operation and Development Guidelines for the Licensing of the Genetic Inventions (2006) (https://www.oecd.org/sti/emerging-tech/36198812.pdf). 11. The User Institution agrees to destroy/discard the Data held, once it is no longer used for the Project, unless obliged to retain the data for archival purposes in conformity with audit or legal requirements. 12. The User Institution will notify the Data Access Committee within 30 days of any changes or departures of Authorized Personnel. 13. The User Institution will notify the Data Access Committee prior to any significant changes to the protocol for the Project. 14. The User Institution will notify the Data Access Committee as soon as it becomes aware of a breach of the terms or conditions of this agreement. 15. The Data Access Committee may terminate this agreement by written notice to the User Institution. If this agreement terminates for any reason, the User Institution will be required to destroy any Data held, including copies and backup copies. This clause does not prevent the User Institution from retaining these data for archival purpose in conformity with audit or legal requirements. 16. The User Institution accepts that it may be necessary for the Data Producers to alter the terms of this agreement from time to time. In the event that changes are required, the Data Producers or their appointed agent will contact the User Institution to inform it of the changes and the User Institution may elect to accept the changes or terminate the agreement. 17. If requested, the User Institution will allow data security and management documentation to be inspected to verify that it is complying with the terms of this agreement. 18. The User Institution agrees to distribute a copy of these terms to the Authorized Personnel. The User Institution will procure that the Authorized Personnel comply with the terms of this agreement. 19.This agreement (and any dispute, controversy, proceedings or claim of whatever nature arising out of this agreement or its formation) shall be construed, interpreted and governed by the laws of France and shall be subject to the exclusive jurisdiction of the France courts. Agreed for User Institution (Name, Title, Date, Signature): Principal Investigator (Name, Title, Date, Signature): I confirm that I have read and understood this Agreement. Agreed for the Data Access Committee (Name, Title, Date, Signature): APPENDIX I – DATASET DETAILS & DATA ACCESS COMMITTEE APPENDIX II – PROJECT DETAILS APPENDIX III – PUBLICATION POLICY APPENDIX I – DATASET DETAILS & DATA ACCESS COMMITTEE Dataset reference (EGA Study ID, Dataset Accession Numbers and Dataset Details): Name of the project that created the dataset : ICARUS BREAST01 Data Producers Institution(s): Gustave Roussy, 114, rue Edouard Vaillant – 94805 VILLEJUIF Cedex, FRANCE Names of other data producers/collaborators (Name, Email, Job Title): Specific limitations on areas of research: File access: Data can be held in unencrypted files on an institutional compute system, with Unix user group read/write access for one or more appropriate groups but not Unix world read/write access behind a secure firewall. Laptops holding these data should have password protected logins and screenlocks (set to lock after 5 min of inactivity). If held on USB keys or other portable hard drives, the data must be encrypted. Name of the Data Access Committee: Data Access Committee Members (Name, Email, Job Title): Principal Investigator Maria Fernanda Mosele (Mariafernanda.MOSELE@gustaveroussy.fr) Barbara Pistilli (Barbara.PISTILLI@gustaveroussy.fr) Fabrice Andre (FABRICE.ANDRE@gustaveroussy.fr) Head of Bioinformatics platform Marc Deloger (Marc.DELOGER@gustaveroussy.fr) Bio-informatician Yoann Pradat (Yoann.PRADAT@gustaveroussy.fr) Data Manager Alicia Tran Dien (Alicia.TRAN-DIEN@gustaveroussy.fr) Data Protection Officer Clara BECHET (Clara.BECHET@gustaveroussy.fr) APPENDIX II – PROJECT DETAILS (to be completed by the Requestor) Details of dataset requested i.e., EGA Study and Dataset Accession Number: Brief abstract of the Project in which the Data will be used (500 words max): User Institution(s): All Individuals who the User Institution to be named as registered users (Name, Email, Job Title, Supervisor): All Individuals that should have an account created at the EGA (Name, Email, Job Title): APPENDIX III – PUBLICATION POLICY The Data Access Committee anticipates that the dataset could be useful to other qualified researchers for a variety of purposes. However, some areas of work are subject to a publication moratorium. The publication moratorium covers any publications (including oral communications) that describe the use of the dataset. For research papers, submission for publication should not occur until the Data Access Committee have published their own global analysis or twelve (12) months after these data were first made available on the relevant hosting database, unless the Data Access Committee has provided written consent to earlier submission. In any publications based on these data, please describe how the data can be accessed, including the name of the hosting database (e.g., The European Genome-phenome Archive at the European Bioinformatics Institute) and its accession numbers (e.g., EGAS00000000029), and acknowledge its use in a form agreed by the User Institution with the Data Access Committee.

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS50000000542 Exome Sequencing
EGAS50000000543 RNASeq

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF50000179696 fastq.gz 818.7 MB
EGAF50000179697 fastq.gz 763.2 MB
EGAF50000179698 fastq.gz 5.5 GB
EGAF50000179699 fastq.gz 5.6 GB
EGAF50000179700 fastq.gz 6.4 GB
EGAF50000179701 fastq.gz 6.4 GB
EGAF50000179702 fastq.gz 3.9 GB
EGAF50000179703 fastq.gz 3.9 GB
EGAF50000179704 fastq.gz 10.2 GB
EGAF50000179705 fastq.gz 10.1 GB
EGAF50000179706 fastq.gz 2.3 GB
EGAF50000179707 fastq.gz 2.2 GB
EGAF50000179708 fastq.gz 1.1 GB
EGAF50000179709 fastq.gz 1.1 GB
EGAF50000179710 fastq.gz 3.5 GB
EGAF50000179711 fastq.gz 3.6 GB
EGAF50000179712 fastq.gz 5.4 GB
EGAF50000179713 fastq.gz 5.4 GB
EGAF50000179714 fastq.gz 1.9 GB
EGAF50000179715 fastq.gz 1.9 GB
EGAF50000179716 fastq.gz 4.1 GB
EGAF50000179717 fastq.gz 4.1 GB
EGAF50000179718 fastq.gz 4.8 GB
EGAF50000179719 fastq.gz 4.7 GB
EGAF50000179720 fastq.gz 4.6 GB
EGAF50000179721 fastq.gz 4.5 GB
EGAF50000179722 fastq.gz 5.2 GB
EGAF50000179723 fastq.gz 5.1 GB
EGAF50000179724 fastq.gz 2.7 GB
EGAF50000179725 fastq.gz 2.8 GB
EGAF50000179726 fastq.gz 2.5 GB
EGAF50000179727 fastq.gz 2.5 GB
EGAF50000179728 fastq.gz 3.0 GB
EGAF50000179729 fastq.gz 3.1 GB
EGAF50000179730 fastq.gz 3.3 GB
EGAF50000179731 fastq.gz 3.4 GB
EGAF50000179732 fastq.gz 8.5 GB
EGAF50000179733 fastq.gz 8.3 GB
EGAF50000179734 fastq.gz 4.0 GB
EGAF50000179735 fastq.gz 4.1 GB
EGAF50000179736 fastq.gz 5.9 GB
EGAF50000179737 fastq.gz 6.1 GB
EGAF50000179738 fastq.gz 1.4 GB
EGAF50000179739 fastq.gz 1.4 GB
EGAF50000179740 fastq.gz 866.3 MB
EGAF50000179741 fastq.gz 894.9 MB
EGAF50000179742 fastq.gz 4.6 GB
EGAF50000179743 fastq.gz 4.7 GB
EGAF50000179744 fastq.gz 2.0 GB
EGAF50000179745 fastq.gz 2.0 GB
EGAF50000179746 fastq.gz 4.9 GB
EGAF50000179747 fastq.gz 4.9 GB
EGAF50000179748 fastq.gz 20.2 GB
EGAF50000179749 fastq.gz 20.5 GB
EGAF50000179750 fastq.gz 4.1 GB
EGAF50000179751 fastq.gz 4.2 GB
EGAF50000179752 fastq.gz 4.0 GB
EGAF50000179753 fastq.gz 3.9 GB
EGAF50000179754 fastq.gz 4.7 GB
EGAF50000179755 fastq.gz 4.7 GB
EGAF50000179756 fastq.gz 10.8 GB
EGAF50000179757 fastq.gz 10.7 GB
EGAF50000179758 fastq.gz 4.4 GB
EGAF50000179759 fastq.gz 4.4 GB
EGAF50000179760 fastq.gz 4.5 GB
EGAF50000179761 fastq.gz 4.4 GB
EGAF50000179762 fastq.gz 4.9 GB
EGAF50000179763 fastq.gz 4.9 GB
EGAF50000179764 fastq.gz 4.3 GB
EGAF50000179765 fastq.gz 4.4 GB
EGAF50000179766 fastq.gz 1.9 GB
EGAF50000179767 fastq.gz 1.9 GB
EGAF50000179768 fastq.gz 6.8 GB
EGAF50000179769 fastq.gz 7.0 GB
EGAF50000179770 fastq.gz 2.9 GB
EGAF50000179771 fastq.gz 3.0 GB
EGAF50000179772 fastq.gz 2.0 GB
EGAF50000179773 fastq.gz 1.9 GB
EGAF50000179774 fastq.gz 5.7 GB
EGAF50000179775 fastq.gz 5.7 GB
EGAF50000179776 fastq.gz 9.5 GB
EGAF50000179777 fastq.gz 9.7 GB
EGAF50000179778 fastq.gz 4.3 GB
EGAF50000179779 fastq.gz 4.4 GB
EGAF50000179780 fastq.gz 6.2 GB
EGAF50000179781 fastq.gz 6.1 GB
EGAF50000179782 fastq.gz 9.3 GB
EGAF50000179783 fastq.gz 9.2 GB
EGAF50000179784 fastq.gz 1.8 GB
EGAF50000179785 fastq.gz 1.8 GB
EGAF50000179786 fastq.gz 3.8 GB
EGAF50000179787 fastq.gz 3.9 GB
EGAF50000179788 fastq.gz 4.3 GB
EGAF50000179789 fastq.gz 4.2 GB
EGAF50000179790 fastq.gz 3.1 GB
EGAF50000179791 fastq.gz 3.0 GB
EGAF50000179792 fastq.gz 5.8 GB
EGAF50000179793 fastq.gz 5.8 GB
EGAF50000179794 fastq.gz 30.6 GB
EGAF50000179795 fastq.gz 31.3 GB
EGAF50000179796 fastq.gz 4.7 GB
EGAF50000179797 fastq.gz 4.8 GB
EGAF50000179798 fastq.gz 4.7 GB
EGAF50000179799 fastq.gz 4.8 GB
EGAF50000179800 fastq.gz 3.7 GB
EGAF50000179801 fastq.gz 3.6 GB
EGAF50000179802 fastq.gz 3.7 GB
EGAF50000179803 fastq.gz 3.8 GB
EGAF50000179804 fastq.gz 1.6 GB
EGAF50000179805 fastq.gz 1.6 GB
EGAF50000179806 fastq.gz 5.0 GB
EGAF50000179807 fastq.gz 5.0 GB
EGAF50000179808 fastq.gz 11.1 GB
EGAF50000179809 fastq.gz 11.3 GB
EGAF50000179810 fastq.gz 3.5 GB
EGAF50000179811 fastq.gz 3.5 GB
EGAF50000179812 fastq.gz 4.3 GB
EGAF50000179813 fastq.gz 4.3 GB
EGAF50000179814 fastq.gz 16.6 GB
EGAF50000179815 fastq.gz 16.4 GB
EGAF50000179816 fastq.gz 5.1 GB
EGAF50000179817 fastq.gz 5.2 GB
EGAF50000179818 fastq.gz 2.6 GB
EGAF50000179819 fastq.gz 2.7 GB
EGAF50000179820 fastq.gz 4.2 GB
EGAF50000179821 fastq.gz 4.3 GB
EGAF50000179822 fastq.gz 4.2 GB
EGAF50000179823 fastq.gz 4.2 GB
EGAF50000179824 fastq.gz 40.4 GB
EGAF50000179825 fastq.gz 41.2 GB
EGAF50000179826 fastq.gz 5.1 GB
EGAF50000179827 fastq.gz 5.2 GB
EGAF50000179828 fastq.gz 2.0 GB
EGAF50000179829 fastq.gz 1.9 GB
EGAF50000179830 fastq.gz 3.9 GB
EGAF50000179831 fastq.gz 3.9 GB
EGAF50000179832 fastq.gz 22.3 GB
EGAF50000179833 fastq.gz 22.4 GB
EGAF50000179834 fastq.gz 3.7 GB
EGAF50000179835 fastq.gz 3.8 GB
EGAF50000179836 fastq.gz 4.8 GB
EGAF50000179837 fastq.gz 4.8 GB
EGAF50000179838 fastq.gz 2.8 GB
EGAF50000179839 fastq.gz 2.9 GB
EGAF50000179840 fastq.gz 4.5 GB
EGAF50000179841 fastq.gz 4.5 GB
EGAF50000179842 fastq.gz 4.5 GB
EGAF50000179843 fastq.gz 4.5 GB
EGAF50000179844 fastq.gz 6.3 GB
EGAF50000179845 fastq.gz 6.4 GB
EGAF50000179846 fastq.gz 4.7 GB
EGAF50000179847 fastq.gz 4.8 GB
EGAF50000179848 fastq.gz 2.5 GB
EGAF50000179849 fastq.gz 2.5 GB
EGAF50000179850 fastq.gz 4.2 GB
EGAF50000179851 fastq.gz 4.2 GB
EGAF50000179852 fastq.gz 8.6 GB
EGAF50000179853 fastq.gz 8.8 GB
EGAF50000179854 fastq.gz 6.4 GB
EGAF50000179855 fastq.gz 6.5 GB
EGAF50000179856 fastq.gz 3.9 GB
EGAF50000179857 fastq.gz 3.8 GB
EGAF50000179858 fastq.gz 5.2 GB
EGAF50000179859 fastq.gz 5.2 GB
EGAF50000179860 fastq.gz 4.8 GB
EGAF50000179861 fastq.gz 5.0 GB
EGAF50000179862 fastq.gz 2.1 GB
EGAF50000179863 fastq.gz 2.1 GB
EGAF50000179864 fastq.gz 3.3 GB
EGAF50000179865 fastq.gz 3.4 GB
EGAF50000179866 fastq.gz 2.8 GB
EGAF50000179867 fastq.gz 2.8 GB
EGAF50000179868 fastq.gz 7.2 GB
EGAF50000179869 fastq.gz 7.1 GB
EGAF50000179870 fastq.gz 5.8 GB
EGAF50000179871 fastq.gz 5.7 GB
EGAF50000179872 fastq.gz 3.3 GB
EGAF50000179873 fastq.gz 3.3 GB
EGAF50000179874 fastq.gz 4.6 GB
EGAF50000179875 fastq.gz 4.7 GB
EGAF50000179876 fastq.gz 1.8 GB
EGAF50000179877 fastq.gz 1.8 GB
EGAF50000179878 fastq.gz 4.5 GB
EGAF50000179879 fastq.gz 4.5 GB
EGAF50000179880 fastq.gz 2.0 GB
EGAF50000179881 fastq.gz 2.0 GB
EGAF50000179882 fastq.gz 4.7 GB
EGAF50000179883 fastq.gz 4.7 GB
EGAF50000179884 fastq.gz 4.8 GB
EGAF50000179885 fastq.gz 5.1 GB
EGAF50000179886 fastq.gz 4.7 GB
EGAF50000179887 fastq.gz 4.6 GB
EGAF50000179888 fastq.gz 11.5 GB
EGAF50000179889 fastq.gz 11.4 GB
EGAF50000179890 fastq.gz 10.7 GB
EGAF50000179891 fastq.gz 10.8 GB
EGAF50000179892 fastq.gz 3.1 GB
EGAF50000179893 fastq.gz 3.1 GB
EGAF50000179894 fastq.gz 4.2 GB
EGAF50000179895 fastq.gz 4.1 GB
EGAF50000179896 fastq.gz 186.0 MB
EGAF50000179897 fastq.gz 188.3 MB
EGAF50000179898 fastq.gz 493.7 MB
EGAF50000179899 fastq.gz 516.1 MB
EGAF50000179900 fastq.gz 2.3 GB
EGAF50000179901 fastq.gz 2.3 GB
EGAF50000179902 fastq.gz 3.5 GB
EGAF50000179903 fastq.gz 3.5 GB
EGAF50000179904 fastq.gz 3.7 GB
EGAF50000179905 fastq.gz 3.7 GB
EGAF50000179906 fastq.gz 1.4 GB
EGAF50000179907 fastq.gz 1.4 GB
EGAF50000179908 fastq.gz 6.4 GB
EGAF50000179909 fastq.gz 6.4 GB
EGAF50000179910 fastq.gz 1.4 GB
EGAF50000179911 fastq.gz 1.4 GB
EGAF50000179912 fastq.gz 3.8 GB
EGAF50000179913 fastq.gz 3.8 GB
EGAF50000179914 fastq.gz 5.6 GB
EGAF50000179915 fastq.gz 5.6 GB
EGAF50000179916 fastq.gz 2.8 GB
EGAF50000179917 fastq.gz 2.8 GB
EGAF50000179918 fastq.gz 3.4 GB
EGAF50000179919 fastq.gz 3.4 GB
EGAF50000179920 fastq.gz 5.4 GB
EGAF50000179921 fastq.gz 5.4 GB
EGAF50000179922 fastq.gz 412.2 MB
EGAF50000179923 fastq.gz 449.7 MB
EGAF50000179924 fastq.gz 1.5 GB
EGAF50000179925 fastq.gz 1.5 GB
EGAF50000179926 fastq.gz 4.0 GB
EGAF50000179927 fastq.gz 4.0 GB
EGAF50000179928 fastq.gz 1.3 GB
EGAF50000179929 fastq.gz 1.3 GB
EGAF50000179930 fastq.gz 1.9 GB
EGAF50000179931 fastq.gz 1.9 GB
EGAF50000179932 fastq.gz 4.3 GB
EGAF50000179933 fastq.gz 4.3 GB
EGAF50000179934 fastq.gz 6.6 GB
EGAF50000179935 fastq.gz 6.6 GB
EGAF50000179936 fastq.gz 7.5 GB
EGAF50000179937 fastq.gz 7.6 GB
EGAF50000179938 fastq.gz 2.8 GB
EGAF50000179939 fastq.gz 2.8 GB
EGAF50000179940 fastq.gz 1.2 GB
EGAF50000179941 fastq.gz 1.3 GB
EGAF50000179942 fastq.gz 1.7 GB
EGAF50000179943 fastq.gz 1.8 GB
EGAF50000179944 fastq.gz 1.5 GB
EGAF50000179945 fastq.gz 1.5 GB
EGAF50000179946 fastq.gz 2.1 GB
EGAF50000179947 fastq.gz 2.1 GB
EGAF50000179948 fastq.gz 3.5 GB
EGAF50000179949 fastq.gz 3.5 GB
EGAF50000179950 fastq.gz 1.5 GB
EGAF50000179951 fastq.gz 1.5 GB
EGAF50000179952 fastq.gz 1.1 GB
EGAF50000179953 fastq.gz 1.1 GB
EGAF50000179954 fastq.gz 2.9 GB
EGAF50000179955 fastq.gz 2.9 GB
260 Files (1.3 TB)