Whole genome sequencing of pancreatic cystic fluid for early detection and diagnosis of pancreatic cancer
Pancreatic cancer (PC) is a leading cause of cancer-related deaths globally. Accurate PC detection at early or premalignant stage, when surgery is effective, would increase survival rates and prevent unnecessary surgery or surveillance. Molecular diagnostic attempts using PCy fluid (PCyF), as a liquid biopsy, to analyze common mutations associated with PC development are yet to contribute to early diagnosis. Whole genome sequencing (WGS) is utilized in various cancers, PC inclusive, for detecting genetic changes associated with carcinogenesis, but not in PCyF due to technical limitations, including isolated DNA purity. The goal of the study was to achieve high quality of WGS from PCyF from 9 patients to enable development of signatures of malignancy. The WGS was performed using Illumina sequencing. Experimental design was at a 50x depth.
- 28/10/2024
- 9 samples
- DAC: EGAC50000000402
- Technology: Illumina NovaSeq 6000
WGS of PCyF for early detection and diagnosis of pancreatic cancer
This dataset contains whole genome sequencing data from pancreatic cystic fluid samples from nine patients pancreatic cancer generated as part of the TEM-PAC and DIA-PAC project
Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.
| Study ID | Study Title | Study Type |
|---|---|---|
| EGAS50000000611 | Whole Genome Sequencing |
This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.
| ID | File Type | Size | Located in | |
|---|---|---|---|---|
| EGAF50000200560 | txt | 320 Bytes | ||
| EGAF50000200561 | fq.gz | 34.0 GB | ||
| EGAF50000200562 | fq.gz | 35.3 GB | ||
| EGAF50000200563 | fq.gz | 44.0 GB | ||
| EGAF50000200564 | txt | 322 Bytes | ||
| EGAF50000200565 | fq.gz | 44.9 GB | ||
| EGAF50000200566 | txt | 322 Bytes | ||
| EGAF50000200567 | fq.gz | 47.3 GB | ||
| EGAF50000200568 | fq.gz | 48.6 GB | ||
| EGAF50000200569 | fq.gz | 41.6 GB | ||
| EGAF50000200570 | txt | 322 Bytes | ||
| EGAF50000200571 | fq.gz | 42.8 GB | ||
| EGAF50000200572 | fq.gz | 31.0 GB | ||
| EGAF50000200573 | fq.gz | 32.5 GB | ||
| EGAF50000200574 | txt | 492 Bytes | ||
| EGAF50000200575 | fq.gz | 28.7 GB | ||
| EGAF50000200576 | fq.gz | 30.1 GB | ||
| EGAF50000200577 | txt | 492 Bytes | ||
| EGAF50000200578 | fq.gz | 43.6 GB | ||
| EGAF50000200579 | txt | 322 Bytes | ||
| EGAF50000200580 | fq.gz | 3.5 GB | ||
| EGAF50000200581 | fq.gz | 45.4 GB | ||
| EGAF50000200582 | fq.gz | 3.9 GB | ||
| EGAF50000200583 | txt | 832 Bytes | ||
| EGAF50000200584 | fq.gz | 2.4 GB | ||
| EGAF50000200585 | fq.gz | 2.6 GB | ||
| EGAF50000200586 | txt | 1.0 kB | ||
| 27 Files (562.3 GB) | ||||