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Oncogenic FOXL2C134W has gain-of-function chromatin remodeling activity that reprograms glucocorticoid receptor occupancy to promote ovarian granulosa cell tumor growth

This dataset contains bam files from the whole exome sequencing performed on granulosa cell tumors and 7 sequencing experiments performed on human-derived KGN granulosa cell tumor cells and isogenic cell lines. The latter include transcription factor ChIP-seq for Foxl2 as well as transcription factor ChIP-seq for Foxl2 and GR under dexamethasone treatment and untreated conditions, two ATAC-seq data sets, two RNA-seq data sets, and Histone marks ChIP-seq.

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Department of Genomic Medicine Data Access Agreement

DATA ACCESS AGREEMENT This Data Access Agreement (“Agreement”), effective as of the ____ day of _________________, 20__ (“Effective Date”), is by and between The University of Texas M. D. Anderson Cancer Center, an institution of The University of Texas System and an agency of the State of Texas, with an address at 1515 Holcombe Boulevard, Houston, Texas 77030 (“Provider”), and ________________________________ (“Recipient”) on behalf of its investigator _______ (“Recipient Investigator”) (collectively, the “Parties”; each, a “Party”). RECITALS Provider maintains the following de-identified data in the European Genome-phenome Archive (EGA) managed by the European Bioinformatics Institute ________________ (“Data”), and Provider is willing to allow Recipient to access such Data from the EGA for the internal noncommercial research purposes of _______________ (“Purpose”), pursuant to the terms of this Agreement. In consideration of the mutual promises and covenants herein, and for other good and valuable consideration, the receipt and sufficiency of which is hereby acknowledged, the Parties agree as follows: 1. The Data will be used solely for the Research by Recipient Investigator at Recipient, and may not be transferred to any other investigator or to any third party without prior written permission from Provider. The Material may not be used for any purpose other than the Research, including without limitation for any commercial purpose or for research in human subjects (including, without limitation, in diagnostic testing). 2. Neither Recipient nor Recipient Investigator shall disclose Data to any person or party other than the Recipient Investigator hereunder without Provider’s prior written consent. 3. The Data will be used in compliance with all applicable laws, regulations, and guidelines applicable to the Data, including without limitation any applicable export controls. 4. In any publication resulting from use of the Data, Recipient and Recipient Investigator shall acknowledge Department of Genomic Medicine (“Provider Investigator”) and Provider as the provider of the Data. 5. This Agreement shall be effective as of the Effective Date and shall remain effective until completion of the Research. Either Party may terminate this Agreement with or without cause upon thirty (30) days’ written notice to the other Party. Upon expiration or termination of this Agreement for any reason, Recipient shall destroy all Data received pursuant to this Agreement. 6. Any notice permitted or required as provided for herein shall be in writing and to the contact and address as noted below or as may be provided by either party to the other in writing from time to time. Notice to Provider shall be to: Chief Legal Officer The University of Texas M. D. Anderson Cancer Center 7007 Bertner Ave., 1MC11.3433, Suite 1674 Houston, Texas 77030 Phone: 713-745-6633; Facsimile: 713-745-6029 With a copy to: The University of Texas M. D. Anderson Cancer Center 2 1515 Holcombe Blvd., FCT 8.5025 Office of Research Administration Attn: Executive Director, Research Administration Houston, TX 77030 Phone: 713-792-3672; Facsimile: 713-792-7455 Notice to Recipient shall be to: [insert] 7. In the event Protected Health Information (“PHI”), as defined by the federal Health Insurance Portability and Accountability Act of 1996 (“HIPAA”), as amended, is inadvertently created, accessed by, and/or disclosed to Recipient in connection with this Agreement, Recipient will immediately notify the Provider and will return to Provider or destroy such PHI, in accordance with the Provider’s instructions. Pending return or destruction of any PHI, Recipient shall maintain the confidentiality of all Data (including the PHI) and use appropriate safeguards to prevent access to, use, or disclosure of Data (including the PHI). 8. PROVIDER MAKES NO REPRESENTATION OR WARRANTY CONCERNING THE MATERIAL, INCLUDING WITHOUT LIMITATION, WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE OR ANY OTHER WARRANTY, EXPRESS OR IMPLIED. 9. Recipient Investigator and Recipient accept all liability for any use of the Data and for any loss, claim, or damage which may arise from or in connection with this Agreement or the use, handling or storage of the Data and in no event shall Provider or Provider Investigator be liable for any such use, loss, claim or damage. [Insert Recipient Name Here] THE UNIVERSITY OF TEXAS M. D. ANDERSON CANCER CENTER By: By: Name: Name: Title: Title: Date: Date: Read and Understood: Recipient Scientist: Provider Scientist: [Insert Name and Title Here] [Insert Name and Title Here] Date: Date:

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS50000000622 Cancer Genomics

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF50000200942 encrypted 4.2 GB
EGAF50000200943 encrypted 3.9 GB
EGAF50000200944 encrypted 4.4 GB
EGAF50000200945 encrypted 3.6 GB
EGAF50000200946 encrypted 4.5 GB
EGAF50000200947 encrypted 4.3 GB
EGAF50000200948 encrypted 5.0 GB
EGAF50000200949 encrypted 9.0 GB
EGAF50000200950 encrypted 4.0 GB
EGAF50000200951 encrypted 3.1 GB
EGAF50000200952 encrypted 3.0 GB
EGAF50000200953 encrypted 2.8 GB
EGAF50000200954 encrypted 3.0 GB
EGAF50000200955 encrypted 2.3 GB
EGAF50000200956 encrypted 2.4 GB
EGAF50000200957 encrypted 2.6 GB
EGAF50000200958 encrypted 1.7 GB
EGAF50000200959 encrypted 2.1 GB
EGAF50000200960 encrypted 2.9 GB
EGAF50000200961 encrypted 2.1 GB
EGAF50000200962 encrypted 3.1 GB
EGAF50000200963 encrypted 3.2 GB
EGAF50000200964 encrypted 2.1 GB
EGAF50000200965 encrypted 1.8 GB
EGAF50000200966 encrypted 2.8 GB
EGAF50000200967 encrypted 3.2 GB
EGAF50000200968 encrypted 2.5 GB
EGAF50000200969 encrypted 3.8 GB
EGAF50000200970 encrypted 2.6 GB
EGAF50000200971 encrypted 2.2 GB
EGAF50000200972 encrypted 2.9 GB
EGAF50000200973 encrypted 1.2 GB
EGAF50000200974 encrypted 1.9 GB
EGAF50000200975 encrypted 4.4 GB
EGAF50000200976 encrypted 1.2 GB
EGAF50000200977 encrypted 2.2 GB
EGAF50000200978 encrypted 2.6 GB
EGAF50000200979 encrypted 1.7 GB
EGAF50000200980 encrypted 1.9 GB
EGAF50000200981 encrypted 3.1 GB
EGAF50000200982 encrypted 2.1 GB
EGAF50000200983 encrypted 1.6 GB
EGAF50000200984 encrypted 1.5 GB
EGAF50000200985 encrypted 2.1 GB
EGAF50000200986 encrypted 1.8 GB
EGAF50000200987 encrypted 1.2 GB
EGAF50000200988 encrypted 1.6 GB
EGAF50000200989 encrypted 1.9 GB
EGAF50000200990 encrypted 3.5 GB
EGAF50000200991 encrypted 8.2 GB
EGAF50000200992 encrypted 8.2 GB
EGAF50000200993 encrypted 8.4 GB
EGAF50000200994 encrypted 7.6 GB
EGAF50000200995 encrypted 7.5 GB
EGAF50000200996 encrypted 6.9 GB
EGAF50000200997 encrypted 5.6 GB
EGAF50000200998 encrypted 6.0 GB
EGAF50000200999 encrypted 6.7 GB
EGAF50000201000 encrypted 4.0 GB
EGAF50000201001 encrypted 5.5 GB
EGAF50000201002 encrypted 4.1 GB
EGAF50000201003 encrypted 4.4 GB
EGAF50000201004 encrypted 4.2 GB
EGAF50000201005 encrypted 4.2 GB
EGAF50000201006 encrypted 4.0 GB
EGAF50000201007 encrypted 2.7 GB
EGAF50000201008 encrypted 4.3 GB
EGAF50000201009 encrypted 5.3 GB
EGAF50000201010 encrypted 4.3 GB
EGAF50000201011 encrypted 4.8 GB
EGAF50000201012 encrypted 2.6 GB
EGAF50000201013 encrypted 5.1 GB
EGAF50000201014 encrypted 4.6 GB
EGAF50000201015 encrypted 2.8 GB
EGAF50000201016 encrypted 4.8 GB
EGAF50000201017 encrypted 4.8 GB
EGAF50000201018 encrypted 4.5 GB
EGAF50000201019 encrypted 4.6 GB
EGAF50000201020 encrypted 5.8 GB
EGAF50000201021 encrypted 4.3 GB
EGAF50000201022 encrypted 5.0 GB
EGAF50000201023 encrypted 4.9 GB
EGAF50000201024 encrypted 4.9 GB
EGAF50000201025 encrypted 5.0 GB
EGAF50000201026 encrypted 3.9 GB
EGAF50000201027 encrypted 3.4 GB
EGAF50000201028 encrypted 3.1 GB
EGAF50000201029 encrypted 2.7 GB
EGAF50000201030 encrypted 3.4 GB
EGAF50000201031 encrypted 3.1 GB
EGAF50000201032 encrypted 3.3 GB
EGAF50000201033 encrypted 2.8 GB
EGAF50000201034 encrypted 3.9 GB
EGAF50000201035 encrypted 6.3 GB
EGAF50000201036 encrypted 5.9 GB
EGAF50000201037 encrypted 13.0 GB
EGAF50000201038 encrypted 5.1 GB
EGAF50000201039 encrypted 3.5 GB
EGAF50000201040 encrypted 3.4 GB
EGAF50000201041 encrypted 3.4 GB
EGAF50000201042 encrypted 3.2 GB
EGAF50000201043 encrypted 2.3 GB
EGAF50000201044 encrypted 2.1 GB
EGAF50000201045 encrypted 2.9 GB
EGAF50000201046 encrypted 3.0 GB
EGAF50000201047 encrypted 3.2 GB
EGAF50000201048 encrypted 2.4 GB
EGAF50000201049 encrypted 3.4 GB
EGAF50000201050 encrypted 2.6 GB
EGAF50000201051 encrypted 3.5 GB
EGAF50000201052 encrypted 2.7 GB
EGAF50000201053 encrypted 3.5 GB
EGAF50000201054 encrypted 2.7 GB
EGAF50000201055 encrypted 3.3 GB
EGAF50000201056 encrypted 3.4 GB
EGAF50000201057 encrypted 19.7 GB
EGAF50000201058 encrypted 18.3 GB
EGAF50000201059 encrypted 11.0 GB
EGAF50000201060 encrypted 21.4 GB
EGAF50000201061 encrypted 21.6 GB
EGAF50000201062 encrypted 18.1 GB
EGAF50000201063 encrypted 21.7 GB
EGAF50000201064 encrypted 19.7 GB
EGAF50000201065 encrypted 15.5 GB
EGAF50000201066 encrypted 18.9 GB
EGAF50000201067 encrypted 19.5 GB
EGAF50000201068 encrypted 47.9 GB
EGAF50000201069 encrypted 19.9 GB
EGAF50000201070 encrypted 24.2 GB
EGAF50000201071 encrypted 43.5 GB
EGAF50000201072 encrypted 3.7 GB
EGAF50000201073 encrypted 4.0 GB
EGAF50000201074 encrypted 3.7 GB
133 Files (785.9 GB)