Raw sequencing data from chromosome conformation capture, RNA sequencing and chromatin assays in human primary monocytes
This dataset contains raw sequencing data from eQTL Capture Hi-C, ATAC-seq and RNA-seq experiments in monocytes isolated from 34 healthy male donors, as well as from Hi-C, 4C-seq and CTCF ChIP-seq in subsets of individuals. The data are released as paired-end Illumina FASTQ files. Hi-C and Capture Hi-C used DpnII digestion and Tn5-based low-input library preparation. In Capture Hi-C, this was followed by targeted capture with custom-designed biotinylated RNA probes targeting ~1100 eQTL regions. ATAC-seq was performed on PFA-fixed cells using a digitonin-based protocol. 4C-seq and CTCF ChIP-seq were performed using standard protocols.
- 23/12/2024
- 34 samples
- DAC: EGAC50000000445
- Technology: Illumina NovaSeq 6000
Access to data from Ray-Jones et al., Nat Comms 2024
Thanks for your interest in our datasets. Please follow the link above to our Data Access Request form, which will require you to provide a project description and the signatures of the data users and your institutional contact. The document is hosted on Google Drive. Go to File -> Download to download it in a format of your choice. Please email the completed document to eqtl-chic-dac-WC@groups.imperial.ac.uk.
Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.
| Study ID | Study Title | Study Type |
|---|---|---|
| EGAS50000000756 | Epigenetics |