Whole-genome sequencing data of human hematopoietic stem and progenitor cells in post-transplant clonal hematopoiesis
This dataset contains BAM files of whole-genome sequencing data of single human HSPCs after colony expansion, for three individuals who harbor a DNMT3A mutant clonal hematopoiesis clone in their blood system after hematopoietic cell transplantation. 29 samples are present in this dataset; 10 samples for LTHIT005, 10 samples for LTHIT131, and 9 samples for LTHIT069. In the sample name, samples are annotated for being DNMT3A wildtype (wt) or mutant (mut), except for LTHIT069 (wt samples: F13, H4, K2, L16, N12, mut samples: C8, E10, L9, N5). Whole-genome sequencing was performed after standard Illumina WGS library preparation and sequenced on a Novaseq 6000 using 150 bp paired-end sequencing. The sequencing depth is 15x genome coverage, or 50Gbases per sample.
- 01/09/2025
- 29 samples
- DAC: EGAC00001001864
- Technology: Illumina NovaSeq 6000
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Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.
| Study ID | Study Title | Study Type |
|---|---|---|
| EGAS50000000919 | Whole Genome Sequencing |
This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.
| ID | File Type | Size | Quality Report |
Located in
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| EGAF50000329351 | bam | 29.6 GB |
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| EGAF50000329352 | bam | 24.5 GB |
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| EGAF50000329353 | bam | 26.4 GB |
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| EGAF50000329354 | bam | 29.2 GB |
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| EGAF50000329355 | bam | 21.9 GB |
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| EGAF50000329356 | bam | 21.6 GB |
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| EGAF50000329357 | bam | 22.4 GB |
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| EGAF50000347923 | bam | 27.7 GB |
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| EGAF50000347924 | bam | 32.3 GB |
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| EGAF50000347925 | bam | 22.9 GB |
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| EGAF50000347926 | bam | 36.4 GB |
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| EGAF50000347927 | bam | 46.7 GB |
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| EGAF50000347928 | bam | 48.2 GB |
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| EGAF50000347929 | bam | 52.8 GB |
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| EGAF50000347930 | bam | 47.4 GB |
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| EGAF50000347931 | bam | 43.5 GB |
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| EGAF50000347932 | bam | 43.9 GB |
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| EGAF50000347933 | bam | 43.2 GB |
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| EGAF50000347934 | bam | 41.6 GB |
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| EGAF50000347935 | bam | 39.8 GB |
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| EGAF50000347936 | bam | 37.1 GB |
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| EGAF50000347937 | bam | 31.4 GB |
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| EGAF50000347938 | bam | 34.8 GB |
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| EGAF50000347939 | bam | 35.5 GB |
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| EGAF50000347940 | bam | 36.0 GB |
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| EGAF50000347941 | bam | 53.6 GB |
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| EGAF50000347942 | bam | 39.7 GB |
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| EGAF50000347943 | bam | 41.4 GB |
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| EGAF50000347944 | bam | 38.6 GB |
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| 29 Files (1.1 TB) | ||||