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Survival and safety of laser interstitial thermal therapy and adjuvant pembrolizumab in recurrent high-grade astrocytoma: a Phase 1/randomized Phase 2b trial

This dataset is the immune profiling of the trial patients. Cryopreserved PBMCs obtained from the patients at different time points were processed to single-cell transcriptomic or TCR libraries using 10x next GEM single Cell 5' v2 kit. We also performed whole exome sequencing (WES) of the tumor to identify the mutation burden. The WES data was generated by sequencing company Novogene. There are total of 69 of single cell libraires, 69 of single cell TCR libraries, and 13 of tumor WES data being generated from 18 trial patients recruited at University of Florida.

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Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS50000001144 RNASeq

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Quality Report
Located in
EGAF50000404150 vcf 35.5 MB
EGAF50000404151 vcf 31.9 MB
EGAF50000404152 vcf 37.2 MB
EGAF50000404153 fastq.gz 7.1 GB
EGAF50000404154 fastq.gz 4.6 GB
EGAF50000404155 fastq.gz 27.7 GB
EGAF50000404156 fastq.gz 2.2 GB
EGAF50000404157 fastq.gz 7.8 GB
EGAF50000404158 fastq.gz 6.9 GB
EGAF50000404159 fastq.gz 2.0 GB
EGAF50000404160 fastq.gz 8.5 GB
EGAF50000404161 fastq.gz 1.4 GB
EGAF50000404162 fastq.gz 6.8 GB
EGAF50000404163 fastq.gz 27.2 GB
EGAF50000404164 fastq.gz 5.3 GB
EGAF50000404165 fastq.gz 5.4 GB
EGAF50000404166 fastq.gz 21.2 GB
EGAF50000404167 fastq.gz 29.5 GB
EGAF50000404168 fastq.gz 4.2 GB
EGAF50000404169 fastq.gz 2.4 GB
EGAF50000404170 fastq.gz 6.7 GB
EGAF50000404171 fastq.gz 14.0 GB
EGAF50000404172 fastq.gz 6.1 GB
EGAF50000404173 fastq.gz 25.5 GB
EGAF50000404174 fastq.gz 1.8 GB
EGAF50000404175 fastq.gz 23.7 GB
EGAF50000404176 fastq.gz 7.5 GB
EGAF50000404177 fastq.gz 6.4 GB
EGAF50000404178 fastq.gz 2.0 GB
EGAF50000404179 fastq.gz 7.6 GB
EGAF50000404180 fastq.gz 29.1 GB
EGAF50000404181 fastq.gz 55.6 GB
EGAF50000404182 fastq.gz 6.9 GB
EGAF50000404183 fastq.gz 26.8 GB
EGAF50000404184 fastq.gz 1.9 GB
EGAF50000404185 fastq.gz 6.7 GB
EGAF50000404186 fastq.gz 7.2 GB
EGAF50000404187 fastq.gz 1.6 GB
EGAF50000404188 fastq.gz 5.6 GB
EGAF50000404189 fastq.gz 23.8 GB
EGAF50000404190 fastq.gz 24.1 GB
EGAF50000404191 fastq.gz 11.6 GB
EGAF50000404192 fastq.gz 2.1 GB
EGAF50000404193 fastq.gz 7.2 GB
EGAF50000404194 fastq.gz 27.6 GB
EGAF50000404195 fastq.gz 29.2 GB
EGAF50000404196 fastq.gz 7.0 GB
EGAF50000404197 fastq.gz 7.7 GB
EGAF50000404198 fastq.gz 33.9 GB
EGAF50000404199 fastq.gz 6.6 GB
EGAF50000404200 fastq.gz 25.6 GB
EGAF50000404201 fastq.gz 6.2 GB
EGAF50000404202 fastq.gz 23.4 GB
EGAF50000404203 fastq.gz 7.7 GB
EGAF50000404204 fastq.gz 26.8 GB
EGAF50000404205 fq.gz 3.2 GB
EGAF50000404206 fastq.gz 1.2 GB
EGAF50000404207 fastq.gz 4.4 GB
EGAF50000404208 fastq.gz 2.0 GB
EGAF50000404209 fastq.gz 7.8 GB
EGAF50000404210 fq.gz 3.7 GB
EGAF50000404211 fastq.gz 1.4 GB
EGAF50000404212 fastq.gz 5.0 GB
EGAF50000404213 fastq.gz 6.1 GB
EGAF50000404214 fastq.gz 1.4 GB
EGAF50000404215 fastq.gz 5.0 GB
EGAF50000404216 fastq.gz 1.2 GB
EGAF50000404217 fastq.gz 4.4 GB
EGAF50000404218 fastq.gz 1.5 GB
EGAF50000404219 fastq.gz 5.4 GB
EGAF50000404220 fastq.gz 1.9 GB
EGAF50000404221 fastq.gz 3.8 GB
EGAF50000404222 fastq.gz 1.3 GB
EGAF50000404223 fastq.gz 1.3 GB
EGAF50000404224 fastq.gz 4.5 GB
EGAF50000404225 fastq.gz 1.3 GB
EGAF50000404226 fastq.gz 4.4 GB
EGAF50000404227 fastq.gz 8.1 GB
EGAF50000404228 fastq.gz 33.7 GB
EGAF50000404229 fastq.gz 6.6 GB
EGAF50000404230 fastq.gz 25.4 GB
EGAF50000404231 fastq.gz 6.7 GB
EGAF50000404232 fastq.gz 5.6 GB
EGAF50000404233 fastq.gz 21.8 GB
EGAF50000404234 fastq.gz 6.9 GB
EGAF50000404235 fastq.gz 1.3 GB
EGAF50000404236 fastq.gz 5.0 GB
EGAF50000404237 fastq.gz 1.5 GB
EGAF50000404238 fastq.gz 1.3 GB
EGAF50000404239 fastq.gz 1.5 GB
EGAF50000404240 fastq.gz 5.7 GB
EGAF50000404241 fastq.gz 2.9 GB
EGAF50000404242 fastq.gz 10.4 GB
EGAF50000404243 fastq.gz 1.2 GB
EGAF50000404244 fastq.gz 6.3 GB
EGAF50000404245 fastq.gz 1.3 GB
EGAF50000404246 fastq.gz 4.8 GB
EGAF50000404247 fastq.gz 1.3 GB
EGAF50000404248 fastq.gz 4.7 GB
EGAF50000404249 fastq.gz 7.0 GB
EGAF50000404250 fastq.gz 932.0 MB
EGAF50000404251 fastq.gz 3.2 GB
EGAF50000404252 fastq.gz 5.2 GB
EGAF50000404253 fastq.gz 7.5 GB
EGAF50000404254 fastq.gz 1.6 GB
EGAF50000404255 fastq.gz 5.6 GB
EGAF50000404256 fastq.gz 2.2 GB
EGAF50000404257 fastq.gz 1.9 GB
EGAF50000404258 fastq.gz 4.4 GB
EGAF50000404259 fastq.gz 24.2 GB
EGAF50000404260 fastq.gz 6.9 GB
EGAF50000404261 fastq.gz 26.6 GB
EGAF50000404262 fastq.gz 6.0 GB
EGAF50000404263 fq.gz 3.4 GB
EGAF50000404264 fq.gz 2.7 GB
EGAF50000404265 fq.gz 2.7 GB
EGAF50000404266 fq.gz 2.9 GB
EGAF50000404267 fq.gz 2.6 GB
EGAF50000404268 fq.gz 3.1 GB
EGAF50000404269 fq.gz 3.3 GB
EGAF50000404270 fq.gz 2.9 GB
EGAF50000404271 fq.gz 3.1 GB
EGAF50000404272 fq.gz 3.2 GB
EGAF50000404273 fq.gz 3.0 GB
EGAF50000404274 fq.gz 3.8 GB
EGAF50000404275 fq.gz 2.9 GB
EGAF50000404276 fq.gz 2.5 GB
EGAF50000404277 fastq.gz 6.2 GB
EGAF50000404278 fastq.gz 7.3 GB
EGAF50000404279 fastq.gz 29.2 GB
EGAF50000404280 fastq.gz 25.6 GB
EGAF50000404281 fastq.gz 26.2 GB
EGAF50000404282 fastq.gz 29.5 GB
EGAF50000404283 fastq.gz 7.2 GB
EGAF50000404284 fastq.gz 23.0 GB
EGAF50000404285 fastq.gz 21.5 GB
EGAF50000404286 fastq.gz 21.4 GB
EGAF50000404287 fastq.gz 2.0 GB
EGAF50000404288 fastq.gz 7.4 GB
EGAF50000404289 fastq.gz 1.2 GB
EGAF50000404290 fastq.gz 2.5 GB
EGAF50000404291 fq.gz 2.4 GB
EGAF50000404292 fq.gz 2.6 GB
EGAF50000404293 fq.gz 3.6 GB
EGAF50000404294 fq.gz 2.8 GB
EGAF50000404295 fq.gz 2.9 GB
EGAF50000404296 fq.gz 3.2 GB
EGAF50000404297 fq.gz 3.3 GB
EGAF50000404298 fq.gz 3.5 GB
EGAF50000404299 fq.gz 3.7 GB
EGAF50000404300 fq.gz 3.2 GB
EGAF50000404301 fastq.gz 7.8 GB
EGAF50000404302 fastq.gz 7.0 GB
EGAF50000404303 fastq.gz 26.6 GB
EGAF50000404304 fastq.gz 6.3 GB
EGAF50000404305 fastq.gz 23.1 GB
EGAF50000404306 fastq.gz 29.0 GB
EGAF50000404307 fastq.gz 6.3 GB
EGAF50000404308 fastq.gz 24.1 GB
EGAF50000404309 fastq.gz 9.5 GB
EGAF50000404310 fastq.gz 6.8 GB
EGAF50000404311 fastq.gz 23.1 GB
EGAF50000404312 fastq.gz 7.0 GB
EGAF50000404313 fastq.gz 27.5 GB
EGAF50000404314 fastq.gz 7.4 GB
EGAF50000404315 fastq.gz 29.5 GB
EGAF50000404316 fastq.gz 6.8 GB
EGAF50000404317 fastq.gz 9.4 GB
EGAF50000404318 fastq.gz 5.3 GB
EGAF50000404319 fastq.gz 1.7 GB
EGAF50000404320 fastq.gz 6.1 GB
EGAF50000404321 fastq.gz 7.1 GB
EGAF50000404322 fastq.gz 9.4 GB
EGAF50000404323 fastq.gz 1.7 GB
EGAF50000404324 fastq.gz 6.1 GB
EGAF50000404325 fastq.gz 7.6 GB
EGAF50000404326 fastq.gz 2.0 GB
EGAF50000404327 fastq.gz 5.4 GB
EGAF50000404328 fastq.gz 7.2 GB
EGAF50000404329 fastq.gz 9.6 GB
EGAF50000404330 fastq.gz 37.1 GB
EGAF50000404331 fastq.gz 1.5 GB
EGAF50000404332 fastq.gz 6.1 GB
EGAF50000404333 fastq.gz 4.4 GB
EGAF50000404334 fastq.gz 1.4 GB
EGAF50000404335 fastq.gz 5.2 GB
EGAF50000404336 fastq.gz 1.1 GB
EGAF50000404337 fastq.gz 7.6 GB
EGAF50000404338 fastq.gz 7.7 GB
EGAF50000404339 fastq.gz 6.9 GB
EGAF50000404340 fastq.gz 26.4 GB
EGAF50000404341 fastq.gz 1.6 GB
EGAF50000404342 fastq.gz 5.8 GB
EGAF50000404343 fastq.gz 1.7 GB
EGAF50000404344 fastq.gz 7.7 GB
EGAF50000404345 fastq.gz 6.2 GB
EGAF50000404346 fastq.gz 2.2 GB
EGAF50000404347 fastq.gz 8.8 GB
EGAF50000404348 fastq.gz 6.2 GB
EGAF50000404349 fastq.gz 24.2 GB
EGAF50000404350 fastq.gz 4.9 GB
EGAF50000404351 fastq.gz 5.1 GB
EGAF50000404352 fastq.gz 7.5 GB
EGAF50000404353 fastq.gz 7.3 GB
EGAF50000404354 fastq.gz 28.5 GB
EGAF50000404355 fastq.gz 5.9 GB
EGAF50000404356 fastq.gz 23.2 GB
EGAF50000404357 fastq.gz 7.9 GB
EGAF50000404358 fastq.gz 30.4 GB
EGAF50000404359 fastq.gz 23.2 GB
EGAF50000404360 fastq.gz 2.5 GB
EGAF50000404361 fastq.gz 23.3 GB
EGAF50000404362 fastq.gz 6.9 GB
EGAF50000404363 fastq.gz 7.8 GB
EGAF50000404364 fastq.gz 28.5 GB
EGAF50000404365 fastq.gz 4.3 GB
EGAF50000404366 fastq.gz 29.3 GB
EGAF50000404367 fastq.gz 1.4 GB
EGAF50000404368 fastq.gz 6.1 GB
EGAF50000404369 fastq.gz 23.8 GB
EGAF50000404370 fastq.gz 7.4 GB
EGAF50000404371 fastq.gz 2.3 GB
EGAF50000404372 fastq.gz 8.6 GB
EGAF50000404373 fastq.gz 8.0 GB
EGAF50000404374 fastq.gz 28.9 GB
EGAF50000404375 fastq.gz 6.5 GB
EGAF50000404376 fastq.gz 25.4 GB
EGAF50000404377 fastq.gz 8.1 GB
EGAF50000404378 fastq.gz 8.5 GB
EGAF50000404379 fastq.gz 2.0 GB
EGAF50000404380 fastq.gz 7.1 GB
EGAF50000404381 fastq.gz 1.7 GB
EGAF50000404382 fastq.gz 1.9 GB
EGAF50000404383 fastq.gz 1.9 GB
EGAF50000404384 fastq.gz 2.1 GB
EGAF50000404385 fastq.gz 20.3 GB
EGAF50000404386 fastq.gz 29.5 GB
EGAF50000404387 fastq.gz 24.3 GB
EGAF50000404388 fastq.gz 1.6 GB
EGAF50000404389 fastq.gz 5.8 GB
EGAF50000404390 fastq.gz 6.7 GB
EGAF50000404391 fastq.gz 1.1 GB
EGAF50000404392 fastq.gz 26.2 GB
EGAF50000404393 fastq.gz 5.9 GB
EGAF50000404394 fastq.gz 26.5 GB
EGAF50000404395 fastq.gz 7.7 GB
EGAF50000404396 fastq.gz 29.9 GB
EGAF50000404397 fastq.gz 6.3 GB
EGAF50000404398 fastq.gz 5.8 GB
EGAF50000404399 fastq.gz 2.0 GB
EGAF50000404400 fastq.gz 1.2 GB
EGAF50000404401 fastq.gz 7.4 GB
EGAF50000404402 fastq.gz 27.3 GB
EGAF50000404403 fastq.gz 7.8 GB
EGAF50000404404 fastq.gz 7.0 GB
EGAF50000404405 fastq.gz 1.2 GB
EGAF50000404406 fastq.gz 4.3 GB
EGAF50000404407 fastq.gz 9.0 GB
EGAF50000404408 fastq.gz 35.7 GB
EGAF50000404409 fastq.gz 2.6 GB
EGAF50000404410 fastq.gz 1.4 GB
EGAF50000404411 fastq.gz 2.0 GB
EGAF50000404412 fastq.gz 5.1 GB
EGAF50000404413 fastq.gz 8.6 GB
EGAF50000404414 fastq.gz 6.0 GB
EGAF50000404415 fastq.gz 3.0 GB
EGAF50000404416 fastq.gz 8.7 GB
EGAF50000404417 fastq.gz 34.6 GB
EGAF50000404418 fastq.gz 6.3 GB
EGAF50000404419 fastq.gz 24.5 GB
EGAF50000404420 fastq.gz 6.5 GB
EGAF50000404421 fastq.gz 25.8 GB
EGAF50000404422 fastq.gz 28.1 GB
EGAF50000404423 fastq.gz 24.7 GB
EGAF50000404424 fastq.gz 7.6 GB
EGAF50000404425 fastq.gz 6.9 GB
EGAF50000404426 fastq.gz 1.3 GB
EGAF50000404427 fastq.gz 8.0 GB
EGAF50000404428 fastq.gz 25.4 GB
EGAF50000404429 fastq.gz 25.4 GB
EGAF50000404430 fastq.gz 6.5 GB
EGAF50000404431 fastq.gz 2.4 GB
EGAF50000404432 fastq.gz 25.1 GB
EGAF50000404433 fastq.gz 7.5 GB
EGAF50000404434 fastq.gz 1.6 GB
EGAF50000404435 fastq.gz 8.4 GB
EGAF50000404436 fastq.gz 33.2 GB
EGAF50000404437 fastq.gz 6.3 GB
EGAF50000404438 fastq.gz 6.5 GB
EGAF50000404439 fastq.gz 1.7 GB
EGAF50000404440 fastq.gz 5.2 GB
EGAF50000404441 fastq.gz 23.0 GB
EGAF50000404442 fastq.gz 30.4 GB
EGAF50000404443 fastq.gz 6.5 GB
EGAF50000404444 fastq.gz 2.2 GB
EGAF50000404445 fastq.gz 26.1 GB
EGAF50000404446 fastq.gz 4.7 GB
EGAF50000404447 fastq.gz 8.2 GB
EGAF50000404448 fastq.gz 25.6 GB
EGAF50000404449 fastq.gz 23.2 GB
EGAF50000404450 fastq.gz 5.9 GB
EGAF50000404451 fastq.gz 1.6 GB
EGAF50000404452 fastq.gz 24.4 GB
EGAF50000404453 fastq.gz 5.4 GB
EGAF50000404454 fastq.gz 6.0 GB
EGAF50000404455 tsv.gz 2.6 MB
EGAF50000404456 mtx.gz 2.8 GB
EGAF50000404457 tsv.gz 183.2 kB
EGAF50000404458 csv 121.5 MB
EGAF50000404459 RDS 12.2 GB
EGAF50000404460 vcf 41.3 MB
EGAF50000404461 vcf 40.5 MB
EGAF50000404462 vcf 39.7 MB
EGAF50000404463 vcf 35.5 MB
EGAF50000404464 vcf 46.6 MB
EGAF50000404465 vcf 38.8 MB
EGAF50000404466 vcf 33.7 MB
EGAF50000404467 vcf 36.4 MB
EGAF50000404468 vcf 65.5 MB
EGAF50000404469 vcf 32.0 MB
320 Files (3.1 TB)