About file location

As the EGA is co-managed by the EMBL-EBI and CRG, files could be located in the UK and/or Spain, as indicated by their respective flags.

Alternatively, files could be located in one of the international Federated EGA nodes, as indicated next to the node's flag.
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EM-seq data from plasma cfDNA samples of ALS patients, control and C9-carriers

This dataset contains targeted EM-seq data from 61 plasma cfDNA samples spanning 20 sporadic ALS, 10 C9orf72-ALS, 10 asymptomatic C9orf72 expansion carriers, and 21 non-disease controls. Libraries were prepared with the NEBNext Enzymatic Methyl-seq (EM-seq) kit, captured using the Twist Human Methylome Panel (3.98 M CpGs; 123 Mb), and sequenced on Illumina NovaSeq 6000 (150 bp paired-end; ~45× on-target depth) with unmethylated lambda DNA spike-in and a 20% PhiX balance library. The dataset includes per-sample gzipped FASTQ files (R1/R2) and minimal metadata.

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ALS cfDNA Data Access Agreement

These terms and conditions govern access to the managed access datasets generated by Dr. Sebastian Michels(sebastian.michels@uni-ulm.de) at University of Ulm, Ulm, Germany (details of which are set out in Appendix I) to which the User Institution has requested access. In signing this agreement, the User Institution agrees to be bound by these terms and conditions. Definitions Authorized Personnel: The individuals at the User Institution to whom Dr. Sebastian Michels grants access to the Data. This includes the User, the individuals listed in Appendix II and any other individuals for whom the User Institution subsequently requests access to the Data. Details of the initial Authorized Personnel are set out in Appendix II. Data: The managed access datasets to which the User Institution has requested access. Data Producers: Dr. Sebastian Michels and the collaborators listed in Appendix I responsible for the development, organization, and oversight of these Data. External Collaborator: A collaborator of the User, working for an institution other than the User Institution. Project: The project for which the User Institution has requested access to these Data. A description of the Project is set out in Appendix II. Publications: Includes, without limitation, articles published in print journals, electronic journals, reviews, books, posters and other written and verbal presentations of research. Research Participant: An individual whose data form part of these Data. Research Purposes: Shall mean research that is seeking to advance the understanding of genetics and genomics, including the treatment of disorders, and work on statistical methods that may be applied to such research. User: The principal investigator for the Project. User Institution(s): The Institution that has requested access to the Data. 1. The User Institution agrees to only use these Data for the purpose of the Project (described in Appendix II) and only for Research Purposes. The User Institution further agrees that it will only use these Data for Research Purposes which are within the limitations (if any) set out in Appendix I. 2. The User Institution agrees to preserve, at all times, the confidentiality of these Data. In particular, it undertakes not to use, or attempt to use these Data to compromise or otherwise infringe the confidentiality of information on Research Participants. Without prejudice to the generality of the foregoing, the User Institution agrees to use at least the measures set out in Appendix I to protect these Data. 3. The User Institution agrees to protect the confidentiality of Research Participants in any research papers or publications that they prepare by taking all reasonable care to limit the possibility of identification. 4. The User Institution agrees not to link or combine these Data to other information or archived data available in a way that could re-identify the Research Participants, even if access to that data has been formally granted to the User Institution or is freely available without restriction. 5. The User Institution agrees only to transfer or disclose these Data, in whole or part, or any material derived from these Data to the Authorized Personnel. Should the User Institution wish to share these Data with an External Collaborator, the External Collaborator must complete a separate application for access to these Data. 6. The User Institution agrees that the Data Producers, and all other parties involved in the creation, funding or protection of these Data: a) make no warranty or representation, express or implied as to the accuracy, quality or comprehensiveness of these Data; b) exclude to the fullest extent permitted by law all liability for actions, claims, proceedings, demands, losses (including but not limited to loss of profit), costs, awards damages and payments made by the Recipient that may arise (whether directly or indirectly) in any way whatsoever from the Recipient’s use of these Data or from the unavailability of, or break in access to, these Data for whatever reason and; c) bear no responsibility for the further analysis or interpretation of these Data. 7. The User Institution agrees to follow the Fort Lauderdale Guidelines (http://www.wellcome.ac.uk/stellent/groups/corporatesite/@policy_communications/documents/web_document/wtd003207.pdf ) and the Toronto Statement (http://www.nature.com/nature/journal/v461/n7261/full/461168a.html). This includes but is not limited to recognizing the contribution of the Data Producers and including a proper acknowledgement in all reports or publications resulting from the use of these Data. 8. The User Institution agrees to follow the Publication Policy in Appendix III. This includes respecting the moratorium period for the Data Producers to publish the first peer-reviewed report describing and analyzing these Data. 9. The User Institution agrees not to make intellectual property claims on these Data and not to use intellectual property protection in ways that would prevent or block access to, or use of, any element of these Data, or conclusion drawn directly from these Data. 10. The User Institution can elect to perform further research that would add intellectual and resource capital to these data and decide to obtain intellectual property rights on these downstream discoveries, only with written permission from Dr. Sebastian Michels. In this case, the User Institution agrees to implement licensing policies that will not obstruct further research and to follow the U.S. National Institutes of Health Best Practices for the Licensing of Genomic Inventions (2005) (https://www.icgc.org/files/daco/NIH_BestPracticesLicensingGenomicInventions_2005_en.pdf ) in conformity with the Organization for Economic Co-operation and Development Guidelines for the Licensing of the Genetic Inventions (2006) (http://www.oecd.org/science/biotech/36198812.pdf ). 11. The User Institution agrees to destroy/discard the Data held, once it is no longer used for the Project, unless obliged to retain the data for archival purposes in conformity with audit or legal requirements. 12. The User Institution will notify Data Producers within 30 days of any changes or departures of Authorized Personnel. 13. The User Institution will notify Data Producers prior to any significant changes to the protocol for the Project. 14. The User Institution will notify Data Producers as soon as it becomes aware of a breach of the terms or conditions of this agreement. 15. Data Producers may terminate this agreement by written notice to the User Institution. If this agreement terminates for any reason, the User Institution will be required to destroy any Data held, including copies and backup copies. This clause does not prevent the User Institution from retaining these data for archival purpose in conformity with audit or legal requirements. 16. The User Institution accepts that it may be necessary for the Data Producers to alter the terms of this agreement from time to time. As an example, this may include specific provisions relating to the Data required by Data Producers other. If changes are required, the Data Producers or their appointed agent will contact the User Institution to inform it of the changes and the User Institution may elect to accept the changes or terminate the agreement. 17. If requested, the User Institution will allow data security and management documentation to be inspected to verify that it is complying with the terms of this agreement. 18. The User Institution agrees to distribute a copy of these terms to the Authorized Personnel. The User Institution will procure that the Authorized Personnel comply with the terms of this agreement. 19. The User Institution warrants that it has obtained approval by the local institutional review board/research ethics committee (IRB/REC) before the Project commences. 20. This agreement (and any dispute, controversy, proceedings or claim of whatever nature arising out of this agreement or its formation) shall be construed, interpreted and governed by the laws of England and Wales and shall be subject to the exclusive jurisdiction of the English courts.

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS50000001267 Epigenetics

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Quality Report
Located in
i
EGAF50000432267 fastq.gz 3.4 GB
EGAF50000432268 fastq.gz 3.8 GB
EGAF50000432269 fastq.gz 6.2 GB
EGAF50000432270 fastq.gz 5.6 GB
EGAF50000432271 fastq.gz 6.3 GB
EGAF50000432272 fastq.gz 6.8 GB
EGAF50000432273 fastq.gz 4.5 GB
EGAF50000432274 fastq.gz 4.9 GB
EGAF50000432275 fastq.gz 3.4 GB
EGAF50000432276 fastq.gz 3.7 GB
EGAF50000432277 fastq.gz 3.0 GB
EGAF50000432278 fastq.gz 2.7 GB
EGAF50000432279 fastq.gz 8.3 GB
EGAF50000432280 fastq.gz 9.1 GB
EGAF50000432281 fastq.gz 4.8 GB
EGAF50000432282 fastq.gz 4.3 GB
EGAF50000432283 fastq.gz 5.6 GB
EGAF50000432284 fastq.gz 6.2 GB
EGAF50000432285 fastq.gz 3.7 GB
EGAF50000432286 fastq.gz 4.1 GB
EGAF50000432287 fastq.gz 4.8 GB
EGAF50000432288 fastq.gz 4.3 GB
EGAF50000432289 fastq.gz 3.6 GB
EGAF50000432290 fastq.gz 3.9 GB
EGAF50000432291 fastq.gz 3.9 GB
EGAF50000432292 fastq.gz 3.5 GB
EGAF50000432293 fastq.gz 5.8 GB
EGAF50000432294 fastq.gz 5.3 GB
EGAF50000432295 fastq.gz 7.1 GB
EGAF50000432296 fastq.gz 8.1 GB
EGAF50000432297 fastq.gz 4.3 GB
EGAF50000432298 fastq.gz 4.7 GB
EGAF50000432299 fastq.gz 6.5 GB
EGAF50000432300 fastq.gz 7.1 GB
EGAF50000432301 fastq.gz 3.9 GB
EGAF50000432302 fastq.gz 4.3 GB
EGAF50000432303 fastq.gz 3.6 GB
EGAF50000432304 fastq.gz 4.0 GB
EGAF50000432305 fastq.gz 3.2 GB
EGAF50000432306 fastq.gz 3.5 GB
EGAF50000432307 fastq.gz 3.0 GB
EGAF50000432308 fastq.gz 3.3 GB
EGAF50000432309 fastq.gz 3.0 GB
EGAF50000432310 fastq.gz 3.3 GB
EGAF50000432311 fastq.gz 2.7 GB
EGAF50000432312 fastq.gz 3.0 GB
EGAF50000432313 fastq.gz 10.7 GB
EGAF50000432314 fastq.gz 11.6 GB
EGAF50000432315 fastq.gz 11.6 GB
EGAF50000432316 fastq.gz 12.6 GB
EGAF50000432317 fastq.gz 10.8 GB
EGAF50000432318 fastq.gz 11.8 GB
EGAF50000432319 fastq.gz 4.2 GB
EGAF50000432320 fastq.gz 4.7 GB
EGAF50000432321 fastq.gz 3.8 GB
EGAF50000432322 fastq.gz 4.2 GB
EGAF50000432323 fastq.gz 4.9 GB
EGAF50000432324 fastq.gz 4.4 GB
EGAF50000432325 fastq.gz 3.3 GB
EGAF50000432326 fastq.gz 3.7 GB
EGAF50000432327 fastq.gz 3.0 GB
EGAF50000432328 fastq.gz 3.3 GB
EGAF50000432329 fastq.gz 3.7 GB
EGAF50000432330 fastq.gz 4.1 GB
EGAF50000432331 fastq.gz 4.8 GB
EGAF50000432332 fastq.gz 4.3 GB
EGAF50000432333 fastq.gz 12.0 GB
EGAF50000432334 fastq.gz 11.2 GB
EGAF50000432335 fastq.gz 12.6 GB
EGAF50000432336 fastq.gz 13.5 GB
EGAF50000432337 fastq.gz 11.0 GB
EGAF50000432338 fastq.gz 11.9 GB
EGAF50000432339 fastq.gz 10.0 GB
EGAF50000432340 fastq.gz 11.0 GB
EGAF50000432341 fastq.gz 13.2 GB
EGAF50000432342 fastq.gz 12.2 GB
EGAF50000432343 fastq.gz 12.1 GB
EGAF50000432344 fastq.gz 13.1 GB
EGAF50000432345 fastq.gz 11.2 GB
EGAF50000432346 fastq.gz 12.3 GB
EGAF50000432347 fastq.gz 3.1 GB
EGAF50000432348 fastq.gz 3.4 GB
EGAF50000432349 fastq.gz 3.6 GB
EGAF50000432350 fastq.gz 3.3 GB
EGAF50000432351 fastq.gz 4.6 GB
EGAF50000432352 fastq.gz 4.2 GB
EGAF50000432353 fastq.gz 3.3 GB
EGAF50000432354 fastq.gz 3.7 GB
EGAF50000432355 fastq.gz 4.2 GB
EGAF50000432356 fastq.gz 4.6 GB
EGAF50000432357 fastq.gz 3.9 GB
EGAF50000432358 fastq.gz 4.3 GB
EGAF50000432359 fastq.gz 3.8 GB
EGAF50000432360 fastq.gz 4.2 GB
EGAF50000432361 fastq.gz 2.8 GB
EGAF50000432362 fastq.gz 3.1 GB
EGAF50000432363 fastq.gz 2.9 GB
EGAF50000432364 fastq.gz 3.2 GB
EGAF50000432365 fastq.gz 3.6 GB
EGAF50000432366 fastq.gz 3.9 GB
EGAF50000432367 fastq.gz 4.3 GB
EGAF50000432368 fastq.gz 4.6 GB
EGAF50000432369 fastq.gz 5.4 GB
EGAF50000432370 fastq.gz 5.9 GB
EGAF50000432371 fastq.gz 4.3 GB
EGAF50000432372 fastq.gz 3.9 GB
EGAF50000432373 fastq.gz 4.8 GB
EGAF50000432374 fastq.gz 5.4 GB
EGAF50000432375 fastq.gz 3.3 GB
EGAF50000432376 fastq.gz 3.7 GB
EGAF50000432377 fastq.gz 3.5 GB
EGAF50000432378 fastq.gz 3.8 GB
EGAF50000432379 fastq.gz 4.2 GB
EGAF50000432380 fastq.gz 4.7 GB
EGAF50000432381 fastq.gz 3.6 GB
EGAF50000432382 fastq.gz 3.9 GB
EGAF50000432383 fastq.gz 3.6 GB
EGAF50000432384 fastq.gz 3.9 GB
EGAF50000432385 fastq.gz 3.4 GB
EGAF50000432386 fastq.gz 3.8 GB
120 Files (664.8 GB)