Transcriptomic analysis of hiPSC-derived vascular cells from CADASIL and isogenic control patient lines
Bulk-RNA sequencing from hiPSC-derived cells (hiPSC; Endothelial Cells; Neural Crests Cells; Vascular Smooth Muscle Cells) from CADASIL patient lines (n=3) and respective isogenic-controls (n=3). CADASIL is a hereditary brain small vessel disease caused by pathogenic variants in the NOTCH3 gene, which lead to deposits of NOTCH3 protein in the walls of small arteries. This causes pathological vessel wall changes including degeneration of vascular smooth muscle cells. To investigate the impact of pathogenic NOTCH3 variants in hiPSC and differentiated cells we performed a bulk-RNA sequencing.
- 11/03/2026
- 24 samples
- DAC: EGAC50000000744
- Technology: Illumina HiSeq X
Policy: Orlova-group LUMC
Restricted access because the study concerns patient data which should not be traced back to the patients. We will require citation plus acknowledgement.
Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.
| Study ID | Study Title | Study Type |
|---|---|---|
| EGAS50000001507 | Transcriptome Analysis |
This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.
| ID | File Type | Size | Quality Report |
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| EGAF50000518655 | fq.gz | 1.8 GB |
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| EGAF50000518656 | fq.gz | 1.9 GB |
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| EGAF50000518657 | fq.gz | 2.0 GB |
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| EGAF50000518658 | fq.gz | 2.1 GB |
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| EGAF50000518659 | fq.gz | 2.2 GB |
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| EGAF50000518660 | fq.gz | 2.2 GB |
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| EGAF50000518661 | fq.gz | 2.0 GB |
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| EGAF50000518662 | fq.gz | 2.1 GB |
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| EGAF50000518663 | fq.gz | 2.1 GB |
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| EGAF50000518664 | fq.gz | 2.2 GB |
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| EGAF50000518665 | fq.gz | 2.0 GB |
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| EGAF50000518666 | fq.gz | 2.1 GB |
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| EGAF50000518667 | fq.gz | 2.0 GB |
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| EGAF50000518668 | fq.gz | 2.1 GB |
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| EGAF50000518669 | fq.gz | 2.0 GB |
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| EGAF50000518670 | fq.gz | 2.1 GB |
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| EGAF50000518671 | fq.gz | 2.2 GB |
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| EGAF50000518672 | fq.gz | 2.3 GB |
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| EGAF50000518673 | fq.gz | 1.8 GB |
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| EGAF50000518674 | fq.gz | 1.9 GB |
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| EGAF50000518675 | fq.gz | 1.8 GB |
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| EGAF50000518676 | fq.gz | 1.9 GB |
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| EGAF50000518677 | fq.gz | 2.1 GB |
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| EGAF50000518678 | fq.gz | 2.2 GB |
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| EGAF50000518679 | fq.gz | 2.0 GB |
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| EGAF50000518680 | fq.gz | 2.1 GB |
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| EGAF50000518681 | fq.gz | 2.0 GB |
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| EGAF50000518682 | fq.gz | 2.1 GB |
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| EGAF50000518683 | fq.gz | 2.2 GB |
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| EGAF50000518684 | fq.gz | 2.3 GB |
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| EGAF50000518685 | fq.gz | 2.1 GB |
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| EGAF50000518686 | fq.gz | 2.2 GB |
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| EGAF50000518687 | fq.gz | 2.1 GB |
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| EGAF50000518688 | fq.gz | 2.1 GB |
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| EGAF50000518689 | fq.gz | 2.1 GB |
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| EGAF50000518690 | fq.gz | 2.1 GB |
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| EGAF50000518691 | fq.gz | 2.0 GB |
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| EGAF50000518692 | fq.gz | 2.1 GB |
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| EGAF50000518693 | fq.gz | 2.2 GB |
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| EGAF50000518694 | fq.gz | 2.3 GB |
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| EGAF50000518695 | fq.gz | 1.8 GB |
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| EGAF50000518696 | fq.gz | 2.0 GB |
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| EGAF50000518697 | fq.gz | 2.3 GB |
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| EGAF50000518698 | fq.gz | 2.4 GB |
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| EGAF50000518699 | fq.gz | 2.4 GB |
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| EGAF50000518700 | fq.gz | 2.5 GB |
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| EGAF50000518701 | fq.gz | 2.4 GB |
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| EGAF50000518702 | fq.gz | 2.5 GB |
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| 48 Files (101.0 GB) | ||||