About file location

As the EGA is co-managed by the EMBL-EBI and CRG, files could be located in the UK and/or Spain, as indicated by their respective flags.

Alternatively, files could be located in one of the international Federated EGA nodes, as indicated next to the node's flag.
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Circulating Tumor DNA Analysis Profiles of Repotrectinib in NTRK fusion–positive advanced solid tumors: a phase 1/2 trial

The dataset contains circulating tumor DNA (ctDNA) profiles from frozen plasma samples of 593 patients from the TRIDENT-1 clinical trial. Plasma was processed with centrifugation and automated liquid handling systems, and cell-free DNA was extracted using the Qiagen QIAsymphony platform. ctDNA libraries were constructed with the Guardant360 2.11 assay, which used targeted, hybridization-based capture and barcoding of cfDNA fragments for digital analysis, followed by high-throughput sequencing on the Illumina NextSeq 550 instrument. Sequencing data were processed and interpreted using the Bioinformatics Pipeline (BIP v3.5.2 or later) for variant calling and quantification and managed within LabVantage LIMS (v3.7 or later) to support sample tracking and workflow integration. Aligned read files are provided in bam and bai formats.

DUO:0000026
version: 2021-02-23

user specific restriction

This data use modifier indicates that use is limited to use by approved users.

DUO:0000027
version: 2021-02-23

project specific restriction

This data use modifier indicates that use is limited to use within an approved project.

Requests for access the BMS accession numbers in EGA should be directed to the BMS FastTrack portal - https://fasttrack.bms.com/. This externally facing website serves as BMS’ request portal for all ISRs (both clinical and non-clinical), as well as for requests for data generated as a part of a BMS study. This portal is facilitated by BMS’ Clinical Trial Transparency organization.

Purpose Below you will find general notes and tips for when you are creating an ISR Request. General Notes and Tips • * [Asterisks] indicate a required field within the interface • You will not be able to move on to the next page if a required field is not completed • Periodically click Save (located at the bottom right corner on any form) in order to save your information. If you do not have all the information, which is necessary to submit your request, click Save and a draft will be available for you on your homepage when you are ready to return to the form. The forms do not auto-save. • FastTrack has a security time-out feature. After sixty (60) minutes of inactivity, you will be required to log back into the system. o If you are working on a record and leave it open while performing other tasks, it is recommend that you navigate to the bottom of the record and click Save to prevent you from losing data you have entered • You can return to any section of the form at any point by clicking the tabs at the top of the page or clicking Back in the lower left of the page We are committed to providing you with answers to your questions and concerns. Please contact us using the information below, and we will respond to your inquiry as quickly as possible. Technical Support Main Number: +1 844-439-5499 (US only) For Outside US, please see the “International BMS Help Desk Phone Number Guide” Main Email: hd-sci-apps@bms.com