RNA sequencing of untreated and treated KRAS-mutated metastatic colorectal cancer PDX-derived organoids.
RNA sequencing was performed on patient-derived xenograft (PDX)-derived organoid models of metastatic colorectal cancer (mCRC). The aim of this study was to characterize the transcriptional landscape of KRAS-mutant mCRC cells in response to therapeutic strategies targeting the EGFR and KRAS signaling pathways. Transcriptomic profiling was conducted following drug treatments to investigate molecular changes associated with single and combination therapies. A total of 24 samples were analyzed.
- 30/03/2026
- 24 samples
- DAC: EGAC50000000068
- Technology: Illumina NovaSeq X
DUO:0000007 version: 2021-02-23
disease specific research
This data use permission indicates that use is allowed provided it is related to the specified disease.
ModifiersMONDO:0005575
General policy for IRCC datasets
Translational Cancer Medicine laboratory of Candiolo IRCC institute. Dataset available on request
Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.
| Study ID | Study Title | Study Type |
|---|---|---|
| EGAS50000001700 | Transcriptome Sequencing |
This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.
| ID | File Type | Size | Quality Report |
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| EGAF50000701213 | fastq.gz | 3.4 GB |
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| EGAF50000701214 | fastq.gz | 2.9 GB |
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| EGAF50000701215 | fastq.gz | 3.1 GB |
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| EGAF50000701216 | fastq.gz | 3.8 GB |
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| EGAF50000701217 | fastq.gz | 4.6 GB |
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| EGAF50000701218 | fastq.gz | 3.1 GB |
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| EGAF50000701219 | fastq.gz | 3.3 GB |
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| EGAF50000701220 | fastq.gz | 4.9 GB |
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| EGAF50000701221 | fastq.gz | 4.4 GB |
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| EGAF50000701222 | fastq.gz | 4.6 GB |
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| EGAF50000701223 | fastq.gz | 4.5 GB |
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| EGAF50000701224 | fastq.gz | 4.7 GB |
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| EGAF50000701225 | fastq.gz | 3.5 GB |
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| EGAF50000701226 | fastq.gz | 3.8 GB |
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| EGAF50000701227 | fastq.gz | 4.2 GB |
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| EGAF50000701228 | fastq.gz | 4.5 GB |
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| EGAF50000701229 | fastq.gz | 4.4 GB |
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| EGAF50000701230 | fastq.gz | 4.7 GB |
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| EGAF50000701231 | fastq.gz | 4.4 GB |
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| EGAF50000701232 | fastq.gz | 4.7 GB |
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| EGAF50000701233 | fastq.gz | 3.7 GB |
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| EGAF50000701234 | fastq.gz | 3.9 GB |
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| EGAF50000701235 | fastq.gz | 3.1 GB |
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| EGAF50000701236 | fastq.gz | 3.3 GB |
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| EGAF50000701237 | fastq.gz | 3.2 GB |
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| EGAF50000701238 | fastq.gz | 3.4 GB |
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| EGAF50000701239 | fastq.gz | 4.1 GB |
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| EGAF50000701240 | fastq.gz | 4.3 GB |
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| EGAF50000701241 | fastq.gz | 4.7 GB |
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| EGAF50000701242 | fastq.gz | 5.0 GB |
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| EGAF50000701243 | fastq.gz | 3.0 GB |
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| EGAF50000701244 | fastq.gz | 3.2 GB |
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| EGAF50000701245 | fastq.gz | 2.8 GB |
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| EGAF50000701246 | fastq.gz | 3.0 GB |
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| EGAF50000701247 | fastq.gz | 3.8 GB |
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| EGAF50000701248 | fastq.gz | 4.0 GB |
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| EGAF50000701249 | fastq.gz | 3.7 GB |
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| EGAF50000701250 | fastq.gz | 3.9 GB |
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| EGAF50000701251 | fastq.gz | 4.0 GB |
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| EGAF50000701252 | fastq.gz | 4.3 GB |
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| EGAF50000701253 | fastq.gz | 3.5 GB |
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| EGAF50000701254 | fastq.gz | 3.7 GB |
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| EGAF50000701255 | fastq.gz | 4.6 GB |
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| EGAF50000701256 | fastq.gz | 5.0 GB |
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| EGAF50000701257 | fastq.gz | 3.2 GB |
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| EGAF50000701258 | fastq.gz | 4.0 GB |
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| EGAF50000701259 | fastq.gz | 4.5 GB |
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| EGAF50000701260 | fastq.gz | 4.8 GB |
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| 48 Files (189.4 GB) | ||||