About file location

As the EGA is co-managed by the EMBL-EBI and CRG, files could be located in the UK and/or Spain, as indicated by their respective flags.

Alternatively, files could be located in one of the international Federated EGA nodes, as indicated next to the node's flag.
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Bulk RNA-seq (FASTQ) – melanoma samples

This dataset comprises raw FASTQ files from bulk RNA sequencing of metastatic melanoma lymph node samples collected from patients with differential responses to immune checkpoint inhibitor therapy. RNA was extracted from tumour tissue, enriched for polyadenylated transcripts, and libraries were prepared using standard Illumina protocols. Sequencing was performed on an Illumina platform to generate high-quality paired-end reads. The dataset includes multiple patient samples with associated clinical annotations, enabling analysis of tumour-intrinsic transcriptional programs linked to immunotherapy response and resistance.

Request Access

DUO:0000015
version: 2021-02-23

no general methods research

This data use modifier indicates that use does not allow methods development research (e.g., development of software or algorithms).

DUO:0000018
version: 2021-02-23

not for profit, non commercial use only

This data use modifier indicates that use of the data is limited to not-for-profit organizations and not-for-profit use, non-commercial use.

DUO:0000019
version: 2021-02-23

publication required

This data use modifier indicates that requestor agrees to make results of studies using the data available to the larger scientific community.

DUO:0000020
version: 2021-02-23

collaboration required

This data use modifier indicates that the requestor must agree to collaboration with the primary study investigator(s).

DUO:0000021
version: 2021-02-23

ethics approval required

This data use modifier indicates that the requestor must provide documentation of local IRB/ERB approval.

DUO:0000042
version: 2021-02-23

general research use

This data use permission indicates that use is allowed for general research use for any research purpose.

DUO:0000044
version: 2021-02-23

population origins or ancestry research prohibited

This data use modifier indicates use for purposes of population, origin, or ancestry research is prohibited.

Controlled Access Policy for Melanoma Immunotherapy Resistance Dataset

Access to this dataset is controlled and granted by the Data Access Committee (DAC) in accordance with participant consent, institutional policies, and applicable ethical and legal frameworks. The dataset comprises genomic, transcriptomic, and associated clinical data derived from human melanoma samples, including bulk RNA sequencing, single-cell RNA sequencing, and T cell receptor sequencing data. Data will be made available to qualified researchers for bona fide scientific research purposes. Access requests must include a clear research proposal, evidence of appropriate institutional approvals (e.g. Human Research Ethics Committee approval or equivalent), and confirmation of secure data storage and handling procedures.

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS50000001722 Transcriptome Sequencing

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Quality Report
Located in
i
EGAF50000728619 fastq.gz 2.2 GB
EGAF50000728620 fastq.gz 451.7 MB
EGAF50000728621 gz 534.3 MB
EGAF50000728673 fastq.gz 979.2 MB
EGAF50000728674 fastq.gz 1.6 GB
EGAF50000728675 fastq.gz 1.1 GB
EGAF50000728676 fastq.gz 1.7 GB
EGAF50000728677 fastq.gz 1.4 GB
EGAF50000728678 fastq.gz 1.3 GB
EGAF50000728679 fastq.gz 1.2 GB
EGAF50000728680 fastq.gz 1.5 GB
EGAF50000728681 fastq.gz 886.6 MB
EGAF50000728682 fastq.gz 610.1 MB
EGAF50000728683 fastq.gz 678.3 MB
EGAF50000728684 fastq.gz 438.4 MB
EGAF50000728685 fastq.gz 331.8 MB
EGAF50000728686 fastq.gz 497.8 MB
EGAF50000728687 fastq.gz 328.9 MB
EGAF50000728688 fastq.gz 366.6 MB
EGAF50000728689 fastq.gz 431.8 MB
EGAF50000728690 fastq.gz 466.0 MB
EGAF50000728691 fastq.gz 386.5 MB
EGAF50000728692 fastq.gz 381.1 MB
EGAF50000728693 gz 637.2 MB
EGAF50000728694 gz 720.1 MB
EGAF50000728695 gz 580.5 MB
EGAF50000728696 gz 771.4 MB
EGAF50000728697 gz 702.1 MB
EGAF50000728719 fastq.gz 1.4 GB
29 Files (24.5 GB)