About file location

As the EGA is co-managed by the EMBL-EBI and CRG, files could be located in the UK and/or Spain, as indicated by their respective flags.

Alternatively, files could be located in one of the international Federated EGA nodes, as indicated next to the node's flag.
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TCR-seq (10x VDJ) – melanoma samples

This dataset comprises raw FASTQ files generated from T cell receptor (TCR) sequencing of metastatic melanoma samples using the 10x Genomics V(D)J platform. Single-cell suspensions were processed to generate paired gene expression and V(D)J libraries, with this dataset containing the V(D)J-enriched libraries targeting TCR α and β chains. Sequencing was performed on an Illumina platform to enable reconstruction of TCR clonotypes and analysis of clonal expansion. The dataset includes samples from patients with varying responses to immune checkpoint inhibitor therapy, supporting investigation of T cell clonality, antigen specificity, and immune dynamics associated with treatment response and resistance.

Request Access

DUO:0000015
version: 2021-02-23

no general methods research

This data use modifier indicates that use does not allow methods development research (e.g., development of software or algorithms).

DUO:0000018
version: 2021-02-23

not for profit, non commercial use only

This data use modifier indicates that use of the data is limited to not-for-profit organizations and not-for-profit use, non-commercial use.

DUO:0000019
version: 2021-02-23

publication required

This data use modifier indicates that requestor agrees to make results of studies using the data available to the larger scientific community.

DUO:0000020
version: 2021-02-23

collaboration required

This data use modifier indicates that the requestor must agree to collaboration with the primary study investigator(s).

DUO:0000021
version: 2021-02-23

ethics approval required

This data use modifier indicates that the requestor must provide documentation of local IRB/ERB approval.

DUO:0000042
version: 2021-02-23

general research use

This data use permission indicates that use is allowed for general research use for any research purpose.

DUO:0000044
version: 2021-02-23

population origins or ancestry research prohibited

This data use modifier indicates use for purposes of population, origin, or ancestry research is prohibited.

Controlled Access Policy for Melanoma Immunotherapy Resistance Dataset

Access to this dataset is controlled and granted by the Data Access Committee (DAC) in accordance with participant consent, institutional policies, and applicable ethical and legal frameworks. The dataset comprises genomic, transcriptomic, and associated clinical data derived from human melanoma samples, including bulk RNA sequencing, single-cell RNA sequencing, and T cell receptor sequencing data. Data will be made available to qualified researchers for bona fide scientific research purposes. Access requests must include a clear research proposal, evidence of appropriate institutional approvals (e.g. Human Research Ethics Committee approval or equivalent), and confirmation of secure data storage and handling procedures.

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS50000001722 Transcriptome Sequencing

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Quality Report
Located in
i
EGAF50000728630 fastq.gz 2.1 GB
EGAF50000728631 fastq.gz 2.2 GB
EGAF50000728642 fastq.gz 2.4 GB
EGAF50000728643 fastq.gz 2.5 GB
EGAF50000728644 fastq.gz 2.5 GB
EGAF50000728645 fastq.gz 2.3 GB
EGAF50000728646 fastq.gz 2.0 GB
EGAF50000728647 fastq.gz 2.1 GB
EGAF50000728648 fastq.gz 2.2 GB
EGAF50000728649 fastq.gz 2.3 GB
EGAF50000728656 fastq.gz 1.9 GB
EGAF50000728657 fastq.gz 2.0 GB
EGAF50000728658 fastq.gz 2.1 GB
EGAF50000728659 fastq.gz 2.2 GB
EGAF50000728660 fastq.gz 3.1 GB
EGAF50000728661 fastq.gz 3.3 GB
EGAF50000728662 fastq.gz 2.0 GB
EGAF50000728663 fastq.gz 2.1 GB
EGAF50000728664 fastq.gz 2.3 GB
EGAF50000728665 fastq.gz 2.5 GB
EGAF50000728710 fastq.gz 2.9 GB
EGAF50000728711 fastq.gz 3.1 GB
EGAF50000728712 fastq.gz 1.9 GB
EGAF50000728713 fastq.gz 2.0 GB
24 Files (56.1 GB)