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High Grade Serous Ovarian Cancer Whole Exome Sequencing

Whole exome sequencing (WES) was performed on genomic DNA (50–200 ng) extracted from high-grade serous ovarian cancer (HGSOC) tumor tissue and matched buffy coat or normal tissue. DNA was sheared using a Covaris E220 system to generate fragments of approximately 150–200 bp. Sequencing libraries were prepared using the Agilent SureSelect XT Low Input Library Preparation Kit with unique dual indices. Tumor libraries were enriched using a custom SureSelect V6 + UTR + OneSeq LowRes capture probe set, while germline libraries were enriched using the Agilent SureSelect Human All Exon V6 capture kit supplemented with custom probes. Libraries underwent initial quality control sequencing on the Illumina MiSeq platform, followed by pooled sequencing on the Illumina NovaSeq 6000 using a 300-cycle kit. Archived here are the BAM files for each sample.

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DUO:0000006
version: 2021-02-23

health or medical or biomedical research

This data use permission indicates that use is allowed for health/medical/biomedical purposes; does not include the study of population origins or ancestry.

DUO:0000018
version: 2021-02-23

not for profit, non commercial use only

This data use modifier indicates that use of the data is limited to not-for-profit organizations and not-for-profit use, non-commercial use.

Policy for access to human ovarian cancer whole exome sequencing data

The purpose of this policy is to establish the terms and conditions under which access will be granted to the deposited raw sequencing data. The dataset comprises whole exome sequencing data generated from high grade serous ovarian cancer (HGSOC) tumor tissue and matched buffy coat or normal samples. 1. The User Institution agrees to only use these Data for the purpose of the Project and only for Research Purposes. The Data may be used solely for non-commercial purposes and may not be shared, distributed, or sold to any third parties. 2. The User Institution agrees to preserve, at all times, the confidentiality of these Data. In particular, it undertakes not to use, or attempt to use, these Data to compromise or otherwise infringe the confidentiality of information on Research Participants. 3. The User Institution agrees to protect the confidentiality of Research Participants in any research papers or publications that they prepare by taking all reasonable care to limit the possibility of identification. 4. The User Institution agrees not to link or combine these Data with other information or archived data available in a way that could re-identify the Research Participants, even if access to that data has been formally granted to the User Institution or is freely available without restriction. 5. The User Institution agrees only to transfer or disclose these Data, in whole or in part, or any material derived from these Data, to the named Authorized Personnel. Should the User Institution wish to share these Data with an External Collaborator, the External Collaborator must complete a separate application for access to these Data. The User Institution must take reasonable precautions to protect the Data from unauthorized access. 6. The User Institution agrees that the Data Producers, and all other parties involved in the creation, funding, or protection of these Data: a) make no warranty or representation, express or implied, as to the accuracy, quality, or comprehensiveness of these Data; b) exclude to the fullest extent permitted by law all liability for actions, claims, proceedings, demands, losses (including but not limited to loss of profit), costs, awards, damages, and payments made by the Recipient that may arise (whether directly or indirectly) in any way whatsoever from the Recipient’s use of these Data or from the unavailability of, or break in access to, these Data for whatever reason; and c) bear no responsibility for the further analysis or interpretation of these Data. 7. The User Institution agrees to include a proper acknowledgement of the Data Producers in all reports or publications resulting from the use of these Data, including citation of the original publication. 8. The User Institution agrees to follow the Publication Policy in Appendix III. This includes respecting the moratorium period for the Data Producers to publish the first peer-reviewed report describing and analyzing these Data. 9. The User Institution agrees not to make intellectual property claims on these Data and not to use intellectual property protection in ways that would prevent or block access to, or use of, any element of these Data, or conclusions drawn directly from these Data. 10. The User Institution agrees to securely destroy the Data held upon completion of the approved Project. 11. The User Institution accepts that it may be necessary for the Data Producers to alter the terms of this agreement from time to time. In the event that changes are required, the Data Producers or their appointed agent will contact the User Institution to inform it of the changes and the User Institution may elect to accept the changes or terminate the agreement.

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS50000001730 Exome Sequencing
EGAS50000001731 Exome Sequencing

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Quality Report
Located in
EGAF50000735289 bam 13.8 GB
EGAF50000735290 bam 15.6 GB
EGAF50000735291 bam 15.2 GB
EGAF50000735292 bam 20.0 GB
EGAF50000735293 bam 15.1 GB
EGAF50000735294 bam 15.9 GB
EGAF50000735295 bam 13.7 GB
EGAF50000735296 bam 15.5 GB
EGAF50000735297 bam 12.8 GB
EGAF50000735298 bam 16.1 GB
EGAF50000735299 bam 13.6 GB
EGAF50000735300 bam 14.6 GB
EGAF50000735301 bam 14.7 GB
EGAF50000735302 bam 24.1 GB
EGAF50000735303 bam 13.6 GB
EGAF50000735304 bam 14.0 GB
EGAF50000735305 bam 15.3 GB
EGAF50000735306 bam 17.7 GB
EGAF50000735307 bam 13.4 GB
EGAF50000735308 bam 16.4 GB
EGAF50000735309 bam 15.8 GB
EGAF50000735310 bam 16.4 GB
EGAF50000735311 bam 15.7 GB
EGAF50000735312 bam 17.2 GB
EGAF50000735313 bam 14.7 GB
EGAF50000735314 bam 35.7 GB
EGAF50000735315 bam 35.9 GB
EGAF50000735316 bam 27.1 GB
EGAF50000735317 bam 26.8 GB
EGAF50000735318 bam 27.9 GB
EGAF50000735319 bam 28.8 GB
EGAF50000735320 bam 28.7 GB
EGAF50000735321 bam 24.2 GB
EGAF50000735322 bam 10.9 GB
EGAF50000735323 bam 37.8 GB
EGAF50000735324 bam 26.2 GB
EGAF50000735325 bam 21.0 GB
EGAF50000735326 bam 34.6 GB
EGAF50000735327 bam 35.7 GB
EGAF50000735328 bam 45.3 GB
EGAF50000735329 bam 25.2 GB
EGAF50000735330 bam 33.4 GB
EGAF50000735331 bam 28.8 GB
EGAF50000735332 bam 30.1 GB
EGAF50000735333 bam 39.1 GB
EGAF50000735334 bam 34.5 GB
EGAF50000735335 bam 26.8 GB
EGAF50000735336 bam 27.3 GB
EGAF50000735337 bam 32.4 GB
EGAF50000735338 bam 32.8 GB
50 Files (1.1 TB)