High Grade Serous Ovarian Cancer Whole Exome Sequencing
Whole exome sequencing (WES) was performed on genomic DNA (50–200 ng) extracted from high-grade serous ovarian cancer (HGSOC) tumor tissue and matched buffy coat or normal tissue. DNA was sheared using a Covaris E220 system to generate fragments of approximately 150–200 bp. Sequencing libraries were prepared using the Agilent SureSelect XT Low Input Library Preparation Kit with unique dual indices. Tumor libraries were enriched using a custom SureSelect V6 + UTR + OneSeq LowRes capture probe set, while germline libraries were enriched using the Agilent SureSelect Human All Exon V6 capture kit supplemented with custom probes. Libraries underwent initial quality control sequencing on the Illumina MiSeq platform, followed by pooled sequencing on the Illumina NovaSeq 6000 using a 300-cycle kit. Archived here are the BAM files for each sample.
- 02/09/2026
- 25 samples
- DAC: EGAC50000000834
- Technology: Illumina NovaSeq 6000
- Archive: European Genome-phenome Archive (EGA)
DUO:0000006 version: 2021-02-23
health or medical or biomedical research
This data use permission indicates that use is allowed for health/medical/biomedical purposes; does not include the study of population origins or ancestry.
DUO:0000018 version: 2021-02-23
not for profit, non commercial use only
This data use modifier indicates that use of the data is limited to not-for-profit organizations and not-for-profit use, non-commercial use.
Policy for access to human ovarian cancer whole exome sequencing data
The purpose of this policy is to establish the terms and conditions under which access will be granted to the deposited raw sequencing data. The dataset comprises whole exome sequencing data generated from high grade serous ovarian cancer (HGSOC) tumor tissue and matched buffy coat or normal samples. 1. The User Institution agrees to only use these Data for the purpose of the Project and only for Research Purposes. The Data may be used solely for non-commercial purposes and may not be shared, distributed, or sold to any third parties. 2. The User Institution agrees to preserve, at all times, the confidentiality of these Data. In particular, it undertakes not to use, or attempt to use, these Data to compromise or otherwise infringe the confidentiality of information on Research Participants. 3. The User Institution agrees to protect the confidentiality of Research Participants in any research papers or publications that they prepare by taking all reasonable care to limit the possibility of identification. 4. The User Institution agrees not to link or combine these Data with other information or archived data available in a way that could re-identify the Research Participants, even if access to that data has been formally granted to the User Institution or is freely available without restriction. 5. The User Institution agrees only to transfer or disclose these Data, in whole or in part, or any material derived from these Data, to the named Authorized Personnel. Should the User Institution wish to share these Data with an External Collaborator, the External Collaborator must complete a separate application for access to these Data. The User Institution must take reasonable precautions to protect the Data from unauthorized access. 6. The User Institution agrees that the Data Producers, and all other parties involved in the creation, funding, or protection of these Data: a) make no warranty or representation, express or implied, as to the accuracy, quality, or comprehensiveness of these Data; b) exclude to the fullest extent permitted by law all liability for actions, claims, proceedings, demands, losses (including but not limited to loss of profit), costs, awards, damages, and payments made by the Recipient that may arise (whether directly or indirectly) in any way whatsoever from the Recipient’s use of these Data or from the unavailability of, or break in access to, these Data for whatever reason; and c) bear no responsibility for the further analysis or interpretation of these Data. 7. The User Institution agrees to include a proper acknowledgement of the Data Producers in all reports or publications resulting from the use of these Data, including citation of the original publication. 8. The User Institution agrees to follow the Publication Policy in Appendix III. This includes respecting the moratorium period for the Data Producers to publish the first peer-reviewed report describing and analyzing these Data. 9. The User Institution agrees not to make intellectual property claims on these Data and not to use intellectual property protection in ways that would prevent or block access to, or use of, any element of these Data, or conclusions drawn directly from these Data. 10. The User Institution agrees to securely destroy the Data held upon completion of the approved Project. 11. The User Institution accepts that it may be necessary for the Data Producers to alter the terms of this agreement from time to time. In the event that changes are required, the Data Producers or their appointed agent will contact the User Institution to inform it of the changes and the User Institution may elect to accept the changes or terminate the agreement.
Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.
| Study ID | Study Title | Study Type |
|---|---|---|
| EGAS50000001730 | Exome Sequencing | |
| EGAS50000001731 | Exome Sequencing |
This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.
| ID | File Type | Size | Quality Report |
Located in
i
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|---|---|---|---|---|
| EGAF50000735289 | bam | 13.8 GB |
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| EGAF50000735290 | bam | 15.6 GB |
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| EGAF50000735291 | bam | 15.2 GB |
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| EGAF50000735292 | bam | 20.0 GB |
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| EGAF50000735293 | bam | 15.1 GB |
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| EGAF50000735294 | bam | 15.9 GB |
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| EGAF50000735295 | bam | 13.7 GB |
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| EGAF50000735296 | bam | 15.5 GB |
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| EGAF50000735297 | bam | 12.8 GB |
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| EGAF50000735298 | bam | 16.1 GB |
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| EGAF50000735299 | bam | 13.6 GB |
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| EGAF50000735300 | bam | 14.6 GB |
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| EGAF50000735301 | bam | 14.7 GB |
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| EGAF50000735302 | bam | 24.1 GB |
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| EGAF50000735303 | bam | 13.6 GB |
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| EGAF50000735304 | bam | 14.0 GB |
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| EGAF50000735305 | bam | 15.3 GB |
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| EGAF50000735306 | bam | 17.7 GB |
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| EGAF50000735307 | bam | 13.4 GB |
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| EGAF50000735308 | bam | 16.4 GB |
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| EGAF50000735309 | bam | 15.8 GB |
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| EGAF50000735310 | bam | 16.4 GB |
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| EGAF50000735311 | bam | 15.7 GB |
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| EGAF50000735312 | bam | 17.2 GB |
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| EGAF50000735313 | bam | 14.7 GB |
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| EGAF50000735314 | bam | 35.7 GB |
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| EGAF50000735315 | bam | 35.9 GB |
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| EGAF50000735316 | bam | 27.1 GB |
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| EGAF50000735317 | bam | 26.8 GB |
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| EGAF50000735318 | bam | 27.9 GB |
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| EGAF50000735319 | bam | 28.8 GB |
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| EGAF50000735320 | bam | 28.7 GB |
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| EGAF50000735321 | bam | 24.2 GB |
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| EGAF50000735322 | bam | 10.9 GB |
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| EGAF50000735323 | bam | 37.8 GB |
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| EGAF50000735324 | bam | 26.2 GB |
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| EGAF50000735325 | bam | 21.0 GB |
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| EGAF50000735326 | bam | 34.6 GB |
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| EGAF50000735327 | bam | 35.7 GB |
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| EGAF50000735328 | bam | 45.3 GB |
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| EGAF50000735329 | bam | 25.2 GB |
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| EGAF50000735330 | bam | 33.4 GB |
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| EGAF50000735331 | bam | 28.8 GB |
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| EGAF50000735332 | bam | 30.1 GB |
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| EGAF50000735333 | bam | 39.1 GB |
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| EGAF50000735334 | bam | 34.5 GB |
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| EGAF50000735335 | bam | 26.8 GB |
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| EGAF50000735336 | bam | 27.3 GB |
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| EGAF50000735337 | bam | 32.4 GB |
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| EGAF50000735338 | bam | 32.8 GB |
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| 50 Files (1.1 TB) | ||||
