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Longitudinal Studies of Brain Structure and Function in MPS Disorders
Study
phs001328
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Childhood Cancer Data Initiative (CCDI): Molecular Characterization across Pediatric Brain Tumors and Other Solid and Hematologic Malignancies for Research, Diagnostic, and Precision Medicine
Study
phs002517
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Integrating Genomic and Transcriptomic Data to Identify Breast Cancer Susceptibility Genes
Study
phs003535
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Epi4K: Gene Discovery in 4,000 Epilepsy Genomes
Study
phs000653
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Effectiveness and Safety of Intermittent Antimicrobial Therapy for the Treatment of New Onset Pseudomonas Aeruginosa Airway Infection in Young Patients With Cystic Fibrosis (EPIC-BioLINCC)
Study
phs004067
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Profiling Genome-Wide Circulating ncRNAs for the Early Detection of Lung Cancer
Study
phs004166
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Psychophysiological Investigation of Myocardial Ischemia (PIMI-BioLINCC)
Study
phs004183
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Effects of 2DG, Galactose, or Oligomycin on the epigenome remodeling induce by T cells activation.
Study
EGAS00001007115
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Lindsey E. Jones et al. Patient-derived cells from recurrent tumors that model the evolution of IDH-mutant glioma. Neuro-Oncology Advances, 2020. We established robust, versatile, and well-characterized Patient Derived Cells (PDC) of an IDH1-mutant astrocytoma and an IDH1-mutant oligodendroglioma that represents defined evolutionary stages of chemotherapy-induced hypermutation. The PDCs retain tumor subtype defining features over time as well as classic hallmarks of cancer, including anchorage independent growth and cell immortality. The integrated phylogenies composed of PDCs,single-cell-derived PDCs, patient-derived xenografts, and corresponding spatiotemporal tumor tissue samples also provide new insight into the clonality, evolutionary pattern, and immense mutational load of hypermutated IDH mutant gliomas.
Study
EGAS00001003992
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The subclonal architecture of metastatic breast cancer: Results from a prospective community-based rapid autopsy program 'CASCADE'
Study
EGAS00001002153