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• Exome sequencing of blastic plasmacytoid dendritic cell neoplasms

  Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive haematological malignancy derived from precursors of plasmacytoid dendritic cells. Due to the rarity of BPDCNs our knowledge of their molecular pathogenesis was until recently confined to observations describing reccurent chromosomal deletions involving chromosomes 5q, 12p, 13q, 6q, 15q and 9. A recent publication went on to delineate the common deleted regions using aCGH and demonstrated that these centred around known tumour suppressor genes including CDKN2A/B (9p21.3), RB1 (12p13.2-14.3), CDKN1B (13q11-q12) and IKZF1 (7p12.2). These mutations are found recurrently in several different cancers and in most cases are thought to be involved in tumour progression rather than initiation. However, the well-defined nature and cellular ontogeny of these neoplasms suggests strongly that they share one or a few characteristic mutations as has been demonstrated for other uncommon but well-defined neoplasms such as Hairy Cell Leukemia (BRAF) and ovarian Granulosa Cell tumours (FOXL2).

  Dataset EGAD00001000406

• MethylationEPIC_850K

  This dataset includes IDAT files from 160 samples (57 primary prostate cancers, 95 proste-derived brain metastases, and 7 normal tissues). The samples were profiled using the Illumina Infinium MethylationEPIC BeadChips (850K)

  Dataset EGAD00010002372

• Raw NGS data of primary AML samples

  Raw NGS data of primary Acute Myeloid Leukemia samples. The libraries were obtained with Sophia Genetics Myeloid Solution kit, targeting 30 genes involved in AML.

  Dataset EGAD50000000506

• Convergent genetic adaptation in human tumors developed under systemic hypoxia and in populations living at high altitudes

  Genomic files, including whole-exome and RNA-seq data from tumors and cell lines, were generated and analyzed in this study.

  Dac EGAC50000000484

• Single cell RNA sequencing of samples from core and periphery of human glioblastoma

  Samples taken from various regions of three human glioblastomas were subject to single cell RNA sequencing.

  Dataset EGAD50000002080

• Proteomics of 7-member healthy family (father, mother, their three biological daughters and monozygotic twin sons)

  The dataset contains proteomics data of seven healthy family members. The samples were taken from peripheral blood mononuclear cells.

  Dataset EGAD00001009985

• Live slow-frozen human tumor tissues scRNA

  Bam files of 17 samples from 11 different patients. The scRNAseq data were obtained using the 10X 3' Gene Expression kit.

  Dataset EGAD00001009284

• Concepción Aguilera belongs to the Department of Biochemistry and Molecular Biology II from the University of Granada and is head of the molecular biology research group BIONIT (CTS-461).

  Dac EGAC00001000779

• GM

  metabolite levels measured by general metabolomics (Boston, USA) (the data is raw abundance. Mapping was applied on log10 transformed data)

  Dataset EGAD00010002148

• Genetic Susceptibility and Biomarkers of Platinum-Related Toxicities

  The Platinum Study is an R01-funded, multicenter study of testicular cancer survivors that characterizes both long-term cisplatin-induced peripheral neuropathy (CisIPN) and cisplatin-associated ototoxicity, i.e., permanent, bilateral hearing loss. We collected data abstracted from medical records (e.g., cumulative cisplatin dose), conducted audiometric examinations, and administered self-report questionnaires, which included CisIPN symptoms.

  Study phs001621