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• Inter and intra - tumor heterogeneity in Colorectal Cancer

  We used high depth massive parallel sequencing analyses to study 27 CRC (colorectal cancer) patients, with a total of 97 tumors (both primary and matched metastases) in addition to healthy control samples. We found inter-tumor concordance for coding mutations; in contrast, gene copy numbers were found to be highly discordant between primary tumors and metastases as validated by fluorescent in-situ hybridization. in a further step, we dissected a single tumor into 68 spatially defined samples and sequenced them separately. Here we identify evenly distributed coding mutations in APC and TP53 in all tumor areas, yet highly variable gene copy numbers in numerous genes.

  Study EGAS00001002150

• A110632A

  Whole genome sequencing for single cells for library A110632A 1151 cells; filetype=bam

  Dataset EGAD00001007094

• A110632B

  Whole genome sequencing for single cells for library A110632B 892 cells; filetype=bam

  Dataset EGAD00001007095

• A118833A

  Whole genome sequencing for single cells for library A118833A 919 cells; filetype=bam

  Dataset EGAD00001007096

• A118833B

  Whole genome sequencing for single cells for library A118833B 1147 cells; filetype=bam

  Dataset EGAD00001007097

• A118845B

  Whole genome sequencing for single cells for library A118845B 1209 cells; filetype=bam

  Dataset EGAD00001007098

• A118869A

  Whole genome sequencing for single cells for library A118869A 1165 cells; filetype=bam

  Dataset EGAD00001007099

• A118869B

  Whole genome sequencing for single cells for library A118869B 1124 cells; filetype=bam

  Dataset EGAD00001007100

• A95626A

  Whole genome sequencing for single cells for library A95626A 1040 cells; filetype=bam

  Dataset EGAD00001007103

• A95634B

  Whole genome sequencing for single cells for library A95634B 1335 cells; filetype=bam

  Dataset EGAD00001007105

• A95646A

  Whole genome sequencing for single cells for library A95646A 1071 cells; filetype=bam

  Dataset EGAD00001007106

• A95653B

  Whole genome sequencing for single cells for library A95653B 1342 cells; filetype=bam

  Dataset EGAD00001007107

• A95663B

  Whole genome sequencing for single cells for library A95663B 1364 cells; filetype=bam

  Dataset EGAD00001007108

• A95675A

  Whole genome sequencing for single cells for library A95675A 668 cells; filetype=bam

  Dataset EGAD00001007109

• A95731B

  Whole genome sequencing for single cells for library A95731B 1307 cells; filetype=bam

  Dataset EGAD00001007110

• A96115B

  Whole genome sequencing for single cells for library A96115B 1201 cells; filetype=bam

  Dataset EGAD00001007112

• A96118A

  Whole genome sequencing for single cells for library A96118A 1193 cells; filetype=bam

  Dataset EGAD00001007113

• A96130B

  Whole genome sequencing for single cells for library A96130B 1267 cells; filetype=bam

  Dataset EGAD00001007114

• A96178A

  Whole genome sequencing for single cells for library A96178A 788 cells; filetype=bam

  Dataset EGAD00001007115

• A96178B

  Whole genome sequencing for single cells for library A96178B 846 cells; filetype=bam

  Dataset EGAD00001007116

• A96181C

  Whole genome sequencing for single cells for library A96181C 1216 cells; filetype=bam

  Dataset EGAD00001007117

• A96225B

  Whole genome sequencing for single cells for library A96225B 959 cells; filetype=bam

  Dataset EGAD00001007119

• A96225C

  Whole genome sequencing for single cells for library A96225C 1034 cells; filetype=bam

  Dataset EGAD00001007120

• A96240A

  Whole genome sequencing for single cells for library A96240A 1493 cells; filetype=bam

  Dataset EGAD00001007121

• A98172A

  Whole genome sequencing for single cells for library A98172A 898 cells; filetype=bam

  Dataset EGAD00001007123

• A98256A

  Whole genome sequencing for single cells for library A98256A 1372 cells; filetype=bam

  Dataset EGAD00001007124

• A98256B

  Whole genome sequencing for single cells for library A98256B 1437 cells; filetype=bam

  Dataset EGAD00001007125

• A98257B

  Whole genome sequencing for single cells for library A98257B 1286 cells; filetype=bam

  Dataset EGAD00001007126

• A98258B

  Whole genome sequencing for single cells for library A98258B 1357 cells; filetype=bam

  Dataset EGAD00001007127

• A98274B

  Whole genome sequencing for single cells for library A98274B 1295 cells; filetype=bam

  Dataset EGAD00001007128

• A98282A

  Whole genome sequencing for single cells for library A98282A 1198 cells; filetype=bam

  Dataset EGAD00001007129

• A98283A

  Whole genome sequencing for single cells for library A98283A 1137 cells; filetype=bam

  Dataset EGAD00001007130

• A98285A

  Whole genome sequencing for single cells for library A98285A 1422 cells; filetype=bam

  Dataset EGAD00001007131

• A98295B

  Whole genome sequencing for single cells for library A98295B 1381 cells; filetype=bam

  Dataset EGAD00001007132

• A110673B

  Whole genome sequencing for single cells for library A110673B 1153 cells; filetype=bam

  Dataset EGAD00001007603

• A118830A

  Whole genome sequencing for single cells for library A118830A 912 cells; filetype=bam

  Dataset EGAD00001007604

• A118862A

  Whole genome sequencing for single cells for library A118862A 1070 cells; filetype=bam

  Dataset EGAD00001007605

• A118862B

  Whole genome sequencing for single cells for library A118862B 1152 cells; filetype=bam

  Dataset EGAD00001007606

• A95623B

  Whole genome sequencing for single cells for library A95623B 1363 cells; filetype=bam

  Dataset EGAD00001007608

• A95697B

  Whole genome sequencing for single cells for library A95697B 1233 cells; filetype=bam

  Dataset EGAD00001007610

• A95700A

  Whole genome sequencing for single cells for library A95700A 1172 cells; filetype=bam

  Dataset EGAD00001007611

• A95703A

  Whole genome sequencing for single cells for library A95703A 740 cells; filetype=bam

  Dataset EGAD00001007612

• A96233A

  Whole genome sequencing for single cells for library A96233A 637 cells; filetype=bam

  Dataset EGAD00001007622

• A95730A

  Whole genome sequencing for single cells for library A95730A 739 cells; filetype=bam

  Dataset EGAD00001007614

• A96114A

  Whole genome sequencing for single cells for library A96114A 798 cells; filetype=bam

  Dataset EGAD00001007615

• A96124B

  Whole genome sequencing for single cells for library A96124B 1241 cells; filetype=bam

  Dataset EGAD00001007616

• A96155C

  Whole genome sequencing for single cells for library A96155C 1316 cells; filetype=bam

  Dataset EGAD00001007617

• A96162A

  Whole genome sequencing for single cells for library A96162A 1505 cells; filetype=bam

  Dataset EGAD00001007618

• A96183B

  Whole genome sequencing for single cells for library A96183B 1191 cells; filetype=bam

  Dataset EGAD00001007619

• A96226B

  Whole genome sequencing for single cells for library A96226B 1274 cells; filetype=bam

  Dataset EGAD00001007621

• A98168A

  Whole genome sequencing for single cells for library A98168A 1294 cells; filetype=bam

  Dataset EGAD00001007624

• A98168B

  Whole genome sequencing for single cells for library A98168B 1290 cells; filetype=bam

  Dataset EGAD00001007625

• A98234A

  Whole genome sequencing for single cells for library A98234A 1240 cells; filetype=bam

  Dataset EGAD00001007626

• A98244A

  Whole genome sequencing for single cells for library A98244A 1271 cells; filetype=bam

  Dataset EGAD00001007628

• A98253A

  Whole genome sequencing for single cells for library A98253A 1250 cells; filetype=bam

  Dataset EGAD00001007629

• A98253B

  Whole genome sequencing for single cells for library A98253B 1388 cells; filetype=bam

  Dataset EGAD00001007630

• A98254A

  Whole genome sequencing for single cells for library A98254A 1490 cells; filetype=bam

  Dataset EGAD00001007631

• A98255B

  Whole genome sequencing for single cells for library A98255B 1394 cells; filetype=bam

  Dataset EGAD00001007632

• A98271A

  Whole genome sequencing for single cells for library A98271A 1190 cells; filetype=bam

  Dataset EGAD00001007633

• A98289A

  Whole genome sequencing for single cells for library A98289A 1066 cells; filetype=bam

  Dataset EGAD00001007634

• A98290B

  Whole genome sequencing for single cells for library A98290B 869 cells; filetype=bam

  Dataset EGAD00001007635

• A98305A

  Whole genome sequencing for single cells for library A98305A 986 cells; filetype=bam

  Dataset EGAD00001007637

• A108732A

  Whole genome sequencing for single cells for library A108732A 1139 cells; filetype=bam

  Dataset EGAD00001007592

• A108833B

  Whole genome sequencing for single cells for library A108833B 866 cells; filetype=bam

  Dataset EGAD00001007594

• A108842A

  Whole genome sequencing for single cells for library A108842A 1477 cells; filetype=bam

  Dataset EGAD00001007595

• A108863A

  Whole genome sequencing for single cells for library A108863A 1301 cells; filetype=bam

  Dataset EGAD00001007597

• A110618A

  Whole genome sequencing for single cells for library A110618A 1184 cells; filetype=bam

  Dataset EGAD00001007599

• Single Cell Genome Sequence for DLP+ library A118389B

  Single Cell Genome Sequence for Telomerase immortalized breast epithelium cell line 184-hTERT 85.14 p20 cell line AT135 on DLP+ library A118389B

  Dataset EGAD00001009433

• Single Cell Genome Sequence for DLP+ library A118782A

  Single Cell Genome Sequence for high grade serous ovarian carcinoma patient-derived xenograft SA1050B passage 1, patient-derived xenograft SA1050E passage 1 on DLP+ library A118782A

  Dataset EGAD00001009435

• Single Cell Genome Sequence for DLP+ library A118808A

  Single Cell Genome Sequence for high grade serous ovarian carcinoma patient-derived xenograft SA1096B passage 1 on DLP+ library A118808A

  Dataset EGAD00001009440

• Single Cell Genome Sequence for DLP+ library A118812B

  Single Cell Genome Sequence for high grade serous ovarian carcinoma patient-derived xenograft SA1180C passage 1 on DLP+ library A118812B

  Dataset EGAD00001009442

• Single Cell Genome Sequence for DLP+ library A118816A

  Single Cell Genome Sequence for high grade serous ovarian carcinoma patient-derived xenograft SA1180C passage 1 on DLP+ library A118816A

  Dataset EGAD00001009444

• Single Cell Genome Sequence for DLP+ library A118857B

  Single Cell Genome Sequence for high grade serous ovarian carcinoma patient-derived xenograft SA1184D passage 1 on DLP+ library A118857B

  Dataset EGAD00001009445

• Single Cell Genome Sequence for DLP+ library A95663A

  Single Cell Genome Sequence for high grade serous ovarian carcinoma patient-derived xenograft SA1053F passage 1 on DLP+ library A95663A

  Dataset EGAD00001009446

• Single Cell Genome Sequence for DLP+ library A95668A

  Single Cell Genome Sequence for high grade serous ovarian carcinoma patient SA1162SA on DLP+ library A95668A

  Dataset EGAD00001009447

• Single Cell Genome Sequence for DLP+ library A95670A

  Single Cell Genome Sequence for triple negative breast cancer patient-derived xenograft SA501 passage 5 on DLP+ library A95670A

  Dataset EGAD00001009448

• Single Cell Genome Sequence for DLP+ library A95670B

  Single Cell Genome Sequence for triple negative breast cancer patient-derived xenograft SA501 passage 6 on DLP+ library A95670B

  Dataset EGAD00001009449

• Single Cell Genome Sequence for DLP+ library A95717A

  Single Cell Genome Sequence for high grade serous ovarian carcinoma patient-derived xenograft SA1096A passage 1 on DLP+ library A95717A

  Dataset EGAD00001009450

• Single Cell Genome Sequence for DLP+ library A95722A

  Single Cell Genome Sequence for triple negative breast cancer patient-derived xenograft SA604 passage 6 on DLP+ library A95722A

  Dataset EGAD00001009451

• Single Cell Genome Sequence for DLP+ library A96109A

  Single Cell Genome Sequence for triple negative breast cancer patient-derived xenograft SA501 passage 2 on DLP+ library A96109A

  Dataset EGAD00001009452

• Single Cell Genome Sequence for DLP+ library A96113A

  Single Cell Genome Sequence for high grade serous ovarian carcinoma patient-derived xenograft SA1049A passage on DLP+ library A96113A

  Dataset EGAD00001009453

• Single Cell Genome Sequence for DLP+ library A96130A

  Single Cell Genome Sequence for triple negative breast cancer patient-derived xenograft SA609 passage 8 on DLP+ library A96130A

  Dataset EGAD00001009454

• Single Cell Genome Sequence for DLP+ library A96142B

  Single Cell Genome Sequence for high grade serous ovarian carcinoma patient SA1162SA on DLP+ library A96142B

  Dataset EGAD00001009455

• Single Cell Genome Sequence for DLP+ library A96154A

  Single Cell Genome Sequence for triple negative breast cancer patient SA1135, patient SA1162SA on DLP+ library A96154A

  Dataset EGAD00001009456

• Single Cell Genome Sequence for DLP+ library A96161A

  Single Cell Genome Sequence for triple negative breast cancer patient-derived xenograft SA604 passage 8 on DLP+ library A96161A

  Dataset EGAD00001009457

• Single Cell Genome Sequence for DLP+ library A96173A

  Single Cell Genome Sequence for triple negative breast cancer patient-derived xenograft SA501 passage 15 on DLP+ library A96173A

  Dataset EGAD00001009459

• Single Cell Genome Sequence for DLP+ library A96174A

  Single Cell Genome Sequence for triple negative breast cancer patient-derived xenograft SA501 passage 11 on DLP+ library A96174A

  Dataset EGAD00001009460

• Single Cell Genome Sequence for DLP+ library A96175A

  Single Cell Genome Sequence for triple negative breast cancer patient-derived xenograft SA604 passage 7 on DLP+ library A96175A

  Dataset EGAD00001009461

• Single Cell Genome Sequence for DLP+ library A96177C

  Single Cell Genome Sequence for triple negative breast cancer patient-derived xenograft SA604 passage 6 on DLP+ library A96177C

  Dataset EGAD00001009462

• Single Cell Genome Sequence for DLP+ library A96180A

  Single Cell Genome Sequence for triple negative breast cancer patient-derived xenograft SA604 passage 6 on DLP+ library A96180A

  Dataset EGAD00001009463

• Single Cell Genome Sequence for DLP+ library A96187A

  Single Cell Genome Sequence for triple negative breast cancer patient-derived xenograft SA501 passage 11, patient-derived xenograft SA609 passage 7 on DLP+ library A96187A

  Dataset EGAD00001009464

• Single Cell Genome Sequence for DLP+ library A96189A

  Single Cell Genome Sequence for high grade serous ovarian carcinoma patient-derived xenograft SA1049C passage 1 on DLP+ library A96189A

  Dataset EGAD00001009465

• Single Cell Genome Sequence for DLP+ library A96190B

  Single Cell Genome Sequence for high grade serous ovarian carcinoma patient-derived xenograft SA1051A passage 1 on DLP+ library A96190B

  Dataset EGAD00001009466

• Single Cell Genome Sequence for DLP+ library A96192A

  Single Cell Genome Sequence for high grade serous ovarian carcinoma patient-derived xenograft SA1093C passage 1, patient SA1147 on DLP+ library A96192A

  Dataset EGAD00001009467

• Single Cell Genome Sequence for DLP+ library A96194A

  Single Cell Genome Sequence for high grade serous ovarian carcinoma patient-derived xenograft SA1053B passage 1 on DLP+ library A96194A

  Dataset EGAD00001009468

• Single Cell Genome Sequence for DLP+ library A96194B

  Single Cell Genome Sequence for high grade serous ovarian carcinoma patient-derived xenograft SA1053E passage 1 on DLP+ library A96194B

  Dataset EGAD00001009469

• Single Cell Genome Sequence for DLP+ library A96200B

  Single Cell Genome Sequence for high grade serous ovarian carcinoma patient-derived xenograft SA1052D passage 1 on DLP+ library A96200B

  Dataset EGAD00001009470

• Single Cell Genome Sequence for DLP+ library A96205B

  Single Cell Genome Sequence for high grade serous ovarian carcinoma patient-derived xenograft SA1049A passage 1 on DLP+ library A96205B

  Dataset EGAD00001009471

• Single Cell Genome Sequence for DLP+ library A96206B

  Single Cell Genome Sequence for high grade serous ovarian carcinoma patient-derived xenograft SA1050F passage 1 on DLP+ library A96206B

  Dataset EGAD00001009472

• Single Cell Genome Sequence for DLP+ library A96207A

  Single Cell Genome Sequence for high grade serous ovarian carcinoma patient-derived xenograft SA1051A passage 1 on DLP+ library A96207A

  Dataset EGAD00001009473