Search Results - EGA European Genome-Phenome Archive

June 2016 data update for reference epigenomes generated at Centre for Epigenome Mapping Technologies, Genome Sciences Center, B.C. Cancer Agency as part of the International Human Epigenome Consortium.

June 2016 data update (bam/fastq for CEMT0062, CEMT0068, CEMT0072, CEMT0086, CEMT0087 ChIP-Seq and RNA-Seq) for reference epigenomes generated at Centre for Epigenome Mapping Technologies (Canadian Epigenetics, Environment and Health Research Consortium), Genome Sciences Center, B.C. Cancer Agency, Vancouver, Canada as part of the International Human Epigenome Consortium.

Dataset EGAD00001002239

A case of colorectal cancer with ERBB2 c.2264T>C (p.Leu755Ser) mutation

This data set contains next generation sequencing (NGS) data of two serial tumor samples (primary and a metastasis) from a patient with colorectal cancer showing an ERBB2 c.2264T>C (p.Leu755Ser). NGS was performed using the Illumina TruSeq Amplicon Cancer Panel (TSACP, Illumina) covering 212 amplicons in 48 cancer associated genes on the Illumina MiSeq sequencing platform. The dataset contains two BAM files.

Dataset EGAD00001002252

Trimmed bam-files from whole genome sequencing data from plasma DNA

Single-end sequencing data (trimmed to 60bp) of 104 plasma samples from donors without tumors (male=50; female=54) were merged and used to establish coverage profiles around the TSS and to establish a gene expression prediction algorithm. Dataset includes merged alignements of low coverage whole genome sequencing from plasma DNA from 50 male, 54 female non-cancer donors. Furthermore, 2 patients with metastasized breast cancer were sequenced on a NextSeq with higher depth.

Dataset EGAD00001002254

Breast Cancer -Very young women with ER+ tumor

Corresponding data set is composed of whole exome sequencing of Korean ER positive breast cancer under 35. This set provides 100 alignment files from normal-tumor paired whole exome sequencing of 50 patients. This is a part of total project data set.

Dataset EGAD00001002256

Mitochondrial peroxiredoxin 3 is a tractable cancer therapeutic target modulated by SLC7A11

This study is aimed at elucidating the anti-tumor mechanism and therapeutic potential of the PRX3 inhibitor thiostrepton in mesothelioma by investigating its effects on mitochondrial redox homeostasis, oxidative stress–induced apoptosis, and tumor suppression in preclinical and clinical settings. Mesothelioma explants are treated with thiostrepton and subjected to RNA sequencing under baseline, untreated control, and thiostrepton-treated conditions to characterize treatment-induced transcriptional alterations and identify molecular pathways associated with therapeutic response and resistance.

Study EGAS50000001827

Whole exome sequencing data of germline and two independent primary leukemias of five patients

The contribution of genetic predisposing factors to the development of pediatric acute lymphoblastic leukemia (ALL), the most frequently diagnosed cancer in childhood, has not been fully elucidated. Children presenting with multiple de novo leukemias are more likely to suffer from genetic predisposition. Here, we selected five of these patients and analyzed the mutational spectrum of normal and malignant tissues.

Dataset EGAD00001002266

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June 2016 data update for reference epigenomes generated at Centre for Epigenome Mapping Technologies, Genome Sciences Center, B.C. Cancer Agency as part of the International Human Epigenome Consortium.

A case of colorectal cancer with ERBB2 c.2264T&gt;C (p.Leu755Ser) mutation

Trimmed bam-files from whole genome sequencing data from plasma DNA

Breast Cancer -Very young women with ER+ tumor

Mitochondrial peroxiredoxin 3 is a tractable cancer therapeutic target modulated by SLC7A11

Whole exome sequencing data of germline and two independent primary leukemias of five patients

Genome and transcriptome sequence data from a breast cancer patient

Genome and transcriptome sequence data from a breast cancer patient

Genome and transcriptome sequence data from an ovarian cancer patient

Genome and transcriptome sequence data from a breast cancer patient

Genome and transcriptome sequence data from a uterine sarcoma patient

Genome and transcriptome sequence data from a cholangiocarcinoma patient

Genome and transcriptome sequence data from a breast cancer patient

Genome and transcriptome sequence data from a breast cancer patient

Genome and transcriptome sequence data from a breast cancer patient

Genome and transcriptome sequence data from an ovarian cancer patient

Genome and transcriptome sequence data from a breast cancer patient

Genome and transcriptome sequence data from an ovarian cancer patient

Genome and transcriptome sequence data from a duodenal malignancy patient

Genome and transcriptome sequence data from a melanoma patient

Exome and transcriptome sequence data from a breast cancer patient

Genome and transcriptome sequence data from a lung cancer patient

Genome and transcriptome sequence data from a breast cancer patient

Genome and transcriptome sequence data from a primary unknown cancer patient

Genome and transcriptome sequence data from a breast cancer patient

Genome and transcriptome sequence data from a Ewing sarcoma patient

Genome and transcriptome sequence data from an unknown cancer patient

Genome and transcriptome sequence data from a breast cancer patient

Genome and transcriptome sequence data from a breast cancer patient

Genome and transcriptome sequence data from a breast cancer patient

Genome and transcriptome sequence data from a liposarcoma patient

Genome and transcriptome sequence data from a breast cancer patient

Genome and transcriptome sequence data from an oligodendroglioma patient

Genome and transcriptome sequence data from a metastatic breast carcinoma patient

Genome and transcriptome sequence data from a metastatic colorectal cancer patient

Genome and transcriptome sequence data from a squamous cell carcinoma of vulva patient

Genome and transcriptome sequence data from a metastatic melanoma patient

Genome and transcriptome sequence data from a vulvar metastatic melanoma patient

Genome and transcriptome sequence data from a retroperitoneal leiomyosarcoma patient

Genome and transcriptome sequence data from a squamous cell carcinoma of anal canal patient

Genome and transcriptome sequence data from a metastatic myxofibrosarcoma patient

Genome and transcriptome sequence data from a right breast carcinoma patient

Genome and transcriptome sequence data from a carcinoma of left lower outer quadrant patient

Genome and transcriptome sequence data from a breast cancer patient

Genome and transcriptome sequence data from an adenocarcinoma of primary unknown cancer patient

Genome and transcriptome sequence data from a breast cancer patient

Genome and transcriptome sequence data from a metastatic colorectal cancer patient

Genome and transcriptome sequence data from a ductal carcinoma of left breast patient

Genome and transcriptome sequence data from a metastatic colorectal cancer patient

Genome and transcriptome sequence data from an infiltrating ductal carcinoma of right breast patient

A case of colorectal cancer with ERBB2 c.2264T>C (p.Leu755Ser) mutation