Basic phenotypes for SPGRX cohort.
Lab values for Hostage1 cohort.
Lab values for INMUNGEN_CoV2 cohort.
Basic phenotypes for INMUNGEN_CoV2 cohort.
Lab values for Hostage4 cohort.
Basic phenotypes for Hostage4 cohort.
Lab values for Hostage3 cohort.
Basic phenotypes for Hostage1 cohort.
Lab values for Hostage2 cohort.
Lab values for GEN_COVID cohort.
Basic phenotypes for GEN_COVID cohort.
Lab values for BelCovid2 cohort.
The biomarker development study consisted of two parts: discovery and validation. The first part was the discovery and verification phase of biomarkers using two different platforms: transcriptomic and miRNA. The salivary transcriptomes of 63 GC samples and 31 non-GC controls were profiled using Affymetrix HG U133+2.0 microarrays (Affymetrix, Santa Clara, CA). The identified exRNA candidates were verified by quantitative real-time PCR (RT-qPCR) using all 94 of the original samples. In the discovery phase for the miRNA biomarkers, 10 early-stage GC samples and 10 non-GC controls were selected. The salivary miRNAs of these samples (n=20) were profiled using the TaqMan MicroRNA Array (Applied Biosystems, Foster City, CA). MicroRNA candidates were verified using TaqMan miRNA Assay (Thermo Scientific, Grand Island, NY). The second part of the study was to validate these verified exRNA biomarker candidates with exRNA samples extracted from an independent cohort of 100 GC and 100 non-GC saliva samples. The cohort was not balanced for demographics on gender and smoking history but more accurately reflected the diagnostic setting where our proposed final model could be implemented. Reprinted from "Li F, Yoshizawa MJ, Kim K, Kanjanapangka J, Grogan T, Wang X, Elashoff D, Ishikawa S, Chia D, Liao W, Akin D, Yan X, Lee M, Choi R, Kim S, Kang S, Bae J, Sohn T, Lee J, Choi M, Min B, Lee J, Kim J, Kim Y, Kim S, Wong D. (2018) Development and Validation of Salivary Extracellular RNA Biomarkers for Noninvasive Detection of Gastric Cancer. Clin Chem. PMID: 30097497 DOI: 10.1373/clinchem.2018.290569", with permission from American Association for Clinical Chemistry (United States).
Access can be granted by contacting Hyo Song Kim (hyosong77@yuhs.ac).
Data access committee for the Endoresist project of panel sequencing: Professor Johan Hartman
DAC for the management of dataset own by CReATe Fertility Centre.
DAC for human glioblastoma single cell sequencing samples